共查询到18条相似文献,搜索用时 125 毫秒
1.
莲心碱对离体猪冠状动脉条收缩性能的影响 总被引:3,自引:0,他引:3
目的:观察莲心碱(Lien)拮抗氯化钾(KCl),乙酰胆碱(Ach)和组铵(Hist)所致猪冠状动脉条收缩的作用。方法:离体平滑肌实验方法。结果:不同剂量莲心碱对Kcl,Ach,Hist量效曲线均呈非竞争性拮抗作用,pD'2值分别为4.78,3.85和4.25。莲心碱和维拉帕米(Ver)均能抑制组胺诱导的依内钙收缩,而对氯化钙诱导的依外钙收缩作用较弱。结论:莲心碱具有扩张冠脉的作用,且对冠脉平滑肌细胞依内钙性收缩及依外钙性收缩均有抑制作用。 相似文献
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OBJECTIVETo observe the antagonism of on contraction of porcine artery strips induced by KCl, acetyl choline (Ach) and histamine (Hist) respectively. METHODUsing experimental methol of smoth muscle. RESULTSDifferent dosage of O,O-Diethyl-liensinine had no 相似文献
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目的观察莲心碱二乙醚拮抗KCl,乙酰胆碱(Ach)和组胺(Hist)所致猪冠状动脉条收缩的作用。方法离体平滑肌实验方法,观察莲心碱二乙醚对KCl,Ach,Hist所致猪冠状动脉条收缩曲线的影响以及在无Ca2+克氏液中,对Hist引起猪冠状动脉条第一相收缩和Ca2+引起第二相收缩的影响。结果不同剂量莲心碱二乙醚可使KCl,Ach,Hist所致冠脉条收缩量效曲线呈非竞争性拮抗作用,对冠脉条第一相和第二相收缩都有明显的抑制作用。结论莲心碱二乙醚具有扩张冠脉的作用,此作用与拮抗细胞内钙的释放和抑制外钙内流有关。 相似文献
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HPLC同时测定莲子心中莲心碱和甲基莲心碱的含量 总被引:5,自引:0,他引:5
用HPLC法同时测定了莲子心中莲心碱和甲基莲心碱的含量。色谱系统流动相为二氯甲烷-异丙醇-二乙胺(75∶25∶0.2),紫外检测波长282nm,方法的平均回收率分别为99.6%和101.2%,RSD分别为0.80、1.58%。 相似文献
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二苯甲酰莲心碱抗实验性心律失常的作用 总被引:2,自引:0,他引:2
目的:研究二苯甲酰莲心碱抗实验性心律失常的作用。方法:采用乌头碱、哇巴因、氯化钙3种抗心律失常模型。结果:二苯甲酰莲心碱5mg.kg^1可明显提高乌头碱所致大鼠,哇巴因致豚鼠发生室性早搏,室性心动过速,室颤及心脏停搏用量,延长氯化钙诱发大鼠出现心律失常的时间,缩短窦律恢复时间,提高窦律恢复律,延长死亡时间及降低死亡率,结论:二苯甲酰莲心碱具有广泛的抗心律失常作用。 相似文献
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甲基莲心碱的药理作用 总被引:21,自引:0,他引:21
甲基莲心碱是一种双苄基异喹啉类生物碱。该文就甲基莲心碱的扩血管、降压 ,抗心律失常 ,抗血小板聚集 ,抗血栓形成 ,抗氧化 ,抗有机磷农药中毒 ,抗瘢痕形成以及化疗增敏等药理作用作一综述 相似文献
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左旋荷包牡丹碱对猪冠状动脉条收缩效应的影响 总被引:5,自引:0,他引:5
目的 观察左旋荷包牡丹碱(L-dicentrine,L-D)对K^ ,5-HT Hist,Ca^2 引起的猪冠状动脉条收缩效应的影响。方法 利用猪冠状动脉条的离体实验法,观察对其收缩的影响。结果 L-D对K^ ,5-HT,Hist,Ca^2 诱发的猪冠状动脉平滑肌的收缩有显的拮抗作用,量效曲线显示:L-D呈现非竞争性拮抗方式。在无Ca^2 液中,L-D能抑制5-HT诱发的猪冠状动脉收缩,说明5-HT对猪冠状动脉依赖细胞内Ca^2 所致的收缩有明显的抑制作用,而对外Ca^2 所致的收缩无明显的影响。结论 L-D具有松弛猪冠状动脉条的作用,同时也提示冠状动脉平滑肌可能存在5-HT受体。 相似文献
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Yu Liu Longgang Niu Wenjing Zhang Lijuan Cui Xuanping Zhang Yueqin Liang Mingsheng Zhang 《Pharmacological reports : PR》2009,61(4):681-689
The actions and mechanisms of taurine on vascular contractions have been studied in the isolated porcine coronary artery. Taurine depressed histamine-, serotonin-, KCl- and CaCl2-induced contractions in a concentration-dependent manner, with maximal contractions being depressed by 43.4%, 46.2%, 33.3% and 43.3%, respectively. Taurine relaxed arterial rings that were precontracted by either 30 mM KCl or 0.3 μMU46619, a thromboxane A2 analog, in a concentration-dependent manner, and the maximal relaxations were 39.4% and 38.7%, respectively. The vasorelaxations were nearly abolished by pretreatment with either the inward rectifier K+ channel (KIR) inhibitor, BaCl2 or the ATP sensitive K+ channel (KATP) inhibitor, glibenclamide, and were attenuated by the Ca2+-activated K+ channel (KCa) inhibitor tetraethylammonium. Denudation of the endothelium, and treatment with the nitric oxide synthase inhibitor, L-NAME, the cyclooxygenase inhibitor, indomethacin, or the voltage gated K+ channel (KV) inhibitor 4-aminopyridine did not affect the relaxation. The present results show that taurine antagonizes and relaxes the contractions of the porcine coronary artery, and suggest that the activation of KIR,KATP and Kca may be involved in taurine-induced relaxation of the porcine coronary artery. 相似文献
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Shizuo Yamada Toshiko Yamazawa Yoshimitsu Harada Henry I. Yamamura Koichi Nakayama 《European journal of pharmacology》1988,150(3):373-376
The specific binding of (-)-[3H]QNB (quinuclidinyl benzilate) in membrane fractions of porcine coronary artery was saturable, of high affinity and stereoselective. It has been shown that there exist (-)-[3H]QNB binding sites with high (Ki = 12 nM)- and low(Ki = 1010 nM)-affinity for pirenzepine in the coronary artery but predominantly low-affinity sites in cardiac muscle. AF-DX 116 and gallamine showed a lower affinity to ( - )-[3H]QNB binding sites in the coronary artery compared to cardiac muscle. Thus, the present study suggests that porcine coronary artery contains a significant number of muscarinic receptors, probably both M1 and M2 subtypes. 相似文献
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目的 评价胃网膜右动脉(RGEA)在冠脉旁路移植术中可行性。方法选取实验用猪80例,随机分为实验组(40例)和对照组(40例),两组均行心脏不停跳搭桥术,实验组采用乳内动脉-前降支、RGEA-后降支的方式搭桥,对照组采用乳内动脉-前降支、大隐静脉-后降支的方式搭桥。记录并比较两组手术时间、术中出血量,桥血管流量和搏动指数、术后24小时内心包纵隔引流管引流量和术后总机械通气时间。结果 实验组的手术时间和术后总机械通气时间较对照组增加(P<0.01),实验组与对照组的术中出血量,桥血管流量和搏动指数、术后24小时内心包纵隔引流管引流量与对照组无显著差异(P>0.05)。结论 胃网膜右动脉是可供选择的动脉移植物之一,在冠脉外科有良好的可行性和应用前景。 相似文献
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为了了解冠状动脉上苯环利定(Phency-clidine,Phe)受体及阿片受体的分布,利用猪冠状动脉的大、小支作了离体血管放射自显影研究,显微镜下观察到,猪冠脉壁上有与[3H]Phe和[3H]Etor-phine特异结合位点,它们均主要分布于冠脉的外膜上。通过[3H]Ohmefentanyl自显影观察,冠脉上未见特异结合颗粒,提示冠脉上的阿片受体不是μ型。 相似文献
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目的探讨不同介入途径治疗复杂冠状动脉病变的临床疗效和可行性。方法选取614例有复杂冠状动脉病变冠心病患者,其中经桡动脉途径患者304例(桡动脉组),股动脉途径患者310例(股动脉组),观察介入手术成功率、卧床时间、术后发生并发症等情况。结果 2组患者在年龄、性别、危险因素等方面比较,差异均无统计学意义(P〉0.05);桡动脉组手术成功率为97.7%,股动脉组为98.1%,2组成功率差异无统计学意义(P〉0.05);桡动脉组术后并发症发生率明显低于股动脉组(P〈0.05);卧床时间明显短于股动脉组(P〈0.05);平均住院时间及住院期间主要心血管事件发生率差异无统计学意义(P〉0.05)。结论经桡动脉途径介入治疗冠状动脉复杂病变成功率高,且术后并发症发生率低,不增加心血管事件。 相似文献
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Sasaki T Hashimoto M Nosaka S Hanada T Saitoh Y Yamauchi M Nakayama K Masumura S Tamura K 《Clinical and experimental pharmacology & physiology》2000,27(9):680-683
1. To clarify the mechanism of the cardioprotective effect of nicorandil (2-nicotinamidoethyl-nitrate ester), the effects of nicorandil and nitric oxide (NO) donors on the release of ATP, ADP, AMP and adenosine from arterial segments and cultured endothelial cells of the porcine coronary artery were examined. 2. Nicorandil significantly increased the release of total adenyl purines from arterial segments and from cultured endothelial cells. 3. Cromakalim, an ATP-sensitive K+ channel opener, did not affect the release of total adenyl purines from coronary artery segments. 4. s-Nitroso-N-acetyl-D,L-penicillamine and isosorbide dinitrate, NO donors, significantly increased the release of total adenyl purines from coronary artery segments. 5. These results demonstrate that nicorandil stimulates ATP release from the coronary artery by acting not as an ATP-sensitive K+ channel opener, but as a nitrate, thus suggesting the cardioprotective properties of nicorandil. 相似文献
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目的 系统评价杂交冠状动脉血运重建术(HCR)与冠状动脉旁路移植术(CABG)治疗多支冠状动脉疾病
中远期疗效与并发症。方法 系统检索Embase、PubMed、Web of Science、Cochrane Central Registry of Controlled Trials
(Central)、万方数据、中国知网,筛选符合纳入标准的文献,并计算每项研究中的比值比(odds ratio,OR)和95%置信
区间(95%CI),采用RevMan 5.3软件进行Meta分析。结果 9篇文献纳入研究,累计研究对象4 030例,其中1 142例
接受HCR治疗,2 888例接受传统CABG治疗。Meta分析结果显示:(1)中远期随访中HCR组术后全因病死率(OR=
0.72,95%CI:0.54~0.96)和主要心脑血管事件(MACCE,OR=0.54,95%CI:0.35~0.82)均低于CABG组。而在血运重
建(OR=0.90,95%CI:0.61~1.34)及心肌梗死或心绞痛发生率(OR=0.51,95%CI:0.18~1.41)方面差异无统计学意义。
(2)中期随访中 HCR 组的 MACCE 发生率低于 CABG 组(OR=0.31,95%CI:0.15~0.66),而全因病死率(OR=0.79,
95%CI:0.52~1.22)、血运重建(OR=0.77,95%CI:0.30~1.96)以及心肌梗死或心绞痛发生率(OR=0.71,95%CI:0.05~
9.46)等差异无统计学意义。(3)远期随访中HCR组术后全因病死率(OR=0.67,95%CI:0.46~0.98)及心肌梗死或心绞
痛发生率(OR=0.32,95%CI:0.15~0.68)均低于 CABG 组。而在 MACCE(OR=0.72,95%CI:0.43~1.21)与血运重建
(OR=0.93,95%CI:0.60~1.45)方面差异无统计学意义。结论 HCR相比CABG可降低多支冠状动脉病变患者的中
期MACCE和远期全因病死率、心肌梗死或心绞痛发生率。 相似文献