子宫内膜异位症合并不孕患者腹腔镜术后药物治疗妊娠结局分析

目的:探讨子宫内膜异位症(EMT)合并不孕患者腹腔镜术后联合药物治疗对妊娠结局的影响。方法:回顾性分析2006年1月至2011年6月在北京朝阳医院妇产科行腹腔镜手术且随访资料完整的230例EMT合并不孕患者的临床资料,采用方差分析EMT术前r-AFS分期(Ⅰ~Ⅳ期)与术后是否行药物治疗(孕三烯酮组、GnRHa组与未用药组)对各种妊娠结局及不同性质的妊娠结局(良好结局与不良结局)的影响。结果:1术后妊娠135例,妊娠率为58.7%。230例患者中术前4种r-AFS分期的妊娠率比较,差异无统计学意义(P0.05)。135例妊娠患者术前4种r-AFS分期间不同妊娠结局的比较,差异无统计学意义(P0.05)。有妊娠结局的126例患者术前4种r-AFS分期在良好或不良妊娠结局之间比较,差异无统计学意义(P0.05)。2230例患者中,GnRHa组与孕三烯酮组、未用药组相比,其发生的不同妊娠结局比较,差异有统计学意义(P0.05)。有妊娠结局的患者中GnRHa组与未用药组相比,良好结局与不良结局的比较,差异有统计学意义(P0.05),而孕三烯酮组与未用药组相比,差异无统计学意义(P0.05)。结论:术前r-AFS分期对于腹腔镜术后妊娠率及妊娠结局无影响。术后使用GnRHa对于导致不同的妊娠结局有一定的影响,对良好妊娠结局的影响有作用,而孕三烯酮作用不明显。     

子宫内膜异位症合并不孕患者术后妊娠影响因素分析

目的探讨子宫内膜异位症(内异症)合并不孕患者腹腔镜术后妊娠的影响因素。方法回顾性分析2007年1月至2011年12月在山西医科大学第二医院进行腹腔镜手术治疗的内异症合并不孕、随访资料完整的66例患者的临床资料,随访术后妊娠相关因素。结果 66例患者术后3年累积妊娠率为56.1%;术后第1、2、3年的妊娠率分别为40.9%、13.6%和1.5%,组间比较差异有统计学意义(P<0.05)。使用促排卵治疗是术后妊娠的保护因素(OR=0.191,P<0.05),而年龄、不孕类型、不孕时间为危险因素(OR=6.281、5.427、7.890,P<0.05);是否使用促性腺激素释放激素激动剂(GnRHa)、不同r-AFS分期及不同临床病理类型术后妊娠率比较差异无统计学意义(P>0.05)。结论患者年龄、不孕时间、不孕类型、是否使用促排卵药物是影响内异症合并不孕患者术后妊娠率的相关因素。     

宫-腹腔镜联合治疗子宫内膜异位症合并不孕患者术后妊娠的影响因素分析

目的:探讨宫-腹腔镜联合治疗子宫内膜异位症(EMT)合并不孕患者术后妊娠的影响因素。方法:选择2012年4月至2014年4月于厦门市妇幼保健院行宫-腹腔镜联合治疗的EMT合并不孕患者共340例为研究对象,随访18~42月,分析影响术后妊娠率的临床因素。结果:292例完成随访,随访率85.88%(292/340),术后妊娠165例(56.51%)。其中术后1~6月、7~12月、13~24月、25~42月分别妊娠115例(39.38%)、40例(13.70%)、8例(2.74%)、2例(0.68%),差异有统计学意义(χ~2=11.76,P0.05)。多因素分析结果显示:年龄≥35岁、不孕年限≥3年、r-AFS分期高是影响患者术后妊娠的独立危险因素(OR=10.45、3.03、3.74,P0.05);继发不孕、使用促排卵治疗是影响术后妊娠的独立保护因素(OR=0.23、0.33,P0.05)。结论:EMT合并不孕患者采用宫-腹腔镜联合治疗可获得较好的术后妊娠率,术后1年内是妊娠最佳时机。患者年龄≥35岁,不孕年限≥3年,r-AFS分期高可影响术后妊娠率,使用促排卵药物治疗对提高妊娠率有益。     

腹腔镜术后联合药物治疗子宫内膜异位症合并不孕对妊娠结局的影响

目的 探讨腹腔镜术后联合药物治疗子宫内膜异位症合并不孕对妊娠结局的影响.方法 选取90例行腹腔镜手术治疗的子宫内膜异位症合并不孕患者,采用抽签法分为对照组、研究A组与研究B组,每组30例.对照组不采用药物治疗,研究A组采用孕三烯酮治疗,研究B组采用促性腺激素释放激素激动剂治疗.比较三组不同分期妊娠成功率、临床疗效及妊娠...     

腹腔镜下子宫内膜异位症生育指数在子宫内膜异位症合并不孕中的应用研究

目的:探讨腹腔镜下子宫内膜异位症生育指数(EFI)对子宫内膜异位症(EMT)合并不孕患者的生育力评估的临床价值。方法:回顾性分析在我院进行腹腔镜手术治疗的EMT合并不孕、随访资料完整的118例患者的临床资料进行EFI评分,随访术后妊娠情况。结果:118例患者术后3年累积妊娠率为46.6%;术后第1、2、3年的妊娠率分别为28.8%、14.4%和3.4%,组间比较差异有统计学意义(P<0.05)。EFI评分9～10分、5～8分、≤4分者的术后3年累积妊娠率分别为76.2%、47.4%、10.5%,术后3年累积妊娠率与EFI评分、术后使用促排卵药物治疗呈正相关(tau-b=0.367,0.439;P<0.01);与美国生育协会修订的EMT分期(r-AFS)标准及使用促性腺激素释放激素激动剂(GnRH-a)无相关性(tau-b=0.006,0.076;P>0.05)。不同临床类型的术后3年累积妊娠率间两两比较,差异均无统计学意义(P>0.05)。结论:腹腔镜下EFI评分用于评估EMT合并不孕患者的生育力,指导后续治疗有重要的参考意义,可根据EFI评分,综合评估患者的生育状况,选择个体化的后续治疗方案;EMT合并不孕患者不建议长期期待以提高患者的妊娠率。     

子宫内膜异位症相关性不孕患者腹腔镜术后生殖预后的影响因素分析

目的:探讨子宫内膜异位症(EMT)相关性不孕患者腹腔镜术后生殖预后的影响因素.方法:回顾性分析2009年7月至2011年4月宁夏医科大学附属医院收治并经腹腔镜治疗,术后病理证实诊断的EMT 75例患者的临床资料和随访术后1年内妊娠情况,统计学分析影响术后妊娠的相关因素.结果:单因素分析中,年龄、是否合并子宫腺肌病、术后是否规范用药、术后是否接受辅助生殖技术为EMT相关性不孕患者腹腔镜术后生殖预后的影响因素(P =0.000).多因素分析显示年龄、术后是否接受辅助生殖技术、是否合并子宫腺肌病为EMT的独立影响因素(P＜0.05).结论:年龄、术后是否接受辅助生殖技术、是否合并子宫腺肌病为EMT相关性不孕患者腹腔镜术后生殖预后的重要影响因素,应将腹腔镜术后相关影响因素综合分析,更加客观地判断生殖预后.     

卵巢子宫内膜异位囊肿合并不孕患者术后治疗探讨

目的:探讨卵巢子宫内膜异位囊肿合并不孕的患者术后治疗策略。方法:将腹腔镜下卵巢子宫内膜异位囊肿剥除术后要求妊娠的62例不孕患者随机分为期待组(n=31)和GnRH-a组(n=31)。期待组腹腔镜手术后随访观察,避免使用激素类药物;GnRH-a组腹腔镜手术后月经第1日给予GnRH-a治疗:达菲林3.75 mg皮下注射,1次/28 d,连用3次停药。所有患者随访24个月,观察24个月内妊娠情况。结果:期待组12个月内妊娠率为41.9%(13/31),13~24个月内妊娠率为22.2%(4/31),24个月累积妊娠率为54.8%(17/31)。GnRH-a组1年内妊娠率为48.4%(15/31),13~24个月内妊娠率为18.8%(3/31),24个月累积妊娠率为58.1%(18/31)。期待组与GnRH-a组比较,12个月内妊娠率、24个月累积妊娠率组间均无统计学差异(P0.05)。结论:初步临床观察,卵巢子宫内膜异位囊肿剥除术后使用GnRH-a在提高EMs合并不孕患者妊娠率方面未显示出优势。     

子宫内膜异位症生育指数(EFI)对EMs相关不孕妇女腹腔镜术后自然妊娠的预测价值

目的:探讨子宫内膜异位症生育指数(EFI)对EMs相关不孕患者腹腔镜术后自然妊娠率的预测价值。方法:回顾分析2008年1月至2012年3月于我院行腹腔镜治疗的730例EMs相关不孕患者,根据手术发现进行EFI评分,并随访其妊娠情况和妊娠结局。比较不同EFI分值患者的自然妊娠率,Kaplan-Meier生存分析法计算累积妊娠率,采用Log-rank检验进行比较。结果:完成随访的548例患者的总妊娠率为43.43%(238/548)。EFI评分8~10分者的总妊娠率为54.55%(168/308),8、9、10分的妊娠率分别为53.66%(66/123)、51.75%(74/143)和66.67%(28/42),各分值间比较差异无统计学意义(P=0.225)。EFI 7分者的妊娠率为42.27%(41/97),低于8~10分者,差异有统计学意义(P=0.035);EFI 4~6分的妊娠率为21.71%(28/129),4、5、6分的妊娠率分别为17.86%、19.05%和25.42%,各分值间比较差异无统计学意义(P=0.638),显著低于7分者(P=0.000)。EFI 0~3分的妊娠率为7.14%(1/14)。术后不同时间的妊娠率有统计学差异(P=0.000)。r-AFS分期I~IV期的妊娠率分别为45.23%(57/126)、47.33%(71/150)、44.08%(67/152)和44.17%(53/120),无统计学差异(P=0.939)。结论:EFI能较好地预测接受腹腔镜手术的EMs相关不孕患者的术后生育力。     

子宫内膜异位症不孕患者的腹腔镜诊断与治疗

我院自 1995～ 1998年经腹腔镜诊断子宫内膜异位症 (内异症 )不孕患者 141例 ,现将诊疗情况回顾总结如下。一、资料与方法1.研究对象 :1995年 1月至 1998年 12月因不孕症入院行腹腔镜诊治的患者共 342例 ,其中经腹腔镜及病理检查诊断为内异症的患者 141例。年龄在 2 4～ 36岁之间 ,平均 30 8岁。不孕时间 1～ 8年 ,平均 4 6年。2 .方法 :月经干净后前半周期 ,在全身麻醉或局部麻醉下行腹腔镜检查及治疗 ,观察并记录子宫和双侧附件等盆腔情况 ,并常规在腹腔镜下行美蓝通液。应用激光烧灼、电凝、电切子宫内膜异位灶、卵巢异位囊肿 ,分解盆腔…     

子宫内膜异位症合并不孕患者期待处理后妊娠与控制性药物刺激卵巢后妊娠情况分析

目的:比较子宫内膜异位症(EM)合并不孕患者腹腔镜治疗术后期待处理与控制性药物刺激卵巢(COH)后的妊娠情况.方法:回顾性分析在我院行腹腔镜手术后1年内行期待处理(期待组)和COH治疗(COH组)的患者的临床资料.比较两组周期妊娠率及累积妊娠率.两组中再以年龄≤35岁或35岁、术后使用促性腺激素释放激素激动剂(GnRH-a)或不使用GnRH-a及EM分期Ⅰ～Ⅱ期或Ⅲ一Ⅳ期分类后进行多因素Logistic回归,分析两组的相关因素.结果:期待组23l例2309个自然周期,妊娠76例,周期妊娠率3.29%,平均每例10个期待周期的累积妊娠率32.9%;COH组129例187周期,妊娠40例,周期妊娠率21.39%,平均每例1.5个COH周期的累积妊娠率31.01%.两组周期妊娠率比较,差异有统计学意义(P0.05);年龄、术后是否使用药物和EM分期与术后第1年内期待处理后妊娠和COH妊娠情况无相关性(P0.05).结论:EM合并不孕患者腹腔镜手术治疗后,可以考虑短期期待妊娠,COH明显增加周期妊娠率.卵巢功能正常的情况下,年龄不影响妊娠率;术中r-AFS分期对妊娠预测价值有限.     

子宫内膜异位症手术治疗后复发相关因素的分析

目的探讨子宫内膜异位症(内异症)术后复发的相关因素。方法对356例内异症手术治疗患者随访3年,将其中复发的75例患者的临床资料进行回顾性分析,对可能引起复发的相关因素(年龄、临床病理类型、分期、手术方式、术后是否加用米非司酮)进行分析。结果年龄≤24岁患者的复发率为0,与其余4个年龄段(25~29、30~34、35~39、≥40岁,复发率分别为19·8%、19·8%、31·9%和21·6%)比较,差异有统计学意义(χ2=11·212,P<0·05);年龄与复发率有相关关系(P<0·05)。在临床病理类型中,混合型、深部结节型患者的复发率分别为29·2%、33·3%,前者明显高于卵巢型的17·5%(χ2=4·622,P=0·032);复发率与临床病理类型有相关关系(P<0·05)。复发率随着内异症分期的增高而增加(P<0·05);Ⅰ~Ⅱ、Ⅲ、Ⅳ期患者的复发率分别为12·9%、22·5%、55·6%,Ⅰ~Ⅱ期与Ⅲ、Ⅳ期患者的复发率分别比较,差异均有统计学意义(χ2=5·129,χ2=33·899,P均(0·05)。Ⅲ期内异症患者腹腔镜手术与开腹手术的术后复发率分别为31·3%、11·3%,两者比较,差异有统计学意义(χ2=7·971,P=0·005)。加用米非司酮患者的复发间隔时间为(13±4)个月,未用药患者的复发间隔时间为(7±3)个月,两者比较,差异有统计学意义(t=4·575,P<0·01)。结论内异症的治疗应根据患者年龄、临床病理类型、分期选用创伤小并能较彻底清除病灶的个体化治疗方案。术后短期应用抑制卵巢功能的药物可延长复发间隔时间。     

冻融囊胚移植周期生化妊娠相关因素分析

目的分析冻融囊胚移植周期中导致生化妊娠的相关因素。方法回顾性分析行冻融囊胚移植后生化妊娠的70个周期的临床资料,以同期冻融囊胚移植后正常宫内妊娠的336个周期为对照,比较影响生化妊娠相关因素。结果生化妊娠组年龄比正常宫内妊娠组大,合并亚临床甲状腺功能减退(SCH)及未治疗或治疗后仍不正常的患者生化妊娠组更多,差异有统计学意义(P0.05)。结论重视高龄患者、胚胎移植前纠正SCH,有助于降低冻融囊胚移植周期生化妊娠发生率。     

Pneumoamnion and pregnancy loss after second-trimester laparoscopic surgery

BACKGROUND: Midtrimester laparoscopic surgery is considered safe; however, both maternal and fetal complications can occur. We report a case of midtrimester pregnancy loss with pneumoamnion after laparoscopic appendectomy. CASE: A young woman presented at 21 weeks' gestation with a 3-day history of nausea and severe abdominal pain. Diagnostic laparoscopy was performed with normal appendix and pelvic anatomy noted. Worsening pain prompted a repeat laparoscopic evaluation. A small defect in the uterine serosa was noted, which presumably resulted from inadvertent Veress needle injury. Abdominal computerized tomography was performed, which demonstrated a pneumoamnion. Spontaneous rupture of membranes and labor ensued, resulting in the delivery of a stillborn fetus. CONCLUSION: Inadvertent introduction of the Veress needle into the gravid uterus with subsequent pneumoamnion represents a catastrophic complication of midtrimester laparoscopic surgery.     

Use of nafarelin versus placebo after reductive laparoscopic surgery for endometriosis

Objective: To evaluate the efficacy of the GnRH agonist (GnRH-a) nafarelin compared with placebo administered for 6 months after reductive laparoscopic surgery for symptomatic endometriosis.Design: Randomized, prospective, placebo-controlled, multicenter clinical trial.Setting: Thirteen clinics including private practice and university centers.Patient(s): One hundred nine women aged 18–47 with laparoscopically proven endometriosis and pelvic pain who had undergone reductive laparoscopic surgery for endometriosis.Intervention(s): Patients were randomized to receive either the GnRH-a nafarelin (200 μg twice daily) or placebo for 6 months.Main Outcome Measure(s): Time to initiation of alternative treatment (the length of time from beginning study medication to receiving alternative therapy or to deeming that the study drug was ineffective) and patient-reported and physician-assessed pelvic pain scores.Result(s): The median time to initiation of alternative treatment was > 24 months in the nafarelin group versus 11.7 months in the placebo group. Fifteen (31%) of 49 nafarelin-treated patients required alternative therapy, compared with 25 (57%) of 44 placebo-treated patients. The patients' pelvic pain scores dropped significantly in the nafarelin and placebo groups after 6 months of treatment. Physician summary ratings showed significant improvement in the nafarelin group and no significant changes in the placebo group after 6 months of treatment.Conclusion(s): Compared with placebo, nafarelin administered after reductive laparoscopic surgery for endometriosis significantly delays the return of endometriosis symptoms requiring further treatment.     

腹腔镜保守性手术治疗输卵管妊娠的效果及其影响因素分析

目的 探讨腹腔镜保守性手术治疗输卵管妊娠的效果及其影响因素.方法 2003年1月至2008年12月,对北京安贞医院妇产科226例输卵管妊娠者行腹腔镜保守性手术治疗,152例于术后3～6个月行子宫输卵管造影,其中6例接受了再次腹腔镜探查,以评价手术侧输卵管是否通畅.第1次腹腔镜手术成功207例,手术失败19例;术后3～6个月行子宫输卵管造影,第1次腹腔镜手术成功的207例患者中,患侧输卵管通畅者89例(A组);第1次腹腔镜手术失败、术中及术后改行输卵管切除术(19例)及手术后随访检查患侧输卵管不通者(63例)共计82例(B组).再以妊娠包块最大径线5 cm或血清人绒毛膜促性腺激素(hCG)水平≤2000 IU/L,>2000～<5000 IU/L,≥5000 IU/L为界,分别计算输卵管通畅率.两组患者年龄、孕次、停经时间、输卵管妊娠的侧别及部位、是否破裂、是否合并盆腔粘连等方面比较,差异均无统计学意义(P>0.05).结果 226例患者中,207例患者第1次腹腔镜手术成功,手术成功率为91.6%(207/226),术后3～6个月随访152例,失访55例.A、B组患者术前血清hCG中位水平分别为980(55～12 000)、3150(570～40 000)IU/L,两组比较,差异有统计学意义(P<0.01);A、B组患者输卵管妊娠包块最大径线分别为(3.4±1.3)、(5.0±1.7)cm,两组比较,差异也有统计学意义(P<0.01).A组患者术前中位腹腔内出血量为200(0～1500)ml,B组为300(0～1600)ml,A组活胎率为2%(2/89),B组为11%(9/82),两组比较,差异均有统计学意义(P<0.05).两组共171例患者中,妊娠包块最大径线<5 cm者103例,术后患侧输卵管通畅率为65%(67/103),妊娠包块最大径线≥5 cm者68例,术后患侧输卵管通畅率为32%(22/68),两者比较,差异有统计学意义(P<0.01);血清hCG水平≤2000 IU/L、>2000～<5000 IU/L、≥5000 IU/L者术后患侧输卵管通畅率分别为72%(73/102)、29%(12/42)和15%(4/27),3者分别比较,差异也有统计学意义(P<0.05);logistic回归分析结果显示,术前血清hCG水平(OR=0.277,P<0.01)、输卵管妊娠包块最大径线(OR=0.577,P<0.01)、腹腔内出血量(OR=0.999,P<0.05)均为手术成功率的影响因素.结论 腹腔镜保守性手术对输卵管妊娠希望保留输卵管功能的患者具有安全性和可行性;术前血清hCG水平、输卵管妊娠包块大小及腹腔内出血量是影响手术效果的重要因素.     

Determinant factors of fertility outcomes after laparoscopic colorectal resection for endometriosis

Objective

The aims of this prospective study were to evaluate fertility, pregnancy outcomes and their determinant factors after laparoscopic segmental colorectal resection for endometriosis.

Study design

We studied 83 women who underwent colorectal resection for endometriosis. Thirty-nine women (47%) had an associated infertility and 51 (61.4%) wished to conceive after surgery. Surgical route was exclusive laparoscopy in 77 cases (92.7%) and laparoconversion in 6 (7.3%).

Results

Twenty-nine pregnancies were obtained in 24 patients (43.6%) including 20 spontaneous (69%) and 9 by IVF (31%). The median time to conceive spontaneously was 6 months and 20 months by IVF. Among the 39 infertile women, 18 (46%) conceived during the study period. A relation was found between pregnancy rate and patient age (p = 0.02). Reduction in pregnancy rate was correlated to the presence of adenomyosis (p = 0.04) and high ASRM total score (p < 0.001) as well as exclusive laparoscopy compared to conversion to laparotomy for colorectal resection (p = 0.01).

Conclusion

Adenomyosis and conversion to laparotomy as well as patient age, ASRM score appeared determinant factors of fertility outcome.     

Clinical and quality-of-life outcomes after fertility-sparing laparoscopic surgery with bowel resection for severe endometriosis

STUDY OBJECTIVE: To describe the effect of fertility-sparing laparoscopic excision of endometriosis and bowel resection on clinical and quality-of-life outcomes. DESIGN: Prospective observational cohort study (Canadian Task Force classification II-2). SETTING: Australian tertiary referral center for the surgical treatment of endometriosis. PATIENTS: Seven consecutive patients with known endometriosis involving the bowel. INTERVENTION: Laparoscopic resection of all endometriosis, including laparoscopic bowel resection with end-to-end anastomosis with or without temporary ileostomy. MEASUREMENTS AND MAIN RESULTS: Preoperative and 12-month postoperative data were collected by use of visual analogue scores for dysmenorrhea, nonmenstrual pelvic pain, dyspareunia, and dyschezia. Validated research tools (SF12, EuroQOL, and Sexual Activity Questionnaire) also assessed quality of life. Reduction in median pain scores at baseline was demonstrated and at 12 months after operation for dysmenorrhea 71 (interquartile range 43-85) versus 5 (0-10); p=.028, nonmenstrual pelvic pain 74 (48-85) versus 11 (0-18); p=.046, dyspareunia 66 (0-98) versus 5 (0-8); p=.080, and dyschezia 48 (20-64) versus 20 (0-40); p=.173. All measures of quality of life were improved at 12 months after surgery, although not reaching statistical significance because of the small sample size. All three women wishing to conceive after operation have been successful, resulting in three live births at term. There were few complications associated with this surgery. CONCLUSION: Fertility-sparing laparoscopic excision of endometriosis with bowel resection results in improvements in all aspects of pain and quality of life. Results appear to parallel published data for conservative resection of endometriosis not involving bowel. For women with severe endometriosis involving bowel, this surgical treatment provides a viable alternative to pelvic clearance and successfully maintains fertility.     

子宫内膜异位症保守性手术后复发的相关因素分析

目的　确定与子宫内膜异位症 (内异症 )保守性手术后病变复发的相关因素。方法对 2 85例保守性手术治疗并经病理证实的内异症患者观察并随访 36个月 ,观察患者年龄、发病年龄、术前孕次、术前产次、后穹窿痛性结节、子宫活动度、血清CA12 5、既往内异症手术史、腹腔镜手术史、内异症病变侧别、术中和术后美国生育学会修订的内异症分期标准 (r AFS ,1985 )评分、术后孕激素治疗 6个月、术后枸橼酸氯米芬 (其他名称 :克罗米酚 )促排卵治疗、术后孕次、术后产次等 31项指标 ,随访中记录病变复发情况及复发时间。应用SPSS软件行COX回归风险分析筛查复发的相关因素。结果共有 83例 (2 9 1% ,83/2 85 )患者复发 ,每年复发例数、复发率和累积复发率为 ,第 1年 4 1例 ,14 4 % (41/2 85 )和 14 4 % (41/2 85 ) ;第 2年 30例 ,10 5 % (30 /2 85 )和 2 4 9% (71/2 85 ) ;第 3年 12例 ,4 2 % (12 /2 85 )和 2 9 1% (83/2 85 )。经单变量分析 ,危险性相关因素为既往有内异症手术史 (OR值为 13 6 30 ,P <0 0 1)、后穹窿有痛性结节 (OR值 6 133,P <0 0 1)、术后应用枸橼酸氯米芬促排卵治疗 (OR值 5 173,P <0 0 1)、左侧盆腔病变 (OR值 4 5 0 3,P <0 0 1)、双侧盆腔病变 (OR值 3 70 9,P <0 0 5 )和术后r AF     

开腹与腹腔镜下输卵管吻合术回顾性队列研究及术后妊娠影响因素分析#br#

【Abstract】?Objective?To evaluate the safety and effectiveness of laparotomic and laparoscopic tubal anastomosis, and evaluate the influencing factors of pregnancy rate. Methods?The clinical data of 356 ligation patients who underwent tubal anastomosis in the First Affiliated Hospital of Zhengzhou University from March 2012 to October 2017 were analyzed retrospectively, including 85 cases of laparotomy and 271 cases of laparoscopy. The differences of perioperative status and postoperative pregnancy rate between the two groups were analyzed, and the independent influencing factors of postoperative pregnancy rate were analyzed. Results?①There was no significant difference in operation time, postoperative fever and exhaust time between the two groups (P>0.05), but laparoscopic bleeding was less[(18.1±12.1) ml, (33.4±22.1) ml], and the pain score was lower[(3.6±0.9), (4.5±0.9) score], duration of hospital stay was shorter[(5.9±0.6) d, (7.1±0.7) d](P<0.05). 2 cases of laparotomic group had abdominal wall incision infection, cases of laparoscopic group all healed well. The cost of laparotomic group was lower than that in laparoscopic group[(9 524±881), (12 903±1 162) yuan](P<0.05).② There was no significant difference in the patency rate of intraoperative anastomosis, residual tube length and ectopic pregnancy rate between the two groups (P>0.05). The uterine pregnancy rate two years after anastomosis was higher in laparoscopic group (76.4%) than in laparotomic group(61.2%)(P<0.05). The postoperative gestation time of the laparoscopic group was (7.6±4.9) months, and the postoperative gestation time of the open group was (8.3±5.3) months, with no statistically significant difference(P>0.05).③ Anastomotic procedure (OR=1.847, 95%CI: 1.028~3.320, P=0.040), age (OR=3.673, 95%CI: 1.690~7.984, P=0.001), multiple pelvic operation history (OR=3.092, 95%CI: 1.650~5.796, P=0.000), and length of residual tube (OR=4.716, 95%CI: 2.552~8.714, P=0.000) were independent factors influencing intrauterine pregnancy rate after anastomosis. There was no significant correlation between body mass index (BMI), length of ligation, method of ligation and site of ligation and pregnancy rate. Conclusion?Compared with open surgery, laparoscopic tubal anastomosis is a better treatment option for patients with tubal ligation. Anastomosis mode, age, history of multiple pelvic surgeries and length of remaining fallopian tubes were the influencing factors of pregnancy rate after anastomosis.