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1.
I. S. Proskuryakova 《Bulletin of experimental biology and medicine》1995,119(6):633-636
It is demonstrated that cytoplasmic extract of rat pup liver stimulates cellular and intracellular regeneration of hepatocytes
exposed to the toxic agent CCl4. Injection of liver cytosol stabilizes lysosomal membranes, increases the coefficient of energy efficiency of mitochondria,
and activates proliferation of polyploid hepatocytes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 656–659, June, 1995
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
2.
T. N. Makarenko G. N. Chernobaeva L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1994,118(6):1303-1306
A satistically significant decrease in the content of cytochromes P-450 and b5 and in the activity of aniline hydroxylase and p-nitroanisole demethylase occurs in rat liver microsomes during the development
of experimental acute fatty hepatosis develoing within a 24-h period after intraperitoneal administration of 125 mg/kg tetracycline
hydrochloride. Under these experimental conditions tetracycline hydrochloride elicits only an insignificant disintegrating
effect on oxidative phosphorylation in liver mitochondria.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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12, pp. 612–615, December, 1994 相似文献
3.
I. Yu. Malyshev P. A. Prodius F. Z. Meerson 《Bulletin of experimental biology and medicine》1995,119(1):20-22
Adaptation to physical loads elicits pronounced anti-ischemic and antireperfusion effects on the isolated heart. By the 20th
min of total ischemia contracture in the hearts of adapted animals is much less than that in the control group. During reperfusion
of hearts from adapted animals the degree of restoration of the contractile force was 6-fold higher, contracture was lesser,
and the total period of tachycardia and fibrillation were 3-fold shorter than in the control.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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1, pp. 25–27, January, 1995
Presented by S. S. Debov, Member of the Russian Academy of Medical Sciences 相似文献
4.
N. G. Kolosova N. A. Solov'eva I. G. Shabalina R. I. Salganik 《Bulletin of experimental biology and medicine》1996,121(3):259-261
It is shown that at the age of 2–3 months S rats with genetically determined hyperproduction of free radicals have the same
content of tocopherol in the heart, epididymal fat, adrenals, liver, and liver mitochondria as Wistar rats but a lower content
of plasma tocopherol. At 10–12 months, the tocopherol content in all studied tissues and organs, except the liver, is higher
than in young S rats and age-matched Wistar rats. This is regarded as a compensatory response facilitating the stabilization
of LPO under conditions of increased free radical formation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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3, pp. 282–284, March, 1996 相似文献
5.
A. G. Globa V. A. Vishnevskii V. S. Demidova O. Yu. Abakumova A. A. Karelin 《Bulletin of experimental biology and medicine》1996,121(3):249-252
Using the method of ATP luminometry it is shown that crude membrane preparations from human and rat hepatocytes accumulate
ATP 20–100 nmol/mg protein during a 1-min incubation under conditions of oxidative phosphorylation. Application of appropriate
inhibitors shows that a possible contamination of the membrane preparations with mitochondria does not contribute to this
ATP accumulation. Phosphatidylcholine, tumor necrosis factor, and cell proliferation factor markedly stimulate the accumulation
of ATP by plasma membraneenriched particles isolated from rat and human liver. The hepatocyte plasma membrane is shown to
be able to synthesize ATP from inorganic phosphate and ADP using the aerobic mechanism. ATP in the plasma membrane is assumed
to participate in the transmembrane signal transduction from growth factors to the cell effector systems.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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3, pp. 271–274, March, 1996
Presented by V. D. Fedorov, Member of the Russian Academy of Medical Sciences 相似文献
6.
M. S. Tverskaya V. V. Karpova A. O. Virganskii D. S. Mel'chenko 《Bulletin of experimental biology and medicine》1995,120(6):1258-1261
The period immediately following massive pulmonary embolism largely determines its further course, that is, whether compensation
will occur or whether heart failure will ensue. Prognostically favorable or unfavorable histochemical characteristics of myocardial
metabolism during this period are revealed in this study.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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12, pp. 647–650, December, 1995
Presented by V. S. Savel'ev, Member of the Russian Academy of Medical Sciences 相似文献
7.
A. S. Dukhanin P. V. Sergeev L. I. Stankevich N. N. Bulaeva 《Bulletin of experimental biology and medicine》1995,119(3):285-287
The effect of the purine receptor ligands N-ethylcarboxamide adenine and adenosine and of the purine antagonists mercaptopurine
and azathioprine on the intracellular cAMP content in human peripheral blood lymphocytes and bone marrow lymphoblasts was
studied. All preparations tested induced an increase in the cAMP level in peripheral blood lymphocytes. The selective immunosuppressive
effect of adenosine antagonists may be due to their ability to modulate the activity of adenylate cyclase in lymphoid cells.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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. 3, pp. 294–296, March, 1995 相似文献
8.
A. S. Dukhanin L. I. Stankevich M. P. Petrova 《Bulletin of experimental biology and medicine》1995,119(2):162-165
It is demonstrated that pertussis toxin and hydrocortisone potentiate the adenosine-induced rise of the cAMP concentration
in lymphocytes. Hydrocortisone elicits an immediate (for the simultaneous addition of adenosine and cortisol) and reversible
effect. The effect of pertussis toxin has a latency and is irreversible. Added together, these agents exert no cumulative
effect. It is assumed that hydrocortisone and pertussis toxin have the same target — The inhibiting regulatory protein Gi.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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2, pp. 171–173, February, 1995
Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences 相似文献
9.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(1):22-25
Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high
and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are
found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products
is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance
to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming
that oxidation plays a major role in the damaging and lethal effects of acute hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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1, pp 26–29, January, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
10.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(2):126-131
The relationship between the intensity of lipid peroxidation and the activity of the antioxidant system in the heart, liver,
and brain is studied in male Wistar rats with low and high resistance to hypoxia tested by being “raised” to an altitude of
11.5 km and in intact outbred rats. It is found that in all groups of rats the content of lipid peroxidation products is highest
in the liver, lower in the heart, and lowest in the brain. In all groups, the rate of the ascorbate-induced lipid peroxidation
is highest in the brain, lower in the liver, and lowest in the heart. The activity of the antioxidant system is highest in
the brain, lower in the liver, and lowest in the heart of low-resistance and outbred rats, while in high-resistance rats it
is the same in all the organs. Thus, the difference in the parameters of lipid peroxidation and, particularly, of the antioxidant
system in the studied organs is most pronounced in rats with a low resistance to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
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2, pp. 138–143, February, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
11.
In contrast to short-term exposure, prolonged exposure to ethanol in the anternatal period is found to inhibit lipid peroxidation
in the brain and liver of rats. Activation of the system of antioxidant defense in the brain and liver is observed after both
short-and long-term exposure to ethanol. After short-term ethanol exposure, limontar normalizes lipid peroxidation.
Translated fromByulleten' Eksperimental'noii Biologii i Meditsiny, Vol. 117, N
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1, pp. 41–44, January, 1994
Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences 相似文献
12.
V. Ya. Brodskii 《Bulletin of experimental biology and medicine》1995,119(5):435-440
The mammalian heart is a polyploid organ. Cardiac myocytes undergo polyploidization in the early postnatal ontogeny, and the
degree of their polyploid depends on the conditions of heart growth. The myocardium of healthy persons is characterized by
considerable individual variability of polyploidy. The principal mechanism by which normal and compensatory growth of the
heart occurs in adult mammals is through increases of cytoplasmic mass in postmitotic myocytes. In the normal myocardium,
the protein mass of myocytes does not correspond to the gene dosage, while their protein mass in a hypertrophic myocardium
becomes a multiple of their ploidy. The capacity of polyploid myocytes to grow so as to double their mass constitutes the
reserve of cardiac growth. This reserve, which is laid down in the early ontogeny, materializes in response to functional
overloading of the heart in adult life.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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5, pp. 454–459, May, 1995
Presented by D. S. Sarkisov, Member of the Russian Academy of Medical Sciences 相似文献
13.
I. V. Stupin P. A. Karmanov A. I. Novokshonov G. G. Belous G. K. Krasyuk V. S. Sergeeva 《Bulletin of experimental biology and medicine》1995,119(4):418-419
Eighty guinea pigs underwent resection of the left lateral lobe of the liver, performed with a beam of ionized plasma. Morphological
analysis 32 and 45 hours after partial hepatectomy revealed minor damage to the parenchyma to a depth of 300–400 μ. Autoradiography
showed proliferative activity in the organ to occur in the early post-operative period.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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4, pp. 431–432, April, 1995
Presented by B. T. Velichkovskii, Member of the Russian Academy of Medical Sciences 相似文献
14.
M. G. Pshennikova V. I. Kuznetsov S. V. Trishkin K. B. Vinnitskaya N. T. Vorob'eva V. A. Tyabenkova T. D. Bol'shakova L. I. Vinnitskii 《Bulletin of experimental biology and medicine》1995,120(1):681-684
Rats were adapted to the continuous action of moderate immobilization stress for 1, 5, and 15 days. Thereafter the threshold
of ventricular fibrillation and the heart rate were compared with biochemical indexes of adrenergic and cholinergic regulation
of the heart, namely, catecholamine, cAMP, and cGMP content, acetylcholinesterase and choline acetyltransferase activity,
the number and affinity of cardiac muscarinic receptors, and the catecholamine content in the adrenals. The threshold of ventricular
fibrillation fell on the 1st day due to a predominance of the adrenergic regulatory effect over the cholinergic. Adaptation
for 5 days is attended by a rise of the threshold of ventricular fibrillation to the norm and by marked bradycardia, both
these shifts being abolished by atropine. Elevation of the heart's resistance to arrhythmias stems from the prevalence of
cholinergic regulation. Equilibrium between the cholinergic and adrenergic effects on the heart was found as a results of
15-day adaptation. The normal threshold of ventricular fibrillation and the increased cardiac resistance to arrhythmia were
preserved and dictated largely by adaptive changes at the cardiomycyte level.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120. N
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7, pp. 36–39, July, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
15.
A. Yu. Tsibulevskii A. I. Sergeev T. K. Dubovaya 《Bulletin of experimental biology and medicine》1995,120(6):1199-1201
Acute poisoning of rats with the hepatotropic poison tetrachloromethane was accompanied by increases in the liver content
of total water and its spin-lattice (T
1) and spin-spin (T
2) relaxation times and by a decrease in theT
1/T
2 ratio, with reversal of the correlation betweenT
1 andT
2. The antihypoxic agent sodium γ-oxybutyrate normalized water metabolism in the liver almost completely. It is concluded that
total water content andT
1 are the more informative parameters for monitoring both toxic liver damage and the efficacy of its pharmacological correction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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12, pp. 584–586, December, 1995
Presented by Yu. A. Vladimirov, Member of the Russian Academy of Medical Sciences 相似文献
16.
R. I. Salganik I. G. Shabalina N. G. Kolosova V. N. Solov'ev N. A. Solov'eva A. R. Kolpakov 《Bulletin of experimental biology and medicine》1995,119(6):605-607
Liver mitochondria of inbred W/SSM rats with inherited increased radical formation reveal the following anomalies: inhibition
of oxidative phosphorylation, a lowered transmembrane potential, and alterations in protein-lipid interaction. The membrane
viscosity and osmotic stability of mitochondria are unaffected.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
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6, pp. 628–631, June, 1995 相似文献
17.
T. N. Makarenko A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1994,118(6):1294-1296
It is demonstrated that intraperitoneal administration of tetracycline hydrochloride in a dose of 125 mg/kg leads to the development
of acute fatty hepatosis in rats within a 24-h period, by which time the maximum accumulation of lipids and triacylglycerides
is observed in the liver. In addition, a direct dependence is established between the severity of fatty hepatosis and a decrease
in the cytochrome P-450 content. The cytochrome P-450 content is a dynamic predictor of tetracycline fatty hepatosis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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12, pp. 603–605, December, 1994 相似文献
18.
T. K. Dubovaya A. Yu. Tsibulevskii A. I. Sergeev 《Bulletin of experimental biology and medicine》1995,120(4):1070-1072
Bilateral subdiaphragmatic truncal vagotomy in rats results in a disturbance of water metabolism in the liver and small intestine
which manifests itself in an increase of the total water content, prolongation of the spin-lattice and spin-spin relaxation,
and in a distortion of the correlation between them. The dynamics of water metabolism is of a onepeak nature in the liver
with a maximum after 7 days, whereas in the small intestine it is of a dual-peak type with peaks at 7 and 30 days. Near-normalization
of the water balance in the digestive organs occurs 220 days later.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
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10, pp. 442–444, October, 1995
Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences 相似文献
19.
Yu. V. Burov A. S. Pivovarov T. N. Robakidze 《Bulletin of experimental biology and medicine》1994,118(5):1166-1169
The effect of amiridine on the local inward acetylcholine current and its volt-ampere characteristic are studied by the two-electrode
method of membrane voltage clamp in identified RPa3 and LPa3helix lucorum neurons pretreated with forskolin, sodium nitroprusside, A23187, and EGTA. The results suggest that second messengers (Ca2+, NO, cGMP, and cAMP) are implicated in the amiridine-mediated regulation of cholinoceptors inHelix lucorum neurons.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
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11, pp. 470–473, November, 1994
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
20.
Effects of some steroid hormones on Ca2+ transport and oxidative metabolism of isolated mitochondria
L. D. Luk'yanova R. A. Eliseev T. N. Makarenko A. I. Matyushin 《Bulletin of experimental biology and medicine》1994,118(6):1307-1310
Effects of prednisolone, estradiol, and testosterone on the transport of Ca2+ and the respiration induced by it in the heart and liver mitochondria of rats were studied. Prednisolone and testosterone
were found to reduce the Ca-accumulating capacity of the mitochondria, the rates of ion entry and exit, and the rate of Ca2+-induced respiration. Estradiol, while inhibiting Ca2+ transport across mitochondrial membrane, did not influence the respiration in the phase of Ca2+ absorption, but accelerated it in the phase of ion exit. These data suggest that due to their lipophilic properties, the
steroids become incorporated in the mitochondrial membrane, thereby changing its viscosity and permeability and limiting the
mobility of transmitter proteins.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 616–618, December, 1994 相似文献