共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate promoter escape by RNA polymerase II
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Mandal SS Chu C Wada T Handa H Shatkin AJ Reinberg D 《Proceedings of the National Academy of Sciences of the United States of America》2004,101(20):7572-7577
3.
4.
5.
Youichiro Wada Yoshihiro Ohta Meng Xu Shuichi Tsutsumi Takashi Minami Kenji Inoue Daisuke Komura Jun'ichi Kitakami Nobuhiko Oshida Argyris Papantonis Akashi Izumi Mika Kobayashi Hiroko Meguro Yasuharu Kanki Imari Mimura Kazuki Yamamoto Chikage Mataki Takao Hamakubo Katsuhiko Shirahige Hiroyuki Aburatani Hiroshi Kimura Tatsuhiko Kodama Peter R. Cook Sigeo Ihara 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(43):18357-18361
6.
7.
The C-terminal domain-phosphorylated IIO form of RNA polymerase II is associated with the transcription repressor NC2 (Dr1/DRAP1) and is required for transcription activation in human nuclear extracts
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Castaño E Gross P Wang Z Roeder RG Oelgeschläger T 《Proceedings of the National Academy of Sciences of the United States of America》2000,97(13):7184-7189
8.
9.
10.
11.
The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. 总被引:28,自引:2,他引:28
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A Yuryev M Patturajan Y Litingtung R V Joshi C Gentile M Gebara J L Corden 《Proceedings of the National Academy of Sciences of the United States of America》1996,93(14):6975-6980
12.
13.
14.
15.
16.
17.
18.
Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II. 总被引:11,自引:0,他引:11
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
H Okamoto C T Sheline J L Corden K A Jones B M Peterlin 《Proceedings of the National Academy of Sciences of the United States of America》1996,93(21):11575-11579
19.
Michito Hirakata Jyotshna Kanungo Akira Suwa Yoshihiko Takeda Joe Craft John A. Hardin 《Arthritis \u0026amp; Rheumatology》1996,39(11):1886-1891
Objective. Previous studies have demonstrated antibodies to the large (220 kd) polypeptide subunit of RNA polymerase II (Pol II) in sera from certain patients with scleroderma. In the present study, we sought to identify the autoantigenic region on this polypeptide. Methods. A recombinant fusion protein, corresponding to the 52-heptapeptide repeat found in the carboxyl terminal domain (CTD) of the large Pol II subunit, was used to identify 15 patient sera that contained autoantibodies. Synthetic peptides CTD7 (representing a single heptapeptide) and CTD18 (representing 2½ heptapeptide repeats) were used in a competitive inhibition assay to define the specificity of these sera and the importance of the CTD as an autoantigen. Results. All 15 sera immunoprecipitated the Pol II subunit from radiolabeled cell extracts, and 11 of them bound the CTD fusion protein in immunoblots. Immunoprecipitation of Pol II was completely inhibited by CTD18 in 5 sera and partially inhibited in 4 additional sera. Conclusion. These results indicate that the CTD heptapeptide repeat is a focal point for autoimmune responses in scleroderma. It is likely that the repetitive sequence and high content of charged residues of this structure contribute to its role as an autoantigen. 相似文献