洁悠神物理抗菌喷雾敷料对口腔癌瘤术后菌群的影响

目的:在口腔癌瘤术后创口局部应用物理抗菌喷雾敷料,了解其对患者口腔菌群的影响,为口腔癌瘤术后感染的预防提供参考。方法:64例口腔癌瘤患者,随机分为治疗组32例和对照组32例。对照组:从手术当日开始,术创采用常规的换药和口腔护理方法。治疗组:从手术当日开始,在术创喷涂洁悠神长效抗菌材料,剂量为0.1mL/次,每日3次,直到术创愈合。观察两组术创外观,进行创面细菌培养。结果:术创均顺利愈合,64例均未出现不良反应,实验组链球菌属、葡萄球菌属、奈瑟菌属检出减少(P<0.05)。结论:口腔癌瘤术创局部使用物理抗菌雾敷料对预防术后感染具有一定的作用。     

物理抗菌材料用于口腔癌术创安全陛的初步观察

目的:观察洁悠神物理抗菌材料用于口腔癌术后预防感染时患者的不良反应情况.方法:从手木当日开始,在口腔、口咽部、鼻咽部以及颈部术创创面(缘)喷洒洁悠神物理抗茵材料,同时行血液学检测.结果:所有患者均未出现明显的痛、痒、过敏等症状,其中有11例患者初次使用时自觉气味欠佳,但仍能够接受并配合治疗.与对照组相比,治疗组患者用药后白细胞,粒细胞,淋巴细胞,血红蛋白,血小板,谷草转氨酶、谷丙转氨酶、白蛋白、球蛋白,尿素氮、肌酐等检测指标均无显著性差异.结论:洁悠神物理抗菌材料作为辅助用药用于口腔癌术后预防感染尚未见明显不良反应.     

物理抗菌材料用于口腔癌术创安全性的初步观察

目的：观察洁悠神物理抗菌材料用于口腔癌术后预防感染时患者的不良反应情况。方法：从手术当日开始,在口腔、口咽部、鼻咽部以及颈部术创创面（缘）喷洒洁悠神物理抗菌材料,同时行血液学检测。结果：所有患者均未出现明显的痛、痒、过敏等症状,其中有11例患者初次使用时自觉气味欠佳,但仍能够接受并配合治疗。与对照组相比,治疗组患者用药后白细胞,粒细胞,淋巴细胞,血红蛋白,血小板,谷草转氨酶、谷丙转氨酶、白蛋白、球蛋白,尿素氮、肌酐等检测指标均无显著性差异。结论：洁悠神物理抗菌材料作为辅助用药用于口腔癌术后预防感染尚未见明显不良反应。     

壳聚糖抗菌成膜喷剂对口腔内手术切口愈合影响研究

目的    探讨壳聚糖抗菌成膜喷剂对口腔内手术切口愈合的影响。方法    选择2013年9月至2014年12月在中国医科大学口腔医学院综合急诊科就诊并行常规口腔内切口手术治疗的小唾液腺黏液囊肿患者60例,随机分为A、B两组,每组30例。A组患者术后给予康复新液含漱,B组患者术后在给予康复新液的基础上加用壳聚糖抗菌成膜喷剂。观察比较两组患者术后切口细菌感染情况、疼痛程度、切口愈合时间、切口愈合情况、不良反应发生率。结果    与A组患者相比,B组患者术后切口细菌检出量低、患者疼痛程度轻、切口愈合时间短、切口愈合质量好,两组差异均有统计学意义（P < 0.05）。两组病例中均未出现不良反应。结论    壳聚糖抗菌成膜喷剂可促进口腔内手术切口的愈合、提高切口愈合质量。     

术前洛铂化疗对口腔鳞癌抑癌基因PTEN表达的影响

目的:研究口腔鳞癌在洛铂术前化疗后PTEN蛋白的表达变化及其临床意义。方法:60例口腔癌患者随机分为2组,术前未行化疗为对照组,术前化疗者为实验组,应用免疫组织化学SP法检测口腔癌患者正常口腔黏膜组织及其癌组织中PTEN蛋白的表达,HE染色法进行临床病理学分析。结果:2组60例正常口腔黏膜组织中PTEN蛋白全部表达,阳性率为100%;对照组中,口腔鳞癌组织中PTEN蛋白的阳性表达率为76.7%,显著低于正常口腔黏膜组织;对照组在高、低分化口腔鳞癌组织中PTEN蛋白的阳性表达率分别为100%、57.1%,差异有统计学意义(P<0.05);PTEN表达阳性率与患者的年龄、性别无显著相关性(P>0.05),与淋巴结转移、病理分级及其临床肿瘤大小之间相关(P<0.05)。实验组口腔鳞癌组织中PTEN蛋白的阳性表达率为100%,显著高于对照组的76.7%(P<0.05),与正常口腔黏膜组织比较无显著相关性(P>0.05)。结论:PTEN基因在口腔鳞癌的发生发展过程起着一定的作用,对判断预后具有一定的意义。术前洛铂化疗可提高口腔鳞癌组织中PTEN的表达。     

甲壳质治疗糜烂型口腔扁平苔藓的临床应用研究

目的:将甲壳质医用敷料用于糜烂型口腔扁平苔藓(OLP)的局部治疗,同时分析糜烂愈合延迟的影响因素。方法:治疗组采用甲壳质贴敷于OLP糜烂面,3次/d×7 d。复诊未完全愈合者再用甲壳质7 d,然后评价2周疗效。对照组采用复方皮质散涂布于OLP糜烂面,3次/d。以上两组的全身治疗均采用抗生素和激素肌肉注射或口服3 d,随后口服氯喹片,0.125 g×2次/d。结果:治疗组糜烂面愈合率27.8%(5/18),对照组愈合率44.4%(16/36),两组愈合率无显著性差异(P>0.05);此外,愈合延迟组的平均年龄(59.5±12.0岁)比愈合组(45.8±12.2岁)大(P<0.01),愈合延迟组的平均糜烂面积(146.1±172.6 mm2)比愈合组(51.5±71.9 mm2)小(P<0.05)。结论:甲壳质医用敷料治疗糜烂型OLP无效,可能与口腔环境湿润、甲壳质不易粘附于糜烂面等方面的原因有关。而OLP糜烂愈合延迟与患者年龄大和糜烂面积小有关,提示老年OLP患者糜烂边缘的基底细胞增殖不活跃,不能为迁移的基底细胞提供新的来源。     

富血小板血浆在抗凝治疗患者拔牙术中的应用

目的:评价富血小板血浆局部应用对抗凝治疗患者拔牙术后出血及拔牙创愈合的影响。方法:选择抗凝治疗需拔牙患者48例随机分为实验组和对照组,另外随机选择从未经抗凝治疗拔牙患者20例作正常对照。拔牙前均行凝血酶原时间和国际标准化率检测。拔牙术后实验组拔牙创置自体富血小板血浆,对照组和正常对照组拔牙创行明胶海绵填塞、可吸收线缝合或填塞加缝合处理,比较三组术后出血情况及拔牙创愈合情况。结果:实验组术后轻度出血1例,对照组术后中度出血1例,轻度出血3例,正常对照组术后轻度出血1例,三组均未出现严重出血病例;10 d后拔牙创软组织愈合实验组优于对照组和正常对照组。结论:富血小板血浆局部应用能有效预防抗凝治疗患者拔牙术后出血,促进拔牙创软组织早期愈合。     

红茴香注射液用于缓解种植术后不良反应的效果评价

目的: 分析红茴香注射液用于缓解口腔种植同期引导骨再生（GBR）术后不良反应的效果。方法: 纳入接受口腔种植同期GBR手术患者90例,随机分为3组,每组30例。试验组患者术后局部注射红茴香注射液,对照组局部注射地塞米松注射液,空白组不注射任何药物。对术后1、3和7天的疼痛、肿胀、伤口愈合和满意度进行观察记录,采用SPSS 25.0软件包进行数据分析。结果: 试验组患者手术第1、3天的术后肿胀、疼痛程度显著低于空白组（P<0.05),伤口愈合程度显著高于空白组（P<0.05）;术后满意度试验组和对照组均显著高于空白组（P<0.05）。结论: 口腔种植同期GBR手术后局部注射红茴香注射液能有效改善术后不良反应。     

rhEGF对口腔癌联合根治术创面愈合的影响

目的:观察rhEGF(金因肽)对口腔癌联合根治术及颈阔肌皮瓣修复组织缺损创面愈合的促进作用.方法:50例口腔癌病例(舌癌、颊癌、口底癌)分为实验组(24例)和对照组(26例),所有病例均行口腔癌联合根治术 颈阔肌皮瓣修复组织缺损,术后治疗相同,实验组加用rhEGF喷雾口内和颈部创面,而对照组不用.术后第9 d观察两组创面愈合时间及愈合率.结果:对照组愈合时间为口内12.4 d,颈部10.6 d,愈合率73.07%,实验组愈合时间为口内9.3 d,颈部7.9 d,愈合率95.83%,两组病例经统计学处理均有显著性差异(P＜0.05).结论:rhEGF对口腔癌联合根治术所造成的巨大创面的愈合及颈阔肌皮瓣的成活具有促进作用.     

前臂皮瓣与胸大肌皮瓣在口腔癌手术缺损修复中的应用

目的:观察前臂皮瓣和胸大肌皮瓣修复口腔癌手术缺损的治疗效果。方法:30例口腔癌患者在常规联合根治术后,随机分为A、B组,每组15例。A组采用前臂桡侧皮瓣游离移植同期修复口腔癌术后口腔颌面部缺损,B组采用胸大肌皮瓣同期修复口腔癌术后口腔颌面部组织缺损;对比两组的修复效果。结果:A组13例(86.67%)前臂皮瓣顺利成活,B组皮瓣成活率100%。A组中有6例患者虎口感觉消失、4例患者供区颜色极深或极浅;B组中有4例女性患者术后两侧乳房不对称。结论:前臂皮瓣和胸大肌皮瓣修复口腔癌手术缺损均具有较高的成功率,两种皮瓣均适用于口腔癌手术缺损修复。     

闭式冲洗留置负压引流治疗口腔颌面部间隙感染患者的疗效观察

目的:研究闭式冲洗留置负压引流治疗口腔颌面部间隙感染的临床价值.方法:回顾性收集2016年6月～2019年9月医院口腔颌面外科收治的89例口腔颌面部间隙感染患者临床资料,按治疗方式分为常规组(常规切开引流,n = 42)与闭式冲洗留置负压引流(vacuum sealing drainage,VSD)组(n = 47)....     

Papilla base incision: a new approach to recession-free healing of the interdental papilla after endodontic surgery

AIM: The purpose of the present study was to describe and evaluate a new incision technique: the papilla base incision. METHODOLOGY: Twenty healthy patients referred for surgical treatment of persisting apical periodontitis, who were free of periodontal disease and had intact interdental papillae were included in the study. The preoperative papilla height was recorded by measuring the distance between the contact point and the most coronal point of the papilla. The papilla base flap, consisting of the papilla base incision and two releasing incisions, was used to expose the bone. The papilla base incision consisted of a shallow first incision at the base of the papilla and a second incision directed to the crestal bone, creating a split thickness flap in the area of the papilla base. Further apically a full thickness flap was raised. Following standard root-end resection and filling, flap closure was achieved with microsurgical sutures. The papilla base incision was sutured with 2-3 interrupted sutures, which were removed 3-5 days after the surgery. The experimental sites were evaluated at the conclusion of the surgery, at suture removal and after 1 month, and compared to the preoperative findings. The healing pattern, complications and postoperative recession were recorded. The experimental sites were observed with a x 3 magnification and graded as to whether a visible scar resulting from the incision could be detected. Twenty experimental sites were analysed. RESULTS: Complete closure of the wound was achieved in all cases after surgery. Except for four patients with delayed healing at suture removal, all other patients displayed rapid healing. No noticeable space was created beneath the contact point area. The change in distance between the reference point and the most coronal point of the papilla comparing the preoperative and the one-month postoperative situation was 0.05 +/- 0.39 mm. The probing depth remained within normal limits. One month postoperatively, observation of the incision demonstrated: four sites with a visible incision line (grade 1), in seven sites the incision defect could be partially detected (grade 2) and nine incisions could not be detected (grade 3). CONCLUSIONS: In patients with healthy marginal periodontal conditions the papilla base incision allows rapid and predictable recession-free healing following marginal surgical exposure of the soft tissues. One month postoperatively the majority of the incisions were completely or partially invisible. Long-term healing will be studied.     

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??Objective    To explore the effect of chitosan antibacterial film spray on healing of intraoral incision. Methods    Totally 60 patients with small salivary gland mucocele were selected in this study?? and they were divided into A and B groups randomly?? each group with 30 cases. After operation?? group A was given Kangfuxin liquid for gargle?? and group B was given  not only Kangfuxin liquid but also chitosan antibacterial film spray. Compare the bacterial infections of incision?? the pain levels?? the time of incision healing?? the quality of incision healing and the incidence of adverse reaction between two groups. Results    After operation?? compared with  group A?? bacteria detected in group B declined?? what’s more?? patients’ feeling of pain was relieved?? the time of incision healing was reduced?? and the quality of incision healing was better. Both groups had no adverse reaction. Conclusion    The chitosan antibacterial film spray can shorten the healing time of intraoral incision and improve the quality of incision healing.     

负压封闭引流辅助冲洗技术在38例口腔颌面颈部重症多间隙感染中的应用效果评价

目的:比较负压封闭引流辅助冲洗技术与传统脓肿切开引流术在口腔颌面颈部重症多间隙感染治疗中的临床效果。方法:回顾2014年6月—2017年5月福建医科大学附属第一医院口腔颌面外科收治的73例口腔颌面颈部重症多间隙感染的患者资料,对运用负压引流辅助冲洗技术和传统脓肿切开引流术的2组患者在疾病治愈时间、切口长度、医师工作量（换药次数）、治疗费用方面进行对比,采用SPSS 22.0软件包对数据进行统计学分析。结果:73例患者中,38例行负压封闭引流辅助冲洗,35例行传统脓肿切开引流,所有患者均治愈。在脓肿治愈时间、手术瘢痕长度、医师工作量等方面,前者显著优于后者（P<0.05）;在治疗费用方面比较,2组差异无统计学意义（P>0.05）。结论:负压封闭引流辅助冲洗技术治疗口腔颌面颈部重症多间隙感染具有良好的临床效果,与传统切开引流治疗相比,具有治疗时间短、疼痛轻、疗效高等优势,值得推广。     

改良美容切口联合胸锁乳突肌瓣在腮腺良性肿瘤切除术中的应用

目的:探究改良美容切口联合胸锁乳突肌瓣在腮腺肿瘤切除术中的应用。方法:选取2016年8月~2020年7月在我院接受腮腺良性肿瘤切除术治疗的104例腮腺良性肿瘤患者,按照随机分组法分为改良美容切口组与联合治疗组,各52例。改良美容切口组选择改良美容切口,联合治疗组选择改良美容切口并采用胸锁乳突肌瓣进行组织缺损区修复。记录患者术后引流量、切口愈合时间,评估患者面神经功能H-B面神经功能分级量表以及BISS评分,以及术后并发症及满意度。结果:与改良美容切口组相比,联合治疗组术后引流量较高,但两组比较无统计学差异(P>0.05)。与改良美容切口组相比,联合治疗组切口愈合时间较低(P<0.05)。与改良美容切口组相比,术后联合治疗组H-B面部神经功能值高,联合治疗组BISS评分低(P<0.05)。联合治疗组并发症总发生率低于改良美容切口组,满意度显著高于改良美容切口组(P<0.05)。结论:在腮腺良性肿瘤切除术中选择改良美容切口联合胸锁乳突肌瓣,切口愈合时间较短,术后能够改善患者面神经功能,提升身体状态,患者满意程度高。     

Self-repair capability of surgically created incisions in TMJ disc: An experimental study on goats

This study was to investigate whether surgically created incisions in discs at different sizes would heal spontaneously. Thirty mature goats were randomly divided into group A (1 mm), group B (3 mm) and group C (5 mm) according to the length of incision on the discs. Five animals in each group were sacrificed at 3 and 6 months postoperatively. The disc and condyle were evaluated by gross, histological and immunohistochemistry examinations. 1-mm discal incisions healed spontaneously with nearly normal gross and histological appearance at 6 months postoperatively, while 3-mm and 5-mm discal incisions failed to heal. Degenerative changes were observed in the fibrocartilage in both 3-mm and 5-mm incision groups, with a greater extent in the 5-mm group. Our results suggested that the TMJ disc of goat has limited self-repair capability to damage, which will be useful for making pre-surgical decisions related to the size and healing period of TMJ disc perforations.