超声乳化加人工晶体植入联合瞳孔再造术治疗葡萄膜炎并发性白内障的临床观察

目的 观察超声乳化加人工晶体植入联合瞳孔再造术治疗葡萄膜炎并发性白内障的临床治疗效果.方法 对14例18眼葡萄膜炎并发性白内障的患者施行白内障超声乳化摘除加人工晶体植入联合瞳孔再造术.结果 术前18眼裸眼视力或矫正视力均≤0.4,术后1周最佳视力≥0.5者14眼,术后1个月、3个月最佳视力≥0.5者均为17眼.术后术眼瞳孔全部接近圆形或椭圆形,部分患者瞳孔直径较术前偏大,无人工晶体明显偏位.14例患者18眼均未出现葡萄膜炎复发.术后瞳孔可保持圆形或椭圆形,术后瞳孔直径2.5～4.0 mm,对光反应良好.结论 超声乳化加人工晶体植入联合瞳孔再造术治疗葡萄膜炎并发性白内障疗效显著,无严重并发症发生,可明显改善患者术后的视觉效果,提高患者术后生活质量.     

超声乳化术治疗色素膜炎并发性白内障

目的 评估色素膜炎并发性白内障超声乳化手术的疗效。方法 钝化分离瞳孔后粘连及剪除机化膜,牵拉扩张瞳孔后,采用原位碎核技术对19例（21只眼）色素膜炎并发性白内障行超声乳化,结果 术后1周矫正视力≥0.5者16只眼（76.2%）,≥0.2者18只眼（85.7%);手术并发症为虹膜损伤,角膜水肿,未见后囊膜破裂及角膜失代偿;术后19只眼（90.5%)恢复圆瞳孔;2只眼（9.5%)瞳孔不规则。结论 超声乳化术治疗色素膜炎并发性白内障,具有对虹膜损伤小,术后前房炎症反应轻,视力早期恢复等优点,值得推广应用。     

超声乳化及人工晶状体植入治疗葡萄膜炎并发白内障

目的:探讨葡萄膜炎并发性白内障的手术技巧及效果。方法:对56例(65眼)葡萄膜炎并发性白内障患者进行超声乳化白内障摘除联合人工晶体植入术的临床资料进行分析。结果:术中发现18眼前囊钙化,22眼后囊膜混浊,虹膜后粘连45眼,瞳孔瞳孔膜闭16眼;术后严重葡萄膜炎5眼;后发障15眼。术后3个月视力均有不同程度提高,矫正≥0.5者37眼;但治术后视力提高程度比常规白内障差(P<0.01)。结论:对葡萄膜炎并发性白内障患者,尽管手术复杂,只要严格掌握手术指征,把握手术时机,提高手术技巧,可以使大部分患者获得更好的视力。     

虹膜拉钩在小瞳孔白内障超声乳化吸除术中的应用

目的 :探讨小瞳孔下白内障超声乳化吸除术中应用虹膜拉钩的手术技巧、手术效果及可行性。方法 :对 3 1例 (3 1眼 )小瞳孔的白内障患者行超声乳化吸除术联合人工晶体植入术 ,术中均使用虹膜拉钩扩大瞳孔 ,术后随访 3～ 1 2月。结果 :术后 3 0眼 (96.7% )瞳孔恢复圆形 ,1眼 (3 .3 % )呈不规则圆形 ;2 9眼 (94% ) ,视力不同程度的提高 ,未出现严重并发症。结论 :小瞳孔下白内障采用虹膜拉钩手术方法 ,术后可获得良好视力和圆瞳孔 ,而无严重并发症 ,是一种较安全的手术方式。     

色素膜炎并发性白内障的手术方式与疗效分析

目的:分析色素膜炎并发白内障的手术方式与治疗效果。方法:选择我院2010年2月至2011年2月32例32只眼色素膜炎并发白内障患者采用超声乳化摘除术,本组患者为观察组;同时选择前期行小切口人工晶体植入术的32例患者作为对照组,所有患者均随访3~12个月,观察两种手术方式治疗后视力恢复情况。结果:两组患者术前视力比较差异无显著性,无统计学意义(P>0.05)。经过不同的手术方式治疗后,两组视力均较治疗前有明显提高,术前术后比较差异具有显著性,有统计学意义(P<0.05)。观察组32例患者术后3个月、6个月、12个月视力提高幅度明显高于对照组,组间比较差异具有显著性,有统计学意义(P<0.05)。结论:超声乳化摘除术治疗色素膜炎并发性白内障视力恢复好,但由于该病术后副反应较重,术后应注意控制炎症及手术时机的选择。     

虹膜后粘连性小瞳孔并发白内障的超声乳化治疗疗效观察

目的研究虹膜后粘连瞳孔异常并发白内障行超声乳化摘出人工晶状体植入术的临床疗效。方法对26例30眼虹膜后粘连小瞳孔及瞳孔闭锁并发白内障行超声乳化白内障摘出及人工晶状体植入术,虹膜后粘连患者用黏弹剂冲洗针头分离粘连,撕囊镊撕除瞳孔区机化膜。结果所有病例术后视力较术前有不同程度的提高,术后视力0.1～0.3者13眼(43.33%),0.4以上者l7眼(56.67%);其中0.8以上者6眼,所有患者瞳孔恢复至圆形或近似圆形。主要并发症为角膜水肿、前房纤维素性渗出。结论术前、术中合理的药物应用联合瞳孔区机化膜撕除,原位超声乳化可使虹膜后粘连小瞳孔并发白内障恢复良好的视力和瞳孔形态,无过多手术并发症。     

小瞳孔白内障超声乳化吸除及人工晶体植入术的临床研究

目的：探讨小瞳孔时的白内障超声乳化术的手术技巧和临床效果。方法：对23例(77眼)散瞳后小瞳孔的白内障患者采用钝性分离及非切开的牵拉法扩大瞳孔,进行连续环形撕囊和原位超声乳化并人工晶状体囊袋内植入术。结果：术后随访4～12个月,所有病例术后视力较术前有不同程度的提高,术后视力0．1～0．2者5眼．0．3～0．5者14眼;0．8以上者8眼。结论：采用钝性分离及非切开的牵拉扩大瞳孔法,可使小瞳孔的白内障完成手术并恢复良好的视力和生理性圆瞳孔或近圆瞳孔,手术并发症少。     

小切口非超声乳化白内障摘除人工晶体植入术治疗小瞳孔白内障疗效分析

目的探讨小切口非超声乳化白内障摘除人工晶体植入术治疗小瞳孔白内障的临床疗效。方法对50例（50眼）小瞳孔白内障患者,行小切口非超声乳化白内障摘除人工晶体植入术,并分析其临床疗效。结果术后瞳孔均保持圆形或椭圆形。术后视力均有不同程度的提高,最佳矫正视力〈0．05者4例,0．05～0．1者8例,0．12～0．25者20例,0．3～0．5者14例,0．8～1．0者4例。未出现严重并发症。结论小瞳孔白内障手术复杂,术中处理好小瞳孔和掌握手术技巧,小瞳孔小切口非超声乳化白内障摘除人工晶体植入术同样可取得良好的临床效果。     

小瞳孔白内障超声乳化手术36例探讨

目的探讨小瞳孔白内障超声乳化手术疗效。方法对36例（48眼）散瞳后瞳孔不足4mm或呈花瓣状,或者在手术操作中未用缩瞳剂而瞳孔缩小至4mm以下的白内障患者行白内障超声乳化手术。结果本组48眼中术后3个月矫正远视力分别为：大于等于0.537眼,小于0.511眼;术后3个月时瞳孔形状5眼瞳孔大于5.0mm,9眼3.5～5.0mm,余瞳孔保持2.5～3.5mm圆形或类圆形,未见有虹膜后粘连者。均未出现严重并发症。结论小瞳孔白内障患者根据具体病情作不同的扩瞳处理,采用超声乳化术治疗是可行的,术后仍可获得生理圆瞳孔或近圆瞳孔,获得良好视力。     

小瞳孔下超声乳化手术治疗白内障的体会

目的探讨采用透明角膜切口超声乳化白内障吸除联合折叠人工晶体植入术治疗小瞳孔白内障的临床疗效。方法对23例（26眼）小瞳孔白内障患者中通过机械性牵拉,撕除瞳孔区及瞳孔缘机化膜,放射状切开瞳孔缘,虹膜拉钩机械牵拉方式扩大瞳孔,采用透明角膜切口超声乳化白内障吸除联合折叠人工晶体植入术,术后随访1~3个月对视力、眼压、术后瞳孔情况、术后并发症进行临床观察。结果本组患者88.46%患者术后最佳矫正视力达0.1以上,术后瞳孔圆形或接近圆形,术后角膜轻度水肿3眼（占11.53%）,1周内消退,1周后虹膜不同程度后粘连2眼（占7.69%）,后发障有2眼（占7.69%）。术中撕开瞳孔区机化膜发现晶状体无混浊1例,术后患者第1日前房炎症反应较正常眼有所加重,无虹膜损伤、后囊破裂,角膜内皮失代偿及晶体核坠落入玻璃体腔等严重并发症的发生。结论采用透明角膜切口对小瞳孔下白内障患者进行超声乳化白内障吸除联合折叠人工晶体植入手术是理想的手术方式,有效地提高了患者的视力,最大限度的维持了瞳孔的生理功能,同时减少了并发症的发生。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.