Interferon for the therapy of condyloma acuminatum

Lymphoblastoid interferon, Wellferon, was used to treat patients with resistant and persistent condyloma acuminatum at initial doses of 5, 3, and 1 million unit/square meter (Mu/M2). The objectives of this study were to evaluate the efficacy and toxicity of, and tolerance to, intramuscular and intralesional interferon. Seventeen patients were treated with 5 Mu/M2, 14 patients with 1 Mu/M2, and 37 patients with 3 Mu/M2; daily administration was followed by three-times-a-week dosing. The complete response rate in patients receiving initial dose of interferon of 5 Mu/M2 was 69%, that for doses of 1 Mu/M2 was 43%, and that for doses of 3 Mu/M2 was 57%. All patients given interferon developed initial elevations of temperature of limited duration, whereas all patients given the 5 Mu/M2 dose had to have the amount reduced because of biologic side effects. However, only five of 37 (14%) of the patients given 3 Mu/M2 required a reduction in the dosage, and no patient given 1 Mu/M2 needed to have the dosage reduced. These studies suggest that interferon is efficacious in the treatment of resistant and persistent condyloma acuminatum, and that the biologic side effects were dose-related, well tolerated, and not life-threatening.     

绝经妇女尖锐湿疣祛疣后复发病例分析

目的 探讨绝经后妇女尖锐湿疣治疗后高复发率的原因。方法 将53例绝经后妇女尖锐湿疣治疗后复发情况与同期采用同样方法治疗的285例生育年龄妇女尖锐湿疣进行比较。结果 53例绝经后妇女尖锐湿疣临床治愈后1个月复发8例，复发率15．1％；3个月复发15例，复发率28．3％。生育年龄组妇女尖锐湿疣临床治愈后1个月复发为21例，复发率7．4％；3个月复发38例，复发率13．3％。两组临床治愈后3个月复发率差异有显著性（P〈0．05）。结论 绝经后妇女尖锐湿疣治疔后复发率高于生育年龄，应当重视老年妇女尖锐湿疣的预防和治疗，特别是对无症状HPV感染的治疗。     

A trial of topical idoxuridine for vulvar condyloma acuminatum

The effect of 0.25% idoxuridine ointment on condyloma acuminatum of the vulva was investigated in a randomized, double-blind, placebo-controlled trial in 24 women. Idoxuridine inhibits DNA synthesis in mammalian cells and is a specific inhibitor of DNA viruses. Of the 24 women with vulvar condyloma acuminatum, 14 applied idoxuridine ointment and 10 a placebo ointment to the lesions twice daily for 2 weeks. In 11 out of 14 patients treated with idoxuridine the condylomata regressed completely. The treatment did not cause any side-effects. None of the women in the placebo group showed regression of the condylomata. Topical idoxuridine therapy is effective and non-toxic; it appears to be most effective for new condylomata.     

Malignant transformation of condyloma acuminatum: report of a case

Condyloma acuminatum is a benign warty lesion, whose malignant change is rarely seen. A 69-year-old woman with a large vulvar condyloma acuminatum, which she had had for about 14 years, underwent a vulvectomy, and a malignant component to the lesion was found unexpectedly. The continuity from a benign to a malignant lesion was evident in the histopathologic examination. Infection with human papillomavirus type 6 was documented by DNA hybridization. The use of a one-step reverse dot blot hybridization with nonisotope DNA probe in this case was convenient and is recommended.     

Clinicopathologic analysis of condyloma acuminatum of the vulva in 165 cases

Condyloma acuminatum of the vulva was diagnosed in 165 cases, of which 117 were identified during mass screening and 48 discovered in the outpatient clinic. The gross appearance and histologic characteristics were described. The lesions were removed surgically in 5 cases, and treated with topical 5-FU ointment in 4. The remaining cases were treated by cryosurgery. A permanent cure was achieved in all cases. The authors emphasize that the importance of condyloma acuminata should not be overlooked on account of its close relationship to vulvar cancer.     

外阴尖锐湿疣合并宫颈病变175例分析

目的：了解外阴尖锐湿疣（CA）患者合并宫颈病变的情况,方法：经病理确诊的175例外阴CA患者在阴道镜下取宫颈组织活检,其中152例应用PCR或免疫组化技术做HPV11／6,18／16分型检测,用同期无外者在阴CA的100例宫颈病理作对照.结果：宫颈CA15例,占病理诊断宫颈HPV感染81例的18．5％,外阴CA得合并宫颈HPV亚临床感染（SPI）和（或）宫颈上皮内瘤变（CIN）占54．9％,明显高于对照组的13．0％（P＜0．001）,宫颈CA及SPI中CIN发生率为50．62％,明显高于宫颈慢性炎症及疣样病变的CIN发生率（P＜0．05）;宫颈光滑组中SPI,CIN,慢性炎症及疣样病变等宫颈病变的发生率较宫颈糜烂组无明显差异,HPV18／16型感染组宫颈CA,SPI和（或）CIN的发生率明显高于HPV11／6型感染组（P＜0．01）。结论：对女性生殖道HPV感染在治疗外在湿疣的同时,更应重视宫颈临床感染,应借助阴道镜,组织病理及分子生物学相关技术早期发现SPI及CIN,早期治疗。     

Giant condyloma acuminatum of the endocervix and lower uterine segment.

A 34-year-old woman presented with lower abdominal pain, dysmenorrhea, dyspareunia and vaginal discharge. A total abdominal hysterectomy was done for persistent, severe uterine pain unresponsive to medical management. Histologic examination of the surgical specimen revealed a large condyloma acuminatum of the endocervix and lower uterine segment. This represents a rare manifestation of a very common venereal disease.     

Toxic shock syndrome following carbon dioxide laser treatment of genital tract condyloma acuminatum

Toxic shock syndrome was observed in the postoperative period in a patient who underwent carbon dioxide laser treatment of genital condyloma acuminatum. Laser vaporization of the vagina produces areas of denuded mucosa. These areas may act as the portal of entry for staphylococcal toxins producing toxic shock syndrome.