生殖器及肛周发疹性瘙痒性兵疹性汗孔角化病1例

报告1例局限于生殖器及肛周的发疹性瘙痒性丘疹性汗孔角化病。患者男性,41岁。阴茎汗孔角化病10年后,在阴囊、肛周出现瘙痒剧烈的红色斑丘疹。皮肤活检显示丘疹的边缘隆起处有角化不全鸡眼样板。     

混合型汗孔角化病

报告1例混合型汗孔角化病.患者男,45岁.面部、背部及四肢出现角化性丘疹20余年,腹股沟、外阴及肛周出现结节5年.皮损组织病理检查符合汗孔角化病表现.     

播散性浅表汗孔角化病并发寻常性银屑病

报告2例播散性浅表汗孔角化病并发寻常性银屑病.例1.男,53岁.头部、下肢红斑鳞屑3年,环形斑块1年.皮肤科检查:头皮鳞屑性红斑,面部、臀部散在边缘堤状隆起而中央轻度萎缩的褐色环状斑块.例2.男,37岁.全身红斑、鳞屑8年,环形斑块2年.皮肤科检查:头皮鳞屑性红斑,躯干、四肢鳞屑性红斑与边缘堤状隆起而中央轻度萎缩的褐色环状斑块混杂分布,两例患者红斑鳞屑性皮损经组织病理检查均符合寻常性银屑病,褐色环状斑块改变均见下方颗粒层消失的柱状角化不全,符合播散性浅表汗孔角化病.诊断:播散性浅表汗孔角化病并发寻常性银屑病.文中对银屑病并发汗孔角化病的可能原因进行了讨论.     

角化性皮肤病

20 0 13170　生殖器及肛周发疹性瘙痒性丘疹性汗孔角化病 1例 /王耀祖 (上海二医大瑞金医院皮肤科 )…∥临床皮肤科杂志 .- 2 0 0 1,30 (2 ) .- 12 5～ 12 6男 ,4 1岁 ,1984年阴茎出现一绿豆大、褐色、略高于皮面的环状损害 ,无明显自觉症状。 1994年阴囊出现黄豆大圆形红色斑丘疹 ,瘙痒剧烈。以后类似皮损逐渐增多 ,累及肛周 ,治疗效果差。皮肤组织病理 :表皮轻度角化过度 ,灶性角化不全处颗粒层消失 ,表皮凹陷处有角化不全鸡眼样板 ,其下颗粒层部分消失 ,表皮棘层不规则肥厚 ,棘细胞排列不规则 ,细胞有异形 ,并有少量异常核分裂 ,真皮浅层…     

播散性浅表性光线性汗孔角化病继发皮肤淀粉样变性1例并文献复习

报告1例播散性浅表性光线性汗孔角化病继发皮肤淀粉样变性。患者女,69岁。躯干及四肢褐色环状斑片30年,加重伴瘙痒1年。皮肤科检查:胸部、右侧肩部及四肢可见散在分布、边界清晰的直径0.3～1.5 cm环形褐色斑片,边缘呈角化性堤状隆起,中央略萎缩凹陷。双侧小腿可见圆形或类圆形直径0.1～0.3 cm褐色丘疹,表面粗糙,质硬,其间可见大小不一的环状或不规则形褐色斑片。右肩部皮损组织病理检查:角化过度,表皮性凹窝中可见角化不全柱,下方无颗粒层,真皮浅层少量淋巴细胞浸润,可见噬色素细胞,符合播散性浅表性光线性汗孔角化病。下肢皮损组织病理检查:角化过度,未见角化不全柱,表皮轻度增生,真皮乳头层增宽,其内有强折光性、轻度嗜伊红物质,其间有裂隙,可见组织细胞和噬色素细胞浸润。刚果红染色阳性,符合皮肤淀粉样变性。诊断:播散性浅表性光线性汗孔角化病继发皮肤淀粉样变性。     

播散性浅表性光化性汗孔角化症1例

<正>1临床资料患者女,58岁。全身出现皮疹伴瘙痒并反复发作23年。23年前夏季患者无明显诱因手部皮肤出现瘙痒,搔抓后起淡红色丘疹,自行外搽皮炎平,疗效较好,但易反复发作。外院多次以"结节性痒疹"予外搽药物(药名不详)和口服盐酸左西替利嗪和扑尔敏治疗,疗效尚可。本次在田间收水稻时皮损复发,瘙痒加剧。门诊以"播散性浅表性光化性汗孔角化     

外生殖器部位的棘层松解性皮病

报告1例发生于外生殖器部位的棘层松解性皮病.患者女,311.外阴、肛周出现灰白色丘疹6个月,无明显疼痛、瘙痒等不适,部分皮损轻度糜烂、结痂.皮损组织病理检查:表皮灶性角化过度、角化不全,棘层肥厚,棘细胞松解,角化不良.表皮下血管增生,淋巴细胞浸润,直接免疫荧光检查阴性.     

播散性浅表光线型汗孔角化症1例

我院发现播散性浅表光线型汗孔 角化症1例,现报告如下。 1病历摘要 患者,男,31岁,以“面部、颈、躯干散在环状角化性褐色小丘疹伴轻度瘙痒10年”来我院就诊。患者10年前无明显诱因先于面颊部出现数个针头大小褐色皮疹,有时伴轻度瘙痒,     

伴炎症反应的汗孔角化病三例

汗管角化症是一种少见的慢性角化性皮肤病,以中央轻度萎缩边缘堤状角质嵴围绕的皮损为特征。组织病理学特征为角样板层。本病一般无临床症状,但伴明显瘙痒的汗孔角化症已经有文献报告,并被命名为“发疹性瘙痒性丘疹型汗管角化症”或“处于炎症反应期的DSP”。笔者近期诊断三例这样的病患并推荐使用“发疹性瘙痒性丘疹型汗管角化症”来命名这一特殊类型的汗孔角化症。     

角化性皮肤病

20060848播散性表浅性光化性汗孔角化症1例/张大维(四川大学华西医院皮肤科),黄俊,王琳…∥临床皮肤科杂志.-2005,34(10).-691女,38岁。颜面部、四肢多数角化性环形浅褐色皮损20年。检查:双面颊可见米粒至扁豆大灰褐色或棕褐色角化性斑疹,呈环形或不规则环形,中央略萎缩凹陷,周围呈角化性锯齿状堤状隆起,质硬,表面粗糙。鼻梁部数个皮损融合呈地图状。四肢运端散在数个类似皮损。组织病理检查:汗孔周边堤状隆起处组织病理改变为角化过度和棘细胞肥大,堤顶有裂沟,沟内有大的角质栓,其下颗粒层消失。图1(刘艳)20060849播散性浅表性光化性汗孔角…     

Creeping eruption on the genitals

A case of filarial infestation of the glans penis, producing "creeping eruption" in an Indian man is described. The 52-year old man developed 3 pruritic, vesicular lesions on the glans penis 4 days before presenting with progressing serpiginous tracts on the glans. The tracks had advanced 6-8 mm per day, leaving crusts at their ends. He had slept on a wet sandy beach 3 days before the lesions appeared. He denied history of sexual contact. There were no other clinical signs of sexually transmitted diseases, and laboratory tests were negative for VDRL. He was diagnosed with filiariform larval infestation of a nematode, probably Ancylostoma species. He was treated with oral diethylcarbamazine 100 mg t.i.d. for 7 days The tracks stopped growing in 3 days and the lesions resolved in 1 week.     

获得性复发性自愈性Blaschko皮炎

报告1例获得性复发性自愈性Blaschko皮炎.患者男,41岁.右胸背部反复出现丘疱疹伴剧烈瘙痒20余年.组织病理示海绵水肿性皮炎.结合临床和组织病理诊断为获得性复发性自愈性Blaschko皮炎.     

Generalized eruptive keratoacanthoma with vitiligo followed by the development of prurigo nodularis: A case report and published work review

Herein, we report a unique case of generalized eruptive keratoacanthoma (GEKA) in a 47‐year‐old Chinese man presenting with extensive pruritic papules and nodules accompanied by oral lesions. He also had a 2‐year history of vitiligo and long‐term experience of working outdoors. Biopsies were consistent with keratoacanthoma . Interestingly, prurigo nodularis (PN) was found in histopathology at 1‐year follow up. To our knowledge, this is the first report describing a case of GEKA with oral lesions complicated with vitiligo and developed with PN.     

疱疹样天疱疮1例

患者男,25岁。头皮红斑脱屑1年伴躯干四肢红斑水疱、瘙痒1月。体检:头皮、躯干及四肢伸侧呈环形或半环形排列的紧张小水疱,尼氏征阴性。皮损组织病理示:表皮内水疱及嗜酸性海绵形成,无棘层松解细胞,真皮混合炎症细胞浸润。直接免疫荧光示C3棘细胞间沉积。诊断:疱疹样天疱疮。     

Erythema gyratum repens responding to cetirizine hydrochloride

We report a case of erythema gyratum repens (EGR) in a 59-year-old man with inoperable pancreatic cancer and liver metastasis. The patient had a widespread erythema with concentric marginal band spreading in waves over the trunk and extremities. Numerous vesicles were seen on the margin of the erythema. The skin lesions were severely pruritic, and his peripheral blood showed marked eosinophilia. He also had palmoplantar hyperkeratosis. A biopsy specimen of the erythema disclosed spongiosis, microvesicles filled with eosinophils, infiltration of eosinophils into the epidermis, and a perivascular infiltrate in the dermis. The skin lesions and pruritus cleared quickly after the administration of cetirizine hydrochloride.     

Localised genital Norwegian scabies in an AIDS patient

OBJECTIVES: We present a case of an AIDS patient with Norwegian scabies manifest by a single, crusted plaque localised to the glans penis. METHODS: A 45 year old man with AIDS presented to our clinic complaining of a red papular pruritic rash on his abdomen and anterior thighs and a single, thick, crusted, non-pruritic lesion on the penis. He had been treated with lindane topically prior to the development of the penile lesion without resolution of the pruritus or red papular lesions. A mineral oil preparation was obtained from the hyperkeratotic penile lesion and revealed numerous mite eggs and faeces. RESULTS: The diagnosis of localised, genital Norwegian scabies was made. The patient was treated with ivermectin 200 micro g/kg per dose taken as two doses, 14 days apart, with complete resolution of both pruritus and skin lesions. CONCLUSIONS: This patient is the first known report of Norwegian scabies localised as a single lesion on the penis. He was successfully treated with oral ivermectin monotherapy.     

Dermatitis artefacta?

A 35-year-old man presented with a 2-month history of intensely pruritic excoriated and crusted linear lesions on the dorsa of the left hand and left forearm (Fig 1). The patient had worked in construction for 2 years, and his job consisted mainly in covering the facades of buildings with cement. The patient was right-handed and used a black rubber glove as a protective measure only on his left hand (Fig 2). He reported that the lesions resolved partially during holidays and weekends and clearly flared in association with his work. There was no history of atopic dermatitis, drug use, or intolerance to metals, rubber, or fruits. On physical examination, linear excoriations with crusts were observed on the dorsa of the left hand, extending to the ventral and dorsal aspects of the forearm, involving the whole area that was in contact with the glove. Lichenified erythematous plaques and excoriations on the dorsal surface of the metacarpophalangeal joints and scaly lesions on the dorsal surfaces of the fingers were also present. On the palm, only discrete hyperkeratosis was seen. The right hand and forearm were free of lesions. He complained of intense pruritus when wearing the rubber glove and admitted to continuous scratching to relieve his discomfort, inducing the linear and excoriated lesions. Treatment with topical corticosteroids was initiated, with progressive resolution of the lesions.     

Neutrophilic eccrine hidradenitis in non-small cell lung cancer

A 75-year-old man was treated for non-small cell lung cancer (NSCLC) (stage IIIb) with three-cycle chemotherapy (cisplatin and paclitaxel) for 3 weeks. No skin lesions were observed during the first and second chemotherapy cycles. After the third chemotherapy cycle, he developed slightly pruritic skin eruptions on the anterior chest. He was treated for 1 month with topical steroid without improvement, and was referred to our dermatologic department. Skin examination revealed slightly elevated, dusky, erythematous, edematous patches on the anterior chest in a bilateral distribution (Fig. 1). Histologic examination of a biopsy specimen taken from the cutaneous lesions showed a neutrophilic infiltrate surrounding the secretory eccrine glands. The epithelial cells of the eccrine ducts and coils were not affected. There was a mild superficial perivascular infiltrate of mainly lymphocytes. These changes were consistent with a diagnosis of neutrophilic eccrine hidradenitis (Fig. 2). He was treated with dapsone, 50 mg/day, and methylprednisolone, 8 mg/day, for 2 weeks, and his skin lesions improved. Two months later the erythematous eruptions recurred on the chest, back, and extremities without the use of any chemotherapeutic agent, and were treated effectively with the same drugs.     

Eosinophilic Pustular Folliculitis in Infancy: Report of Two New Cases

Eosinophilic pustular folliculitis (EPF) is a cutaneous inflammatory follicular disorder of unknown etiology. The diagnosis is made on the basis of clinical and histopathologic features. We describe two patients who had recurrent episodes of pruritic follicular papular and pustular lesions on the face, extremities, and trunk. The eruptions lasted for 1 month with intermittent remissions. Laboratory tests disclosed no infectious or parasitic etiology in patient 2. In patient 1 we isolated methicillin-resistant Staphylococcus aureus in a blood culture. He had sepsis with lung and liver involvement. EPF is a self-limited dermatosis. On occasion, skin lesions may become superinfected, resulting in localized pyoderma or rarely systemic infection (sepsis). Histologically both of our patients showed a moderate mixed inflammatory infiltrate with numerous eosinophils centered around hair follicles. Their lesions responded well to topical corticosteroids.     

Dermatitis herpetiformis presenting as chronic urticaria

Childhood dermatitis herpetiformis (DH) is an immunobullous disease associated with gluten-sensitive enteropathy. This disease is rare in children and is typically characterized by intensely pruritic vesicles on the extensor surfaces. Definitive diagnosis of DH depends on the direct immunofluorescence finding of granular or fibrillar IgA deposits along the basement membrane zone of biopsied perilesional skin. We report an 11-year-old boy with an unusual presentation of DH characterized by a 7-month history of chronic urticaria-like skin lesions. He had evanescent, largely asymptomatic, urticarial wheals on his trunk, face, and extremities that were unresponsive to conventional therapy for urticaria. Skin biopsy specimen findings were consistent with DH and direct immunofluorescence of perilesional skin was diagnostic. The patient had no symptoms of gluten-sensitive enteropathy at the time of diagnosis, and his skin lesions rapidly cleared with dapsone therapy. This patient serves to highlight an unusual presentation of childhood DH and the need to consider this diagnosis when evaluating chronic urticarial lesions in children.