血液系统恶性疾病与血清微量元素的关系探讨

将1993年至1994年6月6日收治的恶性血液疾病患者36例,与健康成人32例的血清微量元素进行测定对比,结果表明:患者的血清锰含量较健康人明显升高(P<0.01),血清锌、铁含量明显降低(P<0.01～P<0.05)。而铜、钙含量无明显差异(P>0.05)。其中,铜、锌、铁、钙含量与国内外文献报道基本一致。体内锰含量与恶性肿瘤的关系各家报道不一,本文提示:恶性血液疾病患者体内锰含量明显升高,是否与发病有关,有待进一步探讨。     

微量元素铜,锌,镉,锰与肝硬化分期和肝癌相关性研究

测定了72例早、晚期肝硬化,20例肝癌和98例正常人血清中铜、锌、镉、锰含量,经Apple-Ⅱ型计算机统计分析,结果表明:早晚期肝硬化、肝癌患者血清中铜、锌、镉、锰、铜/锌和镉/锌比与对照组均有显著差异(P<0.01),且铜、锌、锰、镉/锌比在三组病人之间也有显著差异(P<0.001)。4种元素,两个比值单因素相关分析表明血清铜与锌呈高度正相关(γ=0.684),锰与铜、锌呈高度负相关(γ=-0.3233,-0.4013)。但经多因素逐步判别分析表明只有铜、锰与肝硬化进展和癌变有相关关系。即肝癌时血清铜最高,血清锰最低。     

急性白血病与血清、尿、头发的铜、锌、锰、铬和镍关系的研究

本文对38例急性白血病患者在不同时期测定同一天血清,24小时尿及头发中的铜、锌、锰、铬和镍等含量。结果表明:血清中这5种微量元素的含量最能反映这些微量元素变化与病情变化的关系。急白发病初期有血清铜含量的升高,血清锌含量降低。急白发病初期及恶化期均有血清镍含量升高,缓解期则下降。急白在三个时期血清锰含量均降低。急白在三个时期均有铜/锌比值增大和锰/镍比值减少。结果亦表明:血清镍含量与病情变化有伴随性关系,提示测定血清镍含量可作为急白疗效观察的一个指标。微量元素镍与急性白血病的发病可能有着内在的联系。     

焦化厂职工头发中微量元素与恶性肿瘤高发的关系

本文为了探讨焦化厂职工恶性肿瘤的发病因素，对该厂进行癌死因回顾调查并以钢研所为对照。结果表明，焦化厂癌死亡２６７．１４／１０万，明显高于钢研所的３２．２９／１０万，统计学意义非常显著（Ｐ＜０．００１）。同时本文对焦化厂和钢研所部分职工头发中微量元素进行了分析。测定结果。焦化厂职工头发中锌、钙含量明显低于钢研所，差异显著，分别Ｐ＜０．０５和Ｐ＜０．０１。而焦化厂职工发样铜、铜／锌、锰含量，明显高于钢研所，差异显著，分别Ｐ＜０．０５、Ｐ＜０．０１和Ｐ＜０．００１。两组职工发镁、铁、铅相比无统计学意义Ｐ＞０．０５。同时本文对焦化厂的炼焦和非炼焦职工头发中铜、锌、铁、钙、镁、铅、铜／锌进行了比较，均无统计学差异，Ｐ＞０．０５。本研究认为焦化厂职工头发中锌、钙低，而铜、铜／锌、锰高可能是焦化厂职工恶性肿瘤高发的因素之一，还有待于进一步研究。     

肿瘤患者血清铜锌及其比值测定的意义

目的探讨恶性肿瘤患者血清铜、锌水平和铜／锌比值的应用价值。方法 本文采用美国ＰＥ公司３０３０型原子吸收分光光度计,对１２３０例恶性肿瘤患者,２１０例良性疾病患者和１００例健康成人,进行血清铜、锌水平和铜／锌比值的测定。结果 恶性肿瘤口才的血清铜水平和铜、锌比值明显高于良性疾病组和健康对照组,而血清锌低于健康对照组,有统计学意义。血清铜／锌比值对卵巢癌诊断阳性率为８１．４８％;宫颈癌为７１．０％;肝     

急性白血病患者血清微量元素谱分析

采用ＤＣＰ－ＡＥＳ检测了４０例急性白血病（初发１８例，化疗后２２例）血清中锌、铜、铁、硒、镍、钛等１５种元素含量。结果显示：初发急性白血病患者血清锌、铁、硒、镍、钛均降低，铜、钙、镁、铜／锌比值均升高。化疗达ＣＲ后，血清锌、铜、铜／锌、硒均可正常，而化疗后ＮＲ组上述元素无改变。血清钙、镍、钛化疗后ＣＲ和ＮＲ组均无改善。表明微量元素与急性白血病转归相关。     

滋养细胞肿瘤患者血清微量元素的变化

采用原子吸收光谱法检测１６例滋养细胞肿瘤患者治疗前后血清微量元素铜、锌、锰和铬的含量，结果表明，滋养细胞肿瘤患者血清铜水平和铜／锌比值均显著高于正常未孕对照组（Ｐ〈０．０１）。经手术和ＡＣＭ三联序贯化疗后，随着病情的完全缓解，血清铜水平和铜／锌比值则明显下降（Ｐ〈０．０１），我们认为血清铜水平和铜／锌比值与滋养细胞肿瘤的病情和疗效有关。     

检测妇科肿瘤患者血清铜,锌及铜／锌比值的临床意义

近年来,国内外对肿瘤患者血清微量元素进行了深入的研究。学者们曾报道,肉瘤、消化道癌、宫颈癌等恶性肿瘤患者血清铜(SCu)升高,血清锌(SZn)降低。对妇科肿瘤患者的血清铜锌报道甚少。本文采用生化法对妇科良、恶性肿瘤患者及正常女性血清SCu和SZn水平进行测定,以探讨铜/锌比值与恶性肿瘤及分期的关系。资料与方法一、观察对象我科住院的肿瘤患者95例,其中妇科恶性肿瘤26例(见表1),良性肿瘤69例,包括子宫肌瘤,卵巢瘤等。良、恶性肿瘤的确诊依据为组织学检查,恶性肿瘤的分期按临床检查和术中所见而定,正常女性36     

泌尿系统恶性肿瘤纤维蛋白原降解产物(FDP)

一般认为纤维蛋白原和纤维蛋白原降解产物(FDP)水平升高是恶性肿瘤患者止血功能异常的极为重要的参数。某些作者提出,有关泌尿系统肿瘤,尿中FDP 值可作为膀胱癌的筛选试验和随访标记。FDP 升高和肿瘤级别、活动性及局部浸润明显相关。本文研究了泌尿系恶性肿瘤血清FDP 水平以及肿瘤扩散程度。     

肺癌患者血清铜、锌离子测定的意义

[目的]通过监测血清铜、锌离子浓度及其比值的变化，为肺癌患者术后判断临床疗效及估计预后提供依据。[方法]分别对肺癌，肺部良性病变患者，健康成人及肺癌术后定期化疗者血清铜，锌离子浓度及其比值进行监测。[结果]肺癌病人血化疗的部分肺癌病人铜离子浓度降低，锌浓度升高，铜/锌比值较术前降低。[结论]血清铜，锌离子浓度及其比值的变化可作为肺癌病人判断临床疗效，估计预后的试验依据之一。     

回族血清中微量元素含量与胃癌的相关性研究

目的探讨回族血清中微量元素含量与胃癌的关系。方法采用原子吸收分光光度法对回族胃癌患者和回族非胃癌对照人群血清中锌(Zn)、铜(Cu)、铁(Fe)、镁(Mg)、钙(Ca)、锰(Mn)、镍(Ni)元素含量进行检测,并用SPSS统计软件对实验结果进行配对t检验分析。结果回族胃癌病例组血清中Cu、Cu/Zn、Mn均比对照组高,而Zn、Fe、Ca、Mg、Ni的含量低于对照组。配对t检验结果显示,血清中Cu、Zn、Cu/Zn、Ca、Mg含量差异有统计学意义(P<0.05)。结论回族胃癌的发生、发展与血清内微量元素变化密切相关。高Cu、Cu/Zn比值高以及低Zn、低Ca、低Mg是回族胃癌发生的危险因素。     

血清中微量元素铜,锌,镉,锰与恶性脑瘤关系的研究

本文使用原子吸收分光光度计测定30例恶性脑瘤、50例良性脑瘤患者手术前后血清中微量元素铜、锌、镉、锰含量,并以70例一般神经性疾病患者和98例健康人作对照组。统计结果揭示:1.恶性脑瘤组手术前血清中铜、锌、镉、锰含量显著高于术后(P<0.01),良性脑瘤组除术前血清锰低于术后,余者均显著高于术后(P<0.01),两组脑瘤手术前后铜/锌比差异均无显著性(P>0.05),2.不同病理状态血清铜和铜/锌比改变也有差别,即恶性脑瘤>良性脑瘤>一般脑疾病>健康人,而术后两组脑瘤血清铜水平下降接近正常人,可提示术前血清铜水平在鉴别脑瘤性质及区分一般脑疾病具有潜在的诊断价值;术后血清铜水平对估计恶性和良性脑瘤预后方面有重要意义。     

Some Mineral,trace Element and Heavy Metal Concentrations in Lung Cancer

Objective: We aimed to determine the relationship between some mineral, trace element and heavy metallevels in the patients of lung cancer by measuring serum levels of copper (Cu), lead (Pb), zinc (Zn), iron (Fe),cobalt (Co), cadmium (Cd), manganese (Mn), magnesium (Mg). Methods: A total of 50 lung cancer and humanhealth (30 lung cancer and 20 healthy human) were included in the study. Venous blood samples of each lungcancer were obtained, and serum Cu, Pb, Zn, Fe, Cd, Co, Mn, Mg levels were analysed by Atomic AbsorptionSpectrophotometer measurements. Results: Mg value measured in lung cancer group were lower than the controlgroup and this was statistically significant (P<0.01). Serum Cu level was significantly lower with lung cancercompared to healthy human (P<0.01). Pb level was significantly higher than those of controls (P<0.01). Theserum Zn level was significantly lower in serum of lung cancer group than controls (P<0.01). Serum Mn and Colevels were found increased in lung cancer group than controls (P<0.01). Cd value was higher in lung cancer butit was not statistically significant (p>0.01). The mean concentration of Fe in the serum of lung cancer patientswas higher than in the controls, but the difference was not significant (p>0.01). There was a positive correlationbetween Cd and Pb level, and between Mn and Fe levels in lung cancer. There was a negative correlation betweenCo and Zn levels of healthy human. There was a negative correlation between Co and Mg levels of lung cancer.Conclusions: Serum Cu, Pb, Zn, Fe, Mg, Co, Mn and Cd might be play a role in the patients of lung cancers.Zn may protective as potent lung cancer. In addition, it is suggested that low levels of zinc can induce thepathogenesis of lung cancer.     

恶性淋巴瘤患者血清锌,铜和铜锌比值测定及其临床意义

本文测定６３例恶性淋巴瘤患者的血清Ｃｕ、Ｚｎ，并以８６例正常人作对照。用国产ＧＧＸ－２型原子吸收分光光度计测定，同时平行测定牛血清标准参考物质。测定结果经统计学处理，恶性淋巴瘤患者ＳＣｕ升高，ＳＺｎ显著低于正常对照组；与对照组比较，Ｃｕ／Ｚｎ比值明显升高（Ｐ＜０．０１）。ＮＨＤ弥漫型的Ｃｕ／Ｚｎ比值明显高于结节型（Ｐ＜０．０１）。作者认为恶性淋巴瘤的发展程度与Ｃｎ、Ｚｎ的浓度有关，与Ｃｕ／Ｚｎ比值的升高密切相关。比值升高提示病情发展。所以，Ｃｎ／Ｚｎ比值对恶性淋巴瘤的疗效和予后有一定的参考价值。     

喉癌与微量元素

喉癌与微量元素关系的研究,文献报道不多。本文自1987年开始对血清Zn、Cu、Fe、Se,进行了检测,企图探索与喉癌的关未,从检测结果可以看出喉癌的发生与血清Zn、Cu、Fe、Se的含量有一定关系,可能直接参与了喉癌的发生和发展。     

血清和尿液中MMP-9水平的检测在卵巢癌诊断中的意义

  目的  探讨血清与尿液中MMP-9检测在卵巢癌诊断中的意义。  方法  选取59例卵巢癌患者(恶性组), 52例卵巢良性肿瘤患者(良性组)和40例健康体检妇女(正常对照组)为研究对象。用ELISA方法测定血清和尿液中MMP-9的水平。  结果  恶性组血清和尿液中MMP-9的水平明显高于良性组和正常对照组, 差异有统计学意义(P < 0.01)。良性组血清和尿液中MMP-9水平与正常对照组差异无统计学意义(P > 0.05)。血清与尿液中MMP-9的ROC曲线下面积分别为0.831和0.794(P < 0.01)。血清MMP-9和CA125的联合诊断达到最高的灵敏度93.5%和特异度94.8%。  结论  MMP-9可能与卵巢癌的发生和发展有关, 血清与尿液中MMP-9的检测可以用于卵巢癌的辅助诊断。      

Trace Elements,Heavy Metals and Other Biochemical Parameters in Malignant Glioma Patients

Aim: We aimed to assess relevance of mineral, trace element and heavy metal levels in patients with malignantgliomas. Methods: In this study, erythrocyte catalase (CAT), and carbonic anhydrase (CA), serum copper (Cu.),zinc (Zn), lead (Pb), iron (Fe), cadmium (Cd), cobalt (Co), manganese (Mn), and magnesium (Mg) levels weremeasured in 22 healthy humans and 22 malignant glioma patients. Metal concentrations were assessed by atomicadsorption spectrophotometry, while biochemical methods were used for CAT and CA. Results: The Cd, Fe, Mg,Mn, Pb and Zn levels were significantly elevated in the patients as a whole compared to controls(P<0.05), whileCu was decreased and Co demonstrated no change. Although mean CAT activity were significantly lowered, CAexhibited significant increase. Conclusions: The results of the current study indicate that antioxidant enzymesmay have a role in the genesis of considerable oxidative stress in patients with malignant glioma. CAT and CAseem to play particular roles in the pathophysiology of this disease.     

Altered serum levels of elements in acute leukemia cases in Turkey

Objective: The purpose of the study was to compare serum concentrations of some elements [zinc (Zn), copper (Cu), manganese (Mn), magnesium (Mg), lead (Pb), iron (Fe), cadmium (Cd) and cobalt (Co)] in acute leukemia patients with those of healthy subjects. Methods: The study group consisted of newly diagnosed acute leukemia patients and the controls were matched for socioeconomic stauts and eating habits. The elements levels in the patient group were measured before treatment with an atomic absorption spectrophotometer. The selection criteria for the patients and controls were the lack of recent blood transfusion history and taking any medication with mineral supplement. Results: The acute leukemia group composed of 42 patients and there were 40 persons in the control group. There was no difference between the age of the two groups (p=0.239). Serum levels of Zn, Mg and Mn were significantly lower with acute leukemia than in controls (p<0.001, p=0.011, p<0.001, respectively), while Cu, Pb and Cd were significantly elevated (p=0.003, p<0.001, p<0.001, respectively). There were no significant differences regarding Co and Fe (p=0.323 and p=0.508, respectively) Conclusion: In this study, we found levels of Zn, Mg and Mn to be lowered and of Cu, Pb and Cd to be elevated in patients with leukemia. Further studies are needed to clarify the role of these elements in pathogenesis of acute leukemia.