新生儿高胆红素血症脑干听觉诱发电位检测的意义

目的:观察高胆红素血症对新生儿脑干听觉功能的影响。方法:对208例高胆红素血症新生儿进行脑干听觉诱发电位(BAEP)检测。结果:新生儿高胆红素血症的BAEP异常率为57.21%。以Ⅲ、Ⅴ波异常较多。结论:无症状性高胆红素血症存在脑干听觉功能损害,积极的BAEP检测有重要意义。     

脑干听觉诱发电位检测在新生儿高胆红素血症中的临床意义

目的：观察高胆红素血症对新生儿的听觉和脑干功能的影响。方法：对60例高胆红素血症新生儿进行脑干听觉诱发电位(BAEP)检测，并以30名正常儿作对照。结果：高胆红素血症新生儿BAEP的异常率为55％。主要表现为Ⅰ、Ⅴ波分化不良或波形消失，Ⅰ、Ⅴ波潜伏期延长，Ⅰ—Ⅴ峰间期延长和反应阈升高。结论：新生儿高胆红素血症对其听力和中脑下部有一定程度损害，BAEP对了解新生儿听力及脑干功能障碍有重要价值。     

新生儿高胆红素血症病因与听力损害关系的探讨

目的　探讨新生儿高胆红素血症病因与听力损害之间的关系。方法　分别对不同病因 (溶血、感染、母乳性黄疸 )引起的高胆红素血症和正常新生儿进行脑干听觉诱发电位检测。结果　由溶血和感染因素所致的高胆红素血症脑干听觉诱发电位变化明显。母乳性黄疸所致高胆红素血症脑干听觉诱发电位无变化。结论　早期新生儿因溶血、感染所致高胆红素血症可引起听力损害 ,应及早干预 ,并注意远期随访。     

不同浓度高胆红素血症患儿脑干听觉诱发电位对比分析

目的:分析不同浓度胆红素血症对新生儿脑干听觉诱发电位的影响,为临床治疗和早期评估预后提供依据。方法:根据血清胆红素水平(Sb)的高低将174例患儿分成两组:甲组110例,为相对低胆红素浓度组(Sb≤342μmol/L);乙组64例,为相对高胆红素浓度组(Sb>342μmol/L)。两组进行脑干听觉诱发电位检测并进行比较。结果:174例高胆红素血症新生儿脑干听觉诱发电位共有218耳异常(62.6%),甲、乙两组比较,乙组异常率明显增高(P<0.01),甲、乙两组V波反应阀比较,差异有统计学意义(P<0.01)。结论:高胆红素血症对脑干听觉诱发电位有影响,异常率与浓度升高呈正相关。     

高胆红素血症新生儿脑干听觉诱发电位的研究

目的 :观察新生儿高胆红素血症对外周及脑干听觉传导系统的影响及机制。方法 :根据血清胆红素水平把 4 6例新生儿分成A组 (2 9例 ,5 8耳 ,血清间接胆红素小于 342 μmol/L)和B组 (17例 ,34耳 ,血清间接胆红素大于 342 μmol/L)两组进行脑干听觉诱发电位检测。 结果 :AB两组患儿分别有15耳和 2 2耳出现Ⅴ波反应阈轻度升高 ,两组相比 ,差异有显著意义 (P <0 .0 1)。与A组比较 ,B组患儿BAEP异常率显著增高 (P <0 .0 1) ,其中Ⅰ波、Ⅴ波异常率 ,Ⅰ -Ⅴ间期异常率显著增高 (P <0 .0 1) ,Ⅲ波及Ⅰ -Ⅲ峰间期、Ⅲ -Ⅴ峰间期异常率差异无显著意义 (P >0 .0 5 )。结论 :高胆红素血症可导致新生儿听神经损害 ,血清间接胆红素水平与BAEP异常程度有直接关系     

听觉脑干诱发电位测定与新生儿黄疸相关性的分析

目的探讨听觉脑干诱发电位异常在新生儿黄疸患儿诊断及治疗的意义及相关危险性。方法选择新生儿黄疸患儿116例,检测血清总胆红素(TBC),直接胆红素。并且给予进行听觉脑干诱发电位测定,根据测定结果对黄疸病因及黄疸严重程度进行观察并进一步决定治疗方案。结果与结论新生儿黄疸可以引起听觉脑干诱发电位异常,且电位异常是诊断胆红素脑损害的最早表现也是病情发展的灵敏检测指标,对胆红素脑病的治疗也很大意义。     

高胆红素血症新生儿脑干听觉诱发电位研究

目的:探讨高胆红素血症对新生儿听神经及脑干功能的影响,早期评估其预后.方法:根据血清胆红素水平(UCB)把200例新生儿分成A组(128例,256耳,UCB≤342 μmol/L)和B组(72例,144耳,UCB>342 μmol/L),两组进行脑干听觉诱发电位(BAEP)检测.结果:A、B两组患儿分别有66耳(26%)和92耳(64%)出现V波反应阈升高,两组相比,差异有显著意义(P<0.01).与A组比较,B组患儿BAEP异常率显著增高(P<0.01).BAEP异常表现为I、V波分化不良或波形消失,I、V波潜伏期延长,I-V波间期延长.UCB恢复正常后3个月复查BAEP,恢复正常者A组为85.7%,B组为44.7%,组间比较差异显著(P<0.01).结论:高胆红素血症可导致新生儿听神经和脑干功能损害,血清间接UCB与BAEP异常程度及预后有直接关系.     

28例高胆红素血症新生儿BAEP检测

２８例高胆红素血症新生儿ＢＡＥＰ检测吴悦１金丽萍２隋建美２新生儿高胆红素血症（高胆症）伴胆红素中毒性脑病者常有不同程度的听觉障碍。为探讨用脑干听觉诱发电位（ＢＡＥＰ）评价高胆症新生儿的听觉神经传导通道功能状况，对２８例进行了ＢＡＥＰ检测，现报告如下。...     

新生儿高胆红素血症脑干听觉诱发电位的观察分析

目的 观察高胆红素血症对新生几脑干听觉诱发电位（BAEP）的影响。方法 2005年1月至2006年1月我科收治的足月高胆红素血症的新生儿39例为高胆组，无缺氧史及其它听力及脑损伤高危因素30例为对照组，对其进行脑干听觉诱发电位检查，分析Ⅰ、Ⅲ、Ⅴ波的潜伏期、峰间期等参数，进行t检验。结果 在80dBnHL刺激下，高胆组各波峰潜伏期及峰间期延长，振幅下降，与对照组比较差异有显著性。结论 足月儿高胆红素血症超过256．5umol／L，脑干听觉诱发电位异常，提示有脑损伤，应给予积极治疗，BAEP对临床治疗有意义。     

新生儿高胆红素血症与心肌损伤的临床研究

目的通过检测高胆红素血症新生儿血清中总胆红素和肌钙蛋白、乳酸脱氢酶、肌酸激酶同工酶等的改变观察高胆红素对心肌的影响,探讨新生儿高胆红素血症是否存在对心肌的损害。方法对100例高胆红素血症新生儿进行肝功能和肌钙蛋白、心肌酶谱检测。结果高胆红素血症患儿治疗前、后肌钙蛋白、心肌酶谱改变均具有高度显著性差异(P0.01),即治疗前、后肌钙蛋白转阴。总胆红素、心肌酶谱比较:心肌酶谱的升高与血清胆红素升高有关,差异有显著意义(P0.01)。结论新生儿高胆红素血症可能造成心肌损害,但随着胆红素血症的治愈心肌酶逐渐降至正常,不一定造成心肌细胞的不可逆损害。     

实验性自身免疫性脑脊髓炎脑干听觉通路损害的研究

目的： 探讨实验性自身免疫性脑脊髓炎（EAE）大鼠听觉通路损害的情况，为临床研究提供实验依据。方法： 以豚鼠全脊髓匀浆（GPSCH）为抗原免疫Wistar 大鼠建立 EAE的动物模型，采用诱发电位仪检测实验组与对照组的脑干听觉诱发电位，通过脑干及耳蜗神经核HE染色及Weil髓鞘染色从解剖病理的角度证实脑干及耳蜗神经核损害。通过大鼠行为学的变化及光镜下脑和脊髓的病理改变来确定EAE的成功。结果： EAE大鼠的BAEP改变：左耳：Ⅳ、Ⅴ波潜伏期及Ⅰ-Ⅴ波峰间伏期IPL长于对照组（P<0.05）,右耳：Ⅰ、Ⅱ波潜伏期及Ⅰ-Ⅲ Ⅲ-Ⅴ Ⅰ-Ⅴ波峰间伏期IPL长于对照组（P<0.05）；而Ⅲ、Ⅳ、Ⅴ等波的潜伏期显著长于对照组（P<0.01）。病理图像显示脑干耳蜗神经核HE染色有大量淋巴细胞浸润，呈袖套样改变，髓鞘染色显示弥漫性脱髓鞘病变。结论： Wistar大鼠实验性自身免疫性脑脊髓炎（EAE）听神经通路有损害。     

Noise-induced tinnitus: auditory evoked potential in symptomatic and asymptomatic patients

OBJECTIVES:

We evaluated the central auditory pathways in workers with noise-induced tinnitus with normal hearing thresholds, compared the auditory brainstem response results in groups with and without tinnitus and correlated the tinnitus location to the auditory brainstem response findings in individuals with a history of occupational noise exposure.

METHOD:

Sixty individuals participated in the study and the following procedures were performed: anamnesis, immittance measures, pure-tone air conduction thresholds at all frequencies between 0.25–8 kHz and auditory brainstem response.

RESULTS:

The mean auditory brainstem response latencies were lower in the Control group than in the Tinnitus group, but no significant differences between the groups were observed. Qualitative analysis showed more alterations in the lower brainstem in the Tinnitus group. The strongest relationship between tinnitus location and auditory brainstem response alterations was detected in individuals with bilateral tinnitus and bilateral auditory brainstem response alterations compared with patients with unilateral alterations.

CONCLUSION:

Our findings suggest the occurrence of a possible dysfunction in the central auditory nervous system (brainstem) in individuals with noise-induced tinnitus and a normal hearing threshold.     

Auditory neuropathy in streptozotocin-induced diabetic mouse

An investigation of the mechanism of damage to the peripheral nervous system and central nervous system in diabetes mellitus (DM) is highly important in current neurological research. Auditory neuropathy is a hearing disorder in which the auditory brainstem evoked potential is absent or severely abnormal. This study investigated auditory neuropathy caused by streptozotocin in mouse model. In order to assess diabetic auditory neuropathy, we evaluated auditory brainstem response (ABR) for the evaluation of sensorineural function in peripheral auditory nerve. Auditory middle latency response (AMLR) was employed to assess the middle response in the midbrain. STZ groups significantly increased the absolute latencies IV and the interpeak latencies I-III and I-IV of ABR compared with STZ 0 group. Pa latency of AMLR also significantly increased in proportion to STZ dosage. Taken together, our results demonstrate that STZ-induced DM may impair the auditory pathway from peripheral auditory nerve to midbrain in the mouse model. We suggest that the STZ-induced diabetic mouse model may be useful for the evaluation of auditory pathway impairment by using ABR and AMLR tests.     

P物质样免疫反应成分在人胎儿和新生儿脑干内的分布及在发育过程中的变化——免疫组织化学研究

应用免疫组织化学方法较系统地研究了p物质样免疫反应成分(SP-LI)在人眙儿(胎龄11.5周至35周)及新生儿(生后2天)脑干内的分布及其在发育过程中的变化,结果发现:SP-LI成分在人胎儿脑干最早出现于孕第三个月到孕四个月之间(孕11.5到16周);分布非常广泛,到孕六个月分布基本定型;SP-LI纤维和终末的密度及SP-LI细胞数量都随发育过程而显示一定的变化规律。有明确意义的发现是,参与内脏活动及内脏感觉的结构比参与躯体感觉的结构内SP-LI成分的量多;SP-LI成分出现早且较密集的区域主要为菱脑峡区,随胎龄的增加,此区域内的SP-LI成分也增加。     

Antioxidant Treatments Recover the Alteration of Auditory‐Evoked Potentials and Reduce Morphological Damage in the Inferior Colliculus after Perinatal Asphyxia in Rat

Maturation of the auditory pathway is dependent on the central nervous system myelination and it can be affected by pathologies such as neonatal hypoxic ischemic (HI) encephalopathy. Our aim was to evaluate the functional integrity of the auditory pathway and to visualize, by histological and cellular methods, the damage to the brainstem using a neonatal rat model of HI brain injury. To carry out this morphofunctional evaluation, we studied the effects of the administration of the antioxidants nicotine, melatonin, resveratrol and docosahexaenoic acid after hypoxia‐ischemia on the inferior colliculus and the auditory pathway. We found that the integrity of the auditory pathway in the brainstem was altered as a consequence of the HI insult. Thus, the auditory brainstem response (ABR) showed increased I–V and III–V wave latencies. At a histological level, HI altered the morphology of the inferior colliculus neurons, astrocytes and oligodendricytes, and at a molecular level, the mitochondria membrane potential and integrity was altered during the first hours after the HI and reactive oxygen species (ROS) activity is increased 12 h after the injury in the brainstem. Following antioxidant treatment, ABR interpeak latency intervals were restored and the body and brain weight was recovered as well as the morphology of the inferior colliculus that was similar to the control group. Our results support the hypothesis that antioxidant treatments have a protective effect on the functional changes of the auditory pathway and on the morphological damage which occurs after HI insult.     

腭裂患儿120例电反应测听法脑干听力阈值分析

目的：分析腭裂患儿脑干听力阈值特征。方法：使用电反应测听法检测120例腭裂患儿听力阈值，采用分组对照研究，进行Χ^2检验。结果：①240耳中141耳听力阈值异常，听力障碍发生率为58．8％；②Ⅱ°与Ⅲ°腭裂患儿听力障碍发生率有极显著性差异，P〈0．005；腭裂程度与听力障碍程度之间无相关性，P〉0．75；③3岁前后比较，听力障碍发生率差异极显著，P〈0．005，3—6岁与〉6岁比较无显著差异，P〉0．05。结论：①58．8％腭裂患儿存在不同程度听力障碍；②腭裂程度越重听力障碍发生率越高，但与听力障碍程度无相关性；③患病年龄越小听力障碍发生率越高，3岁前后有极显著性差异。     

85例椎动脉型颈椎病患者的BAEP与EEG分析

本文报道了85例单纯椎动脉型颈椎病患者的脑干听觉诱发电位(BAEP)及脑电图(EEG)描记结果,结果表明:BAEP的异常改变以Ⅰ波,Ⅲ波为主,Ⅴ波异常者较少;BAEP的异常率(38.3％)较EEG的异常率(8.2％)明显为高。提示:(1)单纯椎动脉型颈椎病主要影响内耳,听神经及脑干下部的血供;(2)BAEP对颈椎病引起的椎基底动脉供血不足所致的脑部损害比EEG有较高的敏感性,不失为一种可靠的非创伤性辅助检查手段。     

幼儿言语发育迟缓分析

目的:了解幼儿言语发育迟缓与听力情况.方法:对30例言语发育迟缓患儿,进行了解咨询其家属有关与患儿生活环境客观因素及既往病史,并行听觉脑干诱发电位(ABR)听阈测试.结果:30例ABR波V反应阈为25dBnHL,2例I～V波间期稍延长.通过进一步检查经儿科专科医生会诊,发现有孤独症行为和大脑发育不全18例,诊断不明确者12例.在孤独症和不明确诊断的患儿中存有一些自身与成长环境的客观因素.结论:如果听力正常,言语发育迟缓主要是患儿孤独症与智力低下所致.     

The usefulness of the brainstem auditory evoked potential in the early diagnosis of cranial nerve neuropathy associated with diabetes mellitus

BACKGROUND: An evaluation of the extent and mechanism of damage of the central nervous system in diabetes mellitus is of high value in current neurological research. Electrophysiological abnormalities are frequently present is completely asymatomatic diabetes mellitus (DM) patients. Limited data is available in the use of brainstem auditory evoked potential (BAEP) in DM. AIM: Is to evaluate the efficacy of BAEP as a method useful in the diagnosis of subclinical damage of the central nervous system in DM. MATERIAL AND METHOD: 67 diabetes and 32 healthy controls - age and sex matched - were chosen. The diabetes were of type I and II and more than or less than 10 years duration. The BAEP was elicited by using auditory stimulus by using Dantec Evomatic 4000 evoked potential machine. The latency of component response recored as waves I, III and V, interpeak latency (IPLs) I - III, I - V, III - V and amplitude of waves V. RESULTS: The difference was highly significant in the increased latency of waves I, III and V, interpeak latency (IPLs) I - III, I - V, III - V and amplitude of waves V of each type of diabetes as compared to control. Comparison of the type and duration of diabetes between each other showed no significant difference. CONCLUSION: BAEP recording can represent an objective, clinically useful and non invasive procedure to stress the early impairment both of the auditory nerve and of brainstem function.     

新生儿高胆红素血症MRI检查临床分析

目的探讨磁共振成像（MRI）技术协助诊断胆红素脑病的临床价值。方法回顾性分析2012年1月-2012年12月期间,对本院14例高胆红素血症患儿行头颅MRI检查的临床资料。结果高胆红素血症14例中,有胆红素脑病早期临床表现的5例,有痉挛期临床表现的1例,MRI异常者有5例（去除可疑1例）,均显示双侧苍白球T1WI信号及T2-FLAIR（抑水系列）呈对称性高信号,在T2WI呈正常信号,脑干听觉诱发电位（BAEP）异常有7例。结论 MRI能为早期高胆红素脑病提供客观指标,尤其对临床可疑病例的诊断方面有较高的临床价值。