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目的探讨内分泌治疗联合唑来膦酸治疗前列腺癌骨转移的应用价值。方法入选20例前列腺癌骨转移患者,给予醋酸戈舍瑞林3.6mg皮下注射,第1天,氟他胺250mg口服,2次/d,唑来膦酸4mg静脉注射,第1天,每四周为一周期,每例接受治疗3~8个周期不等。结果本组病例随访6~54周,中位40周,治疗后患者PSA明显下降、Karnofsky Score评分明显升高。18例患者骨痛缓解,中位生存期大于12个月,不良反应可耐受。结论内分泌治疗联合唑来膦酸治疗前列腺癌骨转移有较好疗效,不良反应轻。 相似文献
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王蜀梅 《中国现代药物应用》2014,(2):157-158
目的 探讨唑来膦酸治疗恶性肿瘤骨转移骨痛的临床效果.方法 回顾性分析本院收治的90例恶性肿瘤骨转移骨痛患者的临床资料,根据治疗方法不同分为治疗组和对照组各45例,对照组患者给予帕米膦酸二钠治疗,治疗组患者给予唑来膦酸治疗,比较两组患者的临床疗效.结果 治疗后治疗组患者的总有效率为91.11%,显著高于对照组患者的总有效率77.78%,P<0.05.结论 唑来膦酸治疗恶性肿瘤骨转移骨痛临床效果显著. 相似文献
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骨转移癌顽固性骨痛临床治疗 总被引:1,自引:0,他引:1
恶性肿瘤骨转移的主要临床表现为骨痛、高钙血症及骨折,严重影响患者的生活质量。我科自2 0 0 1年4月至2 0 0 3年2月使用鲑鱼降钙素(密盖息)治疗经放化疗无效的恶性肿瘤骨转移剧烈骨痛患者5 8例,并取得较满意疗效,现报告如下。1 材料和方法1 1 一般资料 本组5 8例均经病理检验,多项影像检查证实为单个部位骨转移灶6例,多个部位骨转移灶5 2例。一般状况评分(KPS)≥30分,预计生存期>2月。1 2 治疗方法 本组5 8例患者均接受密盖息治疗,第1~4天,每天肌注10 0IU ;第5~14天每天肌注5 0IU ;第15天后,隔日肌注5 0IU ,作为维持量,用药时间… 相似文献
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重组人类表皮生长因子在超声乳化白内障摘除术后的应用 总被引:2,自引:0,他引:2
目的 观察重组人类表皮生长因子 (rh EGF)滴眼液对超声乳化白内障术后泪膜的疗效。方法 随机选择两组超声乳化白内障术后患者 ,A组 (74只眼 )术后给予 rh EGF眼液 ;B组 (87只眼 )术后给予赋形剂。分别于术后第 1天、7天、15天、30天进行干眼症状、角膜荧光素染色、泪膜破裂时间 (BU T)及泪液分泌试验观察加以比较 ,并进行统计学分析。结果 术后第 7天两组患者的干眼症状、BU T、泪液分泌量及角膜荧光素着色均有好转 (P<0 .0 1) ,两组间差异无显著性 (P>0 .0 5 ) ;而术后第 15天、30天 A组各项检查结果均有反复 ,与术后第 1天比较差异无显著性 (P>0 .0 5 ) ,B组各项检查结果反复较小 ,与术后第 1天比较 ,差异有显著性 (P<0 .0 5 )。结论 rh EGF滴眼液对超声乳化白内障术后泪膜的修复有促进作用。 相似文献
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目的 探讨Tc-MDP全身骨显像联合血清前列腺特异性抗原(PSA)、血清睾酮(T)对前列腺癌(PC)骨转移的诊断价值.方法 选择2018年3月-2020年7月PC患者87例为对象,所有患者均经病理组织检查确诊,确诊前患者均行Tc-MDP全身骨显像检查;采用电化学发光法测定PSA水平,采用免疫组电化学发光仪测定T水平.比较骨转移与非骨转移患者PSA及T水平;绘制ROC曲线,分析Tc-MDP全身骨显像联合PSA及T在PC骨转移患者中的诊断效能.结果 87例PC患者病理检查骨转移68例,转移率为78.16%;Tc-MDP全身骨显像检查确诊50例,诊断准确率为83.82%(P<0.05);诊断灵敏度为80.88%,特异度为84.21%;骨转移患者PSA水平高于非骨转移者(P<0.05);骨转移患者T水平低于非骨转移者(P<0.05);ROC曲线结果表明:PSA和T在PC骨转移患者中的诊断灵敏度分别为72.49%、85.45%,特异度分别为69.31和60.22%;Tc-MDP全身骨显像联合PSA、T在PC骨转移患者中的诊断灵敏度为82.53%,特异度为94.74%,阳性预测值为98.24%,阴性预测值为60.00%.结论 Tc-MDP全身骨显像联合PSA和T用于前列腺癌骨转移患者中能获得较高的灵敏度及检出率,为临床诊疗提供可靠参考依据. 相似文献
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目的 评价唑来膦酸治疗恶性肿瘤引起骨转移疼痛的有效性和安全性.方法 22例恶性肿瘤骨转移性疼痛的患者每次给予唑来膦酸注射用4 mg,加入0.9%氯化钠注射液100 ml中,静脉滴注15 min以上, 每4周1次,至少连续2次以上.结果 治疗骨转移灶止痛效果:完全缓解(1/22)4.5%,明显缓解(5/22)22.7%,中度缓解(10/22)45.5%,轻度缓解(6/22)27.3%,中位起效缓解时间第2天,中位缓解持续时间26 d.主要不良反应为发热,消化道反应,流感样症状,低血磷及低血钙,但反应轻,不需特殊处理.结论 唑来膦酸治疗恶性肿瘤骨转移有明显镇痛效果,药效维持时间长,不良反应轻,患者易接受. 相似文献
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目的 探讨99 mTc-MDP(99 m锝-亚甲基二膦酸盐)全身骨显像对骨转移瘤的诊断价值.方法 常规采用99 mTC-MDP为显像剂,对临床诊断为肺癌、乳腺癌、前列腺癌的230例患者进行核素全身骨显像.结果 230例癌症患者核素骨显像示骨转移者136例,阳性率58.3%,其中肺癌100例,骨转移68例,阳性率68%;乳腺癌100例,骨转移49例,阳性率49%;前列腺癌30例,骨转移19例,阳性率63%.结论 肺、乳腺、前列腺癌患者核素骨显像对病程分期、治疗方案选择及预后评估均有重要的临床参考价值. 相似文献
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Eye drops made of aloe are a sterile, aqueous extract of fresh leaves of Aloe arborescens Mill., containing necessary additives and neomycin sulphate. The aim of the studies was to establish the technology of eye drops containing biologically active aloe substances and those containing both chemical constituents of aloe and neomycin sulphate. Within the studies, the formulary content and the way of preparing eye drops were determined, criteria were defined and methods of qualitative assessment of drops were proposed. On the basis of the proposed analytical methods, the physicochemical and microbiological stability of the eye drops stored at a temperature of 20-25 degrees C was studied. As the criteria of qualitative assessment of the eye drops, the following analyses were considered: sterility, appearance of the eye drops (clarity), pH, osmotic pressure, density, viscosity, TLC analysis, content of aloenin and aloin, studies of anti-microbial activity of neomycin in the drops, and preservative efficiency of thiomersal in the eye drops. The studies showed that the additives such as: sodium chloride, benzalkonium chloride, chlorhexidine diacetate and digluconate, phenylmercuric borate and Nipagins M and P could not be used to prepare the eye drops because they were involved in pharmaceutical interactions with chemical constituents of aloe in the eye drops. The eye drops containing: aqueous extract of fresh leaves of aloe, boric acid, thiomersal, sodium pyrosulphite, disodium EDTA, beta-phenylethyl alcohol and neomycin sulphate, both freshly prepared and after two years of storage, met the requirements of the Polish Pharmacopoeia (PPh V) mentioned in the monograph Guttae ophthalmicae. They were sterile, clear, their osmotic pressure approximated the osmotic pressure of lacrimal fluid and they were characterized by appropriate pH. Aloenin in the drops was much more stable than aloin. Neomycin after two years of storage retained almost 98% of its starting antimicrobial activity which allows the conclusion that the biologically active aloe substances did not decrease the stability of neomycin in the drops. The preservation assay showed that thiomersal, both in the freshly prepared drops and after two years of storage, maintained antimicrobial activity, which was in accordance with PPh V. 相似文献
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《International journal of pharmaceutics》1991,75(1):R1-R4
The safety of ocularly applied timolol can be increased by administering the drug in polymer matrices instead of eye drops. This study shows that addition of sodium acetate to the monoisopropyl PVM-MA matrices improves the aqueous humor/plasma concentration ratio of timolol about 20-fold as compared to the matrices buffered with disodium phosphate. Thus, sodium acetate seems to decrease specifically the systemic but not the ocular absorption of timolol. 相似文献
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目的了解某三甲医院耳鼻喉科门诊诊断为中耳炎单病种患者治疗药物的使用情况,为医院开展药物利用研究工作、临床合理用药提供参考。方法随机抽查该院耳鼻喉科2013年3~10月间诊断为中耳炎门诊处方的药物使用情况,采用排序和应用频度分析方法进行统计分析。结果用药频度排序前10的药物依次为利福平滴眼液、桉柠蒎肠溶软胶囊、氨溴索片、氧氟沙星滴眼液、氟替卡松鼻喷雾剂、糠酸莫米松鼻喷雾剂、标准桃金娘油肠溶胶囊、布地奈德鼻喷雾剂、枸地氯雷他定片、比拜克胶囊。结论该院耳鼻喉科门诊治疗中耳炎使用药物合理。 相似文献
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A.S. Manjappa Basavaraj K. Nanjwade F.V. Manvi R.S.R. Murthy 《Drug development research》2009,70(6):417-424
Most ocular diseases are treated with topical eye drops. The poor bioavailability and therapeutic response exhibited by these conventional eye drops due to rapid precorneal elimination of the drug may be overcome by the use of in situ gelling systems that are instilled as drops into the eye and undergo a sol‐to‐gel transition in the cul‐de‐sac. The present work describes the formulation and evaluation of an ophthalmic delivery system of the nonsteroidal anti‐inflammatory drug (NSAID), ketorolac tromethamine, based on the concept of pH‐triggered in situ gelation. Polyacrylic acid (Carbopol® 934) was used as the gelling agent in combination with hydroxypropylmethylcellulose (Methocel E15LV), which acted as a viscosity enhancer. The prepared formulations were characterized for clarity, pH, drug content, rheology, and in vivo drug release. Clarity, pH, and drug content of the developed formulations were found to be satisfactory. The developed formulation showed pseudo‐plastic rheology. The formulation with benzalkonium chloride and edetate disodium improved the rate of corneal absorption but not the extent. The developed formulation is a viable alternative to conventional eye drops by virtue of its ability to enhance bioavailability through its longer precorneal residence time and ability to sustain drug release. Also importantly is the ease of instillation afforded and decreased frequency of instillation resulting in better patient acceptance. Drug Dev Res, 2009. © 2009 Wiley‐Liss, Inc. 相似文献
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目的:探讨无防腐剂的磺胺醋酰钠滴眼液和氧氟沙星滴眼液的可行性。方法配制不含防腐剂的磺胺醋酰钠滴眼液、氧氟沙星滴眼液,依据《中国药典》进行微生物限度检查。结果不含防腐剂的磺胺醋酰钠滴眼液、氧氟沙星滴眼液的微生物限度检查结果符合《中国药典》规定。结论无防腐剂的磺胺醋酰钠滴眼液、氧氟沙星滴眼液是可行的。 相似文献
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目的:调查研究汕头市公众眼药水认知情况及使用行为,为开展相关健康教育提供参考。方法:在居民小区、公园、广场和医院候诊室等处随机进行问卷调查,用Epi-data 3.0建立数据库,用Excel和SPSS 18.0软件进行处理分析,计数资料组间比较采用R×C χ2检验。结果:受访者单次单眼使用剂量为1~3滴,联合用药间隔为1~30 min,滴眼药水后带回隐形眼镜的时间间隔为5~60 min,62.6%的受访者认为使用眼药水会产生不良反应,61.1%的受访者认为眼药水中的防腐剂会危害使用者的健康,42.4%的受访者会在使用前检查眼药水是否异常,43.6%的受访者会在使用眼药水前洗手,71.2%的受访者会在使用眼药水前阅读说明书,21.4%的受访者滴眼药水时瓶口会碰到他处且有20.6%的受访者表示不介意瓶口是否碰到他处,37.7%的受访者患眼和健康眼一起滴眼药水,75.9%的受访者用纸巾擦拭溢出的眼药水,62.6%的受访者在使用眼药水出现不适时会停止使用眼药水,61.9%的受访者将眼药水贮藏在阴凉处,47.5%的受访者开封后的眼药水贮藏时间超过3个月。结论:专业机构和媒介应加强眼药水知识的宣传教育。 相似文献
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玻璃酸钠在氯霉素滴眼液中的作用 总被引:1,自引:1,他引:1
目的研究玻璃酸钠(SH)在氯霉素滴眼液中所起的作用。方法采用对比实验法,测定氯霉素滴眼液和含SH的氯霉素滴眼液的运动黏度。给家兔的2只眼结膜囊内分别滴入氯霉素滴眼液和含SH的氯霉素滴眼液各50μL,采集泪液测定药物浓度,对2种滴眼液做家兔眼刺激实验。结果含SH的氯霉素滴眼液比氯霉素滴眼液的运动黏度大,对眼部不引起刺激性,可以延长药物在泪液中的滞留时间。结论SH能增加氯霉素滴眼液的黏度,延长药物在泪液中的滞留时间,提高药物疗效。 相似文献
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盐酸环喷托酯与托吡卡胺和阿托品的临床疗效比较 总被引:2,自引:0,他引:2
目的:观察盐酸环喷托酯、托吡卡胺、硫酸阿托品3种眼用制剂局部点眼后的疗效及不良反应(ADR)。方法:对600例弱视儿童患者按就诊顺序分为3组,每组200例,分别使用1%托吡卡胺滴眼液、1%硫酸阿托品眼用凝胶、1%盐酸环喷托酯滴眼液,观察3组散瞳效果,记录检影结果及患者发生眼部及全身ADR情况。结果:托吡卡胺组眼部及全身ADR均低于硫酸阿托品组及盐酸环喷托酯组(P<0.05),但睫状肌麻痹效果不够充分;盐酸环喷托酯组眼局部及全身ADR均低于硫酸阿托品组(P<0.05),睫状肌麻痹效果与阿托品相当。结论:盐酸环喷托酯睫状肌麻痹完全,散瞳效果好,起效快,持续时间短,ADR低。 相似文献