Short-term effects of fine particulate air pollution on hospital admissions for hypertension: A time-stratified case-crossover study in Taipei

This study was undertaken to determine whether there was a correlation between fine particle (PM_2.5) levels and hospital admissions for hypertension in Taipei, Taiwan. Hospital admissions for hypertension and ambient air pollution data for Taipei were obtained for the period from 2009 to 2013. The relative risk of hospital admissions was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. For the single pollutant model (without adjustment for other pollutants), the risk of hospital admissions for hypertension was estimated to increase by 12% on warm days (>23°C) and 2% on cool days (<23°C), respectively. There was no indication of an association between levels of PM_2.5 and risk of hospital admissions for hypertension. In two-pollutant model, PM_2.5 remained nonsignificant after inclusion of any of the other air pollutants (SO₂, NO₂, CO, or O₃) both on warm and cool days, but a numerically greater response was seen on warm days. Data thus indicate that in Taipei, hospital admissions for hypertension occur as a consequence of factors not related to ambient air exposure.     

Effects of ambient air pollution exposure on frequency of hospital admissions for appendicitis in Taipei,Taiwan

The relationship between exposure to ambient air pollutants and hospital admissions for appendicitis is not known. This study examined whether an association existed between air contaminant levels and frequency of hospital admissions for appendicitis in Taipei, Taiwan. Ambient air pollution and hospital admission data for Taipei were obtained for 2009–2013. Relative risk (RR) of hospital admissions was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single pollutant model, on warm days (> 23°C), number of appendicitis admissions was significantly associated with particulate matter (PM_2.5), nitrogen dioxide (NO₂), carbon monoxide (CO), and ozone (O₃). On cool days (< 23°C), a significant rise in number of admissions for appendicitis was related to PM₁₀, NO₂, and O₃ concentrations. In the two-pollutant models, on warm days, NO₂ and O₃ were significantly associated with increased number of admissions for appendicitis when combined with each of the other pollutants. On cool days, NO₂, O₃, and PM₁₀ remained significant for higher appendicitis admission cases in all two-pollutant models. In conclusion, higher levels of ambient air pollutants may be associated with increase in the risk of hospital admissions for appendicitis in Taipei.     

Air Pollution and Hospital Admissions for Pneumonia in a Subtropical City: Taipei,Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for pneumonia in Taipei, Taiwan. Hospital admissions for pneumonia and ambient air pollution data for Taipei were obtained for the period from 1996–2004. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single pollutant models, on warm days (>23°C) statistically significant positive associations were found in all pollutants. On cool days (<23°C), all pollutants were significantly associated with pneumonia admissions except SO₂. For the two-pollutant model, O₃ and NO₂ were significant in combination with each of the other 4 pollutants on warm days. On cool days, PM_{1 0}, CO, and O₃ remained statistically significant in all the two-pollutant models. This study provides evidence that higher levels of ambient air pollutants increase the risk of hospital admissions for pneumonia.     

Association between fine particulate air pollution and hospital admissions for chest pain in a subtropical city: Taipei,Taiwan

This study determined the association between fine particles (PM_2.5) levels and hospital admissions for chest pain (CP) in Taipei, Taiwan. Hospital admissions for CP and ambient air pollution data for Taipei were obtained for the period 2009–2013. The relative risk of hospital admissions was estimated using a case-crossover approach, after controlling for weather variables, day of the week, seasonality, and long-term time trends. For single-pollutant models (without adjustment for other pollutants), increased frequency of CP admissions was significantly associated with PM_2.5 levels on warm days (>23°C), with an interquartile range rise correlated with a 15% (95% confidence interval = 11–31%) elevation in number of CP admissions. In two-pollutant models, PM_2.5 remained significant after inclusion of each of the other four pollutants: sulfur dioxide (SO₂), nitrogen dioxide (NO₂), carbon monoxide (CO), and ozone (O₃) on warm days. Generally, no marked associations were observed between PM_2.5 levels and risk of CP admissions on cool days in both single- and two-pollutant models. This study provides evidence that higher PM_2.5 concentrations enhance the risk of hospital admissions for CP on warm days.     

Association between ozone air pollution levels and hospitalizations for depression in Taipei: a time-stratified case-crossover study

ABSTRACT

Epidemiologic studies reported an association between exposure to ambient air pollutants and increased mortality rate attributed to suicide and suicide attempts. The investigation sought to determine whether there is an association between short-term ambient ozone (O₃) level exposure and daily hospital admissions for depression in Taipei from 2009 to 2013 using a time-stratified case-crossover design. In our single-pollutant model (with no adjustment for other pollutants), the % increase in daily hospital admissions for depression was 12% on warm days and 30% on cool days, per interquartile range (IQR) rise in O₃ levels, respectively. Ozone levels were significantly correlated with daily number of depression admissions both on warm and cool days. In our two-pollutant models, O₃ levels remained significant after adjusting for other air pollutants, including particulate matter (PM₁₀, PM_2.5), sulfur dioxide (SO₂), nitrogen dioxide (NO₂), and carbon monoxide (CO) both on warm and cool days. Although O₃ levels tended to be higher on warm days, admissions for depression were higher on cool days, suggesting that the relationship between O₃ concentrations and depression may be affected by temperature. Further study is needed to better understand these findings.     

Short-term effects of ozone air pollution on hospital admissions for myocardial infarction: A time-stratified case-crossover study in Taipei

This study was undertaken to determine whether there was a correlation between ambient ozone (O₃) levels and number of hospital admissions for myocardial infarction (MI) in Taipei, Taiwan. Hospital admissions for MI and ambient air pollution data for Taipei were obtained for the period from 2006 to 2010. The relative risk (RR) of hospital admissions for MI was estimated using a time-stratified case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. For the single-pollutant model (without adjustment for other pollutants), increased RR for a number of MI admissions was significantly associated with higher O₃ levels both on warm days (>23°C) and on cool days (<23°C). This observation was accompanied by an interquartile range elevation correlated with a 7% (95% CI = 2%–12%) and 17% (95% CI = 11%–25%) rise in number of MI admissions, respectively. In the two-pollutant models, no significant associations between ambient O₃ concentrations and number of MI admissions were observed on warm days. However, on cool days, correlation between ambient O₃ after inclusion of each of the other five pollutants, particulate matter (PM₁₀ or PM_2.5), sulfur dioxide (SO₂), nitrogen dioxide (NO₂) or carbon monoxide (CO), and number of MI admissions remained significant. This study provides evidence that higher levels of ambient O₃ increase the RR of number of hospital admissions for MI.     

Fine particulate air pollution and hospital admissions for congestive heart failure: a case-crossover study in Taipei

Abstract

This study was undertaken to determine whether there was an association between fine particles (PM_2.5) levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period 2006–2010. The relative risk of hospital admissions was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality and long-term time trends. For the single pollutant model (without adjustment for other pollutants), increased CHF admissions were significantly associated with PM_2.5 both on warm days (>23?°C) and cool days (<23?°C), with an interquartile range increase associated with a 13% (95% CI?=?9–17%) and 3% (95% CI?=?0–7%) increase in CHF admissions, respectively. In the two-pollutant models, PM_2.5 remained significant after the inclusion of SO₂ or O₃ both on warm and cool days. This study provides evidence that higher levels of PM_2.5 increase the risk of hospital admissions for CHF.     

Air Pollution and Hospital Admissions for Congestive Heart Failure in a Tropical City: Kaohsiung,Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for congestive heart failure (CHF) in Kaohsiung, Taiwan. Hospital admissions for CHF and ambient air pollution data for Kaohsiung were obtained for the period 1996–2004. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant models, on warm days (> 25°C) statistically significant positive associations were found in all pollutants except sulfur dioxide (SO₂). On cool days (< 25°C), all pollutants were significantly associated with CHF admissions. For the two-pollutant model, CO and O₃ were significant in combination with each of the other four pollutants on warm days. On cool days, NO₂ remained statistically significant in all the two-pollutant models. This study provides evidence that higher levels of ambient air pollutants increase the risk of hospital admissions for CHF and that the effects of air pollutants on hospital admissions for CHF were temperature dependent.     

Air Pollution and Hospital Admissions for Chronic Obstructive Pulmonary Disease in a Tropical City: Kaohsiung,Taiwan

This study was undertaken to determine whether there is an association between air pollutants levels and hospital admissions for chronic obstructive pulmonary disease (COPD) in Kaohsiung, Taiwan. Hospital admissions for COPD and ambient air pollution data for Kaohsiung were obtained for the period from 1996 to 2003. The odds ratio of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant models, on warm days (≥25°C) statistically significant positive associations were found in all pollutants except sulphur dioxide (SO₂). On cool days (< 25°C), all pollutants were significantly associated with COPD admissions. For the two-pollutant models, CO and O₃ were significant in combination with each of the other four pollutants on warm days. On cool days, NO₂ remained statistically significant in all the two-pollutant models. This study provides evidence that higher levels of ambient pollutants increase the risk of hospital admissions for COPD.     

Fine particulate air pollution associated with increased risk of hospital admissions for hypertension in a tropical city,Kaohsiung, Taiwan

The aim of this study was to assess whether a correlation exists between fine particles (PM_2.5) levels and number of hospital admissions for hypertension in Kaohsiung, Taiwan. Hospital admission frequency and ambient air pollution data were obtained for Kaohsiung for 2009–2013. A time-stratified case-crossover method was used to estimate relative risk for hospital admissions, controlling for weather, day of the week, seasonality, and long-term time trends. Odds ratios and 95% confidence intervals were calculated for a 10 µg/m³ increment of PM_2.5 for lags from days 0 to 6. Data showed no significant associations between PM_2.5 levels and number of hypertension-related hospital admissions on warm days (>25°C). However, on cool days (<25°C), a significant positive association was found with frequency of hypertension admissions in the single-pollutant model (without adjusting for other pollutants) with a 10 µg/m³ rise in PM_2.5 on day of admission (lag 0) associated with a 12% increase in number of admissions for hypertension. In the two-pollutant model, the association of PM_2.5 with rate of hypertension hospitalizations remained significant after including SO₂ or O₃ on lag day 0. Data demonstrate that an association between short-term exposure to PM_2.5 and elevated risk of hypertension-related hospital admissions may exist in Kaohsiung, Taiwan, a tropical city.     

Air pollution and emergency room visits for cardiac arrhythmia in a subtropical city: Taipei,Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and emergency room (ER) visits for cardiac arrhythmia in Taipei, Taiwan. ER visits for cardiac arrhythmia and ambient air pollution data for Taipei were obtained for the period 2000–2006. The relative risk of ER visits was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant model, on warm days (≥23°C), statistically significant positive associations were found for all pollutants except SO₂. On cool days (<23°C), all pollutants were also significantly associated with the number of ER visits for cardiac arrhythmia, except SO₂. For the two-pollutant model, results for O₃ and NO₂ remained statistically significant on both warm and cool days. This study provides evidence that higher levels of ambient air pollutants increase the risk of ER visits for cardiac arrhythmia.     

Air pollution and hospital admissions for asthma in a subtropical city: Taipei, Taiwan

This study was undertaken to determine whether there is an association between exposure to air pollutants levels and number of hospital admissions for asthma in Taipei, Taiwan. Hospital admissions for asthma and ambient air pollution data for Taipei were obtained for the period from 1996 through 2003. The relative risk of hospital admission for asthma was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-air-pollutant model, on warm days (> or = 25 degrees C) statistically significant positive associations were found for SO2, NO2, and CO levels with an increase in asthmatic admissions. On cool days (< 25 degrees C), all air pollutants were significantly associated with elevated asthma admissions except SO2. For the two-air-pollutant model, CO significantly increases hospital admissions for asthma in combination with each of the other four pollutants on warm days. On cool days, NO2 and O3 significantly elevated asthma rates in all the two-air-pollutant models. This study provides evidence that higher levels of ambient air pollutant concentrations increase the risk of hospital admissions for asthma.     

Air pollution and hospital admissions for pneumonia in a subtropical city: Taipei, Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for pneumonia in Taipei, Taiwan. Hospital admissions for pneumonia and ambient air pollution data for Taipei were obtained for the period from 1996-2004. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single pollutant models, on warm days (>23 degrees C) statistically significant positive associations were found in all pollutants. On cool days (<23 degrees C), all pollutants were significantly associated with pneumonia admissions except SO(2). For the two-pollutant model, O(3) and NO(2) were significant in combination with each of the other 4 pollutants on warm days. On cool days, PM(10), CO, and O(3) remained statistically significant in all the two-pollutant models. This study provides evidence that higher levels of ambient air pollutants increase the risk of hospital admissions for pneumonia.     

Air pollution and hospital admissions for chronic obstructive pulmonary disease in a subtropical city: Taipei, Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for chronic obstructive pulmonary disease (COPD) in Taipei, Taiwan. Hospital admissions for COPD and ambient air pollution data for Taipei were obtained for the period 1996-2003. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant model, on warm days (> or = 20 degrees C) statistically significant positive associations were found in all pollutants except sulphur dioxide (SO2). However, statistically significant effects for COPD admissions on cool days (< 20 degrees C) were observed only for SO2 levels. For the two-pollutant model, NO2 and O3 were significant in combination with each of the other four pollutants on warm days. This study provides evidence that higher levels of ambient air pollutants increases the risk of hospital admissions for COPD in Taiwan.     

Air pollution and hospital admissions for congestive heart failure in a subtropical city: Taipei, Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for congestive heart failure (CHF) in Taipei, Taiwan. Hospital admissions for CHF and ambient air pollution data for Taipei were obtained for the period from 1996 to 2004. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant model, the number of CHF admissions was significantly associated with the environmental presence of the contaminants particulate matter (PM(10)), nitrogen dioxide (NO(2)), carbon monoxide (CO), and ozone (O(3)) on warm days (>20 degrees C). However, statistically significant positive effects on increased CHF admissions on cool days (<20 degrees C) was observed only for CO levels. For the two-pollutant model, NO(2) and O(3) were significant in combination with each of the other four pollutants on warm days for enhanced CHF admissions. This study provides evidence that higher levels of ambient air pollutants increase the risk of hospital admissions for CHF.     

Relationship between ozone air pollution and daily suicide mortality: a time-stratified case-crossover study in Taipei

Several studies suggested short-term exposure to air pollution might be associated with suicide mortality, although results have been inconsistent and vary depending upon the type of air contaminants. While seasonal variation associated with suicide was reported to occur and that in the spring and early summer there are peaks in ozone (O₃) distribution, the relationship between these two parameters is not known. The aim of this study was to examine the potential association between O₃ levels and daily mortality rate related to suicide in Taipei for the period 2004–2008 using a time-stratified case-crossover analysis. In our single pollutant model without adjustment for other pollutants, the risk of suicide increased by 11% on warm days and 15% on cool days for each interquartile range (IQR) rise in O₃ concentration, respectively. The relationship was positive but did not reach significance. In our two-pollutant models, O₃ remained non-significant on warm days after inclusion of one of any other ambient air contaminants into the model. However, on cool days, a significant association was found between O₃ levels and enhanced risk of mortality due to suicide after nitrogen dioxide (NO₂) or carbon monoxide (CO) were included. The overall positive but not significant findings of elevated risk of mortality frequently attributed to suicide on days with higher O₃ levels suggest that outdoor exposures to this gaseous contaminant may contribute to increases in daily mortality rate related to suicide.     

Air pollution and hospital admissions for myocardial infarction: are there potentially sensitive groups?

Recent studies showed that air pollution is a risk factor for hospitalization for myocardial infarction (MI). However, there is limited evidence to suggest which subpopulations are at higher risk for MI arising from air pollution. This study was undertaken to examine the modifying effects of specific secondary cardiovascular diagnosis (including hypertension, diabetes, congestive heart failure, and arrhythmias) on the relationship between hospital admissions for MI and exposure to ambient air pollutants. Hospital admissions for MI and ambient air pollution data for Taipei were obtained for the period 1999-2009. The relative risk of hospital admissions for MI was estimated using a case-crossover approach. None of the secondary diagnosis examined showed significant evidence of effect modification. It would appear that the correlation between air pollutant exposure and MI occurrence is not affected by predisposing factors present in other cardiovascular diseases.     

Air pollution and hospital admissions for pneumonia in a tropical city: Kaohsiung, Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for pneumonia in Kaohsiung, Taiwan. Hospital admissions for pneumonia and ambient air pollution data for Kaohsiung were obtained for the period of 1996-2004. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant models, on warm days (= 25 degrees C) statistically significant positive associations were found for all pollutants. On cool days (< 25 degrees C), all pollutants were also significantly associated with number of pneumonia admissions. For the two-pollutant model, O3 and CO were significant in combination with each of the other four pollutants on warm days. On cool days, PM10 and NO2 remained statistically significant in all the two-pollutant models. This study provides evidence that higher levels of ambient air pollutants increase the risk of hospital admissions for pneumonia. The effects of air pollutants on hospital admissions for pneumonia were temperature dependent.     

Air pollution and hospital admissions for congestive heart failure in a tropical city: Kaohsiung, Taiwan

This study was undertaken to determine whether there was an association between air pollutant levels and hospital admissions for congestive heart failure (CHF) in Kaohsiung, Taiwan. Hospital admissions for CHF and ambient air pollution data for Kaohsiung were obtained for the period 1996-2004. The relative risk of hospital admission was estimated using a case-crossover approach, controlling for weather variables, day of the week, seasonality, and long-term time trends. In the single-pollutant models, on warm days (> 25 degrees C) statistically significant positive associations were found in all pollutants except sulfur dioxide (SO(2)). On cool days (< 25 degrees C), all pollutants were significantly associated with CHF admissions. For the two-pollutant model, CO and O(3) were significant in combination with each of the other four pollutants on warm days. On cool days, NO(2) remained statistically significant in all the two-pollutant models. This study provides evidence that higher levels of ambient air pollutants increase the risk of hospital admissions for CHF and that the effects of air pollutants on hospital admissions for CHF were temperature dependent.     

Short-term air pollution exposure is associated with hospital length of stay and hospitalization costs among inpatients with type 2 diabetes: a hospital-based study

Air pollution is a risk factor for type 2 diabetes (T2D), exerting heavy economic burden on both individuals and societies. However, there is no apparent report regarding the influence of air pollutants such as particulate matter (PM_2.5 and PM₁₀), sulfur dioxide (SO₂), carbon monoxide (CO), nitrogen dioxide (NO₂), and ozone (O₃) on financial burden to individuals and societies suffering from T2D. This study aimed to determine whether short-term (no more than 16 d) air pollution exposure was associated with T2D-related length of stay (LOS) and hospitalization expenses incurred by patients. This investigation examined 2840 T2D patients hospitalized from December 17, 2013 to May 31, 2016 in China. Multiple linear regression analysis was applied to determine the association between short-term (no more than 16 d) ambient air pollution, LOS, and hospitalization expenses, controlling for age, gender, ethnicity, marital status, and weather conditions. Sulfur dioxide (SO₂) and carbon monoxide (CO) were significantly positively while nitrogen dioxide (NO₂) was negatively associated with presence of T2D, LOS, and expenses. A 10-μg/m³ rise in 16-d (lag 0–15) average concentrations of SO₂ and CO prior to hospitalization was correlated with a significant elevation in LOS and elevation in expenses in T2D patients. However, a 10-μg/m³ rise in 16-d average NO₂ was associated with marked negative alterations in LOS and hospital costs in T2D patients. Taken together, data demonstrate that exposure to air pollutants impacts differently on LOS and hospitalization costs for T2D patients. This is the first apparent report regarding the correlation between air pollution exposure and clinical costs of T2D in China. It is of interest that air pollutants affected T2D patients differently as evidenced by LOS and clinical expenses where SO₂ and CO exhibited a positive adverse relationship in contrast to NO₂.