Malignant fibrous histiocytoma

A 74-year-old man presented with a malignant fibrous histiocytoma (MFH) on the lower leg. Wide local excision was performed and no recurrence has occurred to date. The pathological features which distinguish MFH from other sarcomas are now well denned and deserve wider recognition.     

Malignant fibrous histiocytoma

A 62-year-old patient presented with slow-growing blue-red tumor on his left forearm for around two years. A biopsy revealed the tumor was a rare malignant fibrous histiocytoma (MFH). The finger-like extensions of MFH in the fatty tissue are responsible not only for the high local recurrence rate, but also increase the metastatic potential and affect the prognosis. For this reason radical surgery with surgical margins of 2?C3 cm is absolutely required. After wide excision, the patient has been alive for years without evidence of local recurrence or distant metastasis.     

Malignant fibrous histiocytoma arising from chronic ulcer

A patient had malignant fibrous histiocytoma that developed in a chronic ulcer. Squamous cell carcinoma can develop on long-standing ulcers, but malignant fibrous histiocytoma developing in an ulcer is extremely rare.     

Malignant fibrous histiocytoma arising on chronic osteomyelitis

We present a case of a primary malignant fibrous histiocytoma of the skin (MFH) arising on chronic osteomyelitis in a 67-year-old woman. Although this condition seems to be a predisposing factor for the onset of the malignancy, MFH complicating chronic osteomyelitis is generally localized at the level of the bone tissue. In the case we report the neoplasm was primitively localized at the dermal and subcutaneous level and presented as a rapidly growing mass.     

Malignant fibrous histiocytoma of the glans penis

A case of malignant fibrous histiocytoma of the penis in a 56-year-old Hispanic man is described. The tumor was composed of a proliferation of atypical spindle cells showing the characteristic storiform growth pattern. Immunohistochemical stains were positive for vimentin and alpha-1-antichymotrypsin and negative for keratin, desmin, and S-100 protein antibodies. The unusual location of this tumor in our patient highlights the ubiquitous distribution of this malignant neoplasm. The clinical and histologic differential diagnosis of this lesion is discussed.     

Malignant fibrous histiocytoma arising from discoid lupus erythematosus

While the association of discoid lupus erythematosus (DLE) and subsequent squamous cell carcinoma is well known, there are no reports in the English-language literature concerning the association of DLE and soft-tissue sarcoma. We describe a patient with DLE and malignant fibrous histiocytoma.     

Malignant fibrous histiocytoma and atypical fibroxanthoma in renal transplant recipients

BACKGROUND: Allograft recipients are at increased risk for skin cancer. The incidence of cutaneous squamous cell carcinoma is 50-250 times higher than in the age-matched control population, and basal cell carcinoma is about 10 times more frequent. The incidence of Kaposi's sarcoma is increased 400 to 500 times over that in a control population of the same ethnic origin. However, the incidence of other types of cutaneous sarcoma in organ allograft recipients is largely unknown. CLINICAL OBSERVATION: Within a 2-year-period, we observed 2 patients with cutaneous malignant fibrous histiocytoma and 1 patient with atypical fibroxanthoma among a cohort of 642 renal transplant recipients. For comparison, the incidence for dermatofibrosarcoma protuberans which is the commonest type of cutaneous sarcoma, is 0.45/100,000 persons/year in the non-immunocompromised population. Our observation represents an incidence of 156/100,000/ year (95% confidence interval Cl 28-489/100,000/year) for cutaneous malignant fibrous histiocytoma and of 78/100,000/year (95% CI 4-368/ 100,000/year) for atypical fibroxanthoma. CONCLUSION: To our knowledge, this is the first report on an elevated incidence of cutaneous malignant fibrous histiocytoma and of atypical fibroxanthoma in renal transplant recipients. Future cohort studies on malignancies in organ allograft recipients should aim at defining this risk more exactly.     

Malignant fibrous histiocytoma of the scalp. Multidisciplinary treatment

BACKGROUND: Malignant fibrous histiocytomas (MFH) are uncommon in the skin, and even less frequent on the scalp. On the scalp they are often very difficult to excise and it is even more difficult to close the resulting wound. OBJECTIVE: To review all malignant fibrous histiocytomas diagnosed and treated in our Department during the past 6 years, and to describe the multidisciplinary procedure employed to treat one special case of aggressive malignant fibrous histiocytoma on the scalp that recurred twice. RESULT: Malignant fibrous histiocytomas represent 0.01% of malignant cutaneous tumors in our area. The immediate results after a multidisciplinary treatment performed on a recurrent malignant fibrous histiocytoma located on the scalp were excellent, but recurrence was observed 6 months later. Two years later we have also treated another case of MFH on the scalp. The same surgical technique was performed, but the patient received high-dose-methotrexate-based neoadjuvant chemotherapy (HD-MTX). One year later, this patient is still alive and no signs of recurrence have been detected. CONCLUSION: When malignant fibrous histiocytoma occurs on the scalp it must be treated immediately by means of an excision with a large peripheral edge of 2 cm from the visual or CAT limits of the lesion, since the first treatment must be definitive.     

动脉瘤样纤维组织细胞瘤

动脉瘤样纤维组织细胞瘤是皮肤纤维瘤的一种少见异型,组织病理特征为在纤维组织细胞瘤结构中出现含有血液的腔隙.其在临床上易误诊为黑素瘤、血管瘤等,因而鉴别诊断具有重要意义.     

Malignant histiocytoma

In a 19 year old woman, suffering from an malignant histiocytoma of the upper lip, X-ray treatment was favored above a mutilating operation. Within 26 months no relapse occurred.     

Squamous cell carcinoma, malignant melanoma and malignant fibrous histiocytoma arising in burn scars

Summary The most common cancer arising from an old burn scar is squamous cell carcinoma, while malignant melanoma is rare. There are only four reports in the literature on the combination of the more common tumour with a malignant melanoma and only two cases of malignant fibrous histiocytoma alone. This paper reports the first occurrence of the combination of all three types of cancer in burn scars of the same patient. The factors that promote malignant transformation, such as immunological factors and karyotype, are discussed. We also performed an immunohistochemical study using anti-p53 antibodies.     

Aneurysmal fibrous histiocytoma: an unusual variant of cutaneous fibrous histiocytoma

Aneurysmal fibrous histiocytoma (AFH) (Santa-Cruz DJ, Kyriakos M. Aneurysmal ('Angiomatoid') fibrous histiocytoma of the skin. Cancer 1981;47:2053-2061) is a distinct but poorly recognized clinicopathological variant of cutaneous fibrous histiocytoma (CFH) that may result from the slow extravasation of blood into the tumour. The resulting lesion can have a very different clinicopathological appearance resulting in diagnostic confusion. We describe a patient with an AFH that presented as a pigmented nodule on the foot and discuss clinical recognition and histological differentiation from other tumours.