大鼠左心室肥厚模型研究概况

对近几年有关左心室肥厚的动物模型研究资料整理、总结，主要有压力负荷型、容量负荷型、肾性高血压型等大鼠心肌肥厚模型，同时也归纳了离体心肌细胞肥厚模型研究方法，以期为左心室肥厚的病因病机研究、临床诊疗方法及开发有效的防治药物提供理论参考。     

排卵功能障碍性不孕症的中医治疗进展

中医对排卵障碍性不孕病因病机、辨证论治、周期调节、针灸的研究皆取得了较大进展，根据有关文献对中医药治疗排卵障碍性不孕症进行综述。     

胰岛素样生长因子系统与肿瘤（文献综述）

恶性肿瘤发病率及死亡率在我国均很高，且就诊时大多已为晚期。因此加强肿瘤病因、病机及诊疗的研究，提高早期诊断率及疗效已成为临床工作的重点；而近年来大量研究表明血液中IGFs水平升高，与乳腺癌、肺癌、肝癌、胃癌、结肠癌等恶性肿瘤发病呈明显正相关，IGFs的信号通路研究有望成为它在肿瘤早期诊断、分子靶向治疗方面提供有力的帮助。     

新药特药

新药特药河南研制成功治疗囊虫病中药河南中医学院疑难病研究中心囊虫病专家课题组研制成功的“速效灭囊灵”、“速效镇癫丹”等系列预防和治疗囊虫药的中药胶囊，对囊虫病的防治具有良好效果。经６０００多名患者服用表明：该系列新药不但能安全迅速有效地杀死寄生在人体...     

慢性疲劳综合征的中医研究

通过对近年来有关慢性疲劳综合征文献的回顾,对慢性疲劳综合征的中医病名、病因病机等方面进行了综述。同时笔者主要从中医整体观念、辨证论治角度出发阐述慢性疲劳综合征近十年病因病机及中医药治疗进展,提出中医药治疗优势,综述中医药治疗慢性疲劳综合征的新路,以期为临床治疗慢性疲劳综合征提供思路。     

中医药防治心肌缺血再灌注损伤的研究进展

中医药是中华民族的宝贵财富,其治疗理念正逐渐被世界所接受,中医以疏通经脉、渗灌气血、濡养心神指导临床,其文献中无心肌缺血再灌注损伤一词,依据其病理过程中表现出的症状,多归属于中医的“胸痹”“心悸”和“真心痛”等范畴,现将MIRI的病理机制及中医药治疗进行整理,了解中医药对MIRI的干预治疗,从而为临床诊疗提供应用价值。     

论中医病因之“毒”

近十余年，关于“毒”的病因病机学理论和临床研究颇多，已引起中医界的广泛关注，解毒法被广泛应用于临床各科。并取得了显著疗效。随着对毒邪的认识的不断系统、深入，如何正确界定“毒”的病因学概念，对中医理论体系的构建和临床实践都将具有十分重要的意义．     

截瘫康系列制剂在哈尔滨问世

哈尔滨市康复截瘫病研究所研制成功截瘫康系列制剂，在治疗外伤性截瘫上取得新进展。外伤性截瘫多发生于生产第一线或交通事故及意外伤害，目前国内外流行的办法是手术减压，并佐以按摩、水针、体疗等，但由于不能引起肌体的根本性变化，因此预后多不理想。我国首家研究外伤性截瘫的哈尔滨市康复截瘫病研究所，在著名老中医王纪元的率领下，经多年反复实践、临床验证，研制成功截瘫康系列制剂。这种能明显促进脊髓感觉和运动神经恢复作用，大幅度提高肌体活力，在一定程度上解决了困扰截瘫病人的大小便失调、四肢无力、活动障碍等症状，为截…     

中医药诊治类风湿关节炎的研究现状

类风湿关节炎（Rheumatoid Arthritis,RA）是一种以慢性、对称性、侵蚀性关节炎损害为主要表现的全身性自身免疫性疾病。中医药治疗RA具有较好的临床疗效。近年RA的病因病机研究以风寒湿三气夹杂理论为基础,多从痰瘀互结、热毒瘀结的角度或者脏腑气血虚损方面进行。治疗上除了使用经典专方外,侧重于中药单体或提取物运用的研究,并提倡综合治疗。虽然中医药在诊治类风湿关节炎取得了很大的进展,但在研究和治疗的系统化及规范化方面尚需进一步的加强。     

中医药传统知识该如何保护

祖上传下来的“宝贝”，必须百倍珍视，因为那不仅仅是遗产，还是一种国家和民族文化的象征。然而，由于没有相关的法律和规范加以保护，中医药传统知识只能眼睁睁地被他人“堂而皇之地掠夺和无偿地坐享成果”。最近结题的“中医药传统知识保护研究”，首次站在国家层面认真探讨了这一问题，并提出了保护措施。尤为可喜的是，“中医药保护与利用”已经作为一项专门内容，于不久前被列入我国的“国家知识产权战略”。     

益气活血解毒法对不稳定性心绞痛患者血管内皮保护与抑制血小板活化作用

观察益气活血解毒法治疗不稳定性心绞痛患者 ,血管内皮保护与抑制血小板活化作用。将 43例不稳定性心绞痛患者 ,随机分为 2个治疗组 :单用西药治疗组 (对照组 )与益气活血解毒法治疗组 (中药组 )。 2组均给予同样的常规西药方案治疗 ,中药组加静脉滴注黄芪注射液 (每日 2 0ml,含黄芪 40 g) ,静脉滴注络泰注射液 (三七总皂甙粉针剂 ,每日 40 0mg) ,口服解毒护心胶囊 (每粒含黄连超细粉碎物 0 .4g、茶多酚 0 .0 8g ,一次 3粒 ,一日 3次 ) ,疗程 2周。 2 0例健康人为正常组。流式细胞仪检测血小板P -选择素 (CD 6 2 p) ,酶联免疫检测血浆假血友病因子 (vWF)。作治疗前后及组间统计学比较。结果 :两治疗组治疗前CD 6 2p、vWF均未见显著差异 ,均显著高于健康组 (P <0 .0 1)。两治疗组治疗后CD 6 2 p、vWF均显著下降 (P <0 .0 5或P <0 .0 1) ,且中药组非常显著地低于对照组 (P <0 .0 1)。结论 :黄芪、三七总皂甙与黄连等配伍体现的益气活血解毒法 ,对不稳定性心绞痛患者 ,有显著的保护血管内皮功能、抑制血小板活化作用。     

中药复方抗呼吸道病毒性疾病研究进展

近年来,据不完全统计,由病原微生物引起的所有呼吸道疾病中,由病毒导致的急性呼吸道感染约占80%,是目前世界范围内发病率最高的疾病。呼吸道病毒,如严重急性呼吸系统综合征冠状病毒 （SARS-CoV）、SARS-CoV-2,甲型流感病毒和呼吸道合胞病毒等,对社会公共卫生安全构成较大威胁,目前,还没有开发出特效药。由于中药具有多组分多靶点的协同作用,在呼吸道病毒疾病的预防、治疗康复和保健方面具有独特的优势,近年来,许多临床医生和研究人员从不同层面对中药治疗呼吸道病毒疾病进行了一系列研究和探索,对中医药的临床疗效和治疗机制有了更清晰的认识。本文通过综述中医药治疗呼吸道病毒疾病的临床疗效研究和作用机制,为中医药更好治疗呼吸道病毒疾病提供有力的证据,以期推动中医药的发展及其在呼吸道病毒疾病方面的潜在应用。     

干细胞、微环境与活血化瘀

BACKGROUND:There is a certain association between stem cells, microenvironment and methods for promoting blood circulation and removing stasis. OBJECTIVE:To propose a perspective of “kidney properties” of promoting blood circulation and removing stasis by elaborating the correlation and interactions of stem cells and microenvironment with methods for promoting blood circulation and removing stasis. METHODS:A computer-based search of Chinese Journal Full-text Database, Wanfang and PubMed was performed for articles published form 2009 to 2015 addressing improving stem cell proliferation and differentiation by promoting blood circulation and removing stasis as well as microenvironments. The keywords were “bone mesenchymal stem cells, transformation, differentiation, blood-activation and stasis-resolved method, microenvironment” in Chinese and English, respectively. Finally, 32 literatures were reviewed. RESULTS AND CONCLUSION:Stem cells homing to the damaged tissue trigger an “environment- dependent differentiation”, that is, stem cells can differentiate into myocardial cells, vascular endothelial cells and other injured tissues and cells under local special microenvironments. Microenvironment as an assembly for integrating dynamic, microscopic changes as well as development of a variety of indices is of great importance for stem cell survival, proliferation and differentiation. Recipes for promoting blood circulation and removing stasis are involved to regulate multi-steps and multi-targets during stem cell homing. Theoretically, this review attempts to investigate correlation among stem cells, microenvironment and methods for promoting blood circulation and removing stasis in association with previous preclinical and clinical findings. Here, we further refine the view of “kidney properties” of promoting blood circulation and removing stasis and clarify that stem cells as the material basis of “kidney properties” of promoting blood circulation and removing stasis is the main executor for promoting blood circulation and removing stasis. This paper is of a certain value for fully revealing the scientific connotation of the theory of promoting blood circulation and removing stasis.     

Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19

Objectives: A significant proportion of discharged COVID-19 patients still have some symptoms. Traditional Chinese medicine (TCM) has played an important role in the treatment of COVID-19, but whether it is helpful for discharged patients is still unknown. The aim of this study was to retrospectively analyze the impacts of TCM treatment on the convalescents of COVID-19.Methods: A total of 372 COVID-19 convalescents from February 21 to May 3 in Shenzhen, China were retrospectively analyzed, 291 of them accepted clinically examined at least once and 191 convalescents accepted TCM.Results: After retrospective analysis of the clinical data of convalescents accepted TCM treatment or not, we found that the white blood cell count, as well as serum interleukin-6 and procalcitonin decreased in TCM group. Serum γ-glutamyl transpeptidase was significantly decreased, while prealbumin and albumin increased in TCM group. Red blood cell, hemoglobin, and platelet count increased in TCM group. The mechanisms of TCM treatment might be the overall regulations, including balanced immune response, improved hematopoiesis and coagulation systems, enhanced functions of liver and heart, increased nutrient intake and lipid metabolism.Conclusions: This study suggested that TCM treatment would be beneficial for discharged COVID-19 patients. However, long-term medical observation and further study with randomized trial should be done to confirm this result. Besides, the potential molecular mechanisms of TCM treatment should be further revealed.     

非酒精性脂肪肝患者中医体质及相关证型研究

近年来,随着本病的发病率逐年上升,对NAFLD患者这一患病群体的中医体质学和中医证型研究也日臻丰富。本文概述NAFLD的中医辨证分型研究和回顾中医体质学说的发展历程,以及归纳整理各医家对NAFLD患者不同体质类型及相关中医证型的研究,通过分析临床研究结果,总结不同体质类型及相关证型的分布规律,旨在为NAFLD的临床预防和治疗提供新思路。     

气象环境因素与脑卒中发病的相关性研究

脑卒中是发病率高、致残率高、致死率高以及复发率高的脑血管疾病,其主要病因有脑小动脉硬化、脑动脉粥样硬化、血管先天发育异常等,常见的危险因素有高血压、糖尿病、高脂血症、心脏病、吸烟等。有研究发现,脑卒中的发病与气象、空气污染存在关联性,异常天气是脑卒中的危险因素之一。本文对气象因素中气温、气压、湿度、空气污染与脑卒中发病关系及发病机制作一综述,旨在为脑卒中的防治提供一定的理论依据。     

中医药防治慢性肾脏病的临床证据及效应机制

慢性肾脏病 (Chronic Kidney Disease, CKD) 是严重危害人类健康的重大疾病。中医药防治 CKD 有特色疗效, 在降低尿蛋白、保护肾功能、延缓CKD进展及缓解相关并发症等方面具有一定的优势。本文梳理了近年来CKD的中医理论新认识,总结了中医药治疗CKD疗效的循证医学证据及其效应机制相关的研究成果,综合当前CKD临床和基础研究及成果转化现状,提出未来研究展望,以期对中医药防治CKD的进一步创新发展有所助益。     

Predictive and Preventive Pathology of Cardiovascular Diseases

The development of genetic models for research on hypertension and stroke, spontaneously hypertensive rats (SHR) and stroke-prone SHR (SHRSP), have contributed not only to the elucidation of the pathogenesis of hypertension-related cardiovascular diseases (CVD) but also to their prediction and prevention. Since both genetic and environmental factors are involved in the pathogenesis of hypertension and stroke in SHR and SHRSP, the detection of the genetic factors and the control of environmental factors have been proven to be useful as predictive and preventive measures against hypertension and related CVD. Early rise in blood pressure, sympathetic overre-sponsiveness, early development of cardiovascular hypertrophy, increased salt sensitivity and membrane abnormalities detected in vascular smooth muscle cells (VSMC) from SHR and SHRSP, which are related to the pathogenesis of hypertension, have been examined for their applicability to the prediction of hypertension in man. Pathogenic mechanisms of stroke in SHRSP have been studied by electron microscopy, and VSMC degeneration and necrosis were noted to start at the outer media of intracerebral arteries which were exposed to local hypoxia and hyponutrition due to limited diffusion through the blood brain barrier. Macrophages are involved in the process of arterionecrosis with fibrin deposition in SHRSP, and their involvement has also been proven immunohistochemically in human autopsy cases. Moreover, reduction of regional cerebral blood flow, hypoxic vulnerability of the brain detected by the NMR techinique and additional cellular abnormalities such as membrane fragility and accelerated lipid incorporation may possibly be applied to the prediction of stroke and atherosclerotic diseases in man. On the other hand, experimental control of cellular, neural and vascular mechanisms of hypertension and stroke in these animal models have been proven to be effective for the prevention of CVD not only pharmacologically but also non pharmacologically by dietary sodium reduction, and increased intake of potassium, calcium, protein and dietary fiber. The applicability of dietary control of hypertension and stroke to humans has been supported by our epidemiological studies in Japan as well as by the WHO coordinated international cooperative study on cardiovascular diseases and alimentary comparison (WHO CARDIAC study). These new experimental and epidemiological findings are extending new horizons in medicine, where the main medical activity should be focused on the prediction of diseases by detecting genetic disposition as well as on prevention by the control of environmental factors. Acta Pathol Jpn 39: 683-705, 1989.     

脐血干细胞移植治疗脑卒中的作用与机制

背景：多项研究表明脐血干细胞移植可以改善脑缺血后的神经功能缺损。 目的：总结脐血干细胞移植治疗脑卒中的研究进展及其作用机制。 方法：由第一作者应用计算机检索2001-01/2011-08 PubMed数据库及万方数据库有关脐血干细胞移植治疗缺血性脑卒中基础研究方面的文献。检索词“umbilical cord blood stem cells,focal cerebral ischemic,transplantation,脐血干细胞,局灶性脑缺血,移植”,共检索到文献50篇,最终纳入符合标准的文献30篇。 结果与结论：脐血干细胞具有自我更新和多向分化潜能,在适当的诱导下可分化为神经细胞。相关研究表明脐血干细胞能缩减脑卒中大鼠的脑梗死体积并改善行为学预后,其机制包括减轻炎症反应,增加营养因子的分泌,促进血管发生和神经纤维重塑等。虽然脐血干细胞在实验研究上取得了较大进展,但仍有许多问题有待解决,如何提高脐血的利用率,如何限制干细胞的过度增殖,整合到损伤部位的移植细胞是否能发挥功能等,待进一步探讨。