共查询到20条相似文献,搜索用时 15 毫秒
1.
T. N. Makarenko G. N. Chernobaeva L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1994,118(6):1303-1306
A satistically significant decrease in the content of cytochromes P-450 and b5 and in the activity of aniline hydroxylase and p-nitroanisole demethylase occurs in rat liver microsomes during the development
of experimental acute fatty hepatosis develoing within a 24-h period after intraperitoneal administration of 125 mg/kg tetracycline
hydrochloride. Under these experimental conditions tetracycline hydrochloride elicits only an insignificant disintegrating
effect on oxidative phosphorylation in liver mitochondria.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
12, pp. 612–615, December, 1994 相似文献
2.
S. V. Sibiryak S. A. Sergeeva S. A. Kryzhanovskii I. L. Krasilova 《Bulletin of experimental biology and medicine》1996,121(2):163-166
A relationship is revealed between macrophage activation, suppression of cytochrome P-450-dependent liver monoxygenases, and
the hydrocortisone level in the sera of mice in response to bacterial lipopolysaccharides and muramyldipeptide.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
2, pp. 177–180, February, 1996
Presented by M. D. Mashkovskii, Member of the Russian Academy of Medical Sciences 相似文献
3.
A. S. Saratikov A. I. Vengerovskii 《Bulletin of experimental biology and medicine》1999,127(4):355-357
Phospholipid-containing hepatoprotectors essentiale and eplir inhibited conversion of cytochrome P-450 into cytochrome P-420
and restored aminopyrine N-demethylase and anilinen-hydroxylase activities of cytochrome P-450 in rats during acute hepatitis induced by CCl4 and allyl alcohol. The polyphenol phytopreparation legalon did not prevent degradation of cytochrome P-450. Differences in
the effects of hepatoprotectors on the impaired antitoxic function of the liver are probably associated with the abilities
of essentiale and eplir to provide phospholipids for regeneration of endoplasmic reticulum membranes of hepatocytes.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 392–394, April, 1999 相似文献
4.
The ability of dimedrol to inhibit o-demethylation of paranitroanisole, which in rat liver is catalyzed by cytochrome P-450,
is demonstratedin vivo andin vitro. The affinity of dimedrol for cytochrome P-450 is higher than that of other xenobiotics. It is suggested that the effect
of dimedrol on the metabolism of paranitroanisole and some other xenobiotics is realized during formation of the enzyme—substrate
complexes between these substances and cytochrome P-450.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 9, pp. 301–304, September, 1997 相似文献
5.
A statistically significant circadian rhythm of hypnogenic effect of hexenal is revealed in intact Wistar rats, with the maximum
recorded in the daytime and the minimum at night, and an amplitude of at least 30% of the mesor. Circadian rhythms of the
analgetic action of hexenal and of α-tocopherol concentrations in the blood serum are found to be in reciprocal relationship.
Experimental hepatosis induced by intragastric administration of CCl4 is attended by alteration of the time organization of the antitoxic function of the liver and of the concentrations of iron,
α-tocopherol, and lipid peroxidation products in the blood collected from the hepatic and portal veins.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
5, pp. 540–543, May, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
6.
S. Mauersberger E. Krgel R. N. Matyashova H.-G. Müller 《Journal of basic microbiology》1987,27(10):565-582
After spheroplast lysis and differential centrifugation the alkane monooxygenase system consisting of cytochrome P-450 and the NADPH-cytochrome P-450 reductase of alkane-grown Candida maltosa cells is enriched in the microsomal fraction. This membrane fraction is nearly free of intact mitochondria (cytochrome oxidase) and peroxisomes (catalase), but contains considerable amounts of plasma membrane fractures (azide insensitive, vanadate-sensitive Mg2+-ATPase) as demonstrated by biochemical an electron microscopic examinations. By means of sucrose density gradient centrifugation it was possible to separate the cytochrome P-450 containing membranes ( = 1,11 g/cm3) from the plasma membranes ( = 1,18 g/cm3). Therefore the cytochrome P-450 alkane monooxygenase system is most likely localized in the endoplasmic reticulum of the yeast cells. For the following enzymatic steps of terminal alkane oxidation to the corresponding fatty acid a quite different subcellular distribution was observed. The fatty alcohol oxidase and aldehyde dehydrogenase activities are mainly localized in the mitochondrial peroxisomal membrane fraction. During the oxidation of n-alkanes by yeast cells the fatty alcohol should be regarded as an intracellular transport from between the cytochrome P-450 containing endoplasmic reticulum and the sites of its further oxidation in peroxisomes and mitochondria. 相似文献
7.
In animals with hereditary degeneration of the retina the level of cytochrome P-450 in the brain microsomal fraction is found
to be higher than that in healthy animals. In rats with hereditary degeneration of the retina the activity of NADPH-cytochrome
P-450 reductase is unchanged in all tissues examined except for the retina, where it is markedly higher than in healthy animals
on postnatal day 90.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
3, pp. 259–261, March, 1994 相似文献
8.
Yu. P. Bel'skii N. V. Zemlyanskaya S. A. Kusmartsev I. M. Agranovich 《Bulletin of experimental biology and medicine》1995,120(2):829-831
The suppressor activity of bone marrow cells not adhering to plastic is shown to appreciably increase after their 48-hour
joint preincubation with mastocytoma P-815 supernatant or WEHI-3 myelomonocytic strain and to be unchanged after incubation
with dupernatants of K-2 erythroleukemic strain or Ehrlich's ascitic carcinoma. P-815, WEHI-3, and K-2 tumors are shown to
produce factors characterized by colony-stimulating activity.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
8, pp. 184–187, August, 1995
Presented by N. V. Vasil'ev, Member of the Russian Academy of Medical Sciences 相似文献
9.
L. F. Gulyaeva L. Yu. Zakharova V. V. Lyakhorich T. S. Morozkova V. I. Kaledin 《Bulletin of experimental biology and medicine》1998,126(2):820-822
Specific activity of cytochrome P-450-1a is detected in the liver of 7 inbred mouse strains sensitive (SWR, C3HA, DD, and
CBA) and resistant (AKR, CC57BR, and C57BL) to o-aminoazotoluene-induced hepatocarcinogenesis: 7-ethoxyresorufin-O-diethylase
and 7-methoxyresorufin-O-dimethylase, induced by benzo(a)pyrene and o-aminoazotoluene. Mice sensitive (CC57BR and C57BL) and
resistant (AKR) to P-450-1a induction were resistant to induction of liver tumor and, similarly, mice both resistant (SWR
and DD) and sensitive (C3HA and CBA) to P-450-1a induction were sensitive to hepatic tumor induction. Therefore, there was
no correlation between inducibility of cytochrome P-450-1a and sensitivity to o-aminoazotoluene-induced hepatocarcinogenesis
at the initial stages of chemical carcinogenesis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 126, No. 8, pp. 201–203, August, 1998 相似文献
10.
V. N. Babin N. V. Chen O. A. Kondrakova Yu. I. Lyakhovetskii I. V. Dobryakova N. F. Dmitrieva A. V. Dubinin 《Bulletin of experimental biology and medicine》1995,119(5):477-479
Gas-liquid chromatographic determination of the levels and profiles of volatile fatty acids (acetic, propionic, and butyric
acids) in saliva samples from healthy volunteers and patients with acute or chronic tonsillitis revealed lowered concentrations
of these acids in the saliva of patients and the presence of disease-specific fatty acid profiles.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
5 pp. 494–496, May, 1995
Presented by I. V. Domaradskii, Member of the Russian Academy of Medical Sciences 相似文献
11.
G. G. Dirlam 《Bulletin of experimental biology and medicine》1994,117(5):562-564
A study of capillaries and pyramidal neurons of the cortex in white rats subjected to ligation of the common carotid artery
reveals that acute reduction of the circulation is characterized by a decreased activity of alkaline phosphatase and Na, K-ATPase
as well as a reduced number of capillaries marked with these enzymes, and a lower activity of butyrylcholine esterase. A decreased
activity of cytochrome oxidase in neurons suggests the existence of intracellular compensatory-adaptive mechanisms.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 558–560, May, 1994
Presented by O. S. Adrianov, Member of the Russian Academy of Medical Sciences 相似文献
12.
A. P. Shepelev A. V. Shestopalov A. A. Ryndich I. M. Staviskii V. V. Yagovkina 《Bulletin of experimental biology and medicine》1995,120(3):970-971
Thin-layer chromatography of DNA-bound lipids of thermolabile and thermoresistantShigella sonnei strains shows a lower content of neutral lipids and higher contents of polyglycerophosphatides and cholesterol in thermoresistant
strains. This is regarded as a factor providing for the active state of DNA.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
9, pp. 332–333, September, 1995 相似文献
13.
A study of kinetic parameters of brain respiratory enzymes revealed that the maximal velocity and the Michaelis apparent constant
for NADH-cytochrome C-reductase are significantly lower in low-resistant rats than in rats with a high resistance to hypoxia.
Adaptation to periodic hypoxia increases total resistance only in low-resistant rats. It is accompanied by an increase in
the values of kinetics parameters for NADH-cytochrome C-reductase and cytochrome oxidase. Kinetic parameters for these enzymes
in the brain of high-resistant rats are either unaltered or even decreased. It is suggested that the first enzymatic complex
of the respiratory chain is one of the limiting or regulating links in energy metabolism determining the brain's resistance
to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 252–255, March, 1996. 相似文献
14.
Wei Huang T. G. Vishnyakova A. V. Bocharov E. V. Zaitseva E. G. Frolova D. D. Sviridov V. S. Repin J. -L. Nano P. Rompal 《Bulletin of experimental biology and medicine》1994,117(1):52-55
It is shown that glucocorticoids play a key regulatory role directed toward the maintenance of an optimal level of binding
and internalization of HDL3 in hepatocytes. Their stimulatory effect on the expression of HDL receptors proves to be independent of changes in the CH
content in parenchymal cells.
Translated fromByulleten' Eksperimentalnoi Biologii i Meditsiny, Vol. 117, N
o
1, pp. 50–53, January, 1994 相似文献
15.
I. V. Zverinskii M. I. Bushma L. F. Legon’kova P. I. Lukienko K. A. Eismont 《Bulletin of experimental biology and medicine》1997,123(4):362-365
Six day after rat liver sonication, the content of cytochrome P-450, rate of NADPH oxidation, activity of NADPH—cytochrome
P-450 reductase, and rate of aniline hydroxylation in the microsomal fraction decrease. After 12 days, the rate of ethylmorphine
N-demethylation also decreases. Intragastral administration of methionine, nicotinamide, and vitamin E for 6 and 12 days activates
these enzymes and uridine 5′-diphosphate glucuronyl transferase.
Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 123, No. 4, pp. 420–423, April, 1997 相似文献
16.
E. S. Dremina T. V. Vakhrusheva V. S. Sharov O. A. Azizova Yu. A. Vladimirov 《Bulletin of experimental biology and medicine》1995,119(2):135-139
It is demonstrated that the content of the primary products of lipid peroxidation reaches the maximum after about 1-h incubation
with Cu2+ and then declines. At a Cu2+ concentration of about 10–15 μM, the content of lipid peroxidation products is maximal; it does not rise with a further increase
in the Cu2+ concentration. Comparison of the kinetics of lipid peroxidation in different lipoprotein fractions shows that low density
lipoproteins are much more strongly oxidized than high density lipoproteins. A strong positive correlation between the amplitude
of the chemiluminescence burst and the diene conjugate content is established in 79 independent measurements.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
2, pp. 144–148, February, 1995 相似文献
17.
A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1995,120(6):1193-1195
After a prolonged (for 30 days) adaptation of rats to intermittent hypoxia, their brains contained lowered levels of mitochondrial
cytochromes, despite an increase in the number of mitochondria in the brain tissue mass, along with similar levels of high-energy
compounds and more protein as compaired to the brains of unadapted controls. A mitochondrial population with novel properties
presumably emerged in the brain. These effects were all more strongly marked in rats with an initially low resistance to hypoxia.
In the liver of hypoxiaadapted animals, unlike in their brain, cytochrome levels in the mitochondrial and microsomal redox
chains were lowered and the biogenesis of mitochondria was much less intensive.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 576–579, December, 1995 相似文献
18.
L. I. Deev E. N. Goncharenko A. A. Baizhumanov M. Ya. Akhalaya S. V. Antonova S. V. Shestakova 《Bulletin of experimental biology and medicine》1997,124(1):665-667
Under the conditions of hyperthermia, carnosine (β-alanine-l-histidine) normalizes tissue contents of lipid peroxidation products, cytochrome P-450, serotonin, and histamine in rats
and increases their survival after extreme hyperthermia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 7, pp. 50–52, July, 1997 相似文献
19.
V. V. Alatyrtsev A. E. Aleksandrov A. U. Lekmanov M. I. Bakanov 《Bulletin of experimental biology and medicine》1995,119(6):608-610
It is shown that in deep acute hypoxic hypoxia the 2,3-diphosphoglycerate content is reduced and the adenosine triphosphate
content unchanged in the erythrocytes of newborn rats. Under the same conditions adult animals show an increase of 2,3-diphosphoglycerate
and a drop in the adenosine triphosphate content in the erythrocytes. The importance of these changes is discussed in terms
of the mechanisms regulating the oxygen-transporting function of erythrocytes during acute hypoxic hypoxia in newborn and
adult animals.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 631–633, June, 1995
Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences 相似文献
20.
V. E. Pogorelyi M. D. Gaevyi E. R. Davidov V. V. Gatsura 《Bulletin of experimental biology and medicine》1995,120(6):1251-1253
The effects of animal and biotechnological cytochrome C and its hemtetradecapeptide in a heme-isomolar dose on the cerebral
bloodflow, oxygen and glucose consumption, and pH of the ischemized brain were studied in cat experiments. Cytochrome of both
types and hemtetradecapeptide increased the consumption of oxygen and glucose by ischemized brain tissue and somewhat reduced
the development of acidosis. The shifts of oxidative metabolism parameters of the ischemized brain correlated with inhibition
of the development of postischemic hypoperfusion of the brain.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 640–642, December, 1995
Presented by P. V. Sergeev, Member of the Russian Academy of Medical Sciences 相似文献