Oxytocin plasma levels in orgasmic and anorgasmic women

The study aimed to evaluate oxytocin (Oxt) serum levels before and after sexual intercourse in women affected by anorgasmia. The sample was constituted of 15 anorgasmic women and 16 orgasmic women. The Female Sexual Function Index (FSFI, cutoff ≤26.55) and the Female Sexual Distress Scale (FSDS, cutoff ≥15) questionnaires were used to assess sexual function and sexual distress, respectively. Serum Oxt levels were measured before sexual intercourse (T0) and 5?min after coital sexual activity (T1). Anorgasmic women had an unpleasant sexual experience (FSFI total score, 20.1?±?1.2;) and were stressed (FSDS score, 19.4?±?1.3), whereas orgasmic women were fully satisfied with their sexual activity (FSFI total score 28.7?±?1.3; FSDS score 11.5?±?1.8). At T0, anorgasmic women had lower levels of Oxt than orgasmic women, 1.8?±?0.2?pg/mL versus 2.1?±?0.5?pg/mL, respectively, [95% CI: (?0.58, ?0.01); p?p?=?.09). Finally, orgasmic women had higher levels of Oxt than anorgasmic women, 4.6?±?0.7?pg/mL versus 2?±?0.4?pg/mL, respectively [95% CI: (?3.02, ?2.17); p?相似文献   

The effect of vulvar lichen sclerosus on quality of life and sexual functioning

Lichen sclerosus (LS) is a chronic skin disorder mostly seen on the female anogenital skin. The aim of this study was to evaluate the quality of life (QoL) and sexuality in female patients with LS and to compare their scores with healthy controls. In addition, we wanted to find factors associated with impaired sexual functioning in patients with LS.

?Members of the Dutch LS foundation and support group were asked to fill in three questionnaires: the Dermatology Quality of Life Index, Female Sexual Function Index (FSFI) and Female Sexual Distress Scale (FSDS). 215 of 368 patients returned their questionnaire (58.4%). Their scores were compared to a control group which consisted of 61 women of similar age (p?=?0.472) without a skin disorder.

?Of all domains of QoL, LS interfered most with sexual functioning. Patients significantly scored lower on all subscales of the FSFI (desire (p?=?0.016), arousal (p?<?0.001), lubrication (p?<?0.001), orgasm (p?<?0.001), satisfaction (p?<?0.001) and pain (p?<?0.001), indicating worse sexual functioning. These problems with sexual functioning brought about significant sexual distress (p?<?0.001). Patients who experienced more influence on their QoL had more sexual difficulties, leading to more sexual distress independent of their age.     

Randomized crossover study investigating daily versus on-demand vulvar Visnadine spray in women affected by female sexual arousal disorder

The aim of the study was to verify the efficacy of vulvar Visnadine spray in premenopausal women affected by female sexual arousal disorder (FSAD). Thirty-eight women aged 25–40 years affected by FSAD were enrolled in the randomized crossover study, by two possible sequences: on-demand, washout, daily (A sequence); and daily, washout, on-demand (B sequence). The Female Sexual Function Index (FSFI) and the Female Sexual Distress Scale (FSDS) were used to assess sexual function and sexual distress, respectively. Color Doppler ultrasonography was used to measure clitoral blood flow. The study had two follow-ups at 30 (T1) and 60 days (T2). Thirty-one women completed the study. Mean (SD) sexual activity and vulvar Visnadine spray usage was 1?±?0.9 weekly during on-demand administration for both the sequences (Vs T0, p?=?NS). The mean sexual activity during daily usage was 2?±?0.9 (Vs T0, p?p?p?p?相似文献   

Impact of vulvovaginal atrophy of menopause: prevalence and symptoms in Italian women according to the EVES study

Abstract

This cross-sectional study included postmenopausal women, aged 45–75?years, with the aim to assess the presence of vulvovaginal atrophy (VVA) confirmed by a clinical assessment in the Italian population attending menopausal/gynecological centers. Apart from baseline variables, women scored vaginal, vulvar and urinary VVA symptoms. Impact of VVA on sexual function and quality of life (QoL) was assessed thorough EuroQoL questionnaire (EQ5D3L), Day-to-Day Impact of Vaginal Aging (DIVA), Female Sexual Function Index (FSFI) and Female Sexual Distress Scale-revised (FSDS-R). A physical examination was carried out in accordance with routine gynecological practice. VVA was confirmed in 90% of the 1226 evaluable patients (aged 59.0?±?7.3?years). The prevalence of postmenopausal women with VVA confirmed by gynecological clinical assessment was 75.3%. The patients with VVA confirmed (n?=?926) had more severe symptoms (p?<?.0005), lower QoL (EQ-visual analog scale, p?=?.008 and DIVA, p?<?.0005) and worsened sexual function (FSFI and FSDS-R, p?<?.0005 for both) when compared with the patients having nonconfirmed VVA (n?=?140). VVA is highly prevalent among postmenopausal Italian women. The objective of VVA confirmation is associated with severe symptoms and impaired QoL and sexual function. A proactive approach of Italian clinicians to promote regular and early gynecological evaluation should be performed in order to delay the advancing of the disorder.     

Sexual Function and Satisfaction in Couples with Infertility: A Closer Look at the Role of Personal and Relational Characteristics

BackgroundResearch to date suggests that couples undergoing assisted reproductive technology (ART) are at a high risk of experiencing sexual difficulties.AimThis dyadic cross-sectional study aimed to provide a better understanding of the infertility-specific personal (ie, emotional, mind-body) and relational stressors associated with the sexual desire, orgasm, arousal, and sexual satisfaction of infertile couples seeking ART.MethodsThe sample included 185 mixed-sex infertile couples seeking ART. Participants completed online the Fertility Quality of Life tool and either the Female Sexual Function Index or the International Index of Erectile Function. Data were analyzed using path analyses based on the Actor-Partner Interdependence Model.OutcomesIndividuals’ own and their partners’ sexual function (desire, orgasm, arousal domains) and sexual satisfaction.ResultsFor men and women, infertility-related emotional stressors were associated with their own and their partner's lower sexual desire. For women, experiencing greater infertility-related emotional stressors was also associated with their partner's lower sexual satisfaction. While experiencing greater infertility-related mind-body stressors was not associated with men and women's own sexual desire, arousal, orgasm, and satisfaction, for women, it was associated with their partner's lower sexual arousal. Lastly, for men and women, infertility-related relational stressors were associated with their own lower sexual arousal, as well as with their own and their partner's lower sexual satisfaction. For women, experiencing greater relational stressors was also associated with their own lower sexual desire and orgasm.Clinical ImplicationsInterventions addressing the emotional, mind-body, and relational spheres of infertile couples seeking ART may help facilitate improvements in sexual function and satisfaction and better serve their needs.Strengths & LimitationsThis study included a large sample of couples. Our sample was heterogeneous with regards to couples’ cause of infertility and treatment stage. The use of an infertility-related measure allowed us to better capture personal and relational stressors specific to couples seeking ART. Given the cross-sectional design of our study, causality between infertility-related stressors and sexual function and satisfaction cannot be inferred. Our sample included predominantly White, mixed-sex individuals with a high level of education, which may reduce the generalizability of our findings.ConclusionCouples’ subjective experience of infertility and treatment (personal and relational stressors) seems to be strongly associated with their sexual health, allowing us to identify potential targets of intervention with couples seeking ART.S.E. Amiri, A Brassard, N.O. Rosen, et al. Sexual Function and Satisfaction in Couples with Infertility: A Closer Look at the Role of Personal and Relational Characteristics. J Sex Med 2021;18:1984–1997.     

Prevalence of and risk factors for sexual dysfunction in young Chinese women according to the Female Sexual Function Index: an internet-based survey

Objectives: Female sexual dysfunction (FSD) is a very common sexual health problem worldwide. The prevalence of FSD in Chinese women is, however, unknown. This is the first study to investigate a large number of young women throughout China via the internet, to determine the prevalence and types of FSD and to identify the risk factors for FSD. Methods: The primary endpoint was the Female Sexual Function Index (FSFI) score, with additional questions on contraception, sexual activity, relationship stability, pregnancy and other factors which may influence sexual function. The online questionnaire was completed by women from 31 of the 34 Chinese provinces. Results: A total of 1618 completed questionnaires were received, and 1010 were included in the analyses after screening (62.4%). The mean age of the respondents was 25.1?±?4.5 years. The mean total FSFI score was 24.99?±?4.60. According to FSFI definitions (cut-off score 26.55), 60.2% of women were at risk of FSD. Based on domain scores, 52 were considered at high risk of dysfunction for pain (5.1%), 35 for orgasm (3.5%), 33 for desire (3.3%), 20 for arousal (2.0%), 6 for satisfaction (0.6%) and 2 for lubrication (0.2%). Conclusions: The prevalence of FSFI scores indicating risk of sexual dysfunction was about 60% in Chinese women. An unstable relationship, pressure to become pregnant, non-use of contraception, negative self-evaluation of appearance and increasing age were significantly associated with FSD in young Chinese women.     

The effect of voluntary termination of pregnancy on female sexual and emotional well-being in different age groups

Introduction: To evaluate the impact of voluntary termination of pregnancy (VTOP) on the psycho-sexological well-being of females before/six months after the abortion.

Methods: A sample of 194 women was recruited from three obstetrics and gynaecological divisions. The women were evaluated for the variables “sexual functioning” with the Female Sexual Function Index (FSFI), “depression” with the Beck Depression Inventory (BDI-II), and “anxiety state” with the Self-Rating Anxiety Scale (SAS) at time 0 (the beginning of the abortion procedure) and time 1 (six months after the abortion). Since 24 women refused to fill out the questionnaires, the final sample was composed of 170 women.

Results: The women showed a slight although significant improvement in the mean FSFI score from time 0 (16.7?±?12.9) to time 1 (20.9?±?13.8) (p?p?=?0.0241). The sub-group of younger women (18–25) showed a lesser increase in FSFI score from time 0 to time 1. In addition, both depression (p?=?0.048) and anxiety (p?Discussion: Voluntary TOP may influence the sexuality of younger females differently from how it influences that of older women. Hence, the sexuality of younger female should be regularly supervised in follow-up examinations.     

Sexual dysfunction in female patients with type 2 diabetes mellitus: a cross-sectional single-centre study among Turkish patients

The aim of the study was to assess the prevalence of female sexual function and related factors in Turkish women with type 2 diabetes mellitus (T2DM). A total of 93 female patients diagnosed with T2DM (age 48.0?±?7.2 years (Mean?±?SD) were included. Data on age, diabetes age, HbA1c level, educational level, diabetes treatment, diabetes-related complications, co-morbid disorders and concomitant medications were recorded, as were the scores obtained using a Female Sexual Function Index (FSFI) questionnaire. Sexual dysfunction was noted in 55.9% of patients including problems related to desire (60.2%), arousal (52.7%), lubrication (55.9%), orgasm (51.6%) and satisfaction (58.1%) as well as pain during sexual intercourse (54.8%). Total scores were correlated negatively to age (r=??0.329, p?=?0.001) and duration of diabetes (r=??0.246, p?=?0.018), while significantly higher in patients with than without hypertension (19.6 vs. 22.4, p?=?0.012) and with than without insulin therapy (20.0 vs. 23.7, p?=?0.050). Our findings indicate the adverse effects of T2DM on sexual function in 55.9% of women in all domains of sexual response cycle, although this seems to be associated with older age, longer duration of diabetes, insulin and antidepressant therapy, presence of hypertension as well as end-organ complications of neuropathy and coronary artery disease (CAD).     

Effect of sexual diary keeping and self-evaluation on female sexual function and depression: A pilot study

Objectives The aim of the trial was to assess the effect of self-evaluation and sexual diary keeping on female sexual function and depressive symptoms in women diagnosed with sexual dysfunction.

Methods A single-arm non-randomised trial included 30 women (53 ± 7 years of age) with female sexual dysfunction (Female Sexual Function Index [FSFI] < 27) and a stable partnership duration of 5–40 years. Female sexual function was assessed by sexual, psychological and gynaecological history taking and validated questionnaires including the FSFI, Female Sexual Distress Scale (FSDS) and Hamilton Depression Scale (HDS), before and after 4 weeks of sexual diary keeping.

Results A subjective improvement in communication of sexual problems was reported by 60% of participants; no participants reported any worsening of communication. FSFI and FSDS scores were, respectively, 18.0 ± 7.7 and 22.0 ± 10.0 at baseline and 20.2 ± 7.2 and 20.6 ± 11.5 after 4 weeks. HDS score decreased from 6.0 ± 4.0 at baseline to 4.4 ± 2.7 after 4 weeks (p = 0.042).

Conclusions Self-evaluation and sexual diary keeping may improve aspects of sexual life, such as couple communication, without a direct effect on variables measured with validated questionnaires on different domains of sexual function.     

Patterns of female sexual dysfunction in premenopausal women with moderate to severe depression in Beni-Suef,Egypt

Background

Depression is a disease of public health concern due to its high morbidity and mortality. Female sexual dysfunction is suggested to be associated with depression. The aim of this study is to investigate the prevalence of sexual disorders among premenopausal women with moderate to severe depression and detect any further correlates.

Sexual Function Questionnaire: Further Refinement and Validation

IntroductionThe Sexual Function Questionnaire (SFQ) is a self‐report outcome measure of female sexual function. It has recently been refined to create a 28‐item version (SFQ28) including the addition of a new arousal‐cognitive domain.AimThis study aimed to validate the SFQ28 in female sexual arousal disorder (FSAD) and hypoactive sexual desire disorder (HSDD) populations and to develop a screening cut‐score for the arousal‐cognitive domain.MethodsWomen with FSAD (n = 222) and HSDD (n = 114) and 303 women without female sexual dysfunction (FSD) completed the SFQ28, the Female Sexual Distress Scale (FSDS), and the Sexual Quality of Life‐Female (SQOL‐F) at a clinic visit. Retests were performed within FSD groups only (FSAD: n = 92, HSDD: n = 183), using postal questionnaires 7–14 days later. The optimal cut‐score for the arousal‐cognitive domain was based on diagnostic tests of sensitivity and specificity from a receiver operating characteristic curve.Main Outcome MeasuresPsychometric analyses.ResultsThe factor analysis confirmed the domain structure of the SFQ28. The SFQ28 demonstrated excellent internal consistency, test retest reliability and known groups validity, and good convergent validity with the FSDS and SQOL‐F for all domains except pain. The sensitivity/specificity analysis determined a screening cut‐score of 5 for the arousal‐cognitive domain.ConclusionGiven the replication of the psychometric data and the cut‐scores for each domain, the SFQ28 is a robust measure that can be used in women with either FSAD or HSDD. Symonds T, Abraham L, Bushmakin AG, Williams K, Martin M, and Cappelleri JC. Sexual function questionnaire: Further refinement and validation. J Sex Med **;**:**–**.     

Neurovegetative disorders of perimenopausal women treated with docosahexaenoic acid (DHA, 625 mg)

The study evaluated the effect of DHA 625?mg in women who experience menopausal symptoms, on sexuality and quality of life (QoL), and on the auditory brainstem response (ABR). Forty-two perimenopausal women were enrolled. The Kupperman Index (KI) was used to evaluate menopause symptoms. The Short Form-36 (SF-36), Female Sexual Function Index (FSFI), and the Female Sexual Distress Scale (FSDS) were used to assess QoL, sexual function, and sexual distress, respectively. Auditory evoked potentials to measure the ABR. The study had one follow-up at 6 months. The women reported an improvement in the KI total score (p?p?p?=?NS). FSFI and FSDS total scores increased (p?p?p?p?p?相似文献   

Intended or Unintended Consequences? The Likely Implications of Raising the Bar for Sexual Dysfunction Diagnosis in the Proposed DSM‐V Revisions: 2. For Women with Loss of Subjective Sexual Arousal

IntroductionBrotto proposes to combine female sexual desire and arousal disorders in the Diagnostic and Statistical Manual of Mental Disorders, fifth edition.AimWe provide evidence that the proposed criteria could potentially exclude from diagnosis or treatment a large number of women with distressing dysfunction in sexual arousal.MethodsRating scale data from nontreatment validation studies of patient‐reported outcome measures including almost 500 women in North America and Europe, including 49 women diagnosed with arousal disorder only, were compared with the proposed criteria.Main Outcome MeasuresThe main measures were an early version of the eDiary (an electronic diary on sexual activity) and four previously validated measures of female sexual dysfunction (FSD), the clinician‐rated Sexual Interest and Desire Inventory—Female and the self‐rated Female Sexual Function Index, Changes in Sexual Functioning Questionnaire, and Female Sexual Distress Scale.ResultsThe women with female sexual arousal disorder (FSAD) scored as manifestly sexually dysfunctional and significantly sexually distressed. They had fewer satisfying sexual events (SSEs) vs. women with no FSD, with a lower proportion of SSEs, and significantly fewer orgasms.ConclusionDespite evidence presented that women with FSAD have clinically disordered sexual function, our data also suggest that the majority of these women with FSAD would meet none of the six proposed “A” criteria for Sexual Interest/Arousal Disorder, raising new validity and utility concerns for the proposed diagnostic classification. Suggestions are made to modify the proposed new criteria so as to include such distressed women. Clayton AH, DeRogatis LR, Rosen RC, and Pyke R. Intended or unintended consequences? The likely implications of raising the bar for sexual dysfunction diagnosis in the proposed DSM‐V revisions: 2. for women with loss of subjective sexual arousal. J Sex Med 2012;9:2040–2046.     

The effect of a drospirenone-containing combined oral contraceptive on female sexual function: a prospective randomised study

Objectives: The study investigated the effects on female sexual function of a progestogen-containing combined oral contraceptives (COCs) with an antiandrogenic profile taken in a continuous regimen.

Methods: In this prospective randomised single-institution study, 80 healthy women with a monogamous partner and an active sexual life were randomised into two groups for a period of 3 months. Women in the exposed group (n?=?40) took a COCs containing 30?μg ethinylestradiol (EE) and 3?mg drospirenone (DRSP) in a 21/7 regimen. Women in the control group (n?=?40) used either a barrier contraceptive method (BCM) or a natural family planning method (NFPM). Participants were asked to complete a set of validated questionnaires to assess sociodemographic variables and measure Female Sexual Function Index (FSFI).

Results: The total FSFI score (p?p?=?0.04) and arousal (p?=?0.03) scores, were significantly lower in the COCs group after 3 months of hormonal contraceptive use compared with baseline. Women using BCM or NFPM showed an improvement in total FSFI score (p?=?0.02). Hormonal contraception with DRSP increased the likelihood of worse sexual function in the desire (odds ratio [OR] 2.47; 95% confidence interval [CI] 1.22, 4.98; p?=?0.01) and arousal domains (OR 2.85; 95%CI 1.34, 5.93; p?=?0.005) and in total FSFI score (OR 2.01; 95%CI 1.45, 2.79; p?Conclusions: The study found evidence that women taking a combined EE/DRSP COCs for 3 months may have a worsening of sexual function as measured by FSFI.     

Sexual function in female patients with obstructive sleep apnea

IntroductionObstructive sleep apnea is defined as repetitive (≥5/hour) partial or complete cessation of breathing during sleep. Whereas obstructive sleep apnea is often considered to be associated with sexual problems in men, studies concerning effects of obstructive sleep apnea on female sexual function and distress are sparse.AimTo investigate sexual dysfunction and sexual distress in female patients with obstructive sleep apnea and to determine which factors are of importance for their sexual function.MethodsWe investigated 80 female patients (ages 28–64) admitted to a sleep laboratory and who after investigation received a diagnosis of obstructive sleep apnea. All subjects answered questions drawn from three self‐administered questionnaires on sexuality. The results were compared with a population sample (N = 240).Main Outcome MeasureData from nocturnal respiratory recordings. Female Sexual Function Index, Female Sexual Distress Scale and four questions from Life Satisfaction‐11 (Lisat‐11).ResultsFemale Sexual Function Index indicated that obstructive sleep apnea patients were at a higher risk for having sexual difficulties. Female Sexual Distress Scale showed significantly more sexual distress in the obstructive sleep apnea group. Manifest Female Sexual Dysfunction (combined data from Female Sexual Function Index and Female Sexual Distress Scale) showed that female patients with obstructive sleep apnea also had more sexual dysfunction. Severity of sleep apnea was, however, not related to any of these indices but consumption of psychopharmaca was. In Lisat‐11, we found that obstructive sleep apnea females scored lower than women in the population sample regarding life as a whole but not regarding domains of closeness.ConclusionsThis study indicates that sexuality of women with untreated obstructive sleep apnea is negatively affected compared with a female population sample. This was not related to severity of obstructive sleep apnea, whereas psychopharmaca may act as an important confounder. Petersen M, Kristensen E, Berg S, Giraldi A, and Midgren B. Sexual function in female patients with obstructive sleep apnea. J Sex Med 2011;8:2560–2568.     

Does the Severity of Overactive Bladder Symptoms Correlate With Risk for Female Sexual Dysfunction?

BackgroundSeveral studies have associated overactive bladder (OAB) with female sexual dysfunction (FSD); however, there are no reports using a quantitative approach to measure OAB severity and to relate OAB to the risk of FSD.AimTo evaluate women with OAB and to correlate the severity of their urinary symptoms with their sexual function.MethodsThis cross-sectional study included 267 women older than 18 years with untreated OAB. All subjects completed the International Consultation on Incontinence Questionnaire Overactive Bladder (ICIQ-OAB) and the Female Sexual Function Index (FSFI).OutcomesLinear regression was used to analyze the association between variables and the numeric FSFI score, and categorical FSFI scores were analyzed using logistic regression. Spearman rank correlation coefficient was used to assess the correlation between ICIQ-OAB results and the different FSFI domains. The significance level was 5%.ResultsSubjects’ mean age was 50.2 ± 11.9 years. Most women were married, had at least three children, and were postmenopausal (54.3%). Mean FSFI total score was 19.2 ± 9.8. For menopausal status, 65.6% of premenopausal women had a risk for FSD vs 86.2% of postmenopausal women. Mean ICIQ-OAB score was 10 ± 3.17. Postmenopausal women had the following risk factors statistically associated with sexual dysfunction: age, ICIQ score, and marital status. For these women, greater OAB severity, especially those with urgency and/or urge incontinence, was associated with worse scores in the arousal, lubrication, orgasm, and sexual pain domains. However, there was no statistically significant association for premenopausal women.Clinical ImplicationsHealth professionals have to pay attention to OAB in women because of the greater risk for FSD in these patients.Strengths and LimitationsThe strength was using a quantitative approach to measure OAB severity in a larger population. Limitations include a convenience sample with no power calculation; exclusion of women who did not have sexual intercourse in the past month; unmeasured distress caused by sexual disorders; and the impossibility of establishing causality between OAB and sexual dysfunction.ConclusionWomen with OAB frequently have a risk for sexual dysfunction. In the postmenopausal group, women with scores indicating severe OAB had worse sexual function, mainly in the arousal, lubrication, orgasm, pain, and total domains.Juliato CRT, Melotti IGR, Junior LCS, et al. Does the Severity of Overactive Bladder Symptoms Correlate With Risk for Female Sexual Dysfunction? J Sex Med 2017;14:904–909.     

Sexual activity and sexual dysfunction of women in the perinatal period: a longitudinal study

Purpose

Reduced sexual activity and dysfunctional problems are highly prevalent in the perinatal period, and there is a lack of data regarding the degree of normality during pregnancy. Several risk factors have been independently associated with a greater extent of Female Sexual Dysfunction (FSD). Therefore, this study aimed to assess the prevalence of sexual inactivity and sexual dysfunctions in German women during the perinatal period and the verification of potential risk factors.

Methods

Questionnaires were administered to 315 women prenatally (TI 3rd trimester) and postpartum (TII 1 week, TIII 4 months), including the Female Sexual Function Index (FSFI), the Edinburgh Postnatal Depression Scale (EPDS), and the Questionnaire of Partnership (PFB).

Results

The frequency of sexual inactivity was 24% (TI), 40.5% (TII), and 19.9% (TIII). Overall, 26.5?34.8% of women were at risk of sexual dysfunction (FSFI score?<26.55) at all measurement points. Sexual desire disorder was the most prevalent form of Female sexual dysfunction. Furthermore, especially breastfeeding and low partnership quality were revealed as significant risk factors for sexual dysfunctional problems postpartum. Depressive symptoms having a cesarean section and high maternal education were correlated with dysfunctional problems in several subdomains.

Conclusions

Findings indicated that women at risk of FSD differed significantly in aspects of partnership quality, breastfeeding, mode of delivery, maternal education, and depressive symptoms. Aspects of perinatal sexuality should be routinely implemented in the counseling of couples in prenatal classes.

     

Female sexual dysfunction in Iranian postmenopausal women: prevalence and correlation with hormonal profile

IntroductionFemale sexual dysfunction is a current and multifactorial status that greatly affects quality of life. Menopause, aging, and probably hormonal instability are some of these drastic factors.AimDetermine the prevalence of sexual dysfunction in Iranian postmenopausal women and the relationship to serum status of sex hormones and sex hormone binding globulin (SHBG).MethodsA total of 149 healthy postmenopausal women aged 43–64, nonhormone therapy user, with intact uterus and ovaries, enrolled in the cross‐sectional study.Main Outcome MeasuresFemale sexual function was evaluated by utilizing the Female Sexual Function Index. Hormonal serum concentration was measured by enzyme‐linked Immunosorbent Assay (ELISA). Also, free testosterone and free estradiol indexes were calculated. The analysis was performed by using SPSS 16.ResultsMean age of sample was 52.19 ± 3.76 with 47.48 ± 36.5 month amenorrhea. In the study, 69.8% of women showed sexual dysfunction in Desire and 61.7% in Arousal, these two being the most affected domains. Lubrication (49.7%), Pain Domain (45.0%), Orgasm (40.3%), and Satisfaction (36.9%) were in later degree among six assessed domains. There was no difference between the two groups—with and without dysfunction—in hormone level and SHBG.ConclusionIn Iranian postmenopausal women, Desire and Arousal are the most prevalent menopausal sexual dysfunctions, and Female Sexual Dysfunction is much more than just a hormonal problem. Moghassemi S, Ziaei S, and Haidari Z. Female sexual dysfunction in Iranian postmenopausal women: Prevalence and correlation with hormonal profile. J Sex Med 2011;8:3154–3159.