595nm脉冲染料激光治疗鲜红斑痣440例回顾性分析

目的总结595 nm脉冲染料激光治疗鲜红斑痣的临床疗效,分析脉冲染料激光在不同分组鲜红斑痣患者中的疗效差异。方法用595nm脉冲染料激光治疗鲜红斑痣共440例。根据患者年龄、皮损类型、皮损面积及治疗次数进行分类,皮肤科医生根据患者治疗前后皮损照片对比评价临床疗效。通过统计学方法分析上述各个因素对疗效的影响。记录各种不良反应和并发症。结果 595 nm脉冲染料激光治疗鲜红斑痣总有效率为83.41%,疗效与患者年龄、皮损类型、皮损面积及治疗次数有关。年龄越小、皮损面积越小者疗效越好,不良反应发生率低。结论 595 nm脉冲染料激光治疗鲜红斑痣总有效率较高,不良反应发生率低。但临床痊愈比例不高,少部分患者对脉冲染料激光治疗无效。     

脉冲染料激光治疗鲜红斑痣的临床疗效评价

目的：探讨影响脉冲染料激光治疗鲜红斑痣疗效的相关因素。方法：应用脉冲染料激光治疗130例鲜红斑痣患者,分析疗效与患者年龄、皮损颜色和病变部位的关系。结果：130例患者经脉冲染料激光治疗有效率为56．2％;经Spearman相关分析．疗效与患者年龄、皮损颜色和部位有相关性;患者年龄越小、皮损颜色越浅疗效越好;项部、耳后部、额颞部皮损疗效显著好于唇部、四肢。结论：脉冲染料激光治疗鲜红斑痣的临床疗效与多种因素相关,宜在婴幼儿期进行治疗。     

脉冲染料激光治疗面部毛细血管扩张162例临床分析

脉冲染料激光 (585nm)是一种直接作用于皮肤血管损害的激光,治疗鲜红斑痣 [1,2],国内已见文献报告 [1,2],本文总结其治疗面部毛细血管扩张的临床疗效,现报告如下。 1一般资料： 162例面部毛细血管扩张患者,男性 5例,女性 147例;年龄 5～ 40岁;其中 89例为面颊片状皮损,最大面积为 60cm2, 33例为鼻翼周边弧形分布皮损, 40例为蜘蛛痣。 2治疗方法：仪器是美国 Candela公司生产的脉冲染料 SPTI- 1b,波长为 585nm,脉宽为 450μ s,光斑直径为 7mm,密度为 7.5～ 8.5 J/cm2。能量密度大小取决于患者年龄、皮肤颜色深浅及部位。治…     

调QALEXLAZR激光治疗太田痣196例临床疗效分析

目的：探讨调Q ALEXLAZR激光（以下简称ALEX激光）治疗太田痣的疗效。方法：我所运用ALEX激光器对196例患者进行了多次皮损区照射治疗。治疗间期3－6个月，对年龄大小、治疗次数、面积大小、皮损类、皮损颜色、皮损部位、不良反应等进行了分组观察研究。结果：其年龄小、面积小、随治疗次数增加疗效越显著，经过1－8次治疗：痊愈80例，显效81例，有效35例，无无效病例。80例痊愈患者平均治愈次数为4．13次。其中1－6岁为3．1次。一般治疗4次左右可以治愈，无1例留下瘢痕.结论：ALEX激光为目前治疗太田痣的一种安全，有效的方法。     

595 nm脉冲染料激光治疗546例鲜红斑痣疗效评价

目的评价595 nm脉冲染料激光治疗鲜红斑痣临床疗效和不良反应。方法应用美国Candela公司生产的595 nm脉冲染料激光治疗鲜红斑痣546例,根据患者年龄、皮损类型等采用不同参数进行激光照射治疗。结果 595 nm脉冲染料激光治疗鲜红斑痣总有效率为70.33%(384/546),疗效与患者年龄、皮损类型等因素关系密切,不良反应发生率低,且耐受性好。结论 595 nm脉冲染料激光治疗鲜红斑痣安全有效。     

400例儿童皮肤血管异常疗效分析

目的 探讨低体重儿与血管瘤发生的关系及染料激光单用和联合药物皮损内注射治疗皮肤血管异常的疗效分析。方法 对209例婴儿血管瘤患儿和100例正常儿童自身健康情况及母孕期情况进行问卷调查分析。 脉冲染料激光治疗毛细血管瘤、微静脉畸形、蜘蛛痣、化脓性肉芽肿的疗效分析。脉冲染料激光联合药物皮损内注射治疗混合性血管瘤进行临床疗效分析。结果 209例婴儿血管瘤患儿低体重儿占33.49％,正常对照组低体重儿占9％。两组比较差异有统计学意义（u = 4.621,P ＜ 0.05）。脉冲染料激光治疗仪治疗毛细血管瘤有效率达到83.69％、治疗微静脉畸形有效率达到92.59％、治疗蜘蛛痣有效率达到100％、治疗化脓性肉芽肿有效率达到50％。脉冲染料激光联合药物皮损内注射治疗混合性血管瘤有效率达到95.59％。结论 低体重儿与血管瘤的发生关系密切。脉冲染料激光治疗毛细血管瘤、微静脉畸形、蜘蛛痣疗效显著。脉冲染料激光联合药物皮损内注射治疗混合性血管瘤疗效更显著。     

595 nm脉冲染料激光治疗鲜红斑痣1560例临床研究

目的 评价595 nm脉冲染料激光治疗不同年龄段鲜红斑痣患者的临床疗效和不良反应。方法 应用美国Candela公司生产的595 nm脉冲染料激光治疗鲜红斑痣1560例,根据患者年龄、皮损类型等采用不同参数进行激光照射治疗。结果 595 nm脉冲染料激光治疗鲜红斑痣总有效率为76.73%（1197/1560）,疗效与患者年龄、皮损类型等因素关系密切,不良反应发生率低,且耐受性好。结论 595 nm脉冲染料激光治疗鲜红斑痣安全有效。     

脉冲染料激光治疗婴幼儿鲜红斑痣108例疗效分析

鲜红斑痣是一种先天性毛细血管发育异常。一般幼年时呈淡红色或粉红色,随年龄增大,皮损颜色逐渐加深、增厚,部分患者 40岁左右出现结节,早期治疗十分必要。我们回顾性总结脉冲染料激光 (pulsed dye laser,PDL)治疗 108例婴幼儿鲜红斑痣的疗效。 一、一般资料 1997年 4月至 1999年 8月,共治疗鲜红斑痣患儿 108例,年龄 10 d至 6岁,平均 3.4岁,男 36例,女 72例。病灶大小 1～ 150 cm2,平均 60 cm2。 86例皮损位于面部, 16例位于颈部, 6例位于上肢。皮损颜色均呈淡红色或粉红色。 二、治疗方法 我们用美国 Candela公司生产的脉冲…     

595nm脉冲染料激光治疗儿童皮肤微静脉畸形疗效分析

目的探讨595nm脉冲染料激光治疗儿童微静脉畸形的疗效。方法应用595nm脉冲染料激光治疗351例皮肤微静脉畸形患儿,观察疗效及副作用。结果 351例患者中治疗次数最少1次,最多13次,间隔4～6周,总有效率43%;皮损位于面部的患儿138例,不同部位皮损治疗次数最少1次,最多13次,有效率在22.7%～44%之间,疗效之间无统计学差异。不良反应发生4例(1.1%)。结论 595nm脉冲染料激光治疗微静脉畸形疗效确切,不良反应少见。     

难治性鲜红斑痣的治疗新进展

鲜红斑痣是一种常见的先天性毛细血管畸形.多年来脉冲染料激光仍是治疗鲜红斑痣的金标准,然而皮损完全清除的患者却很少,部分患者在接受脉冲染料激光治疗达到一定程度后,对脉冲染料激光治疗产生抵抗.抵抗性鲜红斑痣给患者造成心身损害,因此,进一步改善皮损症状对皮肤美容医师仍具有挑战性.难治性鲜红斑痣治疗方法最新进展,主要包括改良的脉冲染料激光、光动力疗法、脉冲染料激光+光动力疗法以及脉冲染料激光+血管扩张抑制剂的联合应用.     

Variable pulse frequency-doubled Nd:YAG laser versus flashlamp-pumped pulsed dye laser in the treatment of port wine stains

The flashlamp-pumped pulsed dye laser (FPDL) is regarded as the gold standard in the treatment of port wine stains. The purpose of this prospective, intra-individual, comparative clinical study was to investigate whether a frequency-doubled variable pulsed Nd:YAG laser (frequency-doubled Nd:YAG) is equally as safe and effective as established lasers. Forty-three patients with port wine stains were included in the study. Test treatments were performed using the frequency-doubled Nd:YAG laser (532 nm; 4 mm psi; 5-50 ms; 5.5 to 15 J/cm2) versus the FPDL (585 nm; 450 micros; 7 mm psi; 6 J/cm2). After 6 weeks, a full lesional treatment was performed using the device and the parameters showing the best clearance and the fewest side effects. The clearance of the lesions was generally good to fair. With the exception of poor results at 5 ms and 5.5 J/cm2 with the frequency-doubled Nd:YAG laser, there were no significant differences between the two laser devices. Scar formation, nevertheless, occurred in only 3% of the FPDL-treated sites versus up to 18% of the frequency-doubled Nd:YAG sites, increasing with pulse duration. In port wine stains, the FPDL remains the therapy of choice because of the somewhat better results and a lower frequency of side effects, especially scarring.     

Five years' experience of treating port wine stains with the flashlamp-pumped pulsed dye laser

Summary During the last 5 years, 640 patients had treatment to their port wine stains (PWS) with a flashlamp-pumped pulsed dye laser. One hundred and fifty-six patients have been discharged for varying reasons, of which 59 (38%) achieved excellent (at least 75%) lightening of their birthmark. Of the remaining patients, those who attended the clinic for the sixth and 12th time for treatment were also assessed to determine the degree of fading achieved in the port wine stain. Our findings confirm that flashlamp-pumped dye laser treatment is safe and effective for the treatment of PWS and that complications are rare. However, the degree of fading achieved is variable and often unpredictable. Fifty-two per cent of facial lesions of different colours achieved over 75% fading as against 18% of non-facial lesions. Sixty-four per cent of those over the age of 50 years had an excellent response whereas only 19% of those below the age of 5 years were able to achieve a similar result. The colour of the port wine stain was found to be of no prognostic value. A search for an accurate and non-invasive method to predict the outcome of flashlamp-pumped pulsed dye laser therapy for PWS is warranted.     

Laser treatment of pediatric vascular lesions: Port wine stains and hemangiomas

Pediatric vascular lesions can be medically threatening and psychologically distressing to patients. This article reviews literature on the laser treatment of two common pediatric vascular lesions, port wine stains and hemangiomas. The purpose of this report was to distinguish the lesions from one another and to present the advantages, disadvantages, complications, and limitations of laser treatment for each lesion type. This review is not a comprehensive inventory but instead highlights the studies that best show promising results or the limitations of laser treatment for the lesions. Overall, port wine stain laser treatment promoted notable clearing with low side effects, whereas hemangioma laser treatment provided inconsistent benefits and severe side effects occasionally. Laser treatment of port wine stains is safe and effective, but laser treatment of hemangiomas remains controversial and is best for lesions without deeper components.     

532 nm KTP激光治疗鲜红斑痣的自身对照研究

目的:比较532 nm KTP激光与脉冲染料激光(PDL)对鲜红斑痣的疗效及安全性。方法:将18例鲜红斑痣患者的自身皮损随机分成KTP激光治疗区及PDL治疗区,分别予以532 nm KTP激光及595 nm PDL治疗,每2~3个月治疗一次,共2~4次。每次治疗前、后即刻及治疗后2~3个月对患者激光治疗后的皮损进行疗效及安全性评价。结果:532 nm KTP激光治疗组及595 nm PDL治疗组治疗后疗效均无显著差异。在一些既往曾接受PDL治疗疗效不佳的患者,经532 nm KTP激光治疗后,皮损取得一定改善。532 nm KTP激光治疗组在治疗时疼痛程度及治疗后紫癜程度均显著低于595nmP DL治疗组。两组均有1例色素沉着发生。结论:532 nm KTP激光治疗鲜红斑痣的疗效较好,不良反应少,安全性好,可以作为鲜红斑痣治疗的另一方案。     

Acquired port wine stains:clinical and psychological assessment and response to pulsed dye laser therapy

Nineteen patients are presented with acquired port wine stains. Acquired port wine stains are uncommon vascular lesions with the appearance of a congenital port wine stain but onset after birth. This is the largest group of patients reported to date. The acquired port wine stain was on the head and neck in 17 patients and in six this was associated with preceding trauma. Psychological assessments in adult patients showed similar morbidity to that seen in patients with congenital port wine stains. This morbidity was improved with successful laser treatment. Pulsed dye laser therapy resulted in complete clearance of the lesion in six (46%) of 13 patients treated. Two further patients had an excellent response.     

Treatment of facial vascular lesions with intense pulsed light

BACKGROUND: Various lasers, particularly the flashlamp-pulsed dye laser, have been proven to be effective in the treatment of facial vascular lesions. Nevertheless, the post-treatment side effects, such as pronounced purpura and changes in pigmentation, have been a matter of concern to patients. OBJECTIVE: To test the efficacy of an alternative treatment option that uses intense pulsed light to provide patients with a more tolerable post-treatment outcome. METHODS: A total of 200 patients were treated with an intense pulsed light source (PhotoDerm ® VL) using various treatment parameters. The patients were treated for facial veins (primarily telangiectasia), facial hemangiomas, rosacea and port wine stains. RESULTS: Of the 188 patients who returned for follow-up after 2 months, 174 achieved 75% to 100% clearance in one to four treatment sessions. The post-treatment side effects were minimal and well tolerated by the patients. There were no instances of scarring or other permanent side effects. CONCLUSION: The PhotoDerm ® VL provides a highly effective and safe alternative to the laser for treatment of facial vascular lesions. The device may achieve improved results for lesions that are resistant to laser therapy. The rate and degree of cosmetic side effects are considerably less than with laser treatment.     

Port wine stains on the lower limb: response to pulsed dye laser therapy

The pulsed tunable dye laser is the established treatment for facial port wine stains (PWSs), particularly in children. There have been very few studies specifically addressing the efficacy of this laser in the treatment of lower limb PWSs. Twenty-seven patients with lower limb PWSs have been treated with the Candela pulsed tunable dye laser. Seventeen patients have been discharged; one patient had greater than 95% clearance of the naevus and three others had a good response to treatment. Ten patients who are continuing treatment have had an average of 9:4 treatments. Only one patient has achieved a good result, and none an excellent result. These results are disappointing compared with published figures for outcome following pulsed tunable dye laser treatment to facial PWSs, and confirm the clinical impression that PWSs on the lower limb do not respond well to pulsed dye laser therapy.     

Treatment of naevi flammei with the argon laser

We report on 901 patients with port wine stains treated by means of an argon laser. The treatment results have been definitively evaluated in 371 patients. They were significantly influenced by the patients' age and by the colour of the lesions. The worst response to the therapy was seen in pink port wine stains in children and juvenile patients (20% good results), in contrast to red and purple lesions in adult patients (80% excellent and good results). The size of the port wine stains did not significantly influence the treatment results, but in extensive lesions homogeneous lightening could not usually be attained and treatment often extended over some years. Port wine stains in the head and neck area responded best to therapy, and lesions on the legs, worst. Altogether, in 60%-70% of adult patients excellent or good results were obtained, the lesions being completely removed or significantly lightened and reduced in size. The side-effects of laser therapy were scar formation (7.3%) and changes in pigmentation (8.6%).     

Patient-reported morbidity following flashlamp-pumped pulsed tunable dye laser treatment of port wine stains

Sixty-two patients with port wine stains completed a questionnaire related to their flashlamp-pumped pulsed tunable dye laser treatment. The treatment wtis well tolerated by the majority. Forty-eight per cent of patients experienced some weeping or crusting after treatment. The major cause of morbidity was protracted bruising following treatment, and this caused a significant restriction of activities in 45% of patients.