盐酸米诺环素软膏在智齿冠周炎治疗中的作用

目的:比较盐酸米诺环素软膏与碘甘油在治疗智齿冠周炎中的疗效。方法:对148例急性发作的智齿冠周炎,经常规冠周冲洗后,分别采用盐酸米诺环素软膏或者碘甘油给予冠周龈袋或者盲袋上药,借以控制或缓解智齿冠周炎的症状。并据患者炎症轻重分为同时口服抗生素组,和无辅助应用抗生素组,结果进行疗效对比,统计学分析。结果:在辅助全身应用抗生素时,两种局部处理措施的疗效基本相同;但在未给予全身抗生素治疗时,盐酸米诺环素软膏的疗效明显高于碘甘油组。结论:相对碘甘油,采用盐酸米诺环素软膏进行智齿冠周炎的治疗,具有一定的优越性。     

盐酸米诺环素软膏在智齿冠周炎治疗中的疗效观察

目的探讨盐酸米诺环素软膏在智齿冠周炎治疗中的临床疗效。方法选择门诊中下颌智齿冠周炎患者200例,随机分为试验组(A组)和对照组(B组)。均常规采用过氧化氢加生理盐水冲洗后,A组冠周袋内放置盐酸米诺环素软膏;B组冠周袋内放置碘甘油。结果经1次治疗后,A组的治愈率为77%,B组为16%,2组之间差异有显著性。结论在智齿冠周炎治疗中使用盐酸米诺环素软膏,有效的改善了临床症状,缩短了疗程,减少了患者的复诊次数,获得了较好的临床疗效。     

盐酸米诺环素软膏治疗急性智齿冠周炎疗效观察

目的 观察盐酸米诺环素软膏(派丽奥软膏)治疗急性智齿冠周炎效果。方法 选取急性智齿冠周炎82例,随机分为治疗组和对照组两组。治疗组常规冠周冲洗后,将派丽奥软膏注入盲袋内;对照组局部冠周冲洗后,盲袋内置入10％碘合剂。5d后复诊评价疗效。结果 治疗组的显效率和有效率均较对照组高(P<0.01),无不良反应发生。结论 派丽奥软膏是一种治疗急性智齿冠周炎的有效的局部用药。     

盐酸米诺环素缓释膜与碘复治疗冠周炎的疗效比较

目的:对比评价盐酸米诺环素缓释膜、碘复对智齿冠周炎的临床治疗效果。方法:选择有智齿冠周炎疾病患者76例。治疗组采用盐酸米诺环素缓释膜,以碘复为对照组。对其临床疗效、细菌清除率等进行比较。结果:盐酸米诺环素缓释膜组有效率90.2%,厌氧菌清除率91.9%;碘复组有效率88.6%,厌氧菌清除率86.5%。二组间无显著性差异(P>0.05)。结论:盐酸米诺环素缓释膜治疗冠周炎与碘复等效;且使用方便,用药次数少,是一种更为理想的冠周炎用药。     

盐酸米诺环素软膏治疗急性智齿冠周炎效果观察

目的观察盐酸米诺环素软膏治疗急性智齿冠周炎临床效果。方法选取急性智齿冠周炎86例,随机分为治疗组44例和对照组42例,分别用盐酸米诺环素软膏和碘甘油进行局部治疗,对比治疗效果。结果治疗组总有效率为95.5%,对照组总有效率为71.4%,两组比较差异有统计学意义（χ2=8.49,P=0.003）,无不良反应发生。结论盐酸米诺环素软膏治疗急性智齿冠周炎的疗效满意。     

盐酸米诺环素软膏联合牛黄解毒片治疗轻症急性冠周炎的临床疗效观察

目的 观察盐酸米诺环素软膏联合牛黄解毒片治疗急性冠周炎的临床疗效。方法 选取临床就诊的240例轻症急性冠周炎患者,随机分成4组,观察组给予盐酸米诺环素软膏袋内上药和口服牛黄解毒片,对照组1给予盐酸米诺环素软膏袋内上药,对照组2给予碘甘油袋内上药和口服牛黄解毒片,对照组3给予碘甘油袋内上药和口服阿莫西林胶囊+甲硝唑片。比较4组临床疗效。结果 观察组经治疗后无不良反应,疗效优于对照组1和对照组2（P<0.01）;与对照组3相比差异无统计学意义（P>0.05）。结论 盐酸米诺环素软膏联合牛黄解毒片治疗轻症急性冠周炎疗效显著,值得临床推广应用。     

艾亚林治疗智齿冠周炎的疗效观察

目的评价艾亚林治疗智齿冠周炎的临床疗效。方法选择门诊智齿冠周炎患者196例,按临床症状不同分为不口服抗生素组(A组)和口服抗生素组(B组),2组分别采用随机单盲对照法,实验组(A1、B1)用艾亚林放于盲袋中1次,对照组(A2、B2)用碘甘油放于盲袋中,每日1次,疗程3~7d,观察艾亚林治疗智齿冠周炎的临床效果。结果A组和B组中艾亚林组与碘甘油组(A1和A2、B1和B2)疗效的优良率无显著性差异(P>0.05),在总有效率中艾亚林组与碘甘油组有差异(P<0.05),艾亚林组疗效优于碘甘油组。结论临床应用艾亚林治疗智齿冠周炎,可以有效地改善临床症状,提高治疗效果。     

盐酸米诺环素软膏与丁硼乳膏治疗急性局限型智齿冠周炎的临床观察

目的：比较盐酸米诺环素软膏（minocycline hydrochloride ointment,商品名为派丽奥）与丁硼乳膏（商品名雅皓乳膏）治疗急性局限型智齿冠周炎的疗效,并以碘甘油治疗作对照。方法：选取急性局限型智齿冠周炎276例．分为3组,局部用3％过氧化氢和生理盐水交替冲洗后擦干,采用以下方式局部给药：A组注入适量盐酸米诺环素仅1次：B组将少量丁硼乳膏停留患区5min后漱13,3次／d,共3d;C组局部置入2％碘甘油,1次／d,共3d。所有治疗组均未全身用药,第4天观察疗效。结果：A、B组症状均有明显改善,总有效率分别为94．68％和87．78％．两组间疗效无显著性差异（P〉0．05）。但A、B组的疗效均好于C组（63．04％）,P〈0．01。结论：盐酸米诺环素与丁硼乳膏治疗急性局限型智齿冠周炎均有较好疗效,其效果明显优于对照组。     

2%盐酸米诺环素软膏辅助治疗慢性牙周炎

目的观察2%盐酸米诺环素软膏治疗慢性牙周炎的临床疗效.方法选取54例慢性牙周炎患者的216颗牙采用自身对照法,随机分为2组,实验组用2%盐酸米诺环素软膏,对照组用碘甘油.观察用药前后的临床症状及牙龈指数(GI)、牙周出血指数(SBI)、牙周袋深度(PD)、牙齿松动度(MD)的变化.结果实验组与对照组疗效相比两者有显著性差异(P＜0.01).结论2%盐酸米诺环素局部用于慢性牙周炎患者,药效持续时间长,能明显改善临床症状.     

米诺环素辅助治疗急性牙周脓肿的临床效果

目的:评估米诺环素在辅助治疗急性牙周脓肿时的临床效果。方法:选择急性牙周脓肿病人65例,随机分为试验组和对照组。试验组33例,采用生理盐水5～10 mL牙周袋内冲洗和20 g/L盐酸米诺环素软膏袋内注射;对照组32例,采用生理盐水5～10 mL牙周袋内冲洗和局部上碘甘油并口服3 d抗生素。分别于基线和处理后第3天检查记录疼痛程度、脓肿大小、松动度、探诊出血、脓性渗出分数。结果:试验组和对照组疼痛程度、脓肿大小、牙松动度、探诊出血、脓性渗出分数各项指标均较治疗前明显改善(P=0.000),两组受试者治疗前后各项指标减轻程度差异无统计学意义(P>0.05)。试验组有效率87.9%,对照组有效率83.9%,二者差异无统计学意义(P>0.05)。试验组有2例在进行盐酸米诺环素牙周袋内注射时诉感疼痛;对照组有5例在服用抗生素后诉有胃肠道不适。结论:米诺环素局部使用辅助治疗急性牙周脓肿可达到传统治疗方法的疗效水平,从而减少口服抗生素的使用。     

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目的系统评价盐酸米诺环素软膏与碘甘油在治疗急性局限型智齿冠周炎中的临床疗效。方法采用计算机检索Cochrane图书馆、PubMed、万方等数据库,纳入盐酸米诺环素软膏与碘甘油治疗急性局限型智齿冠周炎的临床随机对照研究（RCT）,评价纳入研究的方法学质量后采用RevMan5．2软件进行Meta分析。结果共纳入13个研究,共1596例患者,其中盐酸米诺环素软膏组818例,碘甘油组778例。Meta分析结果显示,盐酸米诺环素软膏组的有效率显著高于碘甘油组（Re=1．25,95％CI：1．13～1．39,P〈0．0001）;第4天与第5天复诊时,盐酸米诺环素软膏组的有效率均显著高于碘甘油组（RR=1．22,95％CI：1．04～1．43,P=0．02;RR=1．30,95％CI：1．21～1.39,P〈0．00001）。结论本研究提示盐酸米诺环素软膏治疗急性局限型智齿冠周炎临床疗效优于碘甘油。     

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目的探讨拔除阻生智牙治疗大学生颞下颌关节紊乱病（temporomandibular disorders,TMD）的临床效果。方法选择2009年9月以来广东工业大学医院口腔科青年大学生TMD并智牙阻生患者136例,随机分为2组,每组68例,试验组采取心理＋药物＋局部理疗＋阻生牙拔除术等综合治疗,对照组仅采取心理＋药物＋局部理疗等保守治疗。两组完成治疗后随访观察1年,对比疗效差异。结果试验组总有效率为91.2%,对照组总有效率78.0%,两组疗效差异有统计学意义（P〈0.05）。结论拔除阻生智牙对治疗青年大学生TMD有较好的疗效,可列为青年大学生TMD系列治疗方法之一。     

Comparison of the quality of life of patients with mandibular third molars and mild pericoronitis treated by extraction or by a periodontal approach

We have evaluated and compared the outcomes after conservatively treated and surgically managed third molars in patients with mild pericoronitis at the first, third, and sixth postoperative months, and we rated patients’ quality of life (QoL) using the Oral Health Impact Profile-14 (OHIP-14) index. Of the 128 patients who were originally assessed as eligible we studied 100 patients who fulfilled the protocol, being diagnosed with mild pericoronitis that affected the third molar teeth and who were followed up for six months. Fifty were treated by the periodontal approach and 50 by extraction of third molars. Their oral health-related QoL was assessed using the OHIP-14 index on a personal assessment question form and then repeated at the first, third, and sixth months. The data were analysed using the Mann Whitney, Friedman’s, and Wilcoxon’s test, as appropriate. There was a significant difference between the total OHIP-14 scores at different time points (p < 0.0001). In both groups the three postoperative total OHIP-14 scores were significantly lower than the baseline score, and we noted a further decrease in OHIP-14 scores in the surgical treatment group. Periodontal treatment of mandibular third molar teeth may effectively reduce (but does not eliminate) symptoms, whereas tooth extraction seems to be more effective at the long term.     

盐酸米诺环素缓释剂联合Cortisomol糊剂根管充填治疗逆行性牙髓炎的中期临床评价

目的探讨盐酸米诺环素缓释剂联合Cortisomol糊剂根管充填治疗逆行性牙髓炎的中期临床评价。方法选取2015年1月至2017年1月在我院治疗的逆行性牙髓炎患者277例(277颗牙),随机数字表法分为实验组(n=139,139颗牙)和对照组(n=138,138颗牙)。对照组给予常规根管治疗,实验组给予Cortisomol糊剂根管充填治疗,并于牙周袋内注射盐酸米诺环素缓释剂,1次/周,连续治疗1个月。于治疗1个月后,统计两组的治疗效果、疼痛程度(VAS)、牙周情况[牙龈指数(GI)、牙周袋探诊深度(PD)、菌斑指数(PLI)、出血指数(BI)和牙周附着丧失(AL)]及血清炎症因子水平[白细胞介素-17(IL-17)、白细胞介素-4(IL-4)、肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)]。治疗后随访6个月,统计两组生活质量(SF-36)。结果(1)治疗1个月后,实验组治疗总有效率较对照组高(P<0.05);(2)与对照组比较,治疗1个月后实验组VAS评分较低(P<0.05);(3)与对照组比较,治疗1个月后实验组PLI、PD、BI、GI和AL水平较低(P<0.05);(4)与对照组比较,治疗1个月后实验组血清IL-4、IL-17、TNF-α和IL-8水平较低(P<0.05);(5)治疗后6个月两组SF-36评分较治疗前升高,且实验组较对照组高(P<0.05)。结论牙周袋内注射盐酸米诺环素缓释剂联合Cortisomol糊剂根管充填治疗逆行性牙髓炎,在缓解患者疼痛、改善牙周症状、提高治疗效果及生活质量等方面具有重要价值,可能与IL-4、IL-17、TNF-α和IL-8水平降低有关。     

A Comparative Study Between Bupivacaine with Adrenaline and Carbonated Bupivacaine with Adrenaline for Surgical Removal of Impacted Mandibular Third Molar

Objectives

To compare the effectiveness of bupivacaine with adrenaline with that of carbonated bupivacaine with adrenaline on pain, onset of anesthesia and duration of anesthesia following surgical removal of impacted mandibular third molar.

Study design

All the patients who underwent surgical removal of impacted mandibular third molar and who fulfilled our inclusion and exclusion criteria from 1st June 2013 to 30th June 2014 were included in our study. Patients who were diagnosed as having impacted mandibular third molar were randomly allocated to two groups namely group A (bupivacaine with adrenaline), group B (carbonated bupivacaine with adrenaline). Pain during deposition of local anesthetic, onset of anesthesia and duration of anesthesia were compared between the two groups. The collected data were subjected to statistical analysis by Chi Square test, Mann–Whitney U test.

Results and conclusion

The efficacy of carbonated bupivacaine with adrenaline is more compared with bupivacaine with adrenaline in decreasing pain on deposition of local anesthetic solution and in rapid onset of anesthesia. The duration of anesthesia for carbonated bupivacaine with adrenaline and bupivacaine with adrenaline had no significant difference. The use of carbonated bupivacaine with adrenaline will reduce the patient discomfort both intra-operatively and post-operatively.

     

全颌曲面断层片评价影响第三磨牙萌出因素的研究

目的：探讨应用全颌曲面断层片分析第三磨牙萌出影响因素与头颅侧位片评价的相关性,拓展全颌曲面断层片在121腔正畸临床中的应用。方法：选择39例（男21例,女18例）上下颌第三磨牙均存在的安氏Ⅰ类病例,同期拍摄全颌曲面断层片和头颅侧位片,分别测量11项指标,将两种方法测量结果进行相关性分析。结果：全颌曲面断层片左右两侧各指标的测量结果无统计学差异,全颌曲面断层片和头颅侧位片关于上颌第三磨牙倾斜角度、上下颌萌出间隙及下颌升支长度的指标均具有强相关性（P〈0．01）。相关系数和回归方程显示,全颌曲面断层片和头颅侧位片测量值之间呈明显的线性关系,但二者不能相互替代。结论：应用全颌曲面断层片可以替代头颅侧位片评价第三磨牙萌出的影响因素。     

浓缩生长因子联合盐酸米诺环素软膏治疗干槽症疗效研究

目的 评估浓缩生长因子(CGF)联合盐酸米诺环素软膏在缓解疼痛、控制炎症和促进拔牙窝新生肉芽组织方面治疗干槽症的有效性。方法 选择2021年3月—9月就诊于新疆医科大学附属口腔医院颌面外科门诊的40例干槽症患者,被随机分配两组,分别为：CGF联合盐酸米诺环素软膏组(A组)20例,碘仿纱条组(B组)20例,研究对比两组不同治疗干槽症方法的临床疗效。在第0、1、4、7、14和21天对患者随访检查,采用视觉模拟评分评估疼痛程度、牙龈指数评估牙龈炎症程度、肉芽组织评估拔牙窝软组织的生长程度。结果 与B组相比,A组在缓解疼痛、控制炎症和促进拔牙窝新生肉芽组织生长的效果更好,研究结果差异有统计学意义(P<0.05)。结论 CGF联合盐酸米诺环素软膏治疗干槽症的临床效果良好,值得临床借鉴。     

Effectiveness of nicotine patch for the control of pain,oedema, and trismus following third molar surgery: a randomized clinical trial

The aim of this study was to evaluate the effectiveness of a nicotine patch for the control of pain, oedema, and trismus following lower third molar surgery. A prospective, randomized, triple-blind, split-mouth trial was performed involving 20 patients who underwent two surgical procedures at different times. A patch containing 14 mg nicotine was used in the experimental group, whereas a patch without nicotine (placebo) was used in the control group. The nicotine patch was effective at controlling pain after 4 hours and 8 hours (P =  0.023 and P =  0.005, respectively). The nicotine patch also had a significant effect on the control of oedema at 24 hours (P =  0.002), 48 hours (P =  0.001), and 72 hours (P =  0.005) following the intervention. Postoperative mouth opening was significantly greater among the patients who received the nicotine patch after 72 hours and 7 days. The number of rescue analgesics required was lower (P =  0.026) and the level of satisfaction was significantly higher (P =  0.008) when the patch was used, although higher levels of nausea were found in the nicotine group (P =  0.031 at 30 minutes, P =  0.008 at 4 hours). The nicotine patch was effective at controlling pain, oedema, and trismus following third molar surgery.     

The extraction of first,second or third permanent molar teeth and its effect on the dentofacial complex

The extraction of permanent molar teeth was first introduced in 1976 as a substitution for premolar extraction in cases with mild crowding. Since then, a number of studies have investigated the effect of permanent molar extraction on dentofacial harmony. Undertaking the procedure of molar extraction is most commonly recommended in response to factors such as: gross caries, large restorations and root‐filled teeth, along with its application in the management of anterior open bite and reduction in crowding in facial regions. It has been indicated, however, that before undertaking the extraction of molar teeth it is important to investigate the potential influence of the procedure on other molars, with particular consideration of their eruption path. This is due to the doubt as to the effect of the exact molar teeth extraction and their consequences. In light of this, This review was undertaken to investigate and compare the effect of first, second and the third molar teeth extraction and their subsequent dentofacial complex changes.