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1.
高血压患者血脂,脂蛋白,载脂蛋白及胰岛素分析 总被引:9,自引:0,他引:9
本文就49例高血压患者血脂、脂蛋白、载脂蛋白及血胰岛素(In)水平与40例正常人比较分析发现:高血压患者体重指数(BMI)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDLC)、低密度脂蛋白胆固醇/高密度脂蛋白胆固醇(LDL-c/HDL-C)、载脂蛋白B(apoB)、血糠(G)及In均较对照组显著升高、HDL-C、HDL2-C、apoAI、apoAI/apoB及G/In较对照组显著降低。In水平随BMI增加而升高。相关分析发现:HBP患者In与BMI和apoB呈正相关,与HDL-C、apoAI/apoB呈负相关。G/In与HDL-C呈正相关。血浆TG与HDL-C呈负相关。 相似文献
2.
海口市少年血脂、载脂蛋白相关因素研究(附514例调查分析) 总被引:1,自引:0,他引:1
检测了海口市514例12~15岁少年的血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及载脂蛋白AI(apoAI)、载脂蛋白B1oo(apoB100)水平,并对其影响因素分别与性别、年龄、身高、体重、体质格数(BMI)、收缩压及舒张压作了多元逐步回归分析。结果表明,BMI是影响少年血脂与脂蛋白最主要因素,而apoAI、apoB100的变化主要受血清TC、TG及HDL-C的影响。 相似文献
3.
高血压患者血浆氧化修饰低密度脂蛋白的测定 总被引:1,自引:0,他引:1
目的测定高血压患者血浆氧化修饰低密度脂蛋白(OXLDL)水平并了解其临床意义。方法用ELISA法测定60例高血压患者(其中单纯高血压者32例,合并冠心病者28例)和50例正常对照组血浆OXLDL,并同时测定其他血脂、脂蛋白和载脂蛋白。结果高血压患者血浆中OXLDL较对照组明显升高,男女之间差别无显著性。Ⅰ,Ⅱ,Ⅲ期患者血浆中OXLDL亦明显升高,且各期之间相差无显著性。单纯者和合并冠心病者OXLDL均明显升高,但后者更高。无论LDL-C是否升高,高血压患者血浆OXLDL均升高,但LDL-C升高者OXLDL更高。OXLDL升高者,高血压合并冠心病百分率较高。相关分析表明,血浆OXLDL与TC、LDL-C、ApoB100呈正相关(r=0.25,0.22,0.26,P<0.05,<0.05,<0.025),与HDL-C呈负相关(r=-0.22,P<0.05),与血压、年龄、病程无关。结论高血压患者血浆中OXLDL明显升高,OXLDL升高可能参与高血压致动脉粥样硬化作用,因此治疗时除给予降压治疗之外,应加强抗氧化治疗。 相似文献
4.
对90例85岁以上高龄老人的血脂、脂蛋白和载脂蛋白进行测定,并与陈旧性心肌梗塞(OMI)组对比。结果显示:与OMI组比较,高龄老人血清TC、LDL-C、ApoAⅠ和ApoB_(100)的明显低,而HDL-C/TC、HDL-C/LDL-C和ApoAⅠ/ApoB_(100)明显高;TG、HDL-C和VLDL-C在两组之间无统计学差异。单因素相关分析显示,HDL-C/TC,HDL-C/LDL-C和ApoAⅠ/ApoB_(100)与长寿呈正相关,与OMI呈负相关;而TC、LDL-C、ApoAⅠ和ApoB_(100)则与长寿呈负相关,与OMI呈正相关;HDL-C、TG和VLDL-C与长寿和OMI几乎无相关关系。对各检测指标进行多元逐步回归分析,ApoB_(100)对长寿作用最大,其次为ApoAⅠ/ApoB_(100)和HDL-C.因此认为血清APoB_(100)水平的低值、HDL-C和ApoAⅠ/ApoB_(100)的高值,是高龄老人血脂、脂蛋白和载脂蛋白的特点,亦是长寿的指标。 相似文献
5.
本研究观测了50例老年陈旧性心肌梗塞(OMI)病人空腹血浆胰岛素(IS)水平变化,并探讨其临床意义。结果表明,老年OMI病人空腹血浆IS、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白B(ApoB)及脂蛋白(a)水平明显高于正常老年人,高密度脂蛋白胆固醇(HDL-C)水平明显降低。OMI病人中空腹IS水平与TG、ApoB水平呈显著的正相关性,与HDL-C呈显著的岁相 相似文献
6.
目的:探讨载脂蛋白E(apoE)基因多态性在冠心病(CHD)发生发展中的作用及其对血脂质、脂蛋白水平的影响。方法:应用聚合酶链反应技术和遗传学方法,测定93 例CHD患者和94例正常对照者的apoE基因型;按常规方法测定血浆脂质、脂蛋白水平。结果:共发现5 种apoE基因型,分别为E3/3、E3/2、E4/3、E4/2和E4/4。CHD组apoE4/3 基因型和ε4 等位基因频率及总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)均显著高于对照组(均P< 0.01),apoAI的水平高于对照组(P< 0.05),其他血脂指标无显著性差异( P> 0.05)。在CHD组各亚型之间,TC、LDL-C和apoAI水平之间存在显著性差异(P< 0.05)。结论:apoEε4 等位基因是CHD重要的遗传易患因素,apoE基因多态性亦影响血TC、LDL-C和apoAI水平。 相似文献
7.
急性白血病患者血浆脂蛋白及载脂蛋白的临床研究 总被引:2,自引:0,他引:2
目的:探讨急性白血病患者血脂及载脂蛋白改变的临床意义。方法:用全自动生化分析仪检测94例急性白血病患者血浆中血脂及载脂蛋白的含量。结果;急性白血病组较正常对照组TG、apoB显著升高,而 LDL-C、 HDL-C、apoA I、apoAI/apoB显著下降; AL患者缓解后较治疗前TG、apoB显著下降,而LDL-C、HDL-C、apoA I、apoA I/apoB显著升高。结论:急性白血病患者血脂及载脂蛋白监测是一项对患者疗效判断、病情监测均有重要意义均敏感指标。 相似文献
8.
目的观察血清载脂蛋白CⅡ(apoCⅡ)在高脂蛋白血症及冠心病中的变化特点。方法应用酶联免疫法(ELISA)测定新生儿至老年人群及118例高脂蛋白血症患者、46例冠心病(CHD)、54例急性心肌梗死(AMI)与25例陈旧性心肌梗死(OMI)患者血清apoCⅡ含量,并分析与甘油三酯(TG)、高密度脂蛋白(HDL)的关系。结果脐带血apoCⅡ含量最低,随着年龄增长,apoCⅡ含量逐渐增加。高脂蛋白血症组apoCⅡ显著高于老年健康组(P<0.001),apoCⅡ与TG含量呈正相关(r=0.52,P<0.001),但有10例患者TG很高,而apoCⅡ较低。CHD、AMI和OMI组的apoCⅡ水平随着HDL-C下降而显著低于老年健康组。结论血清apoCⅡ的测定有助于阐明高脂蛋白血症的发病机理及CHD、AMI和OMI患者的血脂紊乱、apoCⅡ水平下降可能是某些病例TG升高的原因之一。 相似文献
9.
为探讨氧化修饰低密度脂蛋白(OXLDL)及抗氧化剂在糖尿病血管病变中的作用,采用酶联免疫吸附双抗体夹心法(ELASA法),测定了60例非胰岛素依赖型糖尿病(NIDDM)病人及30例正常对照者血浆OXLDL水平。结果显示:(1)NIDDM组与正常对照组比较,血浆OXLDL水平显著增高(P<0.01)。NIDDM有血管病变组与无血管病变组比较,血浆OXLDL水平显著增高(P<0.05)。(2)20例NIDDM病人用维生素C及维生素E治疗后,血浆OXLDL水平显著下降(P<0.05)。(3)血浆OXLDL水平与LDL-C、HDL、TG、TC、ApoA1及ApoB均无显著相关性。提示OXLDL可能与糖尿病血管病变的发生和发展有关。抗氧化治疗可能对预防血管病变的发生有一定的作用。 相似文献
10.
甲状腺激素对脂蛋白(a)水平的影响 总被引:5,自引:1,他引:5
甲状腺激素对脂蛋白(a)水平的影响向光大何玉生已知甲状腺激素可影响脂蛋白代谢,包括血浆总胆固醇(TC)、低密度脂蛋白胆固醇(LDLC),高密度脂蛋白胆固醇(HDLC)、载脂蛋白B(apoB)及载脂蛋白A1(apoA1)代谢的影响。最近,国外研究发... 相似文献
11.
目的胰岛素瘤是最常见的胰腺神经内分泌肿瘤,因其临床表现多样,导致诊断困难。影像学诊断尤其是超声内镜(EUS)在胰岛素瘤的诊断中起着重要作用,拥有较高的敏感性和特异性。本研究拟通过明确胰岛素瘤的解剖分布特点,以期有助于提高影像学的诊断准确率和降低漏诊率,尤其是在教育和培训实践中对于EUS的学习者更具有指导价值。
方法回顾性分析解放军总医院第一医学中心病案资料数据库1993年1月至2019年11月经外科手术、病理确诊为胰岛素瘤的患者的临床资料,检索方法采取搜索术后病理诊断为"胰岛素瘤"的病例,通过查阅病例的方法,提取出胰岛素瘤的大小和解剖分布等数据,进一步分析其特点。
结果共检索到确诊为胰岛素瘤的患者116例,其中,男45例、女71例,年龄13~76岁,平均年龄(44.4±14.85)岁。胰岛素瘤单发110例(94.8%)、多发6例(5.2%)。位置分布:头颈部46例(39.7%),单发45例、多发1例;体尾部68例(58.6%),单发65例、多发3例;全胰腺多发2例(1.7%)。病变大小特点:最大径0.4~3.4 cm,平均大小(1.53±0.58)cm。≤1 cm 29例、>1 cm而≤1.5 cm41例、>1.5 cm而≤2.0 cm28例,≤3 cm 15例,>3 cm 3例。年龄与肿瘤的大小相关,≤44岁患者肿瘤平均大小为(1.36±0.51)cm、>44岁患者肿瘤平均大小为(1.70±0.60)cm,P<0.05。头颈部的肿瘤大于体尾部的肿瘤,头颈部肿瘤平均大小(1.66±0.63)cm,体尾部(1.42±0.52)cm,P<0.05。
结论胰岛素瘤在胰腺体尾部较头颈部更好发;绝大多数单发,但可以全胰腺多发;多数小于1.5 cm,肿瘤的大小与患者年龄和肿瘤的解剖分布相关。 相似文献
12.
Most adenomas and carcinomas of the small intestine and extrahepatic bile ducts arise in the region of the papilla of Vater. In familial adenomatous polyposis (FAP) it is the main location for carcinomas after proctocolectomy. In many cases symptoms due to stenosis lead to diagnosis at an early tumor stage. In about 80%, curative intended resection is possible. Operability is the most relevant prognostic factor. Most ampullary carcinomas resp. carcinomas of the papilla of Vater develop from adenomatous or flat dysplastic precursor lesions. They can be sited in the ampulloduodenal part of the papilla of Vater, which is lined by intestinal mucosa. They also can develop in deeper parts of the ampulla, which are lined by pancreaticobiliary duct mucosa. Intestinal-type adenocarcinoma and pancreaticobiliary-type adenocarcinoma represent the main histological types of ampullary carcinoma. Furthermore, there exist unusual types and undifferentiated carcinomas. Many carcinomas of intestinal type express the immunohistochemical marker profile of intestinal mucosa (keratin 7?, keratin 20+, MUC2+). Carcinomas of pancreaticobiliary type usually show the immunohistochemical profile of pancreaticobiliary duct mucosa (keratin 7+, keratin 20?, MUC2?). Even poorly differentiated carcinomas, as well as unusual histological types, may conserve the marker profile of the mucosa they developed from. These findings underline the concept of histogenetically different carcinomas of the papilla of Vater which develop either from intestinal- or from pancreaticobiliary-type mucosa of the papilla of Vater. Molecular alterations in ampullary carcinomas are similar to those of colorectal as well as pancreatic carcinomas, although they appear at different frequencies. In future studies, molecular alterations in ampullary carcinomas should be correlated closely with the different histologic tumor types. Consequently, the histologic classification should reflect the histogenesis of ampullary tumors from the two different types of papillary mucosa. 相似文献
13.
Sergio Muntoni Paola Tagliamonte Federico Sirigu Giovanni Umberto Corsini 《Acta diabetologica》1973,10(6):1300-1307
Summary Palmitic acid oxidation in rat diaphragm homogenate is depressed by biguanide concentrations that are still incapable of inhibiting
oxidative phosphorylation. Glucose oxidation is not directly effected by the same biguanide concentrations: however, the inhibitory
effect of palmitic acid on glucose oxidation is partly removed by biguanides. Inhibition of fatty acid oxidation, which accounts
for most of the metabolic effects caused by these drugs, can be regarded as the fundamental mechanism of action of biguanides.
There is some evidence suggesting that these drugs might interact with carnitine, thus preventing long-chain fatty acids from
being transported across the mitochondrial membrane to the site of oxidation.
Traduzione a cura degli AA. 相似文献
14.
P. Brar G.Y. Kwon I.I. Egbuna S. Holleran R. Ramakrishnan G. Bhagat P.H.R. Green 《Digestive and liver disease》2007,39(1):26-29
BACKGROUND AND AIM: Both the clinical presentation and the degree of mucosal damage in coeliac disease vary greatly. In view of conflicting information as to whether the mode of presentation correlates with the degree of villous atrophy, we reviewed a large cohort of patients with coeliac disease. PATIENTS AND METHODS: We correlated mode of presentation (classical, diarrhoea predominant or atypical/silent) with histology of duodenal biopsies and examined their trends over time. RESULTS: The cohort consisted of 499 adults, mean age 44.1 years, 68% females. The majority had silent coeliac disease (56%) and total villous atrophy (65%). There was no correlation of mode of presentation with the degree of villous atrophy (p=0.25). Sixty-eight percent of females and 58% of males had a severe villous atrophy (p=0.052). There was a significant trend over time for a greater proportion of patients presenting as atypical/silent coeliac disease and having partial villous atrophy, though the majority still had total villous atrophy. CONCLUSIONS: Among our patients the degree of villous atrophy in duodenal biopsies did not correlate with the mode of presentation, indicating that factors other than the degree of villous atrophy must account for diarrhoea in coeliac disease. 相似文献
15.
血吸虫童虫是宿主免疫系统攻击的重要靶标,包括皮肤型、肺型和肝门型童虫。宿主分子对童虫生长发育具有重要作用。童虫生长发育机制包括免疫调节、信号转导、性别发育及凋亡等。肌动蛋白、组织蛋白酶、烯醇化酶和葡萄糖基转移酶等分子为血吸虫童虫生长发育的重要分子。本文对血吸虫童虫生长发育及其机制的研究进展做一综述。 相似文献
16.
目的对临床分离的耐多药结核分枝杆菌相关基因的突变特征进行分析。方法对124例耐多药结核分枝杆菌以及50株敏感株的耐药相关基因(包括异烟肼inh A、kat G、oxyR-ahp C间隔区以及利福平rpo B)进行序列测定,分析其基因突变情况。结果异烟肼耐药inh A基因突变率为14.5%;kat G基因突变率为70.2%(87/124),主要位于315位;oxyR-ahp C间隔区突变率为15.3%;inh A、kat G两种基因同时突变率75.0%,三种基因同时突变率为89.5%。利福平rpo B基因突变的检出率高达95.2%,突变主要发生在531、526、516位点。结论我省耐多药菌异烟肼耐药相关基因最常见突变为kat G 315、inh A C-T(-15)、axyR-ahp C间隔区(-10)C-T,利福平为rpo B531、526、516。结合MDR-TB耐药相关基因的特征分析,可以建立一种快速、准确、特异的适合于我省的检测结核菌耐多药性的新方法。 相似文献
17.
氯硝柳胺悬浮剂的毒性评价 总被引:2,自引:2,他引:2
目的评价氯硝柳胺悬浮剂的毒性,为现场大规模应用灭螺提供依据。方法按照中华人民共和国国家标准GB 15670-1995《农药登记毒理学试验方法》和鱼类毒性试验方法进行。结果经口、经皮肤的LDso雌、雄性大鼠均>5 000 mg/kg,经呼吸道的LCso雌、雄性大鼠均>5 000mg/m3,该药经口、经皮肤、经呼吸道毒性均属微毒类药物;兔眼用药后,观察期内无不良反应,对眼无刺激性;皮肤用药后对皮肤无刺激性。与氯硝柳胺原药、氯硝柳胺乙醇胺盐原药和氯硝柳胺乙醇胺盐可湿性粉剂相比,氯硝柳胺悬浮剂对鱼急性毒性最低。结论氯硝柳胺悬浮剂属微毒类药物,对鱼的毒性低于其乙醇胺盐可湿性粉剂,适合于现场应用。 相似文献
18.
The aim of the study was to assess the quality of life (QOL) and the psychological status of parents of children with juvenile
chronic arthritis (JCA). The QOL, anxiety and depression of the parents of 28 children with JCA were evaluated and compared
to those of the parents of 28 healthy children. Mothers of JCA children and mothers of healthy children reported similar QOL.
The reported anxiety and depression levels were similar for mothers and fathers in both groups. The parents of children with
pauciarticular-type JCA reported lower QOL and higher levels of anxiety and depression than the parents of children with other
types, namely polyarticular and systemic JCA. These findings may be explained by the fact that the pauciarticular patients
had shorter disease duration and were less frequently seen in the outpatient clinic. The QOL of mothers of children with JCA
was found to be slightly impaired in the group of children with pauciarticular JCA. Future larger studies are needed to confirm
these results, as the number of subjects in the three groups was rather low.
Received: 26 September 2001 / Accepted: 8 February 2002 相似文献
19.
Marc B. Taub Thomas A. Peyser J. Erik Rosenquist 《Journal of diabetes science and technology》2007,1(5):685-694
Background
A 5-day in-patient study designed to assess the accuracy of the FreeStyle Navigator® Continuous Glucose Monitoring System revealed that the level of accuracy of the continuous sensor measurements was dependent on the rate of glucose change. When the absolute rate of change was less than 1 mg•dl−1•min−1 (75% of the time), the median absolute relative difference (ARD) was 8.5%, with 85% of all points falling within the A zone of the Clarke error grid. When the absolute rate of change was greater than 2 mg•dl−1•min−1 (8% of the time), the median ARD was 17.5%, with 59% of all points falling within the Clarke A zone.Method
Numerical simulations were performed to investigate effects of the rate of change of glucose on sensor measurement error. This approach enabled physiologically relevant distributions of glucose values to be reordered to explore the effect of different glucose rate-of-change distributions on apparent sensor accuracy.Results
The physiological lag between blood and interstitial fluid glucose levels is sufficient to account for the observed difference in sensor accuracy between periods of stable glucose and periods of rapidly changing glucose.Conclusions
The role of physiological lag on the apparent decrease in sensor accuracy at high glucose rates of change has implications for clinical study design, regulatory review of continuous glucose sensors, and development of performance standards for this new technology. This work demonstrates the difficulty in comparing accuracy measures between different clinical studies and highlights the need for studies to include both relevant glucose distributions and relevant glucose rate-of-change distributions. 相似文献20.
治疗高血压药物的经济学评价 总被引:3,自引:0,他引:3
重视高血压治疗中的经济学评价,对利用我国有限的卫生资源来遏制高血压对人民群众的危害有着重要的现实意义。药物经济学对于药物治疗的成本和治疗的结果给予同样的关注。因为治疗高血压的费用,不仅涉及药物价格,还包括患者的危险水平,降压疗效和对临床终点事件的影响,以及治疗的依从性和安全性。因此药物经济学更强调整体成本和价-效比。低危病人,若非药价低廉,治疗的价-效比不够理想。而在高危的患者,价-效比越小越经济而不是药费越便宜越好。 相似文献