阿仑膦酸钠、阿法骨化醇联合钙剂治疗老年性骨质疏松症的疗效分析

目的:探讨阿仑膦酸钠、阿法骨化醇联合钙剂治疗老年性骨质疏松症(OP)的疗效.方法:应用阿仑膦酸钠、阿法骨化醇联合钙剂治疗68例老年性OP患者,阿仑膦酸钠70 mg,口服,每周1次;阿法骨化醇0.5 μg,口服,每日1次;钙剂600 mg,口服,每日1次.所有患者连续服用3种药物治疗6个月后进行疗效分析.结果:治疗6个月后,患者的骨密度较治疗前有所增加,骨源性碱性磷酸酶和抗酒石酸酸性磷酸酶5b水平较治疗前降低,骨痛症状均有不同程度改善,不良反应轻.结论:阿仑膦酸钠、阿法骨化醇联合钙剂治疗老年性OP有效、安全.     

阿仑膦酸钠和阿法骨化醇联合治疗严重骨质流失和骨质疏松性骨折

背景:阿仑膦酸钠和阿法骨化醇均可抑制骨质疏松性骨折患者骨转换,增加骨矿物密度.目的:观察阿仑膦酸钠和阿法骨化醇联合治疗患有严重骨质流失和骨质疏松性骨折患者的效果.方法:纳入严重骨质流失和骨质疏松性骨折患者,进行阿仑膦酸钠和阿法骨化醇联合治疗2年.结果与结论:相比治疗前,阿仑膦酸钠和阿法骨化醇联合治疗后患者腰椎骨密度增加(P<0.05),随后尿Ⅰ型胶原N末端肽水平和血清碱性磷酸酶活性减少(P<0.05).证实,阿仑膦酸钠和阿法骨化醇联合治疗患有严重的骨质流失和骨质疏松性骨折患者疗效好.     

阿仑膦酸钠和阿法骨化醇联合治疗严重骨质流失和骨质疏松性骨折

背景：阿仑膦酸钠和阿法骨化醇均可抑制骨质疏松性骨折患者骨转换,增加骨矿物密度。目的：观察阿仑膦酸钠和阿法骨化醇联合治疗患有严重骨质流失和骨质疏松性骨折患者的效果。方法：纳入严重骨质流失和骨质疏松性骨折患者,进行阿仑膦酸钠和阿法骨化醇联合治疗2年。结果与结论：相比治疗前,阿仑膦酸钠和阿法骨化醇联合治疗后患者腰椎骨密度增加（P〈0.05）,随后尿Ⅰ型胶原N末端肽水平和血清碱性磷酸酶活性减少（P〈0.05）。证实,阿仑膦酸钠和阿法骨化醇联合治疗患有严重的骨质流失和骨质疏松性骨折患者疗效好。     

医护协同作用下不同途径应用双膦酸盐治疗骨质疏松症患者依从性及效果评价

目的:探讨医护协同作用下不同途径应用双膦酸盐治疗骨质疏松症患者的依从性及效果。方法:将绝经后80例骨质疏松症患者随机分为口服组和静脉组各40例,两组均实施医护协同模式,口服组应用阿仑膦酸钠片口服,静脉组应用唑来膦酸注射液静脉滴注,两组患者同时口服罗盖全和阿法骨化醇胶囊。分别于4周后、3个月、6个月及12个月后进行骨密度测定,比较两组视觉模拟疼痛评分(VAS)评分。结果:治疗后两组骨密度均明显升高,VAS评分均明显降低,与治疗前比较差异均有统计学意义(P0.05)。结论:静脉滴注或口服应用双膦酸盐均安全有效,但静脉应用双膦酸盐能显著提高患者抗骨质疏松用药的依从性。提示加强医护协同作用,增强处理问题的能力,尤其是合理使用给药途径对提高和巩固治疗骨质疏松症疗效和促进患者康复至关重要。     

帕米膦酸二钠对糖皮质激素相关性骨质疏松症患者骨密度的影响

目的探讨帕米膦酸二钠对糖皮质激素相关性骨质疏松症患者骨密度的影响。方法选择2017年1月至2018年3月于某院接受治疗的94例糖皮质激素相关性骨质疏松症患者,根据随机数表法将其分为观察组与对照组,各47例。两组均给予骨化三醇联合钙尔奇D,观察组在此基础上加用帕米膦酸二钠治疗,比较两组血磷、血钙、碱性磷酸酶(AKP)、甲状旁腺激素(PTH)、股骨近端骨密度、腰椎骨密度及服药期间不良反应发生情况。结果观察组治疗1年后血磷、血钙值高于对照组,AKP、PTH水平低于对照组,股骨近端骨密度、腰椎骨密度均高于对照组,差异有统计学意义(P<0.05);服药期间观察组不良反应发生率(2.13%)与对照组(10.64%)对比,差异无统计学意义(P>0.05)。结论帕米膦酸二钠可改善糖皮质激素相关性骨质疏松症患者骨代谢生化指标,增加股骨近端骨密度与腰椎骨密度,且可降低不良反应发生率。     

脊髓损伤患者骨密度变化的分析

目的探讨影响脊髓损伤患者骨密度的因素及骨密度变化的部位差异.方法回顾2000年5月～2002年12月290例脊髓损伤患者经双能X线骨密度仪(Lunar Prodigy型)测得的L4和股骨近端的骨密度资料,对其中进行了2～3次检查的81例患者的骨密度变化进行了进一步的分析. 结果骨密度与年龄、病程、体重指数及脊髓损伤神经学分类国际标准的运动评分等因素的多元逐步回归分析结果显示,L4骨密度与体重指数呈独立正相关(偏回归系数为0.0152, P<0.01;R2=0.059,P<0.01);对股部各测试区域骨密度有显著影响的共同参数依次为病程(偏回归系数为-0.0055～-0.0040,P<0.01)及体重指数(偏回归系数为0.0031～0.0162,P<0.01,Wards三角除外);比较81例患者的骨密度变化百分比[(前1次骨密度-后1次骨密度)/前1次骨密度×100%],L4的骨密度变化百分比(-0.7%)比股骨近端(4.5%)及各分区(3.4%～6.1%)的要小,各部位骨密度分别比较,差异均有极显著性意义(P<0.01);比较股骨近端各分区的骨密度变化百分比,股骨颈的下降程度最小(3.4%), 股骨干(4.2%)和Wards三角(4.9%)次之,股骨转子(6.1%)降低最为严重. 结论脊髓损伤患者骨密度影响因素及变化有部位差异.     

原发性肾脏病患者糖皮质激素性骨质疏松预防用药最佳时间段的探讨

目的探讨原发性肾脏病患者糖皮质激素性骨质疏松预防用药的最佳时间段。方法将应用糖皮质激素治疗的原发性肾小球疾病患者61例随机分为2组，均予阿法骨化醇0．5μg/d口服，碳酸钙750mg每日3次口服；30例服用6个月，31例服用1年。治疗前及治疗后6、12个月时检测患者腰椎（L2-L4）及股骨颈骨密度，同时测定血钙、24h尿蛋白定量、血清白蛋白等常规生化指标。结果2组患者6个月和12个月时腰椎、股骨颈骨密度与治疗前相比均无明显变化（P〉0．05）。结论慢性肾脏病患者应用糖皮质激素的同时予以阿法骨化醇0．5μg/d加钙剂应用6个月可以预防其骨丢失。     

阿仑膦酸盐预防和治疗男性骨质疏松症疗效的系统评价

目的评价阿仑膦酸盐预防和治疗男性骨质疏松症的效果和可能的不良反应。方法电子检索:MEDLINE(1990-2005)、EMBASE(1990-2005)、 Cochrane图书馆临床对照试验资料库(2005年第3期)、Current Controlled Trials、The National Research Register、中国生物医学义献数据库 (1990-2005)和中文科技期刊全文数据库(1990-2005)、中文学术期刊全文数据库(1990-2005),并手工检索相关领域其他杂志。检索时间截止至2005年11月。所有检索均不受语种限制。纳入以有骨质疏松症高危风险或患骨质疏松症男性为研究对象、比较阿仑膦酸盐与其它疗法疗效的随机对照试验,评价纳入研究的质量,并用RevMan 4．28软件进行Meta分析。结果共纳入7个随机对照试验,包括817例患者。Meta分析结果显示,阿仑膦酸盐 钙剂对提高骨质疏松症高危男性患者腰椎骨密度的作用优于单用钙剂[SMD 0．59,95％CI(0．15,1．03),P=0．009];对于降低骨折风险,阿仑膦酸盐 钙剂与单用钙剂相似;对于降低脊柱骨折的风险,2年以上疗程的阿仑膦酸盐治疗优于α-骨化醇,但是对于非脊椎骨折,两者疗效相似;阿仑膦酸盐提高骨密度的效果优于α-骨化醇、钙剂;在预防骨质疏松症、提高骨密度方面,阿仑膦酸盐不如降钙素、α-骨化醇、甲状旁腺激素;阿仑膦酸盐联合甲状旁腺激素优于单独使用阿仑膦酸盐;阿仑膦酸盐联合甲状旁腺激素与单独使用甲状旁腺激素比较,两者对提高骨密度的疗效相似。结论阿仑膦酸盐预防和治疗男性骨质疏松症的疗效优于钙剂;对于提高骨密度,阿仑膦酸盐不如降钙素、α-骨化醇;长期使用阿仑膦酸盐比α-骨化醇更能减少脊柱骨折的风险。阿仑膦酸盐联合甲状旁腺激素与单用甲状旁腺激素比较,两者在治疗男性骨质疏松症方面的效果相似。今后尚需开展更多高质量特别是多中心研究以增加证据的强度。     

云克治疗绝经后2型糖尿病合并骨质疏松症的疗效研究

目的 探讨云克(锝亚甲基二磷酸盐针剂)治疗绝经后2型糖尿病患者合并骨质疏松症疗效观察.方法 诊断明确的绝经后2型糖尿病合并骨质疏松症患者59例随机分为治疗组和对照组,治疗组综合治疗基础上应用锝亚甲基二膦酸盐针剂联合口服钙尔奇D片、骨化三醇胶丸,对照组口服钙尔奇D片、骨化三醇胶丸.结果 治疗组6个月后骨密度不同程度增加,临床症状改善,总有效率93.5％,差异有统计学意义(P＜0.05).结论 云克治疗绝经后2型糖尿病合并骨质疏松症安全有效.     

药物预防全髋关节置换后继发假体周围骨溶解的5年随机对照评价

背景:全髋关节置换后出现轻微的骨溶解,如果能找到理想的药物治疗,不但可减轻痛苦,还可节省医疗费用。目的:观察阿仑膦酸钠和阿法骨化醇联合应用预防全髋关节置换后假体周围骨溶解的效果。方法:75例股骨颈骨折患者行骨水泥型人工髋关节置换后随机分为3组,治疗组给予阿仑膦酸钠和阿法骨化醇口服联合治疗、对照组给予复方氨基酸螯合钙胶囊口服治疗,空白组正常饮食。随访1,3,5年,检测假体周围骨密度值变化、髋关节功能评分,5年后进行影像学评价。结果与结论:髋关节置换后3,5年治疗组骨密度值高于对照组和空白组(P<0.05),置换后5年治疗组骨溶解率低于对照组和空白组(P<0.05)。结果显示阿仑膦酸钠和阿法骨化醇联合应用,在预防髋关节假体置换后继发骨溶解发生的过程中起到了一定的积极作用。     

Bone mineral density after spinal cord injury: a reliable method for knee measurement

OBJECTIVES: To test the interrater reliability of a standardized method to analyze knee bone mineral density (BMD) using dual-energy x-ray absorptiometry (DXA); to compare spine, hip, and knee BMD of people with spinal cord injury (SCI) with able-bodied controls; and to determine the relation between hip BMD and knee BMD in SCI and able-bodied subjects. DESIGN: Criterion standard and masked comparison. SETTING: Primary care university hospital. PARTICIPANTS: A convenience sample of 11 subjects with complete SCI was age and sex matched with 11 able-bodied control subjects. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Four raters analyzed regions of interest according to operational definitions recently developed to standardize the analysis of BMD of the knee. Subjects with chronic SCI and matched controls underwent conventional DXA scans of the spine and hips and "less conventional" scans of the distal femurs and proximal tibias. The relation between hip and knee BMD was analyzed. RESULTS: The knee measurements were highly reliable (femur intraclass correlation coefficient model 2,1 [ICC(2,1)]=.98; tibia ICC(2,1)=.89). Subjects with SCI had lower BMD values than controls at all hip and knee sites (P<.05). Lumbar spine BMD did not differ between groups. Hip BMD was moderately predictive of distal femur BMD (R2=.67), but less correlated with the proximal tibia (R2=.38). CONCLUSIONS: Knee BMD can be reliably analyzed using DXA with this protocol. Subjects with SCI have diminished knee and hip BMD. Low hip BMD is associated with low distal femur BMD.     

The relationship between basal metabolic rate and femur bone mineral density in men with traumatic spinal cord injury

OBJECTIVES: To investigate the relationship between basal metabolic rate (BMR) and hip bone mineral density (BMD) in people with spinal cord injury (SCI) and to determine whether neurologic factors contribute to this relationship. DESIGN: Cross-sectional study. SETTING: Inpatient SCI unit in a rehabilitation hospital. PARTICIPANTS: Thirty men with chronic (time since injury, >1 y) traumatic SCI with an American Spinal Injury Association Impairment Scale grade A or B. Subjects' mean age was 32 years (range, 20-45 y). INTERVENTIONS: All participants were evaluated with neurologic examination to define the level and severity of injury. BMR was determined by indirect calorimetry, and BMD was determined by dual-energy x-ray absorptiometry (DXA). Patients were allocated to osteoporotic, osteopenic, and normal bone density groups according to World Health Organization criteria. DXA was used also to estimate lean- and fat-tissue mass (in kilograms) by standard methods. DXA measurements were performed on the same day as BMR analysis. MAIN OUTCOME MEASURES: DXA and indirect calorimetry. RESULTS: BMR correlated significantly with BMD of the total femur, femur neck, trochanter, and shaft. However, there was no correlation between BMR and femur Ward's triangle. These correlations were stronger in patients with tetraplegia. There was a moderate correlation between BMR and lean tissue mass (r = .66, P < .001), although femur BMD values did not correlate with lean tissue mass in our study group (P > .05). CONCLUSIONS: BMR is closely associated with BMD in men with SCI.     

脊髓损伤后大鼠骨代谢和骨密度变化

目的:了解脊髓损伤后不同时期大鼠骨代谢和骨密度的变化。方法:60只SD大鼠按体重随机分为6组,对20只大鼠采用脊髓横断法在第10胸椎段横断脊髓制作完全性脊髓损伤模型,分为脊髓损伤6周和12周组;20只在同水平处切断棘突、椎板制作假手术对照组,分为假手术6周和12周组;另20只分为正常6周和12周对照组。分别在脊髓损伤后6周和12周时处死动物。结果:脊髓损伤6周、12周时,脊髓损伤组血Ca较对照组明显升高(P<0.05),碱性磷酸酶和骨钙素则较对照组无明显变化(P>0.05)。脊髓损伤6周时,股骨近端、远端骨密度(BMD)均较对照组显著降低(P<0.001),损伤12周时,除股骨近端、远端外,中段BM D也明显降低(P<0.05)。L5BMD在SCI6周和SCI12周与对照组比较差异无显著性意义(P>0.05)。结论:脊髓损伤6周时,大鼠骨代谢已发生明显改变,骨量出现明显丢失,12周时骨代谢稍有改善,但股骨骨量丢失持续存在。     

脊髓损伤对大鼠股骨骨密度与生物力学特性的影响

目的探讨脊髓损伤(spinal cord injury, SCI)对大鼠股骨生物力学和骨密度(bone mineral density, BMD)的影响. 方法将40只3月龄大鼠随机分为SCI组和对照组,SCI组于T10椎体处完全切断脊髓,对照组仅行椎板切除术.于术后3,6周分2批处死动物进行股骨骨密度和生物力学测定. 结果术后3周时SCI组大鼠股骨远端BMD较对照组显著下降(P<0.05);术后6周时SCI组股骨近端BMD与对照组比较,下降差异显著(P<0.05);股骨远端BMD较对照组下降差异非常显著(P<0.01);股骨干BMD与对照组相比有降低趋势,但无统计学意义.术后3周时股骨颈最大载荷、最大变形、结构刚度及能量吸收在2组间差异均无统计学意义.术后6周时最大变形、结构刚度和能量吸收均低于对照组(P均<0.05),最大载荷低于对照组,差异具有极显著性意义(P<0.01). 结论脊髓损伤后松质骨骨密度和生物力学性能的降低先于密质骨.脊髓损伤后6周时SCI组股骨松质骨的骨密度及生物力学参数均显著低于对照组,脊髓损伤后6周的大鼠可作为骨质疏松动物模型.     

太极拳锻炼对绝经后女性骨密度的影响

目的探讨太极拳锻炼对绝经后女性骨密度、骨质疏松发生情况的影响以及不同太极拳锻炼年限对骨密度的影响。方法105 名绝经后女性分为太极拳组(n=54)和对照组(n=51),进行双能X线骨密度检测。结果太极拳组L1、L2、股骨干骨密度值高于对照组(P<0.05),L4、左股骨颈、左Wards 三角区骨密度明显高于对照组(P<0.01);太极拳组骨质疏松患病率(31.48%)略低于对照组(39.22%),但无显著性差异(P>0.05);练习太极拳5 年以上的绝经后女性在L1、L2、左股骨颈、左Wards 三角区、股骨干部位的骨密度值高于练习太极拳小于5 年的绝经后女性(P<0.05)。结论长期锻炼太极拳可改善绝经后女性骨密度水平,降低骨质疏松患病率。     

Bone mineral density after bicycle ergometry training

The effect of functional electrical stimulation (FES) cycle ergometry on bone mineral density (BMD) was investigated in six spinal cord injury (SCI) quadriplegic men. Each subject trained three days a week for six months on an FES cycle ergometer. Pretraining and posttraining BMD measurements of the proximal femur were performed using dual photon absorptiometry. Mean pretraining BMD (percent norm) for the femoral neck, Ward triangle, and trochanter were 66.65, 57.43, and 57.67, respectively. After six months of FES cycle ergometry, mean BMD measurements were 66.15, 57.07, and 55.13, respectively. There was no statistically significant difference between the pretraining and posttraining BMD measurements. All subjects were found to have osteoporotic proximal femurs when BMD was expressed as a percent of their age-matched controls. Bone mineral density measurements were subsequently performed on three additional men with SCI who had exercised for three years with the FES cycle ergometry modality. Their mean BMDs were not significantly different from the experimental group. This study demonstrated that six months of FES cycle ergometry did not produce an increase in BMD.     

Electrical stimulation: can it increase muscle strength and reverse osteopenia in spinal cord injured individuals?

OBJECTIVE: To study the extent to which atrophy of muscle and progressive weakening of the long bones after spinal cord injury (SCI) can be reversed by functional electrical stimulation (FES) and resistance training. DESIGN: A within-subject, contralateral limb, and matching design. SETTING: Research laboratories in university settings. PARTICIPANTS: Fourteen patients with SCI (C5 to T5) and 14 control subjects volunteered for this study. INTERVENTIONS: The left quadriceps were stimulated to contract against an isokinetic load (resisted) while the right quadriceps contracted against gravity (unresisted) for 1 hour a day, 5 days a week, for 24 weeks. MAIN OUTCOME MEASURES: Bone mineral density (BMD) of the distal femur, proximal tibia, and mid-tibia obtained by dual energy x-ray absorptiometry, and torque (strength). RESULTS: Initially, the BMD of SCI subjects was lower than that of controls. After training, the distal femur and proximal tibia had recovered nearly 30% of the bone lost, compared with the controls. There was no difference in the mid-tibia or between the sides at any level. There was a large strength gain, with the rate of increase being substantially greater on the resisted side. CONCLUSION: Osteopenia of the distal femur and proximal tibia and the loss of strength of the quadriceps can be partly reversed by regular FES-assisted training.     

脉冲电磁场及阿仑膦酸钠对脊髓损伤大鼠骨质量的影响

目的探讨早期应用脉冲电磁场（PEMFs）和／或阿仑膦酸钠（ALN）对脊髓损伤（SCI）后大鼠骨质量的影响。方法将62只3月龄雌性sD大鼠随机分为5组，其中假手术组仅行椎板切除术，SCI组、SCI＋ALN组、SCI＋PEMFs组及SCI＋PEMFs＋ALN组行脊髓完全横断术，后3组于术后1周时分别给予ALN和／或PEMFs治疗；于术后8周时取材，检测各组大鼠股骨骨密度值、生物力学指标以及胫骨近端骨组织形态计量学等指标。实验所得数据比较采用单因素方差分析及析因分析。结果早期应用ALN和／或PEMFs均可使股骨骨密度、股骨弹性载荷、最大载荷等生物力学指标增高，胫骨近端骨小梁面积百分比也同时增大，骨小梁宽度增加。结论早期应用ALN和／或PEMFs均可抑制SCI后骨量丢失，增强抗骨折能力，阻止胫骨近端微观结构的退变，提示早期应用ALN及PEMFs有助于防治SCI后骨质疏松，但其具体治疗机制还有待进一步研究。     

不同性别、年龄及不同骨骼部位骨质疏松检出率的比较

背景早期诊治骨质疏松( osteoporosis, OP)目前仍以骨密度( bone mineral density, BMD)的测定为标准.但在测定中随不同性别、不同年龄、骨骼不同部位的 OP检出率不同,有必要分析这种差别. 目的比较不同性别随增龄在骨骼不同部位骨质疏松检出率的不同. 设计以患者为研究对象的横断面调查. 单位一所军队炮兵总医院的内分泌科. 对象本研究在解放军第二炮兵总医院内分泌科完成.选择 2000- 09/2002- 01在本院门诊就诊的患者共 147例,其中男 54例,女 93例,年龄 50～ 78岁.按年龄分为 3组,即 50～ 59岁组、 60～ 69岁组和 70～ 79岁组,各组人数分别为 46例(男 13例,女 33例), 66例(男 26例,女 40例)和 35例(男 15例,女 20例).纳入标准①年龄≥ 50岁,女性均为绝经后;②符合 WHO推荐的 OP诊断标准 [1].排除标准患肝、肾、心脏、胃肠道等脏器慢性疾病及糖尿病、甲亢等内分泌疾病引起的继发性骨质疏松者. 方法每个受试者详细填写病史调查表,准确测量身高和体质量,并计算体质量指数( kg/m2).应用本院新型 Norland Excell plus 双能 X线骨密度吸收仪( DEXA)测定每一受试者的 L2- 4及股骨近端(股骨颈、 Ward' s三角、大转子) BMD值( g/cm2).将所测值与同性别年轻成年人正常数据比较,得出 T评分(即 SD). 主要观察指标①不同性别、年龄、部位 OP检出结果比较;②年龄及体质量指数与 BMD的相关性. 结果女性更年期以腰椎 OP为主(χ 2=10.14,P< 0.01),随年龄增加腰椎和股骨颈均出现 OP的检出率增加 (χ 2=7.41,P< 0.05);男性 60岁以后以单纯股骨颈 OP增加明显(χ 2=9.11,P< 0.05);女性较男性更易患单纯腰椎 OP及腰椎和股骨颈均出现 OP(χ 2=8.04,P< 0.05;χ 2=14.26,P< 0.01);女性年龄与股骨颈、 Ward, s三角及大转子区 BMD有明显负相关( r=- 0.364,- 0.389,P< 0.01;r=- 0.504,P< 0.001);体质量指数与 L2～ 4、股骨颈和大转子 BMD有明显正相关( r=0.306,0.329,0.338,P< 0.05). 结论 OP的检出率随骨骼测量部位和年龄的变化而变化.正确认识和评价这些客观现象,对 OP的诊治具有重要意义.     

低频振动对脊髓损伤继发骨质疏松的影响

目的了解低频振动对脊髓损伤（SCI）继发骨质疏松（OP）大鼠骨代谢和骨质量的影响。方法50只SD大鼠采用脊髓全切横断法在第10胸椎处横断脊髓制作完全性SCI模型,并随机分为SCI6周对照组（SCI6w）、SCI12周对照组（SCI12w）、振动6周组（Vi6w）、振动12周组（Vi12w）和SCI6-12周振动组（Vi6-12w）,每组10只;振动组分别于SCI后第4天（Vi6w组、Vi12w组）、第7周（Vi6-12w组）开始接受振动干预,振动频率20Hz,加速度0.15g,10min/次,2次/d,6d/周,Vi6w组和Vi6-12w组共振动6周,Vi12w组振动12周。分别在振动结束1d后处死动物,进行骨代谢血生化指标、骨密度（BMD）、骨形态计量学和生物力学性能测试。结果Vi6w组大鼠血Ca和股骨近端BMD较对照组改善（P〈0.05）;Vi12w组第5腰椎最大载荷较对照组升高（P〈0.05）;Vi6-12w组大鼠骨代谢和骨质量未见明显变化。结论早期开始的低频振动干预可改善SCI继发OP,但存在部位差异;后期进行的振动干预不能改善SCI继发OP,但可防止其进展。