Influence of aging on systolic left ventricular wall motion velocities along the long and short axes in clinically normal patients determined by pulsed tissue doppler imaging.

Our objective was to evaluate the influence of aging on left ventricular (LV) regional systolic function along the long and short axes in clinically normal patients. We recorded LV wall motion velocity patterns at the mid-wall portion of the middle of the LV posterior wall in the parasternal long-axis view (short-axis direction) and at the endocardial portion of the middle of the LV posterior wall in the apical long-axis view (long-axis direction) with pulsed tissue Doppler imaging in 80 normal patients (age range 15 to 78 years). In all patients the LV pressure curve and its first derivative (dP/dt) were recorded. The systolic wave of the LV posterior wall motion velocity pattern exhibited 2 peaks, the first (Sw(1)) and second (Sw(2)) systolic waves. No significant changes were seen with aging in the percent LV fractional shortening determined by M-mode echocardiography, LV ejection fraction determined by left ventriculography, the peak Sw(1) and Sw(2) along the short axis, the peak Sw(2) along the long axis, and the peak dP/dt. The peak Sw(1) along the long axis correlated inversely with age (P <.0001) but did not correlate significantly with the peak dP/dt. These results suggest that shortening of the longitudinal fibers in early systole is impaired with increased age in healthy individuals. This impairment results in insufficient spherical change in the LV cavity, although global LV pump function and myocardial contractility are maintained.     

Effect of aging on diastolic left ventricular myocardial velocities measured by pulsed tissue Doppler imaging in healthy subjects.

We evaluated the effect of aging on diastolic left ventricular (LV) wall motion velocity in 80 healthy persons with the use of pulsed tissue Doppler imaging. The wall motion velocity patterns were recorded at the middle regions of the LV posterior wall and ventricular septum in the parasternal (along the short axis) and apical (along the long axis) LV long-axis views. In the posterior wall, the peak early diastolic wall motion velocities (Ews) along both axes correlated inversely with age (long axis: r = -0.61, P <. 0001; short axis: r = -0.55, P <.0001), and the peak atrial systolic wall motion velocities(Aws) along both axes correlated directly with age (long axis: r = 0.59, P <.0001; short axis: r = 0.65, P <.0001). In the ventricular septum, the Ew along the long axis correlated inversely with age (r = -0.51, P <.0001), and the Aws along both axes correlated directly with age (long axis: r = 0.57, P <.0001; short axis: r = 0.53, P <.0001). The Ews along both axes at the posterior wall correlated directly with the peak early diastolic transmitral flow velocity. The Aws along both axes at the ventricular septum and posterior wall correlated directly with the peak atrial systolic transmitral flow velocity. The times from the second heart sound to the peak of the early diastolic waves of the ventricular septum and posterior wall along both axes significantly increased with age. The times from the aortic component of the second heart sound to the peak of the early diastolic motion velocities along both axes were significantly longer at the ventricular septum than at the posterior wall. Pulsed tissue Doppler imaging may be useful for evaluating the effect of aging on diastolic LV function in healthy persons.     

Assessment of regional systolic and diastolic wall motion velocities in highly trained athletes by pulsed wave Doppler tissue imaging.

We studied the relationship between left ventricular (LV) function and the increased LV mass in 18 highly trained rowing athletes (14 men, 4 women; mean age 20.7 +/- 4.5 years) using pulsed wave Doppler tissue imaging (PWDTI). Thirteen untrained volunteers, matched for age and body mass index, acted as control participants. Peak systolic, early diastolic (Ev), and late diastolic (Av) myocardial velocities (cm/s); Ev/Av ratio; and isovolumic relaxation time (ms) were measured at the level of basal lateral wall and basal posterior interventricular septum (bas-IVS) segments. In comparison with control participants, athletes showed a greater LV cavity size (P <.05), wall thickness (IVS, P <.001; posterior wall, P <.01), and mass index (P <.001). In athletes, systolic velocity of bas-IVS had increased (P <.001) and was positively correlated with IVS thickness (r = 0.66, P <.005) and LV mass index (r = 0.71, P <.001). Of the PWDTI-measured diastolic indexes, Ev/Av ratio significantly increased in athletes in comparison with control participants in both the examined segments (bas-IVS, P <.05; basal lateral wall, P <.05). When Ev and Av were separately considered, a different behavior was found in the 2 segments: Ev significantly increased in the basal lateral wall (P <.005); Av significantly decreased in the bas-IVS. The increase in the systolic velocity of bas-IVS suggests that septum greatly contributes to the longitudinal LV systolic shortening and increase of stroke volume in athletes compared with untrained participants. Moreover, the behavior of PWDTI diastolic velocities suggests a more effective relaxation activity in the longitudinal axis at the level of lateral wall. This study suggests therefore the usefulness of PWDTI in the assessment of functional properties of "athlete's heart" and differentiation from pathologic cardiac conditions.     

组织多普勒成像评价舒张性心力衰竭患者左心室长轴收缩功能

目的　检测舒张性心力衰竭 (DHF)患者左心室长轴收缩功能,探讨其临床意义。方法　选取DHF患者 30例、收缩性心力衰竭(SHF)患者 32例和正常人 34例,应用组织多普勒成像 (TDI)测定二尖瓣环收缩期峰值运动速度(SM)、位移(DS)和心电图QRS波起始至收缩波起始间期。结果　SM 在正常人、DHF和SHF分别为(7. 32±0. 65 )cm/s、( 5. 09±0. 93 )cm/s和 ( 3. 58±0. 72 )cm/s,呈现正常人 >DHF>SHF的变化 (P<0. 001),DS呈现同样逐渐减小的变化 (P<0. 001 )。左心室长轴收缩功能障碍发生率在DHF和SHF分别为81. 6% 和 95. 8% (P<0. 001)。结论　多数DHF患者存在左心室长轴收缩功能异常,TDI估测左心室长轴收缩功能在心力衰竭患者心脏功能评价中具有重要价值。     

Assessment of left ventricular systolic and diastolic function by Doppler tissue imaging in patients with preinfarction angina.

BACKGROUND: The aim of this study was assessment of left ventricular (LV) systolic and diastolic function by pulsed wave Doppler tissue imaging (DTI) in patients with or without preinfarction angina in acute myocardial infarction. METHODS: We prospectively evaluated 31 consecutive patients (4 women, 27 men; age 58 +/- 10 years) with a first acute myocardial infarction. LV systolic and diastolic function was assessed by classic methods and DTI on the third day during acute myocardial infarction. Patients were divided into 2 groups according to the presence (group 1; n = 10) or absence (group 2; n = 21) of preinfarction angina. Mitral inflow velocities and early diastolic mitral annular velocity (Em), late diastolic mitral annular velocity (Am), peak systolic mitral annular velocity, Em/Am, the ratio of early diastolic mitral inflow velocity (E) to Em, and myocardial performance index were calculated by DTI. RESULTS: Group 1 had significantly higher Em and Em/Am than group 2 (11.3 +/- 3.34 cm/s vs 7.4 +/- 2.07 cm/s, P <.0001; 1.01 +/- 0.38 cm/s vs 0.6 +/- 0.2 cm/s, P =.001, respectively). The E/Em ratio and myocardial performance index were significantly lower in group 1 than in group 2 (5.1 +/- 2.92 vs 8.10 +/- 3.15, P=.018; 0.49 +/- 0.15 vs 0.65 +/- 0.24, P =.042, respectively). Wall-motion score index was lower in those with preinfarction angina than in those without (1.6 +/- 0.36 vs 1.9 +/- 0.39; P =.04, respectively). Peak systolic mitral annular velocity and Am were not statistically different between groups (9.4 +/- 1.84 vs 8.3 +/- 2.03, P =.172; 11.7 +/- 3.07 vs 12.1 +/- 3.34, P =.72, respectively). There were no significant differences between the 2 groups regarding transmitral E velocity, atrial contraction mitral inflow velocity (A), E/A ratio, isovolumetric relaxation time, and deceleration time of the mitral E wave (P =.91, P =.08, P =.58, P =.81, and P =.71, respectively). CONCLUSION: LV diastolic function was better in patients with preinfarction angina than in patients without. This condition could not be detected by conventional mitral inflow Doppler velocities, but could be detected by DTI. This preliminary evidence shows that DTI is better than conventional mitral Doppler indices in the assessment of a favorable LV diastolic function in patients with preinfarction angina.     

应用多普勒组织成像技术观察正常人心脏室壁运动的频谱特征

目的:应用多酱勒组织成像技术测量正常人室壁运动速度,研究其频谱特征,为量化分析室壁运动提供客观依据。 方法:按美国超声心动图学会推荐的16节段左室分段法,应用多普勒组织声像技术的速度图模式,观察了40例正常人左室壁共640个节段的心肌运动频谱,对每一节段的频谱曲线进行定量分析。 结果:正常人的室壁运动频谱有特征性表现,在心电图Q波后出现等容收缩波(isovolumic constrictive wave,IVC)、收缩波(systolic wave,S),于心 电图T波后依次出现等容舒张波(isovolumic relaxation wave,IVR)、早期舒张波(early diastolic wave,E)、反向波(reverse wave,R)、晚期舒张波(atrial constrictive wave,A),其中S波、E波、A波在所有节段出现,且不同节段的峰值速度不同,但各波的最高峰值速度均在各基底段出现,其中各波的最高值分别为(12.00±3.18)cm/s(侧壁基底段)、(14.72±4.35)cm/s(侧壁基底段)、(9.74±2.80)cm/s(下壁基底段),所有节段中S波的最低值均大于5 cm/s;IVC、IVR及R波在部分节段出现,节段间峰值差异部分有意义。同一室壁心肌的运动速度从近侧到远侧节段逐渐减低。左室后壁、侧壁、下壁的S波、E波、A波峰值分别大于相对应的左室前间隔、后间隔、前壁的各节段。 结论:正常人心脏室壁运动有其特有的规     

组织多普勒成像评价左心室舒张功能障碍患者的左心室长轴收缩功能

目的 探讨左心室舒张功能障碍患者的左心室长轴收缩功能变化特征。方法 选取健康志愿者30例（Ⅰ组），左心室舒张功能障碍患者60例分为松弛性减低组（Ⅱ组）32例和假性正常化充盈组（Ⅲ组）28例，应用组织多普勒成像（TDI）模式，分别取心尖四腔心和二腔心切面，将取样容积先后置于二尖瓣环后间隔、侧壁、前壁和下壁处，记录4个位点二尖瓣环运动频谱，测量或计算舒张早期峰值速度（EM）、心房收缩期峰值速度（AM）、EM／AM比值、收缩期峰值速度（SM）、收缩期位移（DS，即收缩波时间速度积分）及收缩前期时间（PCTM，即心电图QRS波起始与收缩波起始之间期），并对3组数据进行比较分析。结果SM和DS在Ⅱ、Ⅲ组明显小于Ⅰ组（P〈0．01或P〈0．05），在各组间呈逐渐减小趋势，即Ⅰ组〉Ⅱ组〉Ⅲ组；而各组间PCTM差异无统计学意义（P〉0．05）。左心室长轴收缩功能减低发生率在Ⅱ、Ⅲ组分别是35．3％和67．2％（P〈0．01）。结论 左心室舒张功能障碍患者存在一定程度长轴收缩功能障碍，且其受损程度随着舒张功能障碍进展而加重，因而采用TDI评估左心室长轴收缩功能对全面评价患者心脏功能具有重要价值。     

Reference ranges for tissue Doppler measures of maternal systolic and diastolic left ventricular function.

OBJECTIVES: Tissue Doppler imaging (TDI) is an echocardiographic technique that evaluates longitudinal myocardial tissue velocities during left ventricular systolic and diastolic function, relatively independently of loading conditions. Limited data are available regarding maternal cardiac function using TDI. The aim of this study was to construct reference charts for TDI indices in normal pregnancy. METHODS: This was a cross-sectional study on 104 pregnant women at 11-38 weeks of gestation and 19 non-pregnant controls. Doppler echocardiography was used to assess transmitral inflow velocities during diastole (peak velocity of early (E) and late (A) atrial filling), whilst TDI at the septal and lateral margins of the mitral annulus measured diastolic velocities (peak velocity of early (E') and late (A') diastolic filling) and peak systolic velocity (S'). The left ventricular filling index (E : E' ratio) was derived. The Tei index (ratio of isovolumetric time to ejection time) was measured. RESULTS: Systolic function assessed by TDI S' velocity was unaltered at the septal and lateral margins, although S' velocity at the lateral margin was higher (12%, P = 0.028) in the first two trimesters, compared to non-pregnant controls. Diastolic function was modified as demonstrated by an increase in A velocity (P P = 0.024). Similarly, A' increased at the septal and lateral margins ( P < 0.001 and P = 0.02, respectively), resulting in a decrease in E' : A' ratios at the septal and lateral mitral margins ( P = 0.001 and P = 0.001, respectively). E : E' at both mitral margins and Tei index were unaltered. CONCLUSION: This study gives normal ranges for TDI indices in pregnancy. TDI demonstrated modified longitudinal systolic and diastolic function. Future studies will evaluate the potential of this technique in pregnancies complicated by hypertension and cardiac disease. Published by John Wiley & Sons, Ltd.     

Echocardiographic analysis of systolic and diastolic left ventricular wall motion during transient myocardial ischemia

Left ventricular (LV) wall motion (anterior and posterior) and simultaneous LV pressure were recorded during 30-second left anterior descending (LAD) or circumflex (CX) coronary artery occlusions in open-chest dogs to provide an echocardiographic model of the evolution of wall motion changes during myocardial ischemia. Prominent diastolic echocardiographic motion changes of progressive decrease in LV wall rapid-filling velocities (RFS), slow-filling velocities (SFS), and increased end-diastolic diameter were accompanied by a marked increase in initial and end-diastolic pressures (150% and 70%, respectively; all p < 0.05). Early (within ten seconds) and progressive decrease in rate (SES), amplitude (E), and duration (TTR) of systolic motion were noted with an increased systolic diameter (p < 0.05). Ischemic regions developed a characteristic pattern with early relaxation followed by a diastolic inward motion (DIM). These observations confirm and extend other investigators' findings on the motion of the ischemic myocardium and may be applicable to responses to transient myocardial ischemia noted in humans.     

Abdominal aortic wall motion of healthy and hypertensive subjects: evaluation of tissue Doppler velocity imaging

PURPOSE: To investigate the potential clinical application of tissue Doppler imaging (TDI) for motion measurement of the aortic wall in healthy and hypertensive adults. METHOD: We used TDI to examine 53 hypertensive and 29 sex-matched healthy adults. Maximum velocity of the first and second systolic wall expansion peaks (S1, S2), maximum velocity of early (D) and end (E) diastolic retraction velocity peaks, pulse wave transmit time (PWTT), and stiffness index (beta) of the abdominal aorta were measured and compared as for factors influencing vascular compliance, including age, sex, and blood pressure. RESULTS: Compared with the healthy subjects, the wall motion waveform of hypertensive patients showed absent E, mixed S1 and S2 peaks, and blunted S1. S1 and D were lower in hypertensive than in healthy subjects. Shortened PWTT and increased indicated increased aortic stiffness in both male and female hypertensive subects when compared with controls. Age, diastolic blood pressure (DBP) and sex were the significant independent factors modulating S1, while DBP and age were the significant independent factors modulating D. PWTT was independently influenced by age and systolic blood pressure. CONCLUSION: This study provides evidence that abdominal aortic wall motion measurement with TDI could demonstrate qualitative and quantitative wall motion features differentiating hypertensive from healthy adults. Wall motion velocity and PWTT could reflect abdominal aortic compliance changes related to age, sex, and blood pressure.     

多普勒组织成像定量分析155例冠心病左心室局部收缩和舒张功能

目的 应用多普勒组织成像（ＤＴＩ）技术定量定位分析生理和病理（心肌缺血）状态下左心室局部收缩和舒张功能。方法 研究对象为１５５例确诊冠心病的患者（冠心病组）和４１例年龄匹配的正常人（对照组）。采用心尖四腔、心尖二腔和心尖长轴切面,每个室壁又选择两个取样点分别位于该室壁的基底部和中部,分别显示左心室６个室壁１２个节段运动的情况。ＤＴＩ测量参数包括收缩功能指标：心肌收缩峰值速度（Ｖｓ）和ＶＥ与舒张晚期峰值速度（ＶＡ）的比值（ＶＥ／ＶＡ）。结果 与对照组相比,冠心病组ＤＴＩ可敏感地定量显示出收缩和舒张峰值速度显著下降以及峰值时间的显著延长;前壁心肌梗死时可见病变区多个节段多项ＤＴＩ收缩和舒张功能参数异常,ＤＴＩ收缩与舒张速度指标之间、收缩速度与左室射血分数之间以及舒张功能参数ＶＥ／ＶＡ均值与二尖瓣血流频谱Ｅ／Ａ比值之     

Evaluation of left ventricular diastolic function by pulsed Doppler tissue imaging in mice.

BACKGROUND: Diastolic left ventricular (LV) function is commonly characterized by transmitral flow pattern in human beings. Recently, Doppler tissue imaging (DTI) was introduced to evaluate diastolic function. The aim of our study was to validate DTI in the evaluation of diastolic function in mice. METHODS: We measured indices of diastolic function using pulsed DTI, and transmitral Doppler and LV pressure and its maximal rate of decrease (LVdP/dt(min)), before and 4 weeks after aortic banding in C57BL/6 mice. RESULTS: Peak early diastolic velocity and ratio of peak early-to-late filling velocities, both measured by DTI, were significantly reduced after banding, thereby indicating diastolic dysfunction. Diastolic dysfunction was confirmed by impaired LV dP/dt(min), decreased transmitral early filling velocity, and transmitral early-to-late filling velocity ratio using transmitral Doppler. CONCLUSION: DTI detects diastolic dysfunction caused by chronic pressure overload in mice after aortic banding. DTI is suggested to be implemented as part of routine mouse echocardiography for evaluation of LV diastolic function.     

组织多普勒成像技术评估慢性房颤患者左室壁运动

目的 应用组织多普勒成像技术（DTI）探讨慢性房颤患者的室壁运动特点,为临床诊治提供重要的信息,方法,将研究分为三组,A组为18例正常对照,B组为15例心房大小正常的房颤患者,C组为16例心房扩大的房颤患者,所有患者均无严重瓣膜病或节段性室壁运动异常,采用HP SONOS 5500超声显像仪和脉冲DTI,分别在心尖四腔心切面和胸骨旁长轴切面测定左室侧壁和后壁收缩期峰值速度（VS）,舒张期峰值速度（VE）,心电图QRS波起始至收缩期峰值速度的平均时间T1,心电图QRS波起始至舒张期峰值速度的平均时间T2,平均心率为R－R,结果 （1）A组正常人均有舒张早期和晚期两个波峰（E峰和A峰）,B组和C组房颤患者均只有一个舒张期波峰（E峰）,（2）A组与B组这间的DTI测值差异均无显著性意义（均为P＞0．05）,（3）C组左室侧的VS显著小于A组（P＜0．05）,C组左室后壁的VS,VE均显著大于A组（P均＜0．05）,C组侧壁的T1／（R－R）^1/2,Ts/(R-R)1/2显著高于A组（P均＜0．05）,C组后壁的T1／（R－R）^1/2,T2/(R-R)^1/2与A组比较差异无显著性意义（P均＞0．05）,结论 左房增大的房颤患者左室壁在长轴方向收缩活动减弱,舒张期峰值速度延迟,在短轴方向舒缝活动增强,DTI技术能精确地定量分析房颤患者的室壁活动,可成为评价房颤患者心肌舒缩功能的无创伤性新方法。     

多普勒组织成像定量分析心肌梗死后左心室局部与整体的舒缩功能

目的　采用多普勒组织成像技术 (DTI)观察心肌梗死后左心室壁及二尖瓣环运动 ,定量分析左心室局部与整体的舒缩功能。方法　 18例健康人 ,3 6例心肌梗死患者均行常规二维超声 (2DE)及DTI检查。采用DTI分析心肌梗死后左室壁及二尖瓣环 4个位点的DTI指标 :峰值收缩速度 (VS)、舒张早期速度 (VE)及二尖瓣环 4个位点平均收缩与舒张速度 (VMS、VME)。结果　与健康人比较 ,心肌梗死患者室壁运动异常节段VS、VE显著降低 (P <0 .0 1) ,心肌梗死节段相对应二尖瓣环位点VS 显著降低 (P <0 .0 1) ,心肌梗死节段与非心肌梗死节段相对应二尖瓣环 4个位点VE 均降低 (P <0 .0 1) ;心肌梗死患者射血分数 (EF)与VMS(r =0 .76,P <0 .0 1)、VME(r =0 .68,P <0 .0 1)呈显著正相关 ;VMS≥ 7.0cm/s预测EF≥ 5 0 %的敏感性、特异性分别为76.0 %、81.8%。结论　DTI可定量分析心肌梗死后左室壁局部与整体的舒缩功能 ,为心肌梗死后合理选择治疗措施及预后判断提供新的定量指标     

斑点追踪及组织多普勒成像技术评价甲状腺功能减退患者左室舒缩功能

目的 使用斑点追踪及组织多普勒成像技术观察甲状腺功能减退（甲减）患者左室舒缩功能,了解甲减患者在出现临床心血管并发症前是否存在左室舒张和收缩功能异常。方法 对20例甲减患者和30例健康成人进行检查,测量其左室射血分数、左室中间段组织多普勒运动速度及应变率,并脱机运用QLAB软件进行分析。结果 甲减组和正常组的左室收缩功能和左室中间段组织多普勒运动速度比较,差异无统计学意义（P〉0．05）,左室中间段纵向、径向及圆周应变率比较,差异有统计学意义（P〈0．05）。结论 与组织多普勒成像技术比较,斑点跟踪技术能更好地反映甲减患者左室舒缩功能的减低,为临床早期诊断和治疗提供可靠依据。     

组织多普勒显像评定雄性C57BL/6小鼠心室舒张功能

目的应用组织多普勒显像评定小鼠心室的舒张功能。方法应用组织多普勒、脉冲多普勒及左室内压测定，评定雄性C57BL／6小鼠主动脉结扎前后（4周）心室舒张功能的变化。结果与术前相比，二尖瓣瓣环舒张早期速度（Ea）显著下降，术后二尖瓣瓣环舒张早期速度（Ea）／二尖瓣舒张晚期速度（Aa）显著降低，表明C57BL／6雄性小鼠心室舒张功能失调，并通过测量左室压力最大下降速率和跨瓣血流多普勒参数证实。结论组织多普勒能检测小鼠由于长期压力后负荷引起的心室舒张功能失调。同时组织多普勒可用于常规评定小鼠心室舒张功能。     

多普勒组织成像对高血压左心室肥厚患者左心室舒张功能的评价

目的 应用多普勒组织成像（DTI）技术评价高血压左心室肥厚患者左心室舒张功能，并与二尖瓣血流频谱作对比。方法 研究对象为35例临床与超声诊断的高血压左心室肥厚患者（高心组）和20例正常人（对照组）。采用心尖四腔观，选取室间隔中段，左室侧壁中段，二尖瓣环-室间隔交界处、二尖瓣环一侧壁交界处为取样点，分别显示各部位组织的运动情况，并测量心肌收缩峰速度（Vs）、心肌舒张早期峰值速度（Ve）、舒张晚期峰值速度（VA）及VE与VA比值（VE/VA）。常规测量二尖瓣血流频谱，与DTI参数作对比。结果 与对照组相比，高心组室间隔中段，侧壁中段、二尖瓣环VE、VE/VA均显著下降，各部位VE/VA均与二尖瓣血流频谱E/A之间存在高度相关性；DTI对高血压左心室肥厚患者左心室舒张功能异常的诊断灵敏度高于二尖瓣血流频谱。结论 DTI技术可以定量评价高血压左心室肥厚患者的左心室舒张功能，并且比常规脉冲波多普勒二尖瓣血流参数更加敏感。     

多普勒组织成像研究左室壁节段性运动速度——应用新型的左心室模型体外试验

目的应用自制的左室模型研究组织多普勒成像（TDI）测定左室壁节段性运动速度的可靠性和准确性。方法自制一个左室模型来验证TDI的准确性。该模型以双层气球制作,连接一脉冲流量泵,分设8种泵出量（50～85ml/每搏）。将模型浸入水槽后,以摄像机与TDI同时记录球壁的运动位移和速度。采用GE系统5超声诊断仪,探头频率5MHz。结果M型与二维图像显示气球模型形状和壁运动与左心室十分相似。由TDI测得的球壁运动距离与摄像机同步测量距离相关密切［前壁r=0.97,s     

斑点追踪技术与组织多普勒技术对不同年龄正常人左心室舒张功能的评价

目的应用斑点追踪技术测得解旋率(UntwR)与组织多普勒技术(DTI)评价不同年龄段正常人左心室的舒张功能,并探讨两者的相关性。方法健康体检者94例,按年龄分为青年组(18～45岁)、中年组(46～64岁)和老年组(65～79岁)及高龄组(≥80岁)。取胸骨旁左心室心尖和心底短轴切面二维灰阶图像,用EchoPAC软件行脱机分析并计算UntwR;应用脉冲多普勒测定二尖瓣口血流早期充盈峰峰值速度(E),应用DTI技术测定二尖瓣环室间隔侧舒张早期峰值速度e’,计算两者比值E/e’。结果随年龄增加,UntwR测值逐渐减低,4组间比较差异均有统计学意义(P均0.05);UntwR与E/e’及e’相关系数r分别是0.54,0.53(P均0.01)。结论 UntwR与目前常用的评价左心室舒张功能的多普勒指标相关性良好,UntwR可无创评价由年龄引起的正常人左心室舒张功能的变化。