磁共振成像在女性性功能障碍研究中的应用

女性性功能障碍(FSD)是涉及心理因素、年龄、躯体疾病、药物等多方面的疾病。磁共振成像(MRI)由于其无创性及软组织对比度高,对研究FSD具有优势。大脑MRI检查发现FSD患者和正常性功能女性大脑功能活化部位和信号传导存在显著差异,盆腔MRI发现阴蒂位置和大小与性功能关系密切,并且有助于确定FSD患者病变区域。通过MRI对正常性功能女性和FSD患者中枢神经系统和周围生殖器官对比分析,对探索FSD病因和选择治疗方式有重要价值。     

慢性肾功能衰竭病人的性功能障碍

慢性肾功能衰竭病人性功能障碍十分常见 ,且已成为影响其生活质量的一个重要问题 ,却很少得到关注。其病因包括生理、心理和器质性因素。本文就近年来有关慢性肾功能衰竭病人性功能障碍的发病情况、主要表现形式、评定方法、发病的危险因素和治疗方法等进行了综述。     

配偶参与联合他达拉非治疗心理性ED的体会

<正>勃起功能障碍(erectile dysfauction,ED)是成年男性最常见的性功能障碍之一,病因复杂,其不良性经历、缺乏性知识、人格缺陷、性伴侣关系不协调、压抑、焦虑等是心理性ED的促成因素[1]。我院泌尿男科门诊在诊断为性功能障碍的患者中选出心理性     

十一酸睾酮胶丸和他达拉非治疗伴有睾酮水平低下的勃起功能障碍患者的疗效分析

<正>勃起功能障碍(erectile dysfunction,ED)是指阴茎持续不能达到或维持足够的勃起以完成满意的性交,是成年男性最常见的性功能障碍疾病之一,而且其发病率呈现逐年增加的趋势。ED的病因非常复杂,涉及生理性及心理性等多方面因素,因此治疗采用以药物治疗为主,以心理行为治疗为辅的综合疗法,而其中针对原发疾病的药物治疗一直占据着非常重要的位置。在临床工作中,睾酮水平低下是ED的常见病因之一,其患者年龄分布范围广,既有中老     

阳萎病因相关因素的调查研究

本文采用“男女性功能电脑测评与诊断系统”（英文简称ＳＣＡＳＦ）随机调查７８对阳萎患者夫妇和４６对性功能正常夫妇，调查分为患者本人因素和配偶因素两个方面，内容除男女双方的性功能状况外，还包括与阳萎病因有关的社会因素、家庭因素、情绪因素、躯体因素、药物因素及性心理因素等。结果表明，患者本人的性操作焦虑、性欲减退、配偶的性功能障碍和夫妇之间的性合作缺乏是最常见的阳萎病因相关因素，这些因素在患病组与非患病组之间统计学上有显著性差异（Ｐ＜０．０１），经采用夫妇同步性治疗后，各项因素的“ＳＣＡＳＦ”检测指标均有了明显改善。因此要提高阳萎的治疗效果，应重视对多种病因相关因素进行深入调查和全面分析。     

大数据及人工智能对女性盆底功能障碍性疾病的诊断及风险预测

女性盆底功能障碍(pelvic floor dysfunction,PFD)指女性盆底的肌肉、韧带、结缔组织等支持结构因创伤、退化等因素导致缺陷或松弛而出现的一类疾病,以压力性尿失禁(stress urinary incontinence,SUI)、性功能障碍(sexual dysfunction,SD)和盆腔器官脱垂(pelvic organ prolapse,POP)为主要表现,严重影响女性日常生活^[1]。年龄、妊娠、分娩方式、肥胖等均是其常见的诱发因素^[2]。     

西地那非成功治疗L5-S1椎间盘突出所致女性神经源性性功能障碍

女性性功能障碍可以表现为性欲异常、性唤起异常、器官疾病和性交疼痛。在多数病例，性生理异常是阴蒂和阴道神经血管损伤的结果。阴道和阴蒂都含有勃起组织和PDE-5。据此，PDE-5抑制剂，西地那非被用来研究女性神经源性相关的性功能障碍。Ferrara D报道了1例患者[Int J Urol，2007，14（6）：566-567]，该病例为一个L5-S1椎间盘突出所致的神经性性功能障碍，使用西地那非治疗，并用女性性功能指数记录结果。对女性应用西地那非的讨论，重点在于女性神经血管源性的性生理和性功能。     

伴有性腺功能减退的性功能障碍患者的疗效分析

正ED是指阴茎持续不能达到或维持足够的勃起以完成满意的性交,是成年男性最常见的性功能障碍疾病之一,而且其发病率呈现逐年增加的趋势。ED的病因非常复杂,涉及生理性及心理性等多方面因素,因此治疗方面多采用以药物治疗为主,以心理行为治疗为辅的综合疗法,而其中针对原发疾病的药物治疗     

前列腺疾病与性功能障碍

前列腺疾病和性功能障碍均是泌尿外科及男科的常见多发病，研究结果发现，两者之间还有密切的联系。如前列腺炎和良性前列腺增生症除下尿路症状和疼痛症状外，部分患者还有性功能障碍的表现，如性欲减退、勃起功能障碍(ED)和射精过快等。除此之外，前列腺疾病的治疗方法也可能导致性功能障     

男性慢性肾脏病合并性功能障碍的研究现状

性功能障碍在男性慢性肾脏病(CKD)患者的发病率较普通男性高,其中勃起功能障碍是最常见的临床表现。内分泌系统功能失调与男性CKD患者性功能障碍的发生密切相关,主要包括下丘脑-垂体-性腺轴的紊乱和高泌乳素血症。同时,血管、神经系统、心理、微量元素、药物等因素也参与了发病过程。目前,主要通过量表评估、临床表现及专科检查对男性CKD患者的性功能障碍进行诊断。治疗上以纠正内分泌系统功能紊乱为基础,包括重组人促红细胞生成素、1,25-(OH)_2 D3、溴隐亭、氯沙坦、锌制剂等药物治疗及肾移植治疗。此外,5型磷酸二酯酶抑制剂等性功能障碍的常规治疗方法可作为补充。本文将从男性CKD合并性功能障碍的危险因素、病因、病理生理、诊断及治疗等方面的研究现状进行综述。     

Female sexual arousal disorder: new insights

Epidemiologic investigations of women with female sexual dysfunction (FSD) from well-designed, random-sample, community-based populations are limited. Based on available information, FSD is common and estimated to occur in 22-43% of women. There are limited data on age-related and para-aging risk factors, which are critical to understand when planning treatment and prevention efforts. Based on correlates of FSD, associated risk factors include age, education, history of sexual abuse or sexually transmitted disease, overall state general happiness and physical health. This brief overview attempts to review what is known about the female sexual anatomy, describes factors that may affect female sexual responsiveness, and identifies several areas where additional research is needed to promote understanding of this complex physiological and psychosocial phenomenon. International Journal of Impotence Research (2000) 12, Suppl 4, S152-S157.     

Weibliche sexuelle Dysfunktion

Female sexual dysfunction (FSD) is a very common disorder in Germany with a prevalence of approximately 38%. FSD includes persistent or recurrent disorders of sexual desire, disorders of subjective or genital arousal and pain during intercourse. An overview of the epidemiology, the current definitions of the single domains of FSD, the pathophysiology and recommendations on the treatment of FSD is given.     

Female sexual dysfunction

Female sexual dysfunction (FSD) is a very common disorder in Germany with a prevalence of approximately 38%. FSD includes persistent or recurrent disorders of sexual desire, disorders of subjective or genital arousal and pain during intercourse. An overview of the epidemiology, the current definitions of the single domains of FSD, the pathophysiology and recommendations on the treatment of FSD is given.     

南京市城区女性性功能障碍的调查

目的:女性性功能障碍(FSD)是影响女性生活质量的常见疾病,有关中国女性FSD的报道少见。本研究探讨南京城区女性FSD的发病情况,为制定中国女性FSD的防治策略提供依据。方法:本研究为回顾性调查,调查对象为2008年8月至2009年3月在南京医科大学附属南京市妇幼保健院进行健康体检的20岁以上女性及其女性陪护人。采用女性性功能指数(FSFI)问卷评估性功能,以FSFI评分总分<25分作为FSD的诊断标准。以各单项评分的中位数作为诊断各类型性功能障碍的标准。结果:共发放问卷1 002份,收回有效问卷609份,有效问卷回收率60.8%。本组女性FSFI得分(24.21±4.40)分,随着年龄增长,FSFI评分及各单项评分逐渐下降。本调查各年龄组总的FSD发生率为56.8%,随年龄增长,FSD发生率逐渐增加,<29岁组为47.1%,30~39岁组为57.0%,40~49组为75.0%,50岁以上高达90.3%。最常见的性功能障碍类型为性满意度下降(43.2%),其次为性高潮障碍(41.7%)、性交疼痛(40.2%)、性欲低下(35.1%)、阴道润滑障碍(31.4%)及性唤起困难(29.6%)。结论:FSD是困扰中国城市女性的常见问题,最常见的类型为性满意度下降及性高潮障碍。     

Potential future options in the pharmacotherapy of female sexual dysfunction

Female sexual dysfunction (FSD) is considered a common medical problem estimated to affect millions of women in the westernized countries. FSD has been classified into four different categories including sexual arousal disorder (FSAD), sexual desire disorder (HSDD), orgasmic disorder and sexual pain disorder. The focus of this article is the potential role of pharmacological compounds currently under development, in the treatment of sexual arousal and orgasmic disorders in order to enhance the sexual response in adult females. While a number of potential therapeutic options are available to date, not one of the pharmacological treatment regimens has been yet considered the Gold standard in the management of symptoms of FSD. This article reviews the rationale and potential benefits of using distinct drug formulations in the treatment of FSD.     

Impact of hormones on female sexual function and dysfunction

The female sexual response cycle is a complex system composed of physiologic changes, psychological, and cultural factors. Female sexual dysfunction (FSD) encompasses a variety of sexual problems, including low desire or interest, diminished arousal, difficulties with orgasm, and dyspareunia. Research in female sexual function and dysfunction has lagged significantly behind males despite our current knowledge that FSD can occur in as many of 80% of the female population. Basic science research exists but also identifies serious gaps in our fundamental knowledge of this area. The purpose of this article was to review our current understanding of the effects of hormones on normal physiologic sexual responses in women, female sexual function and dysfunction, and the available treatment options for the various components of FSD.     

高血压对女性性功能的影响

女性性功能障碍(FSD)是一种与年龄相关的进展性疾病,可能影响多达半数的成年妇女,长期以来,FSD未得到重视.高血压是一种常见病、多发病.高血压及抗高血压药物与FSD有密切关系,其中高血压引起的动脉粥样硬化和内皮功能障碍、抗高血压药物对女性性功能的影响尤为显著,现就高血压对女性性功能的影响机制及研究进展作一综述.     

Female sexual dysfunction in a healthy Austrian cohort: prevalence and risk factors

Purpose:Data on prevalence and risk factors for female sexual dysfunction (FSD) are rare, particularly from Europe. Aim of our study was therefore to investigate this issue in a cohort of women undergoing a health investigation.Patients and Methods:A consecutive series of women aged 20–80 years participating in a health-screening project in Vienna underwent a detailed health investigation and completed a 23-item questionnaire on several aspects of FSD including desire, arousal, pain and orgasmic disorders. Prevalence of FSD in different age groups and risk factors for FSD were calculated.Results:A total of 703 women aged 43 ± 15 years entered this study. Within the total study population, 22% reported on desire disorders, 35% on arousal disorders, and 39% on orgasmic problems, all of which increased significantly with age. Pain disorders were reported by 12.8% being most frequently in the women aged 20–39 years. In women aged 60–69 years, still 50% reported having at least “occasionally” sexual desire and 30% had more than two sexual intercourses per month. In this age group, 50% stated that a healthy sexual life is at least moderately important to them. Apart from age few risk factors for FSD were identified. Sportive activity was the only correlate to desire- and arousal disorders, psychological stress for orgasmic disorders.Conclusions:This study provides insights into age-specific changes of FSD in apparently healthy women. The importance of this subject is underlined by the high prevalence of FSD particularly in the elderly paralleled by a persisting interest in sexual activity.     

妇科良性疾病与女性性功能障碍相关性分析

目的探讨妇科良性疾病与女性性功能障碍(FSD)相关性,为防治FSD的发生及防治提供理论依据。方法采用横断面调查方法,选取中等收入城市及农村居民区20岁及其以上女性进行问卷调查,收集其人口学特征及目前所患妇科疾病(经诊断确诊过的疾病)等信息。采用中文版女性性功能量表(FSFI)进行FSD评估,总分小于26.55说明存在FSD。应用多因素非条件Logistic回归模型分析妇科良性疾病与FSD相关性。结果发放问卷1 130份,收回1 068份(回收率94.5%),去除不符合要求问卷80份,共纳入有效问卷988份。988例被访者中妇科良性疾病患者占39.8%(393/988),为患病组,其余为健康组。393例患者中,性功能障碍者占71.2%(280/393),高于健康组性功能障碍患病率(P0.05)。与健康组相比,患病组在总分及性欲、性唤起、性高潮方面的评分分值均较健康组低(P0.05)。多因素非条件Logistic回归分析显示,妇科良性疾病、年龄(≥40岁)及绝经是FSD的独立危险因素,较高的教育水平是其保护性因素。结论 FSD是一个重要的公共卫生问题,甘肃省在妇科良性疾病者中FSD现患率较高,应加强性健康教育,降低FSD发生率。