Sj(o)gren综合征进展

Sj(o)gren综合征(简称SS)系一种自身免疫性疾病,主要表现在外分泌腺的进行性破坏,导致粘、结膜干燥,并伴有各种自身免疫性病症.病变如限于外分泌腺本身者称原发性,若同时伴有其他自身免疫性疾病(如常见为类风湿性关节炎),则称之为继发性.     

细胞凋亡在Sj(o)gren综合征中的作用

在Sjogren综合征中细胞出现异常凋亡现象,这种凋亡是通过Fas/FasL途径和穿孔素/颗粒酶途径实现的.涎腺上皮细胞出现过度凋亡,浸润性淋巴细胞凋亡被抑制,而且在凋亡过程中产生了自身抗体.本文对Sjogren综合症中各种细胞的凋亡和调控进行了综述.     

Répercussion de l’orthodontie sur l’esthétique faciale de l’adulte

The aim of this study is to investigate the impact of orthodontic treatment on facial esthetics in adults using soft tissue esthetic analysis in combination with Tweed Merrifield cephalometric analysis. The key lies in labial posture changes at smile and profile level which will enhance the patient's facial appearance. The problem of facial esthetics is just as crucial as occlusal function and will determine both the orthodontic treatment and the mechanics used in the adult patient.     

L'évolution de notre spécialité

Sans résuméHerrn Professor Dr. Dr. Gustav Korkhaus zum 60. Geburtstag gewidmet     

Sj(o)gren综合征中T细胞亚群值的测定

目的:研究Sj(o)gren综合征中T细胞亚群和免疫球蛋白的变化.方法:应用单克隆抗体技术检测T细胞亚群,用单向免疫扩散法检测IgA、IgG、IgM 结果:Sj(o)gren综合征患者外周血中CD4降低(P＜0.05)、CD8升高(P＜0.05),其程度与病情发展相一致,严重者CD4/CD8倒置.IgA、IgG、IgM均升高(P＜0.05),尤以IgG显著(P＜0.01).结论:Sj(o)gre综合征中存在免疫调节异常.     

Sj(o)gren综合征涎腺组织中凋亡相关基因免疫组化分析

目的: 探讨凋亡相关基因bcl-2、bax、fas、fasL在Sjgren 综合征(Sjgren syndrome,SS)涎腺组织中的表达及其在SS病变发生、发展中的作用.方法:采用SP免疫组化法,检测16例SS涎腺组织和10例正常涎腺组织中Bcl-2、Bax、Fas、FasL的表达情况.结果: Bcl-2在SS腺泡和导管上皮细胞的表达较正常组显著降低,而Bax表达明显增加;Fas、FasL在SS腺泡上皮细胞中的表达均高于正常组,而在导管上皮细胞中的表达均无显著性差异.结论:Bcl-2、Bax、Fas、FasL在SS涎腺组织中的表达发生异常,使得SS涎腺上皮细胞过度凋亡,造成了腺体结构的破坏和分泌功能的丧失;而浸润性淋巴细胞的凋亡被抑制,造成淋巴细胞聚集.     

Pediatric oral lesions: a 15-year review from São Paulo,Brazil

There are few studies on pediatric oral pathologies in the literature. This study presents data from a review of 2,356 biopsies of young patients (birth to 14 years) received over 15 years (1985-2000) in the Oral Pathology Service at the University of Sao Paulo, Brazil. Information about patients (sex, age, race) and histopathological diagnosis was retrieved. Diagnosis data of 2,356 biopsies were classified into 20 groups. There was no significant difference between male (50.0%) and female (49.0%) patients. White is the predominant race (69.0%), and patients ages were concentrated between 9 and 14 years old (70%). Mucocele was the most frequent (13.5%), followed by dentigerous cyst (6.5%) and fibrous hyperplasia (5.4%). Papilloma and Langerhans cells histiocytosis were the most common non-odontogenic benign and malignant tumors, respectively. In the group of odontogenic tumors, odontoma was the most frequent, and ameloblastoma had a significant incidence (27 cases). These data are important in order to detect differences in geographic areas, diagnosis line tendencies and for clinicians to perform judgment to evaluate of the pediatric patients before the biopsy and management of pediatric oral lesions.     

Sj(o)gren综合征临床症状出现频率及诊断价值的研究

目的:对Sjogren综合征中临床症状出现的频率及诊断价值作出客观的评价.方法:34例SS 为研究对象,记录发生于口、眼、阴道、肺、胃、皮肤和肌肉部位的症状,并对个别及成组症状进行统计学分析.结果:对个别症状的逐步回归分析提示:有口干、口腔烧灼感与眼干症状者占被研究病例的94.1%.有64.3%的SS 患者在胃、肌肉、精神、阴道、皮肤、鼻和甲状腺有成组症状出现.提示:必须对全身各系统出现的不同症状引起充分的重视.结论:在SS 患者中,全身各系统出现的个别症状和成组的症状在SS 的诊断中有重要价值.     

Oral verrucous carcinoma: a retrospective study in São Paulo Region, Brazil

Oral verrucous carcinoma (OVC) is a rare variant of squamous cell carcinoma with a characteristic morphology and specific behavior. To date, few studies are available focusing the prevalence and clinicopathologic features of the oral verrucous carcinoma in Brazilian population. A total of 3,500 primary oral well-differentiated squamous cell carcinoma surgically excised in the A.C. Camargo Cancer Hospital and Amaral Carvalho Cancer Hospital, Brazil, from 1980 to 2000 were retrospectively reviewed. Twenty cases of verrucous carcinomas were identified, most of them occurring in older male with age above the sixth decade, the sites frequently affected being the lower lip and the hard palate. Microscopically, the tumor showed a heavily keratinized lesion with compressive invasion pattern, little atypia, and free surgical margins. The local recurrence was verified in 38.5% of the patients with oral verrucous carcinoma; however, regional recurrence and distant metastasis were not verified. The results suggest that, although it is less frequent and with excellent prognosis, the verrucous carcinoma presents a potential for local recurrence that should be considered during the surgical planning of this neoplasm in the oral cavity.     

Évaluation de l’angulation radiculaire mésio-distale pour les images panoramiques et l’impact de l’angulation radiculaire vestibulo-linguale

Panoramic images were taken from an anatomically correct phantom with three different buccolingual angulations for each tooth (Original, 10° buccal root torque, and 10° lingual root torque). The true mesiodistal angulation of each tooth was determined with a three-dimensional coordinate measurement machine. Each tooth had at least one angle measurement that was statistically different from the other mesiodistal angles with different buccolingual orientations. Roots with buccal root orientations were projected more distally than they were in reality; and the roots lingually positioned were projected more mesially. The canine and premolars in both arches were most affected and the phenomenon was more pronounced in the maxilla than the mandible. Buccolingual orientation changes did not affect the root angulation expression on the incisor area.     

芳香化酶在Sj(o)gren综合征涎腺组织中的表达及意义

目的观察Sj(o)gren 综合征(Sj(o)gren's syndrome, SS)涎腺组织和正常涎腺组织中芳香化酶的表达与分布,探讨芳香化酶在SS性激素代谢紊乱中的作用,并为临床上采用芳香化酶抑制剂治疗SS提供参考.方法采用免疫组织化学SP法,检测23例SS涎腺组织和16例正常涎腺组织中芳香化酶的表达情况.结果 SS组与正常组芳香化酶染色阳性率分别为69.57%(16/23)和32.25%(5/16),两组之间有显著差异(P<0.05).结论在SS和正常涎腺组织中,均存在芳香化酶的表达,芳香化酶在SS涎腺组织中表达升高.在SS涎腺组织中,过高表达的芳香化酶可能使局部雄激素转化为雌激素的过程加剧,从而造成ER表达的升高和AR表达的下降.     

Sj(o)gren综合征涎腺组织中雌、雄激素受体的表达

目的: 探讨Sj(o)gren综合征(Sj(o)gren's syndrome, SS)与性激素的关系,以期为临床开展内分泌治疗提供理论依据.方法: 采用免疫组织化学法,检测28例SS涎腺组织和19 例正常涎腺组织中雌激素受体(ER)、雄激素受体(AR)的表达情况.结果: 正常组与SS组ER的阳性率分别为57.89%和 75.00% ,无显著性差异(P>0.05);AR的阳性率分别为84.21%和50.00%,有显著性差异(P<0.05); ER 和 AR 主要位于腺泡和导管上皮细胞胞核内,而淋巴细胞仅偶见染色;SS 唇腺、腮腺、颌下腺、舌下腺组织中, 二者都为弱阳性到阳性染色,表达情况未见明显差异(P>0.05).结论: SS涎腺病变与局部雄激素作用降低或丧失有关,雌、雄激素通过相应受体直接作用于涎腺上皮细胞,影响SS涎腺病变的发生与发展.