原发性中枢神经系统淋巴瘤MRI表现

目的 探讨原发性中枢神经系统淋巴瘤的MRI征象.方法 回顾性分析我院2004-01-2005-09经神经外科手术或活检后病理证实的原发性中枢神经系统淋巴瘤44例的MRI表现,包括病灶数目、大小、分布、形态及增强前后MRI信号的表现.44例原发性中枢神经系统淋巴瘤中,男29例,女15例.年龄12～76岁,平均53岁.结果 病变部位包括脑部41例,脊髓3例.病灶可单发或多发,MRI平扫T1WI大多呈略低信号,T2WI等信号或高信号;增强后病灶大都均匀实质团块状或结节状强化,少数呈环形强化.结论 原发性中枢神经系统淋巴瘤MRI表现有一定特征性.单发或多发病灶明显实质结节状强化,尤其靠近脑脊液腔时,应考虑淋巴瘤可能.     

原发性中枢神经系统淋巴瘤的MRI表现

目的:描述原发性中枢神经系统淋巴瘤的MRI表现,探讨MRI对该病的诊断价值。材料和方法:回顾性分析10例经手术病理证实的原发性中枢神经系统淋巴瘤的MRI表现。结果:10例均为弥漫大B细胞型非霍奇金淋巴瘤。5例为单发,5例为多发,共16个病灶,其中大脑半球8个,基底节4个,右侧背侧丘脑及基底节1个,脑室内3个。10例病变均表现为局灶性肿块,6例边界较清楚,4例边界不甚清楚。T1WI呈稍低或等信号;T2WI呈等或稍高信号。增强扫描7例呈明显均匀强化,1例呈明显脑回样强化,1例中等度强化,1例(放疗后)无强化。2例有侧脑室室管膜线样明显强化。9例存在占位效应。3例瘤周重度水肿,5例瘤周中度水肿,2例瘤周轻度水肿。结论:原发性中枢神经系统淋巴瘤是一种较为罕见的原发性中枢神经系统恶性肿瘤,MRI是诊断该病的重要的无创性检查方法。当男性中老年患者发现颅内,特别是幕上深部脑白质及胼胝体、基底节区实性占位性病变,呈稍长或等T1、稍长或等T2信号,瘤周水肿及占位效应较轻,增强扫描呈明显均匀强化时,应考虑原发性中枢神经系统淋巴瘤的诊断。     

原发性中枢神经系统淋巴瘤MRI表现分析

目的探讨原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)的MRI表现,提高诊断水平。方法回顾性分析我院经病理证实的14例PCNSL患者的MRI资料。14例患者均进行MRI平扫及增强扫描,其中3例患者行MRS。由两名资深MRI诊断医师对MRI图像进行分析,包括病灶的部位、数目、信号特点、强化方式、瘤周水肿、囊变坏死、出血及MRS等。结果1)病灶数目14例患者中单发12例,多发2例,单发病例中有2例病变跨越两个脑叶,1例病变位于左侧小脑半球-小脑蚓部;2)病灶分布右额叶5个,左额叶5个,左顶叶2个,胼胝体2个,左侧大脑脚1个,左侧基底节2个,左右颞叶各1个,左侧小脑半球2个;3)信号特点等T110个,稍长/长T19个;等T28个,稍长/长T211个;DWI稍高信号8个,高信号11个;4)强化特点不均匀强化3例,明显均匀强化11例,软脑膜强化3例,2例多发病例中所有病灶均明显均匀强化;5)瘤周水肿重度水肿2个,中度水肿3个,轻度水肿14个;6)出血及囊变出血2个,囊变2个。结论增强、弥散加权成像联合瘤周水肿对PCNSL的诊断有重要价值,MRS对鉴别诊断有一定的作用。     

颅内原发性中枢神经系统淋巴瘤的MRI表现

目的研究颅内原发性中枢神经系统淋巴瘤（PCNSL）的MR／表现特点。方法回顾性分析8例经手术病理证实的原发性中枢神经系统淋巴瘤的MR／表现。结果8例均为弥漫大B细胞型非霍奇金淋巴瘤。3例为单发,5例为多发,共13个病灶,其中大脑半球8个,基底节区4个,右侧背侧丘脑及基底节区1个。8例病变均表现为局灶性肿块,T1WI呈稍低或等信号;T2WI呈等或稍高信号。增强扫描7例呈明显均匀强化,1例轻度强化。6例瘤周重度水肿,2例瘤周中度水肿。结论原发性中枢神经系统淋巴瘤较为罕见,MRI是诊断该病的重要的无创性检查方法。颅内PCNSL影像学表现多样,但具有一定特征。     

原发性中枢神经系统淋巴瘤的MRI表现与病理学对照研究

目的探讨原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)的MRI表现与病理学特征。资料与方法对10例经病理证实的PCNSL患者的MRI表现及病理资料进行对照研究。结果10例中,单发7例,多发3例,共39个实性结节样病灶。其中,位于额叶4个,颞叶10个,脑室13个,脑干2个,小脑1个,累及胼胝体9个。非实性结节样病灶若干。单发者病灶多呈实性,致密,部分内可见坏死(5个)、出血(3个),与灰质信号相比,T1WI呈等、稍低信号,T2WI呈等、稍高信号,液体衰减反转恢复序列(FLAIR)呈高信号;多发者病灶多松散,部分不成形,表现为斑片状长T1、长T2信号。常规增强扫描后,所有病灶中除1例轻度强化外,余实质部分均呈团块状、结节状均匀明显强化,中心囊变坏死区无强化;弥漫性浸润病变呈点、片状强化。病理上所有PCNSL均为弥漫性大B细胞淋巴瘤。结论病理学基础决定PCNSLMRI表现有一定特征性:(1)单发病灶多位于脑白质深部,多发病灶常呈区域性分布。(2)肿块在T2WI上多呈等或稍高信号。(3)单发病灶多呈团块状均匀强化,多发病灶呈点、片状强化。(4)肿...     

原发性中枢神经系统淋巴瘤的MRI诊断

目的 研究原发性中枢神经系统淋巴瘤(PCNSL)的MRI表现特点,提高对该病的诊断与鉴别诊断率.方法 回顾分析了12例经病理证实的原发性中枢神经系统淋巴瘤的MRI表现.结果 病灶T1WI多呈略低或等信号,T2WI呈等或略高信号;增强扫描多呈明显均匀强化,极少数呈环形强化,肿瘤坏死囊变少见,未见出血、钙化;瘤周水肿相对较轻,占位效应轻.结论 原发性中枢神经系统淋巴瘤MRI表现具有一定特征性,可做出较准确的诊断.     

颅内原发性中枢神经系统淋巴瘤的MRI研究

目的研究颅内原发性中枢神经系统淋巴瘤（PCNSL）的MRI表现特点。资料与方法回顾性分析23例颅内PCNSL的MRI表现。抽取恶性胶质瘤30例、颅内转移瘤30例,共60例归为非PCNSL组作为对照。观察肿瘤部位、分布、信号、形态,并进行统计学分析。结果颅内PCNSL好发于深部脑组织,如胼胝体、丘脑及基底节区,多发病灶多呈区域性分布;肿瘤T2WI多呈等或稍高信号,甚至低信号,扩散加权像（DWI）呈均匀高信号;增强扫描多呈均匀明显强化,肿瘤周围可见“尖突征”。与非PCNSL组之间差异有统计学意义（P〈0．01）。结论颅内PCNSL影像表现多样,但具有一定特征。     

原发性中枢神经系统淋巴瘤的MRI影像诊断及病理特点

目的:分析免疫力正常患者的原发性中枢神经系统淋巴瘤(PCNSL)的MRI特征,提高对该病的术前影像诊断。材料和方法:回顾性分析23例经病理证实的PC-NSL的MRI资料和病理资料。结果:23例PCNSL中,单发16例(69.6%),多发7例(30.4%),共41个病灶,幕上39个病灶,幕下2个病灶。78.0%(32/41)病灶平扫T1WI呈等、低信号,T2WI等、稍低信号,较大的病灶中均未见血管流空;增强后70.7%(29/41)病灶呈均匀实质团块状或结节状明显强化,典型的出现"缺口征"、"尖角征",并靠近蛛网膜下腔;9.8%(4/41)病灶出现囊变,可见"硬环征"。病理证实均为B细胞来源非霍奇金淋巴瘤,除1例为Burkitt淋巴瘤,其余均为弥漫性大B细胞淋巴瘤,镜下肿瘤细胞弥漫分布,瘤细胞大小较一致,胞质少,核大,染色质颗粒粗,15例(65.2%)可见瘤细胞围绕血管呈袖套样浸润,所有病例均未见出血、坏死,钙化。结论:PCNSL的病理学基础决定其MRI表现具有一定特征性,典型的病例,常规MRI多可作出正确的诊断,确诊有赖于病理。     

原发性中枢神经系统淋巴瘤多模态MRI不典型表现及其病理学基础的探讨

目的：探讨免疫功能正常的原发中枢神经系统淋巴瘤（PCNSL）患者不典型MRI表现及其相关病理学基础,以利于PCNSL的正确诊断。方法：回顾性分析2017年8月至2022年8月在我院经组织病理学诊断的PCNSL患者资料。所有患者在治疗前均接受MRI检查,实验室检查显示均无免疫功能缺陷,排除复发性中枢神经系统淋巴瘤及继发性淋巴瘤。由2名医师分别对MRI图像进行判读。结果：31例中枢神经系统淋巴瘤中19例符合入选标准,其中男性11例,女性8例,年龄为（63±9）岁。所有病例均经组织学病理诊断为B细胞淋巴瘤,15例为弥漫性大B细胞淋巴瘤。病灶单发7例,病灶2个4例,病灶3个及以上8例。不典型发病部位包括侧脑室、脑干、小脑半球。不典型影像表现包括：病灶信号不均匀,合并出血及坏死;增强无强化,多发片状、线状强化;呈高灌注;无明显弥散受限。结论：PCNSL表现不典型时容易误诊,多发病灶中更容易出现不典型表现,采用多模态MRI尤其是结合病变表观弥散系数值及磁共振波谱有利于疾病诊断。     

艾滋病相关原发性中枢神经系统淋巴瘤的MRI表现分析

【摘要】目的：探讨获得性免疫缺陷综合征（AIDS）相关原发性中枢神经系统淋巴瘤 （PCNSL）的MRI表现。方法：回顾性分析11例经病理证实的AIDS相关PCNSL患者的临床及MRI资料。结果：11例AIDS相关PCNSL均为弥漫性大B细胞淋巴瘤,男10例,女1例,中位年龄49岁,CD4+T淋巴细胞计数中位数为39个/μL。共14个病灶,以幕上单发为主,主要分布于中线附近,其中单发病灶9例（81.8%）,多发病灶2例（18.2%）,位于幕上8例（72.7%）,幕下3例（27.3%）。T1WI为等低信号,T2WI信号高低不均,实性区以等低信号为主;T2 FLAIR大部分病灶周围见水肿,增强扫描病灶环形强化9个（64.3%）,团状强化3个（21.4%）,结节状强化2个（14.3%）,12个（85.7%）病灶出现不同程度坏死;DWI实性区高信号9个（64.3%）,等信号3个（21.4%）,低信号2个（14.3%）。结论：AIDS相关PCNSL的MRI表现具有一定特异性,仔细分析MRI各序列信号特征,结合临床表现、CD4+T淋巴细胞计数<50个/μL,有助于PCNSL的诊断。     

原发性中枢神经系统淋巴瘤的磁共振成像表现

目的探讨原发性中枢神经系统淋巴瘤（PCNSL）的磁共振成像（MRI）特征及鉴别诊断。方法回顾性分析15例经手术病理证实的PCNSL的MRI表现。结果病理检查均为B细胞来源的弥漫性大B细胞性淋巴瘤。15例PCNSL19个病灶,单发13例（87％）,多发2例（13％）共6个病灶。病灶常位于脑表浅部位和近中线部位,T1wI呈等或稍低信号,T2WI及液体衰减反转恢复序列（FLAIR）呈等或稍高信号,弥散加权成像（DWI）呈高信号。所有病灶均明显强化,增强后病灶大多呈均匀实质团块状或结节状强化,典型的可出现“尖角征”、“握拳征”,3例可见小囊变,呈“硬环征”。结论PCNSL的MRI表现具有一定的特征性,术前MRI检查有助于诊断及鉴别诊断,结合患者影像学及临床资料,术前可作出明确诊断。     

Nonenhancing primary central nervous system lymphoma

Primary central nervous system lymphoma (PCNSL) is rare, although its frequency has increased in recent years. Radiographically, almost all PCNSL enhance on CT and/or MRI, and nonenhancing PCNSL has been thought to be extremely rare. We present PCNSL showing multiple nonenhancing lesions on MRI in an immunocompetent patient.     

Nonenhancing primary central nervous system lymphoma

Primary central nervous system lymphoma (PCNSL) is rare, although its frequency has increased in recent years. Radiographically, almost all PCNSL enhance on CT and/or MRI, and nonenhancing PCNSL has been thought to be extremely rare. We present PCNSL showing multiple nonenhancing lesions on MRI in an immunocompetent patient.     

Imaging of primary central nervous system lymphoma

Primary central nervous system lymphoma (PCNSL) comprises 5% of all primary brain tumours. PCNSL demonstrates a variety of well-documented imaging findings, which can vary depending on immune status and histological type. Imaging features of PCNSL may overlap with other tumours and infection making definitive diagnosis challenging. In addition, several rare variants of PCNSL have been described, each with their own imaging characteristics. Advanced imaging techniques including 2-[(18)F]-fluoro-2-deoxy-d-glucose ((18)FDG) and (11)C?positron-emission tomography (PET), (201)Tl single-photon emission computed tomography (SPECT), (1)H-magnetic resonance spectroscopy (MRS), and MR perfusion, have been used to aid differentiation of PCNSL from other tumours. Ultimately, no imaging method can definitively diagnose PCNSL, and histology is required.     

Magnetic resonance findings of primary central nervous system T-cell lymphoma in immunocompetent patients

PURPOSE: To describe the MR findings of primary central nervous system T-cell lymphoma (T-PCNSL) in immunocompetent patients. MATERIAL AND METHODS: Seven patients with pathologically proven T-PCNSL were included in our study. The number, location, shape, enhancement pattern, and signal intensity of the tumors were determined. Diffusion-weighted images (DWI) and perfusion-weighted images (PWI) were obtained in four and two patients, respectively. Apparent diffusion coefficients (ADCs) were generated, and regions of interest were defined in each lesion. RESULTS: Four patients with T-PCNSL had a single mass, while the others had multiple lesions (four, three, and two lesions, respectively). All seven cases of T-PCNSL had a supratentorial location: 12 in the subcortical area and 1 in the thalamus. No leptomeningeal involvement was noted. All tumors showed iso- to low T1 and iso- to slightly high T2 signal intensity to the adjacent gray matter. Rim enhancement was seen in 5 of the 7 patients (71.4%), while heterogeneous and homogeneous enhancement was seen in each of two. On DWI and ADC maps, the enhancing lesions showed slight hyperintensity in three patients (mean ADC ratio, 0.92 +/- 0.06) and iso-intensity in the other (ADC ratio, 1.02 +/- 0.05). Cystic areas consistent with necrosis were noted in three patients. High-signal intensity area in the cortex was noted on T1-weighted images in three patients, suggesting hemorrhage. In two patients, the same signal intensity area was noted within the mass. The two masses on the relative cerebral blood volume (rCBV) map demonstrated either similar or slightly higher signal intensity than that of the contralateral white matter. The rCBV ratios of these two masses were 1.27 +/- 0.16 and 1.35 +/- 0.2, respectively. CONCLUSION: T-PCNSLs show a predilection for a subcortical location, a relatively high incidence of cortical or intratumoral hemorrhage, rim enhancement, or cystic-areas consistent with necrosis on magnetic resonance imaging. The lower rCBV ratio of the tumor might be helpful in differentiating T-PCNSL from other brain tumors such as high-grade glioma.     

原发性中枢神经系统淋巴瘤的影像学诊断

原发性中枢神经系统淋巴瘤(primary central nervous system lymphoma,PCNSL)即是原发于脑、脑脊膜、脊髓、眼球等处的恶性非霍奇金淋巴瘤(non-Hodgkin,s lymphoma,NHL),发病率有逐渐增高的趋势.临床工作中此类肿瘤与其他脑肿瘤鉴别困难,本文总结分析经手术病理证实的原发性颅内恶性淋巴瘤16例,总结分析其影像学表现,提高对该病认识. 1资料与方法 1.1 一般资料 收集本院2009-2012年经手术或穿刺后经病理证实为大脑非霍奇金淋巴瘤16例,临床观察6个月无脑外淋巴结肿大,均排除继发型淋巴瘤.术前9例行CT平扫,其中7例行CT增强检查;16例行磁共振平扫加增强.16例中男12例,女4例,年龄17～75岁,平均50.5岁,病程3 d～5个月不等.本组患者人类免疫缺陷病毒(HIV)抗体均为阴性、无器官移植后免疫抑制剂使用史.临床症状表现为头晕、头痛、恶心、呕吐10例,肢体乏力、偏瘫5例,神经精神紊乱1例.     

原发性中枢神经系统血管炎的脑血管造影表现

目的评价脑血管造影在诊断或排除原发性中枢神经系统血管炎（PCNSV）中的价值。方法收集并回顾性分析2002年1月至2008年1月于我科行脑血管造影的近1000例脑血管意外（包括脑出血、脑梗死及蛛网膜下腔出血）患者,其中15例脑血管造影结合相应的临床资料诊断为PCNSV,并对其脑血管造影结果进行系统的观察和分析。结果15例患者中共26支脑血管受累,其中包括7支大脑前动脉,12支大脑中动脉,3支椎动脉,1支基底动脉,3支颈内动脉C2C2段。受累血管腔形态改变表现为局限性狭窄（6支）,多发局限性狭窄（3支）,节段性狭窄（6支）,串珠样改变（4支）,闭塞（5支,其中3支伴侧支循环形成）,动脉瘤形成或瘤样改变2支。结论结合患者的临床资料,全脑血管造影是目前诊断或排除PCNSV重要的和可行的一种检查手段,可以指导临床的正确诊断与治疗。