乙型肝炎病毒和丙型肝炎病毒在肝癌发生中的作用研究进展

肝细胞癌(hepatocellular carcinoma,HCC)是世界上最常见的十大恶性肿瘤之一,目前全世界每年新增5.O×10~6～1.0×11~6病例。在我国,HCC已占恶性肿瘤死亡的第三位。目前对乙型肝炎病毒(hepatitis B Virus,HBV)和丙型肝炎病毒(hepatitis C virus,HCV)感染与HCC发生的关系最为重视。研究表明,全世界现有4亿慢性HBV携带者,80％以上的HCC患者伴有HBV感染,持续HBV感染者发生HCC的机率比正常人高100～200倍;60％～80％HCV感染者将转为慢性,最终将有20％发展为HCC,而HCV相关肝硬化患者15年     

Seroprevalence and genotyping of hepatitis B, hepatitis C and HIV among healthy population and Turkish soldiers in Northern Cyprus

INTRODUCTION Worldwide, two billion people have been infected with hepatitis B virus (HBV), 360 million have chronic infec- tion, and 600 000 die each year from HBV-related liver dis- ease or hepatocellular carcinoma[1]. Meanwhile, hepatitis C virus (HCV)…     

Hepatitis B genotypes： Relation to clinical outcome in patients with chronic hepatitis B in Saudi Arabia

INTRODUCTION Hepatitis B virus (HBV) infection is a global health problem with over 350 million chronic carriers of the virus with the risk of developing chronic hepatitis, cirrhosis or hepatocellular carcinoma (HCC). HBV is a circular, partially double-s…     

丙型肝炎病毒非结构蛋白与宿主细胞蛋白相互作用的研究进展

丙型肝炎病毒(hepatitis C virus,HCV)是继乙型肝炎病毒(hepatitis B virus,HBV)之后另一个导致慢性肝炎、肝硬化和肝癌的常见原因.目前HCV致病及致癌机制仍不清楚,也缺乏针对HCV有效的治疗方法及疫苗预防.肝炎病毒蛋白与受染细胞蛋白之间相互作用是肝炎发病机制研究的热点内容.近年研究...     

血清HBV RNA在临床应用中尚未解决的关键科学问题

乙型肝炎病毒(hepatitis B virus, HBV)感染导致的慢性乙型肝炎(chronic hepatitis B,CHB)难以完全治愈,其根本原因是肝内共价闭合环状DNA(covalently closed circular DNA,cccDNA)持续稳定存在。血清HBV RNA作为cccDNA的下游转录产物,近年越来越多研究表明可用于监测CHB患者的疾病进展和预测预后。为了更好地了解血清HBV RNA,本文梳理了当前尚未解决的三个关键科学问题,包括血清HBV RNA的检测方法学、血清HBV RNA反映cccDNA状态的能力以及HBV RNA与肝细胞癌(hepatocellular carcinoma, HCC)发生、发展的关系,旨在进一步挖掘血清HBV RNA的临床价值。     

甲胎蛋白在乙型肝炎病毒诱导肝癌发生中的作用及临床应用展望

甲胎蛋白(alpha-fetoprotein,AFP)是一种胚胎特异性α-球蛋白,是临床诊断胎儿缺陷和肝细胞癌(hepatocellular carcinoma,HCC)的肿瘤标志物.近年来不断有研究证实,AFP在HCC中发挥信号分子样作用,尤其在乙型肝炎病毒(hepatitis B virus,HBV)诱导的肝癌中,AFP和HBV及HBV编码的x蛋白质(hepatitis B virus protein x,HBx)之间存在相互协同作用,调控并且促进肝癌的发生发展过程.     

Association of promoter polymorphism of the CD14 C （-159） T endotoxin receptor gene with chronic hepatitis B

INTRODUCTION An estimated 350 million persons worldwide are infected with hepatitis B virus (HBV). Hepatitis B carriers are at risk for development of cirrhosis and hepatocellular carcinoma. Persons with chronic hepatitis B infection need life-long monito…     

LIVER AND BILIARY SYSTEM

12.1Hepatitis2006375Identification of hepatitis B virus integra-tion sites in hepatocellular carcinoma tissues frompatients with chronic hepatitis B.TUHong(屠红),etal.Shanghai Can Instit,Shanghai Jiao-Tong Univ,Shanghai200032.Natl Med J China2006;86(18):1…     

Postoperative adjuvant antiviral therapy for hepatitis B/C virus-related hepatocellular carcinoma:A meta-analysis

AIM:To investigate the impact of postoperative antiviral treatment on tumor recurrence and survival of patients with chronic hepatitis B virus(HBV) or hepatitis C virus(HCV) infection-related primary hepatocellular carcinoma(HCC) after curative therapy.METHODS:We performed a meta-analysis of randomized and non-randomized control trials from electronic search and manual search.The fixed effect model of Mantel-Haenszel method and the random effect model of Der Simonian and Laird method were used for homogeneo...     

Rapid quantification of hepatitis B virus DNA by real-time PCR using efficient TaqMan probe and extraction of virus DNA

INTRODUCTION Hepatitis B virus (HBV) is a human hepadnavirus that causes acute and chronic hepatitis and hepatocellular carcinoma[1]. Although an effective vaccine has been available for two decades, an estimated 350 million people worldwide are chronical…     

HBV慢性感染诱导的染色体超倍化及靶向治疗策略

慢性乙型肝炎病毒感染(chronic hepatitis B infection,CHB)诱导肝细胞的染色体超倍化(包括非整倍化和多倍化)及染色体不稳定性,是导致原发性肝细胞癌(primary hepatocytic carcinoma,HCC)发生的主要原因之一.尽管肝细胞对于正常条件下染色体复制的多倍体化具有调节作用,但对于CHB引起的超倍化难以调节从而致癌.研究表明,乙型肝炎病毒(hepatitis B virus,HBV)使得多条信号途径如PLK1/PRC1失调,诱导肝细胞染色体超倍化并发生恶性转化.本论文综述了HBV感染诱导肝细胞染色体超倍化导致肝癌发生的机制以及靶向染色体超倍化药物研究的最新进展.     

乙型肝炎病毒感染合并丙型肝炎病毒感染直接抗病毒药物治疗的描述性研究

目的 分析乙型肝炎病毒（hepatitis B virus,HBV）合并丙型肝炎病毒（hepatitis C virus,HCV）感染者的流行病学特征及直接抗病毒药物（direct-acting antiviral agents,DAA）抗HCV后HBV再激活的发生和预后。方法 收集2008年10月至2020年5月首都医科大学附属北京地坛医院HCV/HBV合并感染并接受抗HCV治疗的患者进行回顾性分析,分析共感染者的感染途径、是否存在肝硬化及肝细胞癌（hepatocellular carcinoma,HCC）,比较患者治疗前后乙型肝炎病毒表面抗原（hepatitis B virus surface antigen,HBsAg）、丙氨酸氨基转移酶（alaninetransminase,ALT）、天门冬氨酸氨基转移酶（aspirate transaminase,AST）、血清总胆红素（total bilirubin,TBil）、血清直接胆红素（direct bilirubin,DBil）、血清白蛋白（albumin,ALB）的变化情况。统计DAA抗HCV的治疗效果及HBV再激活情况。结果 ...     

Effect of hepatitis B virus X gene integration on expression of zinc finger protein ZBTB20 in chronic hepatitis B patients complicated with hepatocellular carcinoma

正Objective To investigate the effect of hepatitis B virus (HBV) X gene integration on expression of zinc finger protein ZBTB20 in chronic hepatitis B (CHB) patients complicated with hepatocellular carcinoma (HCC).Methods Eighteen CHB patients complicated with HCC undergoing surgical treatment in Taizhou Enze Medical Center Enze Hospital and Taizhou Central Hospital from July 2015 to June 2017 were enrolled.Samples of carcinoma tissue,para-carcinoma tissue and corresponding     

Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive

INTRODUCTION Hepatitis B virus (HBV) infection is a serious public health problem worldwide and a major cause of chronic hepatitis, cirrhosis, and hepatocellular carcinoma[1]. Of the approximately 2 billion people who have been infected worldwide, more th…     

酒精合并病毒性肝损伤与肝癌的关系

病毒性肝炎和酒精均是肝细胞癌(肝癌)致病的主要病因, 慢性乙型肝炎病毒(hepatitis Bvirus, HBV)和丙型肝炎病毒(hepatitis C virus,HCV)感染引起肝癌的危险性为正常人10倍以上, 饮酒引起肝癌危险性近2倍, 病毒性肝炎伴饮酒危险性进一步增大. 病毒和酒精协同作用的机制尚未完全清楚, 在多数患者, 两种因素均先通过肝硬化再进展为肝癌. 预防肝炎病毒感染和控制饮酒是预防肝癌的最好手段, 普及乙型肝炎疫苗接种已取得非常好的成绩. 对慢性HBV和HCV感染者应抗病毒治疗, 早期戒酒对预防肝癌的肯定有益, 但尚没有足够证据支持戒酒可减低肝硬化向肝癌发展的风险.     

丙型肝炎病毒非结构蛋白NS3致肝癌机制的研究进展

大量研究显示丙型肝炎病毒(hepatitis C virus,HCV)持续感染肝细胞能导致肝细胞癌(hepatocellular carcinoma,HCC),但其致癌机制目前还不十分清楚.HCV是一种RNA病毒,其基因组不能整合到宿主染色体中引起基因突变,可能是通过其表达的蛋白质引起细胞转化.由于HCV NS3含有多种蛋白酶活性,因而推测HCV NS3在肝细胞癌的形成过程中具有重要作用,本文就HCV NS3致癌机制的研究进展作一综述.     

The relationship between the hepatitis B virus base core and precore/core promoter mutations and the development of cirrhotic hepatocellular carcinoma and noncirrhotic hepatocellular carcinoma

Objective To investigate the mutations of basal core promoter(BCP) and precore(PreC) region of hepatitis B virus(HBV) and the association with the development of hepatocellular carcinoma in patients with chronic HBV infection. Methods Totally 381 untreated HBV patients were recruited from the Department of Infectious     

Hepatocellular carcinoma in patients with chronic hepatitis C virus infection without cirrhosis

AIM:To investigate and characterise patients with chronic hepatitis C virus(HCV) infection presenting with hepatocellular carcinoma(HCC) in the absence of cirrhosis.METHODS:Patients with chronic hepatitis C infection without cirrhosis presenting with HCC over a 2-year period were identified.The clinical case notes,blood test results and histological specimens were reviewed to identify whether additional risk factors for the development of HCC were present.RESULTS:Six patients(five male,one female) with chro...     

本刊常用英文缩写词汇

正甲型肝炎病毒(hepatitis A virus,HAV)乙型肝炎病毒(hepatitis B virus,HBV)丙型肝炎病毒(hepatitis C virus,HCV)人类免疫缺陷病毒(human immunodeficiency virus,HIV)巨细胞病毒(CMV)获得性免疫缺陷综合征(AIDS)血压(BP)肝细胞癌(HCC)红细胞(RBC)白细胞(WBC)血小板(PLT)白蛋白(ALB)总蛋白(TP)血红蛋白(Hb)免疫球蛋白(Ig)甲胎蛋白(AFP)白细胞介素(IL)     

HBV/HCV重叠感染的抗病毒治疗

从全球范围看,乙型肝炎病毒(hepatitis B virus,HBV)和丙型肝炎病毒(hepatitis C virus,HCV)重叠感染估计约有700-2000万人口感染.重叠感染和单一HBV或HCV感染比较,更易发展为肝硬化、肝细胞癌甚至肝衰竭的比例也高,HBV和HCV重叠感染可有四种不同的临床模式,即HCV活动...