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男 ,8岁。入院 12h前进食甘蔗 3节 ,7h后出现阵发性脐周痛 ,频繁喷射性呕吐 ,呕吐物为胃内容物 ,量中等 ,伴哭闹、烦躁。入院前 2h突然抽搐 ,表现为双眼上翻 ,吐沫 ,口周发绀 ,头后仰 ,双拳紧握 ,四肢抽动 ,呼之不应 ,历时约 10min。抽后入睡 ,半小时后清醒 ,1h后再次抽搐 ,约 8min缓解。查体 :T 36 ,R 30 ,P 10 0 ,BP 13 2 / 10kPa ,神志清 ,躁动 ,痛苦面容 ,双瞳孔等大 5mm ,对光反应灵敏 ,颈抗 (- ) ,心肺无异常 ,腹软 ,脐周压痛 ( ) ,肠鸣音活跃 ,神经系统无异常。诊断 :霉变甘蔗中毒 ,中毒性脑病 ?入院后立即催吐 ,5 0 %硫酸镁导泻 … 相似文献
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《Current medical research and opinion》2013,29(3):223-229
SummaryClozapine is a dibenzodiazepine derivative and a truly atypical anti-psychotic. Its therapeutic effects are probably mediated by dopaminergic and serotonergic activity. Although it appears to be the most effective antipsychotic drug for treatment-resistant schizophrenia, its general use is limited because of the risk of agranulocytosis. 相似文献
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Green B 《Current medical research and opinion》2002,18(3):113-117
Amisulpride is a second-generation antipsychotic, a substituted benzamide. It appears to be an effective agent in treating schizophrenia for what are characterised as positive and negative symptoms. The recommended doses are between 400 mg/day and 800 mg/day. Amisulpride demonstrates a good global safety profile, particularly when compared with first-generation antipsychotics, such as haloperidol. There are interesting studies that point towards amisulpride's antidepressant effect in dysthymia speculative on possible roles in affective psychoses and chronic fatigue syndrome. 相似文献