Intracranial contrast-enhanced magnetic resonance venography with 6.4-fold sensitivity encoding at 1.5 and 3.0 Tesla

PURPOSE: To prospectively compare vessel conspicuity and diagnostic image quality between three-dimensional intracranial contrast-enhanced MR venography acquired at 1.5 Tesla (T) and 3.0T, with 6.4-fold sensitivity encoding. MATERIALS AND METHODS: Ten healthy volunteers were imaged on 1.5T and 3.0T MR scanners using eight-element head coil arrays. The intracranial venous vasculature was divided into five groups for evaluation based on vessel size and anatomical location. Two radiologists independently assessed vessel conspicuity, level of artifacts, and diagnostic image quality. Informed consent was obtained, and the study was approved by the institutional review board. RESULTS: With the exception of large cerebral sinuses where 1.5T and 3.0T results were rated as equivalent, 3.0T images demonstrated superior vessel continuity, sharpness, and signal contrast to background tissue than 1.5T for all other intracranial venous vasculature (P < 0.01). No statistical significance in overall image quality was found between 1.5T and 3.0T venograms, and all data sets were deemed sufficient for diagnostic interpretation. CONCLUSION: Whole brain contrast-enhanced venography with 6.4-fold sensitivity encoding is robust and has the potential to become the method of choice for fast visualization of the intracranial venous vasculature. At 3.0T, demonstration of small cerebral vessels is superior to 1.5T.     

Contrast-enhanced first-pass myocardial perfusion magnetic resonance imaging with parallel acquisition at 3.0 Tesla

OBJECTIVE: Magnetic resonance imaging (MRI) at 3 T is significantly different than 1.5 T and needs to be optimized due to increased signal-to-noise ratio (SNR) and specific absorption ratio (SAR). This study tests the hypothesis that first-pass myocardial perfusion MRI using saturation recovery (SR)-TrueFISP with parallel imaging is superior to SR-TurboFLASH and a more achievable technique for clinical application at 3 T. MATERIALS AND METHODS: Myocardial perfusion imaging was performed on 12 subjects using SR-TurboFLASH and SR-TrueFISP sequences combined with parallel imaging. Four myocardial slices were acquired and evaluated by image segmentation. Quality of the measurements was determined from SNR, contrast-to-noise ratio (CNR), enhancement-to-noise ratio (ENR), and myocardial perfusion upslope. Data were analyzed using a 2-way ANOVA with imaging method and segment number as the independent variables. RESULTS: SNR, CNR, ENR, and upslope were significantly higher for SR-TrueFISP versus SR-TurboFLASH (P < 0.001). Significant differences in SNR, CNR, ENR, and upslope were found among the myocardial segments (P < 0.005). CONCLUSIONS: Optimized SR-TrueFISP first-pass myocardial perfusion MRI at 3 T has superior image quality compared with SR-TurboFLASH, independent of the myocardial segment analyzed. However, coil sensitivity nonuniformities and dielectric resonance effects cause signal intensity differences between myocardial segments that must be accounted for when interpreting 3 T perfusion studies.     

Cardiac magnetic resonance parallel imaging at 3.0 Tesla: technical feasibility and advantages

PURPOSE: To quantify changes in signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), specific absorption rate (SAR), RF power deposition, and imaging time in cardiac magnetic resonance imaging with and without the application of parallel imaging at 1.5 T and 3.0 T. MATERIALS AND METHODS: Phantom and volunteer data were acquired at 1.5 T and 3.0 T with and without parallel imaging. RESULTS: Doubling field strength increased phantom SNR by a factor of 1.83. In volunteer data, SNR and CNR values increased by factors of 1.86 and 1.35, respectively. Parallel imaging (reduction factor = 2) decreased phantom SNR by a factor of 1.84 and 2.07 when compared to the full acquisition at 1.5 T and 3.0 T, respectively. In volunteers, SNR and CNR decreased by factors of 2.65 and 2.05 at 1.5 T and 1.99 and 1.75 at 3.0 T, respectively. Doubling the field strength produces a nine-fold increase in SAR (0.0751 to 0.674 W/kg). Parallel imaging reduced the total RF power deposition by a factor of two at both field strengths. CONCLUSIONS: Parallel imaging decreases total scan time at the expense of SNR and CNR. These losses are compensated at higher field strengths. Parallel imaging is effective at reducing total power deposition by reducing total scan time.     

High-resolution magnetic resonance angiography of the renal arteries using parallel imaging acquisition techniques at 3.0 T: initial experience

OBJECTIVE: The purpose of this prospective study was to investigate the feasibility of high-resolution magnetic resonance angiography (MRA) of the kidneys at 3.0 T using parallel data acquisition. MATERIAL AND METHODS: Contrast-enhanced MRA of the renal arteries (RA) was performed in 12 volunteers and 12 consecutive patients (mean age 47.1 +/- 16.3 years) on a 3.0 T MR scanner. For CEMRA, a high-resolution 3-dimensional GRE FLASH sequence was implemented. Images were assessed subjectively on a 0 to 5 scoring scale by 2 reviewers. Quantitative evaluation was done by measuring the contrast-to-noise ratio (CNR) and signal-to-noise ratio (SNR). RESULTS: Diagnostic image quality was acquired in all individuals. In total, 62 RA were found, consisting of 48 main and 14 accessory RA. Overall visibility score for main RA was 4.82 +/- 0.38. RA were identified up to the third-order branches in 88%. In 3 of 12 patients, a hemodynamic relevant stenosis was found and proven by conventional angiogram. CONCLUSION: CEMRA at 3.0 T is advantageous in terms of better SNR and T1 weighting; therefore, measurement time can be reduced and spatial resolution can be increased without corruption of signal yield. Consequently, high-field MRA may be preferred for the evaluation of renal vascular anatomy in potential kidney donors or for the detection of renal artery stenosis.     

Whole-body magnetic resonance angiography at 3.0 Tesla

The quality of magnetic resonance (MR) angiography could be substantially improved over the past several years based on the introduction and application of parallel imaging, new sequence techniques, such as, e.g., centric k-space trajectories, dedicated contrast agents, and clinical high-field scanners. All of these techniques have played an important role to improve image resolution or decrease acquisition time for the dedicated examination of a single vascular territory. However, whole-body MR angiography may be the application with the potential to profit most from these technical advances. The present review article describes the technical innovations with a focus on parallel imaging at high field strength and the impact on whole-body MR angiography. The clinical value of advanced whole-body MR angiography techniques is illustrated by characteristic cases.     

Assessment of myocardial viability using delayed enhancement magnetic resonance imaging at 3.0 Tesla

OBJECTIVE: Cardiac magnetic resonance imaging (MRI) at 3.0 T has recently become available and potentially provides a significant improvement of tissue contrast in T1-weighted imaging techniques relying on Gd-based contrast enhancement. Imaging at high-field strength may be especially advantageous for methods relying on strong T1-weighting and imaging after contrast material administration. The aim of this study was to compare cardiac delayed enhancement (DE) MRI at 3.0 T and 1.5 T with respect to image quality, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) between infarcted and normal myocardium. MATERIALS AND METHODS: Forty consecutive patients with history of myocardial infarction were examined at 3.0 T (n = 20) or at 1.5 T (n = 20). Myocardial function was assessed using cine steady-state-free-precession (SSFP) sequences (TR 3.1 milliseconds, TE 1.6 milliseconds, flip angle 70 degrees , and a matrix of 168 x 256 at 1.5 T and TR 3.4 milliseconds, TE 1.7 milliseconds, flip angle 50 degrees and a matrix of 168 x 256 at 3.0 T), acquired in long- and short-axes views. DE images were obtained 15 minutes after the administration of 0.15 mmol of Gd-DTPA/kg body weight using a segmented inversion recovery prepared gradient echo sequence at 1.5 T (TR 9.6 milliseconds, TE 4.4 milliseconds, flip angle 25 degrees , matrix 160 x 256, bandwidth 140 Hertz/pixel) and at 3.0 T (TR 9.8 milliseconds, TE 4.3 milliseconds, flip angle 30 degrees , matrix 150 x 256, bandwidth 140 Hertz/pixel). For image analysis, standardized SNR and CNR measurements were performed in infarcted and remote myocardial regions. Two independent observers rated image quality on a 4-point scale (0 = poor image quality, 1 = sufficient image quality, 2 = good image quality, 3 = excellent image quality). RESULTS: High diagnostic image quality was obtained in all patients. Rating of mean image quality was 2.2 +/- 0.8 at 1.5 T and 2.5 +/- 0.6 at 3.0 T (P = 0.012) for observer 1 and 2.2 +/- 0.7 at 1.5 T and 2.6 +/- 0.6 at 3.0 T (P = 0.003) for observer 2, respectively. Interobserver agreement was good (kappa = 0.68 at 1.5 T and 0.78 at 3.0 T). SNR measurements yielded a mean SNR of 37.8 +/- 13.9/22.9 +/- 6.0 in infarcted myocardium (P < 0.001) and 5.6 +/- 2.2/5.9 +/- 2.4 in normal myocardium (P = 0.45) at 3.0 T/1.5 T, respectively. CNR measurements revealed mean values of 32.4 +/- 13.0/16.7 +/- 5.4 (P< 0.001) at 3.0 T/1.5 T, respectively. CONCLUSIONS: Delayed enhancement MRI at 3.0 T is feasible and provides superior image quality compared with 1.5 T. Furthermore, using identical contrast doses, increased SNR and CNR values were recorded at 3.0 T.     

脊柱转移瘤的3．0T氢质子磁共振波谱初步观察与分析

目的：初步探讨3．0T脊柱转移瘤氢质子磁共振波谱（^1H-MRS）特点。方法：前瞻性分析23例经临床证实的脊柱转移瘤的^1H-MILS的变化,同时以25例健康组椎体的^1H-MRS作对照,定量分析感兴趣椎体的脂峰与水峰的比率（LWR）及脂肪百分含量（FF％）,并作两组统计学分析。结果：脊柱转移瘤病变椎体MRS脂峰明显降低,水峰略增高,转移瘤组平均LWR为（0．039±0．025）,平均FF％为（3．66±8．66％）,对照组椎体平均LWR为（0．64±0．20）,平均FF％为（37．91±8．66％）,转移瘤组LWR和FF％明显低于正常对照组（t=14．7,P〈0．01和t=19．1,P〈0．01）。结论：脊柱转移瘤^1H-MRS示LWR及FF％值明显降低,与健康对照组比较具有显著性差异,^1H-MRS可以量化的方式分析病变椎体代谢物的变化。     

High-resolution three-dimensional contrast-enhanced blood oxygenation level-dependent magnetic resonance venography of brain tumors at 3 Tesla: first clinical experience and comparison with 1.5 Tesla

RATIONALE AND OBJECTIVES: To evaluate the clinical potential of high-resolution 3D contrast-enhanced blood oxygenation level-dependent MR-Venography (CE-MRV) for primary brain tumors and metastases at 3 Tesla (T) in comparison to 1.5 T. METHODS: Eighteen patients with brain tumors were examined using CE-MRV after application of a standard dose of MRI contrast agent (0.1 mmol/kg gadodiamide). CE-MRV is based on a high-resolution 3D flow-compensated gradient-echo sequence with long echo times that uses the contrast-enhanced blood oxygenation level-dependent effect. This technique was performed using the same volume coverage and acquisition time at both field strengths after performing standard imaging sequences. RESULTS: The higher spatial resolution of CE-MRV at 3 T showed more details within and around tumors than at 1.5 T. Visibility was enhanced by stronger susceptibility weighting and higher intrinsic signal-to-noise at 3 T. Compared with standard imaging protocols, additional information characterized as tubular and nontubular hypointense structures were found within or around lesions on CE-MRV images. CONCLUSIONS: Acquisition of CE-MRV data at 3 T enables spatial resolution to be increased within the same measurement time and with the same volume coverage compared with 1.5 T, thus providing more detailed information. The method may also show the potential to estimate oxygen supply of tumors, especially at high field strengths.     

Renal magnetic resonance angiography at 3.0 Tesla using a 32-element phased-array coil system and parallel imaging in 2 directions

PURPOSE: The aim of the present study was to assess the feasibility of renal magnetic resonance angiography at 3.0 T using a phased-array coil system with 32-coil elements. Specifically, high parallel imaging factors were used for an increased spatial resolution and anatomic coverage of the whole abdomen. MATERIALS AND METHODS: Signal-to-noise values and the g-factor distribution of the 32 element coil were examined in phantom studies for the magnetic resonance angiography (MRA) sequence. Eleven volunteers (6 men, median age of 30.0 years) were examined on a 3.0-T MR scanner (Magnetom Trio, Siemens Medical Solutions, Malvern, PA) using a 32-element phased-array coil (prototype from In vivo Corp.). Contrast-enhanced 3D-MRA (TR 2.95 milliseconds, TE 1.12 milliseconds, flip angle 25-30 degrees , bandwidth 650 Hz/pixel) was acquired with integrated generalized autocalibrating partially parallel acquisition (GRAPPA), in both phase- and slice-encoding direction. Images were assessed by 2 independent observers with regard to image quality, noise and presence of artifacts. RESULTS: Signal-to-noise levels of 22.2 +/- 22.0 and 57.9 +/- 49.0 were measured with (GRAPPAx6) and without parallel-imaging, respectively. The mean g-factor of the 32-element coil for GRAPPA with an acceleration of 3 and 2 in the phase-encoding and slice-encoding direction, respectively, was 1.61. High image quality was found in 9 of 11 volunteers (2.6 +/- 0.8) with good overall interobserver agreement (k = 0.87). Relatively low image quality with higher noise levels were encountered in 2 volunteers. CONCLUSION: MRA at 3.0 T using a 32-element phased-array coil is feasible in healthy volunteers. High diagnostic image quality and extended anatomic coverage could be achieved with application of high parallel imaging factors.     

Hyperpolarized 3He magnetic resonance imaging of ventilation defects in healthy elderly volunteers: initial findings at 3.0 Tesla

RATIONALE AND OBJECTIVES: Hyperpolarized (3)He magnetic resonance imaging ventilation defects have been observed in subjects with respiratory disorders. We quantified (3)He ventilation defects in elderly and middle-aged subjects who had no history of smoking, respiratory, or cardiovascular disorders. MATERIALS AND METHODS: Hyperpolarized (3)He magnetic resonance imaging ventilation defect volume (VDV) and ventilation defect score (VDS) were assessed in eight elderly healthy volunteers (mean 67+/-6 years) scanned twice within 7+/-2 minutes and again 7+/-2 days later. A younger cohort of 24 subjects (mean 44+/-10 years) was also scanned for direct comparison. Four observers blinded to scan timepoint and subject identity scored VDS and manually segmented VDV in all center coronal slices. RESULTS: Center coronal slice ventilation defects were observed in six of eight elderly subjects (ages 63-74 years, 5 males) in all scans acquired and in no middle-aged subjects. At the scan timepoint, mean VDS was 2.7 (mean VDV 52+/-34 cm(3)), whereas for same-day rescan, mean VDS was 2.5 (mean VDV 53+/-35 cm(3)) and at 7-day rescan, mean VDS was 3.6 (mean VDV 48+/-39 cm(3)). Interscan coefficients of variation (COV) for mean VDV was 1.8% (same-day rescan) and 5.3% (7-day rescan) and interobserver COV ranged from 10-12%. CONCLUSION: Elderly subjects have ventilation defects that are reproducible in same-day scanning and 7-day scanning visits. The observation of reproducible pulmonary ventilation defects in otherwise healthy elderly volunteers suggests caution must be used in interpreting results from (3)He studies of elderly subjects.     

Anatomical study of the occipital sinus using contrast-enhanced magnetic resonance venography

The frequency and anatomical features of the occipital sinus (OS) were analyzed in this study by contrast-enhanced magnetic resonance venography (MRV) with enhanced fast gradient echo three-dimensional (EFGRE3D) and we discuss the clinical usefulness of this method. The study included 555 patients who underwent contrast-enhanced MRV with EFGRE3D, and maximum intensity projection (MIP), multiplanar reformation (MPR) and multiprojection volume reconstruction (MPVR) images were obtained for the regions of interest. The frequency, size and communication of the OS with other vessels were assessed. The OS was identified in 209 of the 555 patients (37.7%). There were no statistically significant sex-related differences. The OS was observed less frequently in subjects younger than 50 years. Cranially and/or caudally, some OS were separated and communicated with multiple vessels. In five patients, the straight sinus (StS) communicated directly with the OS and not with the other sinuses; in two patients, the StS communicated with veins other than the OS only via small anastomotic veins. Many morphological differences in the OS can be seen. In addition, some OS function as the main drainage route of the intracranial veins instead of the transverse sinus or sigmoid sinus. In addition to MIP, detailed examination by MPR and MPVR is required for the preoperative evaluation of posterior cranial fossa lesions.     

Supraaortic arteries: contrast-enhanced MR angiography at 3.0 T--highly accelerated parallel acquisition for improved spatial resolution over an extended field of view

PURPOSE: To prospectively use 3.0-T breath-hold high-spatial-resolution contrast material-enhanced magnetic resonance (MR) angiography with highly accelerated parallel acquisition to image the supraaortic arteries of patients suspected of having arterial occlusive disease. MATERIALS AND METHODS: Institutional review board approval and written informed consent were obtained for this HIPAA-compliant study. Eighty patients (44 men, 36 women; age range, 44-90 years) underwent contrast-enhanced MR angiography of the head and neck at 3.0 T with an eight-channel neurovascular array coil. By applying a generalized autocalibrating partially parallel acquisition algorithm with an acceleration factor of four, high-spatial-resolution (0.7 x 0.7 x 0.9 mm = 0.44-mm(3) voxels) three-dimensional contrast-enhanced MR angiography was performed during a 20-second breath hold. Two neuroradiologists evaluated vascular image quality and arterial stenoses. Interobserver variability was tested with the kappa coefficient. Quantitation of stenosis at MR angiography was compared with that at digital subtraction angiography (DSA) (n = 13) and computed tomographic (CT) angiography (n = 12) with Spearman rank correlation coefficient (R(s)). RESULTS: Arterial stenoses were detected with contrast-enhanced MR angiography in 208 (reader 1) and 218 (reader 2) segments, with excellent interobserver agreement (kappa = 0.80). There was a significant correlation between contrast-enhanced MR angiography and CT angiography (R(s) = 0.95, reader 1; R(s) = 0.87, reader 2) and between contrast-enhanced MR angiography and DSA (R(s) = 0.94, reader 1; R(s) = 0.92, reader 2) for the degree of stenosis. Sensitivity and specificity of contrast-enhanced MR angiography for detection of arterial stenoses greater than 50% were 94% and 98% for reader 1 and 100% and 98% for reader 2, with DSA as the standard of reference. Vascular image quality was sufficient for diagnosis or excellent for 97% of arterial segments evaluated. CONCLUSION: By using highly accelerated parallel acquisition, the described 3.0-T contrast-enhanced MR angiographic protocol enabled visualization and characterization of the majority of supraaortic arteries, with diagnostic or excellent image quality (97% of arterial segments) and diagnostic values comparable with those obtained by using CT angiography and DSA for detection of arterial stenoses.     

Time-resolved contrast enhanced magnetic resonance angiography of the head and neck at 3.0 tesla: initial results

OBJECTIVES: We sought to implement and evaluate a high-performance, extended field of view protocol for time-resolved contrast-enhanced magnetic resonance imaging (CEMRA) of the carotid circulation by using a dedicated neurovascular (NV) array coil. MATERIALS AND METHODS: A total of 16 adult volunteers and 20 clinical patients with suspected cerebrovascular disease (15 male, 21 female, 25-82 years of age) were scanned with a fast 3D MRA sequence (TR/TE: 2.16/1 milliseconds, sampling BW: 1090 Hz/pixel), with echo-sharing and parallel acquisition. All studies were performed on a 3.0 T MR system using an 8-channel neurovascular array coil. After injection of 6 mL of gadodiamide at 3 mL/s, a coronal 3D data set with in-plane resolution of 1 x 1.3 was implemented for 10 consecutive measurements each 1.8 seconds apart. The subjects subsequently underwent high spatial-resolution (in-plane: 0.8 x 0.9) CEMRA for comparative analysis. The quality of segmental arterial anatomy and the presence and degree of the arterial stenosis were evaluated by 2 neuroradiologists. The interobserver variability was tested by kappa statistics and comparative analysis between the TR-CEMRA and high spatial-resolution CEMRA was evaluated by mean of the Spearman rank correlation coefficient. RESULTS: Craniocervical arteries were visualized with good image quality and definition in the diagnostic range. Occlusive disease was detected in 42 (reader A) and 44 (reader B) arterial segments with excellent interobserver agreement (kappa =0.89; 95% confidence interval 0.82-0.96). There was a significant correlation between the TR-CEMRA and high spatial-resolution CEMRA (Rs = 0.91 and 0.93, for readers A and B, respectively) for the degree of stenosis. Three aneurysms, 3 AVMs, 1 AV-fistula, and 2 subclavian steals were detected by both observers and were confirmed by correlative imaging. CONCLUSION: Time-resolved CEMRA at 3.0 T is reliable and versatile, providing 3-dimensional time-resolved data sets with high spatial (in plane: 1.3 x 1 mm2) and temporal (1.8 seconds) resolution over a large field of view. The higher signal-to-noise ratio gain at 3.0 T can be used effectively to improve performance of fast imaging and to support aggressive parallel acquisition protocols, as in the present study. Further clinical studies are required to establish the range of applications and the accuracy of the technique.     

Comprehensive cardiac magnetic resonance imaging at 3.0 Tesla: feasibility and implications for clinical applications

OBJECTIVE: The objective of this study was to examine the applicability of high magnetic field strengths for comprehensive functional and structural cardiac magnetic resonance imaging (MRI). SUBJECTS AND METHODS: Eighteen subjects underwent comprehensive cardiac MRI at 1.5 T and 3.0 T. The following imaging techniques were implemented: double and triple inversion prepared FSE for anatomic imaging, 4 different sets of echocardiographic-gated CINE strategies for functional and flow imaging, inversion prepared gradient echo for delayed enhancement imaging, T1-weighted segmented EPI for perfusion imaging and 2-dimensional (2-D) spiral, and volumetric SSFP for coronary artery imaging. RESULTS:: Use of 3 Tesla as opposed to 1.5 Tesla provided substantial baseline signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) improvements for anatomic (T1-weighted double IR: DeltaSNR = 29%, DeltaCNR = 20%, T2-weighted double IR: DeltaSNR = 39%, DeltaCNR = 33%, triple IR: DeltaSNR = 74%, DeltaCNR = 60%), functional (conventional CINE: DeltaSNR = 123%, DeltaCNR = 74%, accelerated CINE: DeltaSNR = 161%, DeltaCNR = 86%), myocardial tagging (DeltaSNRsystole = 54%, DeltaCNRsystole = 176%), phase contrast flow measurements (DeltaSNR = 79%), viability (DeltaSNR = 48%, DeltaCNR = 40%), perfusion (DeltaSNR = 109%, DeltaCNR = 87%), and breathhold coronary imaging (2-D spiral: DeltaSNRRCA = 54%, DeltaCNRRCA = 69%, 3-D SSFP: DeltaSNRRCA = 60%, DeltaCNRRCA = 126%), but also revealed image quality issues, which were successfully tackled by adiabatic radiofrequency pulses and parallel imaging. CONCLUSIONS: Cardiac MRI at 3.0 T is feasible for the comprehensive assessment of cardiac morphology and function, although SAR limitations and susceptibility effects remain a concern. The need for speed together with the SNR benefit at 3.0 T will motivate further advances in routine cardiac MRI while providing an image-quality advantage over imaging at 1.5 Tesla.     

3.0T高场MR全心冠状动脉成像的初步研究

冠心病(CAD)是当今人类首要的致死病因之一.常规的X线冠状动脉造影(CAG)是目前检测CAD的金标准.但是,常规CAG是一种有创且昂贵的检查方法,存在有发生严重并发症的可能[1],而这些检查中仅有1/3患者需要联合进行介入治疗.因此,对于那些低度或者中度的CAD患病风险的患者来说,需要一种无创的检查方法.