阻塞性睡眠呼吸暂停低通气综合征和肥胖及正常体重人群血清瘦素水平的研究

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)、肥胖和正常体重人群的血清瘦素水平。方法:将经PSG检测的患者分为OSAHS组(53例)和单纯肥胖组(41例),另选正常体重者(正常体重组)62例,用放射免疫法测定3组的血清瘦素水平,同时测量每例受检者的身高、体重、颈围、腰围和臀围。结果:①无论男性还是女性,OSAHS组和单纯肥胖组的血清瘦素水平均比正常体重组高(均P<0.05);OSAHS组血清瘦素水平[男(8.06±2.58)μg/L,女(12.83±2.67μg/L)]均高于单纯肥胖组[男(5.75±1.27)μg/L,女(9.83±1.99μg/L)](均P<0.05)。②单纯肥胖组及OSAHS组血清瘦素水平分别与体质指数(BMI)呈显著正相关(均P<0.01),OSAHS组血清瘦素水平与AHI、颈围及腰臀围比(WHR)也呈显著正相关(均P<0.01)。结论:单纯性肥胖患者血清瘦素水平升高与机体内发生瘦素抵抗有关;OSAHS患者的血清瘦素水平与AHI呈正相关,说明OSAHS本身可能是引起血清瘦素升高的因素之一,瘦素可能有兴奋呼吸中枢的作用。     

变应性鼻炎患者血清嗜酸粒细胞阳离子蛋白在特异性免疫治疗中的变化

目的:通过观察变应性鼻炎患者接受特异性免疫治疗前后血清嗜酸粒细胞阳离子蛋白(ECP)的变化,评价免疫治疗的效果,探讨其治疗机制.方法:52例变应性鼻炎患者随机分为治疗组32例和对照组20例,治疗组用舌下含服变应原特异性免疫治疗,对照组给予布地奈德喷鼻,在治疗前后抽静脉血查ECP.结果:治疗组和对照组治疗前血清ECP分别为(26.2±5.9)μg/L和(27.4±6.3)μg/L,差异无统计学意义(P>0.05);治疗后血清ECP分别为(18.3±3.4)μg/L和(23.2±3.7)μg/L,差异有统计学意义(P<0.01).两组治疗后与治疗前相比,血清ECP差异均有统计学意义(治疗组P<0.01,对照组P<0.05).结论:特异性免疫治疗能有效降低患者血清ECP,其可能的免疫机制是有效地抑制了嗜酸粒细胞在鼻腔的聚集与活化,降低其释放ECP的能力,起到治疗作用.     

尿激酶型纤溶酶原激活物及其受体的表达与不明原因鼻出血的相关性研究

目的:探讨不明原因鼻出血患者的发病机制。方法:采用酶联免疫吸附测定法(ELISA法)测定19例不明原因鼻出血患者(鼻出血组)和36例健康体检者(正常对照组)血中尿激酶型纤溶酶原激活物(uPA)及其受体(uPAR)的水平,同时测定凝血4项及用乳胶法作D-二聚体定性测定。结果:鼻出血组治疗前:uPAR(0.14±0.04)μg/L,uPA(0.24±0.09)μg/L;治愈后:uPAR(0.08±0.02)μg/L,uPA(0.18±0.07)μg/L。正常对照组:uPAR(0.07±0.03)μg/L,uPA(0.17±0.05)μg/L。鼻出血组治疗前uPAR、uPA均高于对照组,差异有统计学意义(P<0.05),鼻出血组治疗后与正常对照组比较差异无统计学意义(P>0.05);凝血4项与正常对照组比较均差异无统计学意义(均P>0.05)。结论:不明原因鼻出血患者的uPAR、uPA表达增高原因未明,可能与局部区域由于炎症而使微循环的血管内皮细胞、平滑肌细胞以及血液粒-单核系细胞释放过多的uPAR、uPA有关,高浓度的uPAR、uPA微环境,使鼻腔内血液微环境纤溶活性增高引发纤溶亢进,因而引起局部血液处于低凝状态而引发鼻出血。     

阻塞性睡眠呼吸暂停低通气综合征患者血清瘦素和脂联素检测及临床分析

目的检测阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与非OSAHS患者血清瘦素和脂联素水平,分析与体重指数(BMI)、血压、空腹血糖等一般生理指标及呼吸暂停低通气指数(AHI)等多导睡眠仪(PSG)参数的关系,探讨临床意义。方法研究对象为新诊断的OSAHS患者33例和非OSAHS对照15例。PSG监测结束后,上午8:00~9:00抽取空腹静脉血,ELISA法检测瘦素和脂联素。结果 OSAHS患者中瘦素水平(11.2±12.2 ng/m L)高于对照组(3.8±1.8 ng/m L),脂联素水平(6.13±1.16μg/m L)低于对照组(8.51±3.84μg/m L),差异均有统计学意义(P0.05)。皮尔森分析示瘦素与BMI(r=0.68,P0.05)、颈围(r=0.516,P0.05)、腰围(r=0.531,P0.05)、AHI(r=0.198,P0.05)呈正相关;脂联素与BMI(r=-0.342,P0.01)、颈围(r=-0.324,P0.05)、腰围(r=-0.357,P0.05)、AHI(r=-0.247,P0.05)呈负相关。OSAHS患者中糖尿病与高血压人群的瘦素水平(糖尿病患者14.2±8.2 ng/m L,高血压患者13.8±6.4 ng/m L)高于该人群中未患两种疾病的人群(非糖尿病患者11.8±6.8 ng/m L,非高血压患者10.8±2.1 ng/m L),而脂联素水平前者(糖尿病患者3.83±2.03μg/m L,高血压患者3.01±1.06μg/m L)低于后者(非糖尿病患者5.31±1.84μg/m L,非高血压患者5.48±2.06 ug/m L),差异均有统计学意义(P0.05)。结论 OSAHS患者血清中的瘦素水平升高,脂联素水平降低;瘦素的含量与患者肥胖程度及OSAHS的严重程度呈正相关,但脂联素呈负相关。血清中瘦素水平的升高可能参与OSAHS高血压并发症的发生,OSAHS糖尿病患者比例的增加可能与血清中脂联素表达的降低有关。     

变应性鼻炎患者脱敏治疗前后白细胞介素-18水平变化

目的:探讨白细胞介素18(IL18)在变应性鼻炎(AR)的发病过程中的作用及脱敏治疗的作用机制。方法:以健康者作对照(对照组),用酶联免疫吸附方法检测AR患者(AR组)脱敏治疗(1年)前、后血清IL18水平。结果:AR组脱敏治疗前血清IL18水平(88.33±35.95)ng/L低于对照组(149±47.37)ng/L,2组比较差异有统计学意义(P<0.05)。而AR组脱敏治疗后血清IL18水平(199.22±58.82)ng/L明显升高,与对照组比较差异无统计学意义(P>0.05)。结论:IL18在AR组中低表达,而在脱敏治疗后表达增高,提示IL18在变应性炎症的发生、发展和脱敏治疗中起了重要作用。     

血清嗜酸粒细胞阳离子蛋白水平与变应性鼻炎及慢性鼻-鼻窦炎关系的探讨

目的 探讨变应性鼻炎(allergic rhinitis,AR)和慢性鼻-鼻窦炎伴鼻息肉(chronic rhinosinusitis with polyps,CRSWP)患者血清中嗜酸粒细胞阳离子蛋白(eosinophil cationic protein,ECP)的水平及其与患者鼻部过敏症状的关系.方法 用UniCAP100系统进行吸入物变应原过筛试验Phadiatop和检测血清ECP水平.取87例吸人性AR患者、49例CRSWP患者和20例健康人静脉血,采用荧光酶免疫分析法,检测血清ECP水平.对87例吸入性AR患者进行症状评分.结果 ①吸入性AR组和CRSWP过筛阳性组Phadiatop[中位数(M)和四分位间距[25%,75%]表示,以下同]分别为5185.0[983.0,14469.0]Fu和317.5[125.0,526.8]Fu,健康对照组和CRSWP过筛阴性组分别为43.5[29.0,105.0]Fu和30.0[28.0,43.0]Fu;②吸入性AR组血清ECP为24.8[14.6,49.1]μg/L,CRSWP过筛阳性组和阴性组分别为7.7[3.3,25.6]μg/L和12.5[6.7,16.7]μg/L,健康对照组为8.8[5.4,20.2]μg/L.吸入性AR组ECP明显高于CRSWP过筛阳性组、阴性组和健康对照组,行秩和检验示(z值分别为-2.821,-4.449和-4.028,P值均＜0.05),差异有统计学意义.CRSWP过筛阳性组和阴性组血清ECP较正常对照组无明显升高;③吸入性AR组患者鼻部症状评分(x-±s)为(9.139±1.892),与Phadiatop值呈明显正相关(r=0.854,P＜0.05);与血清ECP水平有一定相关性(r=0.434,P＜0.05).血清ECP和Phadiatop值有一定相关性(r=0.392,P＜0.05).结论 吸入性AR患者症状发作期血清ECP明显升高,且和疾病严重程度有相关性.血清ECP是一种较好且方便的吸入性AR辅助筛查工具,同时还可作为判断患者病情严重程度和预后的客观指标之一.而CRSWP患者血清ECP无明显升高.     

鼻咽癌患者EB病毒潜伏膜蛋白1抗体血清学检测及临床意义

目的:观察EB病毒(EBV)潜伏膜蛋白1(LMP1)抗体在鼻咽癌(NPC)患者血清中的水平,探讨LMP1抗体检测在NPC血清学诊断、预后判断及肿瘤靶向免疫治疗中的临床意义.方法:采用ELISA及Western blot方法,以LMP1融合蛋白检测61例NPC患者(NPC组)、30例鼻咽炎患者(鼻咽炎组)和55例正常人(对照组)血清中LMP1抗体水平.分析LMP1抗体水平与NPC临床病理特征的关系.结果:ELISA方法证实,NPC组LMP1抗体水平明显高于鼻咽炎组及对照组,鼻咽炎组LMP1抗体水平明显高于对照组,组间均差异有统计学意义(均P<0.05).NPC组LMP1抗体水平在NPC不同病理分级及有无淋巴结转移中均差异无统计学意义(均P>0.05).Western blot方法表明,NPC组LMP1抗体的表达均较鼻咽炎组及对照组高.结论:NPC组EBV LMP1抗体水平显著高于鼻咽炎组及对照组,LMP1融合蛋白可考虑作为肿瘤抗原标志物辅助NPC血清学诊断及肿瘤靶向免疫治疗.     

基因重组γ干扰素在治疗变应性鼻炎中的作用

目的研究基因重组γ干扰素在治疗变应性鼻炎中的作用.方法采用随机对照研究方法将60例变应性鼻炎患者分成两组,每组30例,一组予常规脱敏治疗(对照组),另一组予常规脱敏治疗加基因重组γ干扰素治疗(实验组),6个月后比较两组的症状评分、血清白细胞介素-4(IL-4)、嗜酸粒细胞阳离子蛋白(ECP)水平.结果对照组治疗前、后症状评分分别为10.6±2.3和4.2±1.8,血清IL-4水平分别为(545.3±86.2)ng/L和(320.4±76.3)ng/L,ECP水平分别为(24.3±8.2)μg/L和(12.4±6.3)μg/L;实验组治疗前、后症状评分分别为10.8±2.7和3.5±1.6,血清IL-4水平分别为(547.8±84.6)ng/L和(280.4±87.3)ng/L,ECP水平分别为(25.1±7.7)μg/L和(10.4±5.1)μg/L.实验组治疗后症状评分、IL-4和ECP水平均低于对照组(均P<0.05).结论基因重组γ干扰素能改善变应性鼻炎症状,降低血清IL-4、ECP水平,在变应性鼻炎的治疗中发挥着免疫调节作用.     

NOS在分泌性中耳炎所致感音神经性聋中的作用

目的:探讨NOS及NO在分泌性中耳炎(SOM)所致感音神经性聋(SNHL)中的作用。方法:治疗前分别抽取16例伴有SNHL的SOM患者(A组)及16例不伴有SNHL的SOM患者(B组)的中耳积液,检测两组中耳积液内NOS活性和NO含量。结果:A组中耳积液内NO含量(181.19±44.31)μmol/L明显高于B组(137.00±40.67)μmol/L(P<0.01),A组中耳积液内NOS活性(97.69±29.62)U也明显高于B组(75.50±26.99)U(P<0.05)。结论:NO可能通过直接损伤和与其他炎症递质共同作用增强局部炎症反应,在SOM所致的SNHL过程中发挥重要作用。     

变应性鼻炎患者血清氧化应激状态研究

目的 检测变应性鼻炎(allergic rhinitis,AR)患者外周血血清中氧化应激标志物,探讨氧化应激反应在AR发病机制中的作用.方法 留取23例健康人、48例AR患者外周血血清,分别检测氧化应激标志物一氧化氮(nitric oxide,NO)、诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)、总一氧化氮合酶(total nitric oxide synthase,TNOS),脂质过氧化产物丙二醛(malondidehyde,MDA),以及体内主要抗氧化酶超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)水平.采用SPSS 13.0软件对数据进行分析.结果 AR患者血清NO水平((x)±s,以下同)为[(97.92±73.42)μmol/L]较健康对照组[(64.04±29.54)μmol/L]明显升高(t=-0.281,P<0.05);iNOS与TNOS比值(0.51±0.11)较健康对照组(0.45±0.15)明显升高(t=-2.061,P<0.05);血清GSH-Px活性[(258.24±45.25)U/(ml·min)]较健康对照组[(215.11±47.62)U/(ml·min)]明显升高(t=-2.2349,P<0.05)).而AR患者血清SOD活性、MDA含量较健康对照组分别有升高和降低趋势,但差异无统计学意义(Z=-1.656,t=1.922,P值均>0.05).结论 氧化应激反应参与AR病理生理过程,而iNOS-NO通路在AR的发病过程中可能发挥着更为重要的作用.     

Clinical significance of elevated serum sICAM-1 in patients with nasopharyngeal carcinoma]

OBJECTIVE: To study the expression of serum sICAM-1(soluble intercellular adhesion molecule-1) and tissue ICAM-1 in nasopharyngeal carcinoma and its clinical significance. METHODS: Expression of ICAM-1 in frozen sections of 20 normal nasopharyngeal mucosa and 54 nasopharyngeal carcinoma samples were studied with immunohistochemical technique, and levels of serum sICAM-1 in 54 patients with nasopharyngeal carcinoma (NPC group) and 32 healthy adults (normal group) by ELISA. RESULTS: Positive expression (45/54) of tissue ICAM-1 and levels (2,044.48 +/- 640.05) microgram/L of serum sICAM-1 in NPC group were significantly higher than that of 2/20 and (313.70 +/- 114.98) microgram/L in normal group (P < 0.01, respectively), and there was a positive relationship between the expression of tissue ICAM-1 and levels of serum sICAM-1 in nasopharyngeal carcinoma(P < 0.05). The levels (2,177.31 +/- 642.13) microgram/L of serum sICAM-1 in patients with III-IV stages were higher than those (1,847.25 +/- 308.15) microgram/L in I-II stages (P < 0.05), and those (1,678.89 +/- 685.01) microgram/L in patients with no lymph node metastasis lower than that (2,134.34 +/- 609.60) microgram/L in lymph node metastasis (P < 0.05). The levels of serum sICAM-1 decreased significantly from (2,211.42 +/- 717.59) microgram/L to (926.55 +/- 207.72) microgram/L in disappearance of tumor and metastatic lymph node after radiotherapy (P < 0.01). CONCLUSION: sICAM-1 might be involved in the cellular immunopathogenesis of nasopharyngeal carcinoma, and the measurement of the serum sICAM-1 may reflect ability of neoplasm cell in freedom from host immunological surveillance. Dynamic measurement of serum sICAM-1 may be a useful objective index to evaluate NPC prognosis and curative effects.     

鼻咽癌患者鼻咽分泌物中肿瘤坏死因子α含量的临床观察

目的 :探讨鼻咽癌患者鼻咽分泌物中肿瘤坏死因子 α(TNF- α)含量变化的临床意义。方法 :用特制装置收集 2 0例健康者和 5 2例鼻咽癌患者的鼻咽分泌物 ,应用放射免疫技术进行 TNF- α含量测定。结果 :对照组鼻咽分泌物中 TNF- α含量为 (12 .95± 4.6 2 ) pmol/ L,肿瘤组为 (33.6 8± 15 .13) pm ol/ L,肿瘤坏死组为 (6 4.0 0±11.5 7) pm ol/ L。肿瘤组含量明显高于对照组 ,其差异有极显著性意义 (P <0 .0 1) ;肿瘤坏死组含量进一步升高 ,与肿瘤组比较 ,其差异亦有极显著性意义 (P<0 .0 1)。结论 :鼻咽癌患者鼻咽分泌物中 TNF- α含量高于正常人 ,测定鼻咽分泌物中 TNF- α含量有助于鼻咽癌的诊断。     

阻塞性睡眠呼吸暂停低通气综合征患者的血清瘦素水平

目的探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清瘦素水平以及悬雍垂腭咽成形术对瘦素水平的影响。方法对61例经过多道睡眠监测确诊的OSAHS患者行改良悬雍垂腭咽成形术。采用放射免疫测定法,测定OSAHS患者术前、术后以及20例年龄、体重指数相近的单纯打鼾患者(对照组)的血清瘦素水平,分析瘦素与呼吸暂停及低通气指数(AHI)、体重指数(BMI)的关系以及术前、术后血清瘦素水平的变化。结果OSAHS患者与对照组的血清瘦素水平( x±s)分别为(15 3±8 0)μg/L、(6 1±3 1)μg/L,差异有统计学意义(P<0 05)。在OSAHS患者中,轻度、中度、重度患者的血清瘦素水平分别为(9 8±2 1)μg/L、(14 2±6 7)μg/L、(19 3±7 9)μg/L,血清瘦素水平与阻塞程度呈正相关(r=0 68,P<0 01 )。61例中52例有效者术后6个月血清瘦素水平(7 0±1 3)μg/L,与术前(15 2±3 9)μg/L相比,差异有统计学意义(P<0 01),这种差异与BMI无关,而无效者(9例)血清瘦素水平无明显变化。结论OSAHS患者血清瘦素水平增高,且瘦素水平与睡眠呼吸暂停的程度有密切联系;悬雍垂腭咽成形术治疗有效者血清瘦素水平下降。呼吸暂停有可能是导致OSAHS患者体内瘦素水平增高的重要因素。     

鼻咽癌患者外周血CD4+CD25high调节性T细胞分析

目的:探讨鼻咽癌患者外周血CD4 CD25h igh调节性T(Tr)细胞比例变化的特点及其临床意义。方法:采用流式细胞术检测54例初治鼻咽癌患者(鼻咽癌组)和15例健康者(对照组)外周血中CD3 、CD4 、CD8 及CD4 CD25h ighT细胞比例。结果:鼻咽癌患者CD4 T细胞比例、CD4 /CD8 比值均低于对照组(均P<0.05),但CD4 CD25h ighTr细胞比例明显高于对照组(P<0.01)。随疾病进展鼻咽癌患者外周血CD4 CD25h ighTr细胞比例升高[Ⅰ Ⅱ期为(2.28±1.07)%,Ⅲ期为(3.65±1.21)%,Ⅳ期为(4.72±0.87)%],Ⅰ Ⅱ期与Ⅲ、Ⅳ期比较,均P<0.01;Ⅲ期与Ⅳ期比较,P<0.01。结论:CD4 CD25h ighTr细胞可能是鼻咽癌患者免疫抑制的重要原因之一,与鼻咽癌免疫逃逸有关。外周血CD4 CD25h ighTr细胞比例可能成为鼻咽癌一种新的预后判断指标,去除这群细胞可有效诱导肿瘤免疫,为肿瘤治疗提供一种新的方法。     

儿童阻塞性睡眠呼吸暂停低通气综合征对抗利尿激素水平的影响

目的 探讨儿童阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea hypopnea syndrome,OSAHS)对体内抗利尿激素(antidiuretic hormone,ADH)分泌水平的影响.方法 30例确诊为OSAHS的患儿分别于扁桃体+腺样体切除术前和术后行多道睡眠监测,在深睡期取静脉血采用放射免疫技术检测患儿血浆中ADH水平并记录夜间12 h尿量,与20例健康儿童夜间深睡期ADH水平和12 h夜尿量进行比较分析.结果 OSAHS患儿呼吸暂停低通气指数术后2个月由术前(17.4±2.6)次/h(-x±s,下同)下降至(3.3±1.4)次/h,最低动脉血氧饱和度由0.783±0.134上升至0.954±0.062,差异有统计学意义(t值分别为27.68和6.45,P值均＜0.001).OSAHS患儿夜间血浆ADH水平为(63.1±35.2)ng/L,明显低于健康儿童的(85.1±22.2)ng/L,夜尿量(492±90)ml显著高于健康儿童(346±62)ml,差异有统计学意义(t值分别为2.75和6.43,P值均＜0.01);治疗后ADH达(83.1±21.2)ng/L,较术前明显上升(t=2.56,P＜0.05),夜尿量(332±56)ml较术前明显下降(t=7.85,P＜0.001),与健康儿童相比差异均无统计学意义(t值分别为0.17和0.77,P值均＞0.05).结论 OSAHS患儿可能因夜间ADH水平下降导致夜尿增多,解除呼吸道梗阻使患儿睡眠恢复正常,可能促使ADH水平趋于正常,夜间尿量减少.     

Comparison of CYFRA 21-1 and squamous cell carcinoma antigen in detecting nasopharyngeal carcinoma

CYFRA 21-1 is a newly developed tumor marker that is especially useful for detecting squamous cell carcinoma (SCC) of the lung. Squamous cell carcinoma antigen is a proven tumor marker that is especially useful for detecting SCC of the cervix. Our aim in this study was to compare the clinical value of CYFRA 21-1 and SCC antigen in the detection of nasopharyngeal carcinoma (NPC). Serum levels of CYFRA 21-1 and SCC antigen were measured in 80 untreated NPC patients and 77 healthy controls. The cutoff values of CYFRA 21-1 and SCC antigen, determined at the 95th percentile of the 77 healthy controls, were 2.48 ng/mL and 1.49 ng/mL, respectively. The results revealed that the mean serum value of only CYFRA 21-1 was significantly higher in the 80 NPC patients than in the 77 healthy controls, and the detection sensitivity of CYFRA 21-1 for NPC was significantly higher than that of SCC antigen. In conclusion, our results suggest that CYFRA 21-1 is a better tumor marker than SCC antigen for detection of NPC.     

阻塞性睡眠呼吸暂停低通气综合征合并高血压患者睡眠结构分析及血清内皮素-1的测定

OBJECTIVE: To explore the role of endothelin-1 (ET-1) in the pathogenesis of hypertension in obstructive sleep apnea hypopnea syndrome (OSAHS). METHODS: The levels of serum ET-1 in 30 OSAHS patients accompanied by hypertension, 30 normotensive OSAHS patients and 30 healthy controls were measured by ET-1 enzyme immunoassay kit. Meanwhile the correlation about the concentration of ET-1 in OSAHS patients with the clinic, polysomnography (PSG) parameters was analyzed. RESULTS: OSAHS patients with or without hypertension compared with snoring group and normal people, the sleep structure was significantly disturbed. The time percentages of awake and stage I sleep were increased, while stage II sleep decreased significantly in OSAHS patients than those in snoring group (P < 0.01, respectively). There were no significantly difference about the sleep structure in the two OSAHS groups. The levels of serum ET-1 (mean +/- s) were significantly higher in OSAHS patients accompanied by hypertension and normotensive OSAHS patients(42.5 +/- 8.4) ng/L and (38.6 +/- 4.7) ng/L respectively than those in the healthy controls(33.1 +/- 5.4) ng/L (P < 0.01, respectively). In the two OSAHS groups, the levels of serum ET-1 were significantly higher in OSAHS patients accompanied by hypertension than those in the normotensive OSAHS patients (P < 0.05). There were positive correlations between the concentration of ET-1 and the apnea hypopnea index (AHI) in all the 60 OSAHS patients with and without hypertension (r = 0.334, P < 0.01). There were negative correlations between the concentration of ET-1 and the lowest oxygen desaturation in all the 60 OSAHS patients with and without hypertension (r = -0.230, P < 0.05). CONCLUSION: These results indicate that the sleep disordered breathing and hypoxia may contribute to the elevation of ET-1 in the OSAHS patients and OSAHS patients accompanied by hypertension. ET-1 may play an important role in the pathogenesis of OSAHS-induced hypertension.     

扁桃体炎血清可溶性白细胞介素2受体测定及其临床意义

目的 :观察扁桃体炎血清可溶性白细胞介素 2受体 (SIL- 2 R)水平及其临床意义。方法 :采用 EL ISA双抗夹心法检测 6 8例急慢性扁桃体炎及 6 8例正常人血清 SIL- 2 R水平。结果 :初发急性扁桃体炎及慢性扁桃体炎急性发作期患者 SIL - 2 R水平分别为 (6 42 .2± 87.2 )× 10 3u/ L ,(76 2 .3± 90 .5 )× 10 3u/ L ,均显著高于正常对照组的 (2 85 .5± 49.6 )× 10 3u/ L (P <0 .0 1) ,而且后者高于前者 (P <0 .0 1)。慢性扁桃体炎慢性期与正常对照无显著性差异 (P >0 .0 5 ) ,抗生素治疗 3～ 5 d后有效病例血清 SIL - 2 R明显下降。结论 :血清 SIL - 2 R测定对扁桃体炎诊断及疗效判定有一定意义。     

性激素受体表达与鼻咽癌生物学行为的关系

探索性激素受体的表达与鼻咽癌生物学行为的关系。方法：用免疫组化ＬＳＡＢ法，对７１例ＮＰＣ组织标本作雌激素受体和孕激素受体进行测定，并结合ＣＴ扫描结果，临床表现进行分析，结果：７１例中，ＥＲ的－、＋、例数分别为４例、１９例，２７例和２１例；