保护性肺通气对婴儿围体外循环期肺功能的影响

目的 观察体外循环(CPB)中间断肺通气对婴儿肺功能的影响.方法 选取60例1岁以内行室间隔缺损修补术的患儿,分为2组:对照组(n=30)于CPB开始后停止通气;处理组(n=30)于CPB开始心脏停跳后膨肺[用手挤压气囊,使气道压力升到15～20 cm H2O(1 cmH2O=0.098 kPa),维持3～5 s,重复5次],将肺内血液排出,然后静态膨肺(3～5 cm H2O),并每隔10 min膨肺5次.两组患儿均于腔静脉开放后恢复机械通气.检测CPB开始前及CPB结束后2、6、12、24和48 h共6个时点的氧合指数、动脉血氧分压/肺泡氧分压、肺泡-动脉氧分压差和呼吸指数等肺功能指标.结果 在CPB后2、6、12 h,处理组氧合指数、动脉血氧分压/肺泡氧分压高于对照组(P＜0.05);在CPB后2、6、12、48 h,处理组肺泡-动脉氧分压差低于对照组(P＜0.05);在CPB后6、12 h,处理组呼吸指数低于对照组(P＜0.05).结论 在婴儿CPB过程中持续静态膨肺并间断压力膨肺,可以改善术后早期肺的氧合功能,有较好的肺保护作用.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.     

保护性肺通气对婴儿围体外循环期肺功能的影响

Objective To investigate the impact of static inflation and intermittent ventilation on lung function peri-cardiopulmonary bypass(CPB) in infants.Methods Sixty infants of less than 1-year-old,with ventricular septal defect were selected to assigned to two groups:the treatment group(n=30),given static inflation and intermittent ventilation once every 10 minutes during CPB;the control group(n = 30),no ventilation during CPB.Indicators of pulmonary function including OI,PaO2/PAO2,A-aDO2 and RI were recorded before CPB and 2 h,6 h,12 h,24 h and 48 h after CPB.Results At 2 h,6 h,12 h after CPB,OI and PaO2/PAO2 of the treatment group were higher than those of the control group(P＜0.05).A-aDO2 of the treatment group was lower than that of the control group at 2 h,6 h,12 h,48 h after CPB(P＜0.05).RI of the treatment group was lower than that of the control group at 6 h,12 h after CPB(P ＜0.05).Conclusion Static inflation and intermittent ventilation during CPB can improve early oxygenation of lung,and have good lung protection in infants.