胫骨横向骨搬移技术治疗糖尿病足的临床疗效

目的 探讨胫骨横向骨搬移技术治疗糖尿病足的临床疗效.方法 选取2018年8月至2019年11月在我院诊断为糖尿病足的患者21例,男性8例,女性13例,左足12例,右足9例,年龄为51～60岁,平均年龄(55.3±2.3)岁,糖尿病足年程0.5～1.9年,平均(1.6±0.8)年;Wagner分级:3级16例,4级5例;...     

糖尿病足应用胫骨横向骨搬移治疗的护理

目的 探讨应用胫骨横向骨搬移治疗糖尿病足患者的护理方案及效果。方法 总结2017年4月-2019年11月收治的7例糖尿病足患者应用胫骨横向骨搬移治疗的护理方案,包括术前、术后护理,并发症预防护理、康复护理及出院后护理。结果 7例患者均获得随访,其中4例门诊复诊随访,3例门诊和家庭复诊随访。随访时间为3～24个月,平均13.8个月,7例创面全部愈合,足部疼痛、麻痹等症状明显改善或消失,3例术后12个月复查下肢CTA与术前对比,见搬移小腿小动脉有增生表现。结论 应用胫骨横向骨搬移治疗糖尿病足的护理方案能缓解患者术前焦虑,减轻术后疼痛,降低并发症发生,促进糖尿病足创面愈合和功能康复。     

抗生素骨水泥联合改良胫骨横向骨搬移治疗重症糖尿病足

目的 探讨应用抗生素骨水泥联合改良胫骨横向骨搬移治疗重症糖尿病足的临床疗效。方法 选取2018年5月至2021年5月我院收治的24例重症糖尿病足病人,应用抗生素骨水泥联合改良胫骨横向骨搬移治疗。本组病人有5～20年的糖尿病史,其中Wagner 3级病人6例,Wagner 4级病人17例,Wagner 5级病人1例。术后观察创面愈合情况,术前及术后测量患肢皮温、疼痛视觉模拟量表（VAS）评分、患肢感觉阀值、踝肱指数;术前和术后3个月,行双下肢CT血管造影（CT angiography,CTA）。结果 24例病人均获得随访,随访时间为（23.67±5.74）个月（9～36个月）,患肢均保肢成功,创面全部愈合。术后患肢皮温为（31.32±0.52）℃,踝肱指数为0.87±0.16,均较术前显著升高,术后的感觉阈值为（24.81±2.62）Volt,VAS评分为（4.70±0.58）分,均较术前显著降低,差异有统计学意义（P<0.05）。根据病人治疗前后的双下肢血管CTA对比发现,治疗后腿部侧枝动脉增加明显,未见静脉血栓,血流及循环改善。结论 应用抗生素骨水泥联合改良胫骨横向骨搬移治疗重...     

胫骨横向骨搬移技术治疗糖尿病足疗效的Meta分析

目的 探讨胫骨横向骨搬移技术(TTT)治疗糖尿病足疗效的Meta分析.方法 系统检测中国期刊全文数据库、中国生物医学文献数据库、万方数据库、维普中文科技期刊数据库、PubMed、Embase、Cochrane图书馆及中国临床注册中心等有关TTT治疗糖尿病足的随机对照试验,检索时间截止到2020年10月,采用RevMan...     

胫骨横向骨搬移术治疗150例糖尿病足溃疡的疗效观察

目的 探讨胫骨横向骨搬移术对糖尿病足溃疡的临床疗效.方法 选取2014年1月至2019年12月首都医科大学附属北京朝阳医院和北京市隆福医院收治的150例接受胫骨横向骨搬移术治疗的糖尿病足溃疡患者临床资料.统计创面愈合率,比较术前和术后3个月患者的视觉模拟评分法(VAS)评分、创面面积、踝肱指数(ABI)及创面(W)、缺...     

Ilizarov技术胫骨横向骨搬移术治疗糖尿病足

[目的]探讨应用Ilizarov技术胫骨横向骨搬移术治疗糖尿病足的临床疗效。[方法]2014年8月~2016年3月,采用Ilizarov技术胫骨横向骨搬移术治疗糖尿病足患者40例,男26例,女14例,年龄39~79岁,平均56.8岁;左侧22例,右侧18例,按Wagner分级,2级10例,3级22例,4级8例。[结果]40例患者均获得随访,随访时间4~19个月,平均11.5个月,患足均获得愈合(全部保肢),创面平均愈合时间12.6周,患肢疼痛及麻木症状改善甚至消失。[结论]胫骨横向骨搬移术能有效治疗糖尿病足,避免截肢。     

胫骨横向骨搬移联合封闭引流治疗糖尿病足溃疡

[目的]探讨胫骨横向骨搬移术联合封闭引流技术(vacuum sealing drainage,VSD)治疗糖尿病足的临床疗效.[方法]2017年4月～2019年6月本院收治糖尿病足患者45例,其中,23例行胫骨横向骨搬移术联合封闭式负压引流技术治疗(VSD组),22例单纯行胫骨横向骨搬移术治疗(非VSD组);对比两种方...     

胫骨横向骨搬移治疗重度感染糖尿病足

[目的]探讨胫骨横向骨搬移（tibial transverse transport, TTT）治疗合并脓毒症/脓毒症休克的重度糖尿病足的疗效。[方法]回顾性分析2015年4月—2020年8月本院治疗的合并脓毒症/脓毒症休克的重度糖尿病足77例患者的临床资料。首先所有患者均接受矫正休克,改善全身情况,应用敏感抗生素和局部清创等治疗;然后根据医患沟通结果,45例行TTT治疗,32例行传统治疗。比较两组临床及辅助检查结果。[结果]TTT组的住院时间[(21.8±7.6) d vs (28.6±12.0) d, P=0.007]、清创次数[(2.1±0.5)次vs (3.5±1.0)次, P<0.001]、换药次数[(19.7±7.5)次vs (25.1±11.1)次, P=0.013]、出院时创面面积[(68.2±27.4) cm2vs(105.2±20.5) cm2, P=0.003]、住院期间截肢率[8(17.8%) vs 15(46.9%), P=0.006]和死亡率[1(2.2%) vs 7(21.9%), P=0.005]均显著低于传统组。随访时间1～72个月,平均（20.4...     

改良胫骨横向骨搬移术治疗糖尿病足溃疡及脉管炎溃疡

目的 报道改良胫骨横向骨搬移术治疗糖尿病足溃疡及脉管炎溃疡的临床应用和疗效。方法2019年6月-2020年9月,收治糖尿病足溃疡8例、脉管炎溃疡1例,采用改良胫骨横向骨搬移术进行治疗。使用大型骨搬移架7例、小型骨搬移架2例。结果 9例手术顺利完成,术后顺利出院,均获得8～23个月的随访,平均13个月。8例溃疡术后顺利愈合,1例有继发感染、坏死,再次行清创术后出现愈合倾向,缓慢愈合。骨搬移时间4～12周,平均6周,溃疡愈合时间1～26周,平均12周。足趾感觉、血运获得改善,未发生皮瓣坏死、骨折、血栓等并发症。结论 改良胫骨横向骨搬移术是治疗糖尿病足溃疡、脉管炎溃疡一种有效方法,并为提高有效率、降低并发症提供了新的思路和理论依据。     

胫骨横向骨搬移技术联合改良神经松解术治疗糖尿病足溃疡

目的 通过前瞻性随机对照研究,探讨胫骨横向骨搬移（tibial transverse transport,TTT）技术联合改良神经松解术治疗糖尿病足溃疡（diabetic foot ulcer,DFU）的疗效。方法 以2020年2月—2022年2月收治的DFU伴糖尿病周围神经病变患者作为研究对象,其中31例符合选择标准纳入研究。采用随机数字表法将患者分为两组,其中试验组15例采用TTT技术联合改良神经松解术治疗,对照组16例采用单纯TTT技术治疗。两组患者性别、年龄、DFU病程、溃疡面积、Wagner分级,以及术前足部皮温、疼痛视觉模拟评分（VAS）、踝肱指数（ankle-brachial index,ABI）、腓总神经运动神经传导速度（motor nerve conduction velocity,MNCV）、胫神经MNCV、腓深神经MNCV、足跟两点辨别觉（two-point discrimination,2-PD）及腓总神经横截面积（cross-section area,CSA）比较,差异均无统计学意义（P>0.05）。比较两组溃疡创面愈合时间,术前以及术后6、12个月足部...     

骨搬移术治疗胫骨骨折术后感染性大段骨缺损的疗效分析

背景：胫骨骨折术后感染性大段骨缺损的发生率高,治疗困难,效果不理想。目前,骨缺损修复方法包括皮瓣覆盖＋自体骨移植术、异体骨或异种骨移植、带血供腓骨移植、骨延长和骨搬移术。目的：探讨骨搬移术治疗胫骨骨折术后感染性大段骨缺损的疗效。方法：选取2010年9月至2014年9月收治的胫骨骨折术后感染性大段骨缺损患者40例,男24例,女16例;年龄18~64岁,平均（42.8±12.1）岁。将患者随机分成两组各20例,一组采用Orthofix单臂外固定延长架截骨延长,另一组采用Ilizarov环形外固定延长架截骨延长,术后随访对比两组患者的手术时间、手术出血量、HHS膝关节功能评分、Baird-Jackson踝关节功能评分。结果：Orthofix单臂外固定延长架的手术时间较短、手术出血量较少,与Ilizarov环形外固定延长架比较均有统计学差异（P〈0.05）。两组患者的术后HHS膝关节功能评分、Baird-Jackson踝关节功能评分均较术前有明显提高（P〈0.01）。结论：骨搬移术治疗胫骨骨折术后感染性大段骨缺损的疗效佳,可较好地改善患者的膝关节和踝关节功能。其中Orthofix单臂外固定延长架能减少手术创伤,安全性较高,但骨搬运过程中容易发生延长骨成角和偏移;Ilizarov环形外固定延长架的术中应用置入较多钢针,移动时可造成部分皮瓣坏死和血管损伤,应避免在皮瓣覆盖创面的胫骨大段骨缺损患者中使用。     

胫骨骨运输术中对接端新鲜化技术的临床观察

目的:研究胫骨骨运输术中对接端应用骨面新鲜化处理技术的效果。方法:对2014年1月至2019年12月胫骨骨运输术中对接端骨面新鲜化处理手术的20例患者进行分析。其中男15例,女5例;年龄19~62(42.3±11.5)岁;感染性7例,非感染性13例。对接端达到接触后即刻通过使骨面新鲜化处理的手术技术,清除卡入断端的皮肤和软组织,切除硬化封闭的骨端,改善对位,增加接触面积,术中即刻对对接端进行加压,并就近取骨植骨。术后继续逐渐加压。结果:缺损长度5~15(9.2±2.9) cm,从截骨到对接端接触需要26~243(109.1±51.1) d。所有患者对接端达到骨性愈合。达到影像学愈合标准需要3~7(3.7±1.1)个月,20例中15例需要腓骨截骨,其中14例腓骨的截骨端达到骨性愈合。胫骨牵开端的骨痂达到影像学坚实化的时间需要5~28(15.0±6.5)个月,骨愈合指数(bone healing index,BHI)为每厘米需0.8~2.8(1.6±0.5)个月。20例中1例胫骨切口出现感染。拆除外固定架后随访时间为12~73(37.6±20.3)个月,所有患者对接端未发生骨折。结论:胫骨骨运输术中,当对接端接触后尽早进行骨面新鲜化处理能缩短对接端的愈合时间,避免对接端再骨折,术中收集的松质骨和钻孔产生的骨屑能消除缺损和间隙,避免在其他部位取自体骨植骨。     

Transverse Tibial Bone Transport Enhances Distraction Osteogenesis and Vascularization in the Treatment of Diabetic Foot

ObjectiveTo investigate the effect of transverse tibial bone transport on the treatment of Wagner Stage 4 diabetic foot.MethodsFrom January 2017 to October 2019, a total of 19 patients with Wagner Stage 4 diabetic foot ulcers were recruited. All patients were treated with transverse tibial bone transport. A detailed follow‐up was carried out at 1 week, 1 month, 3 months, 6 months, and 1 year after surgery. The wound healing rate and the limb salvage rate at 1 year after the surgery were evaluated. Preoperative and 3‐month postoperative digital subtraction angiography (DSA) were obtained. The level of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) and platelet‐derived growth factor (PDGF) before surgery and on 1st, 4th, 11th, 18th, 28^th, and 35th days after surgery were measured. Operation time, intraoperative blood loss, postoperative complications, visual analog scale (VAS) pain score, skin temperature, Semmes‐weinstein monofilament (SWM), and ankle brachial index (ABI) were also assessed.ResultsThe wound healing rate and the limb salvage rate were both 94.74% in the patients at 1 year after the surgery. DSA showed the thickening of the calf and foot arteries, clear visualization, and a rich vascular network. The levels of VEGF, bFGF, and PDGF on the 11th, 18th, 28^th, and 35th days after surgery were significantly higher than those before surgery (p < 0.05). The EGF level on the 18th, 28th, and 35th days after surgery was significantly higher than that before surgery (p < 0.05). Superficial wound complications occurred in one patient during the hospitalization. There was no movement area infection, skin flap necrosis, tibial fracture, loosening of the external fixator, or rupture in study.ConclusionTransverse tibial bone transport can improve the blood circulation of the affected limbs, promote the healing of diabetic foot wounds, and reduce the amputation rate of the affected limbs. Transverse tibial bone transport can promote the healing of Wagner Stage 4 diabetic foot.     

骨搬移技术联合抗生素局部灌注治疗胫骨慢性骨髓炎骨缺损

正2012年3月~2014年8月,我科采用骨搬移技术联合抗生素局部灌注治疗8例胫骨慢性骨髓炎骨缺损患者,疗效满意,报道如下。1材料与方法1.1病例资料本组8例,男6例,女2例,年龄28~55岁。左侧3例,右侧5例。受伤原因:车祸伤5例,重物砸伤2例,高处坠落伤1例。行骨搬移手术前行3~9次清创手术。细菌培养:金黄色葡萄球菌2例,溶血链球菌2例,克雷伯     

Growth factors in human serum during operative tibial lengthening with the ilizarov method

Despite the widespread clinical use of distraction osteogenesis for limb lengthening, the cellular and molecular mechanisms by which this surgical treatment promotes new bone formation in humans are not well understood. The aim of the research was to study the levels of growth factors (GFs) in the serum of patients that were undergoing tibial lengthening with the Ilizarov method of distraction osteogenesis. Those were patients with unilateral congenital discrepancy of the tibia (n = 12), unilateral posttraumatic tibial shortening (n = 7), and healthy patients that underwent cosmetic bilateral tibial lengthening (n = 10). The study established that unlike the congenital group, the posttraumatic group and healthy subjects showed a significantly evident increase in the levels of angiogenic GFs in their serum on day 10 of distraction. In the congenital group, the changes were not significant at this time point. The levels of TGF‐α, TGF‐β1, and TGF‐β2 tended to decrease on day 10 of distraction and on day 30 of the post‐distraction period in the cosmetic and posttraumatic groups while they grew in the congenital group. Most dynamic changes in the GFs levels during tibial lengthening were noted in the subjects undergoing cosmetic lengthening, and the least ones were in the congenital group. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1966–1970, 2013     

胫骨横向骨搬移结合负压引流治疗糖尿病足溃疡的临床疗效分析

目的 :探讨胫骨横向骨搬移微血管网再生技术结合封闭负压引流治疗伴溃疡形成的糖尿病足的临床疗效。方法:对2015年11月至2016年12月采用胫骨横向骨搬移结合负压引流治疗的19例伴溃疡形成的糖尿病足的临床资料进行回顾性分析,男15例,女4例;年龄42~82岁,平均(64.57±7.14)岁;糖尿病平均病程(14.62±6.19)年;左足12例,右足7例;溃疡面积2 cm×3 cm~8 cm×6 cm;按照Texas分类法进行分类,所有病例为D期,其中2级3例,3级10例,4级6例。手术前后测量踝肱指数及密歇根神经体征评分(MNSI)评价患足周围血管和周围神经功能恢复情况,术后复查血管造影或血管彩超。结果:19例患者中17例术后获得随访,时间3~13个月,平均6.9个月。17例患足创面均得到愈合;术后3个月踝肱指数由术前的0.51±0.20升至0.93±0.18,差异有统计学意义(t=13.63,P=0.000);术后3个月的MNSI为5.76±1.44,优于术前的4.06±1.36,差异有统计学意义(t=7.31,P=0.000)。术后复查血管造影或血管彩超显示患足微血管网再生满意,患足功能达到正常运动和日常生活需要。结论:胫骨横向骨搬移微血管网再生技术可以重建患肢小腿以下微血管网,促进周围血管及周围神经恢复,结合封闭负压引流可促进创面愈合,具有手术简便、疗效确切,保肢成功率高的优点,是治疗糖尿病足溃疡的理想方法之一。     

Donor site morbidity of calcaneal,distal tibial,and proximal tibial cancellous bone autografts in foot and ankle surgery. A systematic review and meta-analysis of 2296 bone grafts

PurposeThis study aims to report on the safety and donor site morbidity of the distal lower extremity (calcaneal, proximal, and distal tibial) cancellous bone autografts. We summarized the findings in a comprehensive infographic illustration. We are unaware of any similar meta-analyses to date.MethodsFollowing the PRISMA guidelines, two independent investigators searched MEDLINE (PubMed), EMBASE, SCOPUS, Google Scholar, and Cochrane databases in December 2020 using the following keywords and their synonyms: ("bone graft", "donor site morbidity", "calcaneal graft", “proximal tibia graft”, and “distal tibia graft”). Besides, the reference lists from previous review articles were searched manually for eligible studies. The primary outcomes of interest were (1) chronic pain, (2) fracture, and (3) infection, whereas the secondary outcomes were (1) neurological complications, (2) sensory disturbance and hypertrophic scars, (3) other complications such as shoe-wear difficulties and gait disturbance. Inclusion criteria were: studies on complications and adverse events of lower extremity bone autografts (calcaneal, proximal tibial, and distal tibial bone autografts) reporting at least one of the desired outcomes. Studies not reporting any of the outcomes of interest or if the full text is not available in English were excluded. Studies reporting on bone marrow aspirate or autografts for non-orthopedic indications were also excluded.ResultsAfter the removal of duplicates, a total of 5981 studies were identified. After screening those records, 85 studies remained for full-text assessment. Out of those, 15 studies qualified for the meta-analysis with a total of 2296 bone grafts. Out of those grafts, 1557(67.8%) were calcaneal grafts, 625 (27.2%) were proximal tibial grafts, and 114 (5%) were distal tibial grafts. In calcaneal bone grafts, there were 28 cases of chronic pain [1.97%, CI:1.10?2.50%, I² = 66%], 5 fractures [0.32%, CI: 0.10?0.60%,I² = 0%], 20 sural neuritis [1.28%, CI:0.70?1.80%, I² = 0%), and no wound infections. In proximal tibial grafts there were 13 cases of chronic pain [2.08%, CI: 1.01?3.2%, I² = 34.5%], 1 fracture [0.16%, CI:0.10?0.50%, I² = 0%], and 3 superficial wound infections [0.48%, CI: 0.10?1.01, I² = 0%]. In the distal tibial grafts there were no cases of chronic pain or wound infections, 1 fracture [0.90%, CI: 0.80?2.6%, I² = 0%], and 5 saphenous neuritis [4.5%, CI: 0.70?8.40%, I² = 65%].ConclusionCalcaneal, distal tibial, and proximal tibial bone autografts are safe with a low rate of overall and major complications. We report an overall complication rate of 6.8%, which is less than half of that previously reported for iliac crest grafts. The authors recommend using distal lower extremity grafts for foot and ankle primary surgeries instead of iliac crest grafts when indicated. Clinical trials with a large sample size are required.     

Regulation of vascular endothelial growth factor on the expression of fracture healing,related factors

Objective ： To study the effect of vascular endothelial growth factor （VEGF）and anti-VEGF on the expression of fracture healing-related factors and observe pathological changes at fractured sites. Methods： Fracture models were established in 105 New Zealand white rabbits and they were randomly divided into control group, VEGF group and anti-VEGF group. The relevant factors expression at fractured sites was assayed and pathological changes were observed in decalcified samples at 8, 24, 72 hours and 1,3,5,8 weeks after fracture. Results： After application of VGEF, the expression of BMP appeared earlier and expression time lasted longer. On the contrary, anti-VEGF completely inhibited the expression of BMP. The fractured sites were filled with fibrous callus, cartilaginous callus and bony callus at the 3rd week and woven bone was constructed at the 5th week. Fracture healing was accomplished at the 8th week in VEGF group. In anti-VEGF polyclonal antibody group, cellular necrosis increased at early period. Continuous focal necrosis was seen in the fractured sites from the 1st week to 5th week. Vascularization reduced obviously at the 3rd week. Conclusions： Fracture healing is a result of mutual regulation and coordination among many factors. VEGF may be an important factor in fracture healing.