Efficacy of stabilisation splint treatment on temporomandibular disorders

Summary The evidence supporting the use of stabilisation splints in the treatment of temporomandibular disorders (TMD) is scarce and a need for well‐controlled studies exists. The aim of this randomised, controlled trial study was to assess the efficacy of stabilisation splint treatment on TMD. The sample consisted of 80 consecutive referred patients who were randomly assigned to the splint group (n = 39) and the control group (n = 41). Subjects in the splint group were treated with a stabilisation splint, whereas subjects in the control group did not receive any treatment except counselling and instructions for masticatory muscle exercises which were given also to the subjects in the splint group. Outcomes were visual analogue scale (VAS) on facial pain intensity and clinical findings for TMD which were measured at baseline and after 1‐month follow‐up. The differences in change between the groups were analysed using regression models. Facial pain decreased and most of the clinical TMD findings resolved in both of the groups. The differences in changes in VAS or clinical TMD findings between the groups were not statistically significant. The findings of this study did not show that stabilisation splint treatment in combination with counselling and masticatory muscle exercises has additional benefit in relieving facial pain and increasing the mobility of the mandible than counselling and masticatory muscle exercises alone in a short time‐interval.     

Efficacy of stabilisation splint treatment on facial pain – 1‐year follow‐up

The aim of this randomised controlled trial was to assess the efficacy of stabilisation splint treatment on TMD‐related facial pain during a 1‐year follow‐up. Eighty patients were randomly assigned to two groups: splint group (n = 39) and control group (n = 41). The patients in the splint group were treated with a stabilisation splint and received counselling and instructions for masticatory muscle exercises. The controls received only counselling and instructions for masticatory muscles exercises. The outcome variables were the change in the intensity of facial pain (as measured with visual analogue scale, VAS) as well as the patients' subjective estimate of treatment outcome. The differences in VAS changes between the groups were analysed using variance analysis and linear regression models. The VAS decreased in both groups, the difference between the groups being not statistically significant. The group status did not significantly associate with the decrease in VAS after adjustment for baseline VAS, gender, age, length of treatment and general health status. The only statistically significant predicting factor was the baseline VAS, which was also confirmed by the mixed‐effect linear model. After 1‐year follow‐up, 27·6% of the patients in the splint group and 37·5% of the patients in the control group reported ‘very good' treatment effects. The findings of this study did not show stabilisation splint treatment to be more effective in decreasing facial pain than masticatory muscle exercises and counselling alone in the treatment of TMD‐related facial pain over a 1‐year follow‐up.     

Efficacy of stabilisation splint treatment on the oral health‐related quality of life–A randomised controlled one‐year follow‐up trial

The aim of this randomised controlled trial was to assess the efficacy of stabilisation splint treatment on the oral health‐related quality of life OHRQoL during a 1‐year follow‐up. Originally, the sample consisted of 80 patients (18 men, 62 women) with temporomandibular disorders (TMD) who had been referred to the Oral and Maxillofacial Department, Oulu University Hospital, Finland, for treatment. Patients were randomly designated into splint (n = 39) and control group (n = 41). Patients in the splint group were treated with a stabilisation splint. Additionally, patients in both groups received counselling and instructions on masticatory muscle exercises. The patients filled in the Oral Health Impact Profile‐14 (OHIP‐14) questionnaire before treatment and at 3 months, 6 months and 1 year. At total, 67 patients (35 in the splint group vs. 32 in the control group) completed the questionnaire at baseline. The outcome variables were OHIP prevalence, OHIP severity and OHIP extent. Linear mixed‐effect regression model was used to analyse factors associated with change in OHIP severity during the 1‐year follow‐up, taking into account treatment time, age, gender and group status. OHIP prevalence, severity and extent decreased in both groups during the follow‐up. According to linear mixed‐effect regression, decrease in OHIP severity did not associate significantly with group status. Compared to masticatory muscle exercises and counselling alone, stabilisation splint treatment was not more beneficial on self‐perceived OHRQoL among TMD patients over a 1‐year follow‐up     

2种咬合板治疗颞下颌关节紊乱病的临床疗效分析

目的：研究松弛型咬合板和稳定型咬合板治疗颞下颌关节紊乱病(TMD)的疗效。方法：选择以口颌面部疼痛为主诉的TMD患者68例(急性30例,慢性38例),每组分别戴用松弛型咬合板和稳定型咬合板,比较分析治疗前、后颞肌前束(TA)、咬肌(MM)肌电值及关节疼痛强度的变化。采用SPSS 11.0 软件包对数据进行方差分析和t检验。结果：①静息状态下,2种咬合板治疗后,患者双侧TA及MM肌电电位均较治疗前显著下降(P<0.05)。②紧咬状态下,松弛型咬合板治疗的急性组患者双侧TA及MM肌电电位均较治疗前显著上升,而慢性组患者仅双侧MM肌电电位较治疗前显著上升(P<0.05);稳定型咬合板治疗组患者双侧TA肌电电位治疗前后无显著差异,仅双侧MM肌电电位较治疗前显著上升。③2种咬合板治疗后,患者疼痛指数均较治疗前显著下降;但松弛型咬合板治疗后,在功能状态下,急性组患者疼痛缓解的程度更显著。结论：松弛型和稳定型咬合板均对咀嚼肌有松弛作用,能缓解TMD疼痛,但松弛型咬合板治疗急性TMD患者的疗效更加显著。     

不同类型咬合板缓解TMD疼痛症状的研究

目的:研究松弛型咬合板和稳定型咬合板缓解颞下颌关节紊乱病(TMD)疼痛症状的疗效。方法:选择TMD患者68例(急性期30例,慢性期38例),每组又分两个亚组,分别戴用松弛型咬合板和稳定型咬合板,使用视觉模拟量表评价患者治疗前后疼痛强度的变化。结果:①戴咬合板后静息状态下急、慢性组患者疼痛指数均较戴咬合板前明显下降(P<0.05),两种咬合板缓解疼痛的程度无明显差异;②戴咬合板后功能状态下急、慢性组患者疼痛指数均较戴咬合板前明显下降(P<0.05),但急性组戴松弛型咬合板疼痛缓解程度更显著。结论:松弛型和稳定型咬合板能缓解TMD疼痛,松弛型咬合板缓解TMD急性患者疼痛症状更显著。     

Comparison of three different options for immediate treatment of painful temporomandibular disorders: a randomized,controlled pilot trial

Objective: The purpose of this study was to compare the short-term effectiveness of three different types of immediate, non-pharmacological intervention for alleviation of the painful symptoms of temporomandibular disorders (TMD).

Material and methods: Thirty-six patients (mean age 41.6?±?16.7 years, 25 females) diagnosed with non-dysfunctional painful TMD received counselling and subsequently were randomly allocated to three treatment groups: patients in Group A received prefabricated oral splints with water-filled elastic pads (Aqualizer^®), those in Group B were provided with vacuum-formed co-polyester oral splints and those in Group C were given appointments to receive Michigan-type hard splints. Clinical examination was conducted, at baseline and after 2 weeks, by use of the RDC/TMD. Current pain intensity was determined by evaluation of graded chronic pain status (GCPS) on a numerical rating scale (NRS). Active maximum mouth opening without pain (AMMOP) was also measured. Paired sample t-tests and one-way analysis of variance with a significance level of p?≤?0.05 were conducted.

Results: After 2 weeks, overall mean current pain was reduced by 41.95% (p?p?p?=?0.56) and C (22.29%, p?=?0.26). After 2 weeks, current pain level for Group B was significantly lower than that for Group C (p?=?0.041). Overall, there was a statistically significant increase of AMMOP (p?=?0.01).

Conclusion: All therapeutic options were pain-reducing. The results from this study suggest that cost-effective and time-effective intervention of counselling combined with use of a vacuum-formed splint is a favourable option for initial, short-term treatment of painful TMD.     

Clinical significance of T2 mapping MRI for the evaluation of masseter muscle pain in patients with temporomandibular joint disorders

Objectives

Masticatory muscle pain is one of the typical symptoms of temporomandibular joint disorders (TMD). T2 mapping (distribution of T2 values) is a notable MRI technique for evaluating water contents in tissues. We investigated the clinical significance of T2 mapping for the evaluation of masticator muscle conditions by comparing the difference in the T2 values between the painful and pain-free sides of the masseter muscle in patients with TMD.

Methods

Seventy-three patients clinically diagnosed with TMD were enrolled in this study. We divided the patients into two groups: a unilateral pain group (patients with unilateral masseter muscle pain) and a painless group (patients without muscle pain). There were 29 patients in the unilateral pain group and 44 patients in the painless group. We compared the difference in the mean T2 values between the painful and pain-free sides of the masseter muscle in the unilateral pain group and between the right and left sides in the painless group.

Results

The mean T2 values of the masseter muscle on the painful side were significantly higher than those on the pain-free side in the unilateral muscle pain group (p < 0.01). In the painless group, there was no significant difference in the mean T2 values between the right and left sides.

Conclusions

It is suggested that T2 mapping is a promising method for evaluating masseter muscle pain caused by edematous change related to TMD through monitoring of the T2 values.     

Headache attributed to masticatory myofascial pain: impact on facial pain and pressure pain threshold

There is no clear evidence on how a headache attributed to temporomandibular disorder (TMD) can hinder the improvement of facial pain and masticatory muscle pain. The aim of this study was to measure the impact of a TMD‐attributed headache on masticatory myofascial (MMF) pain management. The sample was comprised of adults with MMF pain measured according to the revised research diagnostic criteria for temporomandibular disorders (RDC/TMD) and additionally diagnosed with (Group 1, n = 17) or without (Group 2, n = 20) a TMD‐attributed headache. Both groups received instructions on how to implement behavioural changes and use a stabilisation appliance for 5 months. The reported facial pain intensity (visual analogue scale – VAS) and pressure pain threshold (PPT – kgf cm^?2) of the anterior temporalis, masseter and right forearm were measured at three assessment time points. Two‐way anova was applied to the data, considering a 5% significance level. All groups had a reduction in their reported facial pain intensity (P < 0·001). Mean and standard deviation (SD) PPT values, from 1·33 (0·54) to 1·96 (1·06) kgf cm^?2 for the anterior temporalis in Group 1 (P = 0·016), and from 1·27 (0·35) to 1·72 (0·60) kgf cm^?2 for the masseter in Group 2 (P = 0·013), had significant improvement considering baseline versus the 5th‐month assessment. However, no differences between the groups were found (P > 0·100). A TMD‐attributed headache in patients with MMF pain does not negatively impact pain management, but does change the pattern for muscle pain improvement.     

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??Objective??To observe and analyze the clinical effect of the stabilization splint and the occlusal reconstruction treatment on patients with masticatory muscle pain. Methods??Totally 20 patients with masticatory muscle pain who visited General Department and Prosthodontics Department of Affiliated Stomatology Hospital of China Medical University from September 2016 to May 2018 were given the stabilization splint therapy and the occlusal reconstruction treatment. Analyze the visual analogue scale??VAS????electromyographic pattern and Friction temporomandibular joint dysfunction index before treatment??T0????three months after the stabilization splint therapy??T1????when occlusal reconstruction was finished??T2??and three months later??T3??. Results??Statistical analysis showed that VAS??the electromyographic signal of anterior temporalis and masseters in mandibular postural position??asymmetry index of masseter muscles and temporalis muscles and Friction temporomandibular joint dysfunction index in T1??T2 and T3 were significantly lower than those in T0??P < 0.05??. The electromyographic signal were dramatically increased in intercuspal position ??P < 0.05??. No significant difference was shown in VAS??the electromyographic signal of anterior temporalis and masseters??asymmetry index of masseter muscles and temporalis muscles??or Friction temporomandibular joint dysfunction index in T1??T2 and T3??P > 0.05??. Conclusion??The stabilization splint therapy is effective on patients with masticatory muscle pain??and the occlusal reconstruction treatment is able to maintain these effects.     

稳定型咬合板配合咬合重建治疗咀嚼肌疼痛疗效评价

目的　评价稳定型咬合板配合咬合重建治疗咀嚼肌疼痛的疗效。方法　选取2016年9月至2018年5月于中国医科大学附属口腔医院综合科及修复一科行稳定型咬合板及咬合重建序列治疗的咀嚼肌疼痛患者20例。分析治疗前（T0期）、佩戴咬合板3个月后（T1期）、咬合重建完成即刻（T2期）及咬合重建完成3个月后（T3期）的疼痛视觉模拟评分（visual analogue scale,VAS）、肌电图及Friction颞下颌关节紊乱指数的变化。结果　T1、T2、T3期患者VAS评分、下颌姿势位时颞肌咬肌的肌电活性、颞肌咬肌不对称指数及Friction颞下颌关节紊乱指数均较T0期显著降低,差异有统计学意义（均P < 0.05）;最大紧咬牙时颞肌咬肌的肌电活性较T0期明显增高,差异有统计学意义（均P < 0.05）。T1、T2、T3期患者之间的VAS评分、颞肌咬肌的肌电活性、颞肌咬肌不对称指数及Friction颞下颌关节紊乱指数差异无统计学意义（均P > 0.05）。结论　稳定型咬合板可有效治疗咀嚼肌疼痛,咬合重建序列治疗能很好维持其疗效。     

松弛性及稳定性牙合垫对咀嚼肌肌电影响的探讨

目的 探讨松弛性He垫与稳定性He垫对咀嚼肌（咬肌、颞肌前束）肌电的影响。方法 20名健康志愿者不戴He垫与戴松弛性e垫和下颌稳定性He垫时分别作正中紧咬，比较颞肌前束，咬肌肌电积分值的改变。结果 戴人松弛性He垫和稳定性He垫后，颞肌前束，咬肌肌电积分值均有下降，戴松弛性He垫更显著。结论 松弛性He垫和稳定性He垫均对咀嚼肌有松弛作用。     

稳定型咬合板治疗颞下颌关节紊乱病疼痛症状的研究

目的：探讨稳定型咬合板治疗颞下颌关节紊乱病（TMD）疼痛的疗效。方法：TMD疼痛患者61例，急性组28例（男11例，女17例）；慢性组33例（男18例，女15例）。记录治疗前后疼痛指数，双侧颞肌前束（temporal anterior，TA）和咬肌（masseter muscle，MM）牙尖交错位最大紧咬时电位及最大紧咬时咬合接触情况。结果：（1）2组治疗后1月疼痛指数均明显低于治疗前（P〈0．05），治疗前后疼痛强度差值及显效率2组之间无显著差异（P〉0．05）。（2）治疗后无论是急性组还是慢性组TA及MM最大紧咬电位症状侧均较治疗前明显升高（P〈0．05），而非症状侧治疗前后无明显差异（P〉0．05）。（3）治疗后急性组TA和MM肌电不对称指数与治疗前相比均明显降低（P〈0．05）。治疗后肌电不对称指数TA慢性组明显高于急性组（P〈0．05），而MM无明显差异（P〉0．05）。（4）2组治疗前后左、右两侧咬合接触点数、以及咬合接触不对称指数无明显差异（P〉0．05）。结论：稳定型咬合板治疗可以明显缓解TMD疼痛，但对急、慢性疼痛的缓解程度无明显差异。其机制可能与肌功能活动情况易于得到明显改善等生理学基础有关。     

Evaluation of the relationships between contrast-enhanced magnetic resonance characteristics and joint pain in patients with temporomandibular disorders

Objectives

To evaluate the correlations between temporomandibular joint (TMJ) pain and both conventional and gadolinium-enhanced magnetic resonance (MR) imaging characteristics in patients with temporomandibular disorders (TMDs).

Methods

T1-weighted, T2-weighted, and fat-suppressed contrast-enhanced T1-weighted MR imaging were performed in 80 TMD patients with the main complaint of TMJ pain. A kappa statistical analysis was performed to calculate the interobserver agreement between two of three radiologists. The relationships between TMJ pain and various MR findings were analyzed by multiple comparison test, Spearman’s rank correlation test, Chi-square test, Student’s t test, and multivariate logistic regression analysis.

Results

Significant correlations were observed between anterior disk displacement without reduction, joint effusion, and TMJ pain (p < 0.01). The degree of contrast enhancement of the posterior disk attachment was correlated with the severity of TMJ pain, especially spontaneous pain (r = 0.725, p < 0.01), while no correlation was observed in the masticatory muscle pain group. The correlation tended to be higher in the latero-central portions than in the medial portion of the mandibular condyle, although no significant difference was seen.

Conclusions

It has been suggested that fat-suppressed contrast-enhanced MR imaging techniques facilitate better understanding of the sources of TMJ pain, but not masticatory muscle pain, and could reflect TMJ synovial inflammation. The severity of TMJ pain was closely correlated with the degree of contrast enhancement. The above-mentioned correlation had a tendency to be higher in the latero-central portions of the mandibular condyle.

     

The hemodynamic effects of occlusal splint therapy on the masseter muscle of patients with myofascial pain accompanied by bruxism

ABSTRACT

Objective: The aim of this study was to investigate the hemodynamic effects of occlusal splint therapy on masseter muscles of patients with myofascial pain accompanied by bruxism with near-infrared spectroscopy (NIRS).

Methods: Twenty-four patients were randomly divided into two groups, where the study group (n = 12) received occlusal splint therapy and the control group (n = 12) underwent no therapy. Measurements were categorized into four subgroups: painful or painless control and painful or painless splint. Percent changes in deoxyhemoglobin (Hb), oxyhemoglobin (HbO₂), and OXY (HbO₂-Hb) values were calculated during a 1-month period.

Results: Statistically significant inter-session differences between painful-splint and painful-control groups were detected for NIRS oxygenation parameters, whereas inter-session differences between painless groups were statistically insignificant.

Conclusion: The results suggest that occlusal splint usage causes a decrease in hyperemic response, which is indicative of a decrease in masseter muscle contraction strength.     

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咬合板治疗口颌系统的功能紊乱已有100余年历史,并且至今仍在广泛使用.虽然各种假说一直用来解释其作用,但科学证据不多.普遍认为,咬合板具有保护牙齿不被磨耗的作用,但咬合板在颞下颌关节紊乱痛(TMD)处理中的功效始终很难确定.尽管许多研究认为咬合板减少了夜磨牙发生的频率,但并不表明这会消除磨牙症.戴用咬合板会使咀嚼肌和关节疼痛减少,但也可能是安慰剂效应和症状随时间而自然回归的结果.最新的系统回顾和Meta分析显示,合理调改硬质稳定咬合板对治疗TMD疼痛有效,有证据表明其他类型的咬合板包括软质稳定咬合板、再定位咬合板、松弛咬合板也有一些减少TMD疼痛的功效,但其潜在的副效应也存在,建议在密切监测下使用.本文对目前临床上使用的咬合板的种类及其作用机制进行了评述,重点对咬合板特别是稳定咬合板的作用、治疗价值、应用和注意事项等进行了介绍.强调合理选用和调改咬合板是治疗口颌系统功能紊乱能否成功的关键因素.     

Evaluation of the short-term effectiveness of education versus an occlusal splint for the treatment of myofascial pain of the jaw muscles

BackgroundThe authors conducted a clinical trial to compare the effectiveness of an education program with that of an occlusal splint in treating myofascial pain of the jaw muscles across a short period.MethodThe authors assigned 44 patients randomly to two treatment groups; 41 patients completed the study. The first group (four male, 19 female; mean [standard deviation {SD}] age, 31.4 [14.0] years) received information regarding the nature of temporomandibular disorder (TMD) and self-care measures, whereas the second group (five male, 13 female; mean [SD] age, 31.1 [8.8] years) received an occlusal splint. One of the authors evaluated each patient every three weeks during a three-month treatment period. Treatment outcomes included pain-free maximal mouth opening, spontaneous muscle pain, pain during chewing and headache.ResultsAfter three months, changes in spontaneous muscle pain differed significantly between the education and occlusal splint groups (P = .034; effect size = 0.33). Changes in pain-free maximal mouth opening did not differ significantly between groups (P = .528; effect size = 0.20). Changes of headache and pain on chewing did not differ significantly between groups (P ≥ .550, effect size ≤ 0.10).ConclusionsDuring a short period, education was slightly more effective than an occlusal splint delivered without education in reducing spontaneous muscle pain in patients with TMD. Pain-free mouth opening, headache and pain during chewing were not significantly different between the two treatments.     

Pulp Sensitivity: Influence of Sex,Psychosocial Variables,COMT Gene,and Chronic Facial Pain

Introduction

The purpose of this study was to evaluate the associations of variability in pulp sensitivity with sex, psychosocial variables, the gene that encodes for the enzyme catechol-O-methyltransferase (COMT), and chronic painful conditions (temporomandibular disorders [TMDs]).

Effect of treatment with a full-occlusion biofeedback splint on sleep bruxism and TMD pain: a randomized controlled clinical trial

Objectives

The purpose of the present study was to analyze treatment outcome with a full-occlusion biofeedback (BFB) splint on sleep bruxism (SB) and TMD pain compared with treatment with an adjusted occlusal splint (AOS).

Materials and methods

Forty-one patients were randomly allocated to a test (BFB) or a control (AOS) group and monitored over a 3-month period. Output variables were frequency and duration of bruxing events (bursts) and various pain symptoms.

Results

The BFB group showed a statistically significant reduction in the frequency and duration of bursts and a statistically significant improvement in the patients’ global well-being and the facial muscle pain parameter. After the treatment was stopped, the BFB group showed a statistically significant reduction in the average and maximum duration but no statistically significant change in the frequency of bursts.

Conclusions

The tested BFB splint is highly effective in reducing SB at the subconscious level, i.e., without waking the patient, and in achieving improvements in global pain perception. The results suggest that the BFB splint also provides a better treatment option for bruxism-related pain than an AOS. However, further research is needed, and specifically studies with a larger patient population displaying higher levels of pain at baseline.

Clinical relevance

By reducing burst duration and therefore the pathological load on the masticatory apparatus, the BFB splint reduces TMD and bruxism-related symptoms and improves patients’ physical well-being. In the long term, this could prevent damage to the TMJ. This study confirms the effectiveness and safety of this splint.

The universal trial number

U1111-1239-2450

DRKS-ID registration

DRKS00018092

     

Behavioural changes and occlusal splints are effective in the management of masticatory myofascial pain: a short-term evaluation

Summary The aim of this research was to test the hypothesis that treatment with intra‐oral appliances with different occlusal designs was beneficial in the management of pain of masticatory muscles compared with a control group. A total of 51 patients were analysed according to the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) to obtain the diagnosis of masticatory myofascial pain (MMP). The sample was then randomly divided into three groups: group I (n = 21) wore a full coverage acrylic stabilisation occlusal splint; group II (n = 16) wore an anterior device nociceptive trigeminal inhibitory (NTI) system; and group III (n = 14) only received counselling for behavioural changes and self‐care (the control group). The first two groups also received counselling. Follow‐ups were performed after 2 and 6 weeks and 3 months. In these sessions, patients were evaluated by means of a visual analogue scale (VAS) and pressure pain threshold (PPT) of the masticatory muscles. Possible adverse effects were also recorded, such as discomfort while using the appliance and occlusal changes. The results were analysed with Kruskal–Wallis, anova , Tukey’s and Friedman tests, with a significance level of 5%. Group I showed improvement in the reported pain at the first follow‐up (2 weeks), whereas for groups II and III, this progress was detected only after 6 weeks and 3 months, respectively. The PPT values did not change significantly. It was concluded that behavioural changes are effective in the management of pain in MMP patients. However, the simultaneous use of occlusal devices appears to produce an earlier improvement.     

The efficacy of occlusal appliance therapy in patients with temporomandibular disorders of mainly myogenous pain. A randomized controlled trial in a short-term perspective

The aim of the present study was to compare the efficacy of physiotherapy and counselling for the treatment of myofascial pain of the jaw muscles. Sixty-three consecutive myogenous TMD patients, diagnosed according to the RDC-TMD criteria, were assigned to two treatment groups with a balanced-block randomization. The first group received only counselling with general information about self-care of jaw musculature. The second group received the same general information supplemented by self-massage, application of moist heating pads and stretching exercises of the masticatory muscles.
Treatment success was decided on treatment contrast (TC), based on relative changes of sufficiently large anamnestic and clinical scores ( van der Glas and van Grootel, 2000 ). Additional measurements included pressure pain threshold (PPT) of the masseter, anterior temporalis and Achilles' tendon, pain during gum chewing and spontaneous muscle pain scores rated on visual analogue scales (VAS). Data were collected at baseline and 3 months after start of treatment. Mann–Whitney's test and Fisher's exact test were used for statistical analysis. Sixteen patients dropped out from the study: eight from the counselling and eight from the physiotherapy group. The success rate was 13 of 23 (57%) patients for counselling and 18 of 24 (75%) for the physiotherapy group ( P  > 0·05). There was no significant difference between groups in all the other variables.
Over a short-term period, physiotherapy, as used in this protocol, does not appear superior to counselling for the treatment of TMD myofascial pain .