肥胖儿童血清vaspin水平与胰岛素敏感性及糖脂代谢的关系

目的:探讨肥胖儿童血清vaspin水平与胰岛素敏感性及糖脂代谢的关系.方法:收集肥胖儿童34例(肥胖组),男22例,女12例.并随机抽取同年龄健康查体的儿童30例为对照组,男20例,女10例.测定所有受试者体格参数、血清vaspin、血脂、空腹血糖(FPG)及空腹胰岛素(FINS)水平.计算体质指数(BMI)、腰臀比(WHR)、体脂百分比(BF％)、胰岛素抵抗指数(HOMA-IR)、胰岛素敏感指数(ISI)及致动脉粥样硬化指数(AI).比较2组儿童的上述指标,并对肥胖儿童血清vaspin水平与体格参数及糖脂代谢各指标进行相关分析.结果:肥胖组儿童vaspin、腰围(WC)、BMI、BF％、收缩压(SBP)、舒张压(DBP)、FPG、FINS、HOMA-IR、低密度脂蛋白胆固醇(LDL-C)、三酰甘油(TG)、LDL-C/高密度脂蛋白胆固醇(HDL-C)、(TC-HDL-C)/HDL-C均明显高于对照组,而HDL-C、ISI低于对照组.vaspin与BMI、WC、WHR、BF％、TG、FINS、HOMA-IR、(TC-HDL-C)/HDL-C呈正相关,与ISI、HDL-C呈负相关,与年龄、DBP、SBP、FPG、LDL-C、LDL-C/HDL-C、TC无明显相关性.结论:vaspin水平升高可能是胰岛素抵抗的代偿性反应;在肥胖儿童早期,其水平测定可用于评价肥胖程度及胰岛素抵抗程度,并评估成年后发生心脑血管疾病的危险性.     

单纯性肥胖儿童存在代谢综合征状况分析

目的探讨单纯性肥胖儿童与代谢综合征的关系。方法采用随机对照的病例研究方法,分析年龄10～15岁单纯性肥胖儿童(n=40)与非肥胖同年龄组儿童(n=40),分别测体质量指数(BMI)、腰围(WC)、肝脏B超、动脉收缩压(SBP)及舒张压(DBP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FPG)、空腹胰岛素(FIS),计算胰岛素抵抗指数(IRI)。结果肥胖组儿童脂肪肝等肝脏异常发生率、WC、BMI、SBP、DBP、TG、TC、LDL-C、FPG、IRI均高于对照组(P<0.05),HDL-c水平则低于对照组(P<0.01),FIS与BMI呈正相关(P<0.001)。有20%单纯性肥胖儿童符合MS标准。结论肥胖儿童存在脂代谢紊乱,易发脂肪肝,且普遍存在高胰岛素血症和胰岛素抵抗。代谢综合征的各组分表现已经在肥胖儿童中有所显示。     

单纯性肥胖儿童代谢综合征状况分析

目的:探讨单纯性肥胖儿童与代谢综合征的关系.方法:采用随机对照的病例研究方法,分析年龄10～15岁单纯性肥胖儿童(n=40)与非肥胖同年龄组儿童(n=40),分别测体质量指数(BMI)、腰围(WC)、肝脏B超、动脉收缩压(SBP)及舒张压(DBP)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-c)、空腹血糖(FPG)、空腹胰岛素(FIS),计算胰岛素抵抗指数(IRI).结果:肥胖组儿童脂肪肝等肝脏异常发生率、WC、BMI、SBP、DBP、TG、TC、LDL-C、FPG、IRI均高于对照组(P＜0.05),HDL-c水平则低于对照组(P＜0.01),FIS与BMI呈正相关(P＜0.001).有20%单纯性肥胖儿童符合代谢综合征标准.结论:肥胖儿童存在脂代谢紊乱,易发脂肪肝,且普遍存在高胰岛素血症和胰岛素抵抗.代谢综合征的各组分表现已经在肥胖儿童中有所显示.     

早期肥胖患儿胆固醇水平与代谢综合征及动脉粥样硬化的关系分析

目的分析早期肥胖患儿胆固醇(TC)水平与代谢综合征、动脉粥样硬化的关系。方法选择100例早期肥胖儿童(肥胖组)与80例非肥胖(非肥胖组)儿童,收集所有儿童临床资料,记录胰岛素抵抗指数(HOMA-IR),采用超声测定所有儿童颈动脉中膜层厚度(IMT)、血管舒张功能(FMD)、颈动脉血管顺应性(CAC)、腹膜前脂肪最大厚度(Pmax),总结TC在肥胖儿童代谢紊乱、早期动脉粥样硬化形成过程中的作用。结果1肥胖组体质量指数(BMI)、腰围(WC)、收缩压(SBP)、舒张压(DBP)、Pmax、甘油三酯(TG)、TC、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FINS)、超敏C反应蛋白(Hs-CRP)、HOMA-IR、IMT均高于非肥胖组(P<0.05),其脂联素(AD)、FMD、高密度脂蛋白胆固醇(HDL-C)低于非肥胖组(P<0.05);2肥胖组高血压、高胰岛素血症、低HDL-C、高LDL-C、高TG、高TC、内脏脂肪集聚、代谢综合征所占比例均高于非肥胖组(P<0.05);3TC升高组高血压、高胰岛素血症、高LDL-C、低HDL-C、高TG、代谢综合征、内脏脂肪集聚所占比例均高于TC正常组(P<0.05);4TC>5.20mmol/L肥胖儿童患代谢综合征、动脉粥样硬化风险增高。结论 TC上升为肥胖儿童代谢紊乱及动脉粥样硬化的独立危险因素。     

老年人群血尿酸水平及高尿酸血症相关危险因素分析

目的检测老年人群血尿酸(UA)水平,分析高尿酸血症(HUA)的相关危险因素。方法抽取6180例青年、5632例中年和5338例老年人静脉血,检测UA、空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平。分析HUA的相关危险因素。结果老年人UA水平和HUA患病率均高于中、青年人(P<0.01),且随体重指数(BMI)增加而升高;老年男性的UA水平和HUA患病率均高于老年女性(P<0.05或P<0.01)。Pearson相关分析显示,老年人UA水平与年龄、BMI和TG呈正相关(P<0.05),与FBG和HDL-C呈负相关(P<0.05)。Logistic回归分析显示,年龄、高TG和超重或肥胖是HUA的主要危险因素(P<0.05),而高FBG和高HDL-C为保护因素(P<0.05)。结论 HUA是老年人的高发病;其危险因素为年龄、高TG和超重或肥胖,保护因素为高FBG和高HDL-C。     

干部人群腰身指数与心血管疾病危险因素的相关性研究

目的探讨干部人群中作为一种新型腹型肥胖指标的腰身指数(腰围/身高比值,WHtR)与心血管危险因素的相关性。方法对2009年在我院行健康体检的处级干部471例测量血压、身高、体质量和腰围(WC),计算体质量指数(BMI)和WHtR,检测血糖、血脂、尿酸等生化指标,并进行统计学分析。结果 WHtR≥0.5组的年龄、体质量、BMI、WC、SBP、DBP、FBG、2hPBG、CH、TG、UA均显着高于WHtR<0.5组,而HDL-C的结果则相反(P<0.01,P<0.05);WHtR与WC、BMI、体质量、SBP、DBP、2hPBG、TG、UA呈现出正相关关系,与HDL-C则有明显负相关关系(P<0.01,P<0.05)。结论 WHtR与心血管危险因素明显相关,及时控制WHtR可有效改善干部人群的健康状况。     

肥胖者血脂异常的HCT变化与发展结局关系研究

目的 探索肥胖患者血脂异常与红细胞比容(HCT)变化及其发展结局的关系.方法 选取150例血脂异常的肥胖患者为观察组,50例健康者作为对照;测定相关体格指标,计算体重指数(BMI)、腰臀比(WHR),检测2组血清总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),检测2组红细胞压积;根据观察组患者HCT水平分为3组,并随访3年,询问其发展结局.结果 观察组的HCT、TC、TG、LDL-C均显著高于对照组(P<0.05),HDL-C显著低于对照组(P<0.05);TC、TG、HDL-C、LDL-C均与HCT相关(P<0.01),与血脂异常相关的危险因素包括HCT水平、BMI与WHR;HCT高水平者心脑血管疾病发生率显著高于低水平与中水平者(P<0.05).结论 血脂异常的肥胖患者的HCT水平明显上升,HCT与血脂异常存在密切联系,肥胖、HCT水平的升高是血脂异常发生的危险因素,HCT水平高的血脂异常者懼患心脑血管性疾病的风险更大.     

人血清中骨形态发生蛋白质4表达水平与体质量指数的相关性研究

目的研究人群血清中骨形态发生蛋白质4(BMP4)水平与体质量指数(BMI)的相关性,推断血清BMP4水平是否成为肥胖人群发生心血管疾病的危险因素。方法入选180名受试者,根据BMI分为正常体质量组和超重组,采用酶联免疫吸附试验(ELISA)分别测量2组人群血清BMP4的水平。并对BMP4水平与BMI、高敏C反应蛋白(hs-CRP)的相关性进行分析,同时分析BMP4水平与传统心血管危险因素的相关性。结果超重组血清BMP4水平显著高于正常体质量组(P<0.05),与BMI及hs-CRP之间呈正相关(P<0.01);血清BMP4水平与传统的心血管危险因素,包括高密度脂蛋白胆固醇(HDL-C)、空腹血糖,血压无相关性,而与年龄呈正相关。结论超重组BMP4水平与BMI以及hs-CRP呈正相关,是肥胖人群心血管疾病的危险因素。     

学龄儿童人体测量参数及相关生化指标分析

目的探讨学龄儿童人体测量参数与相关生化指标相关性。方法采用分层整群抽样方法, 2021年 3—6月对天津市静海地区学校学龄儿童 1 042例进行体检,并检测相关生化指标,分析其身材、体质量检出情况,并根据其身高标准差积分( Ht SDS)将其分为超高组、正常组、偏矮组及矮小组,比较四组身体测量指标;根据身体质量指数( BMI)将其分为偏轻组、正常组、超重组及肥胖组,比较四组身体测量指标;采用 Spearman相关性分析探索各指标间相关性。结果 1 042例儿童中,超高身材检出率为 14.01%,正常身材检出率为 71.11%,偏矮身材检出率为 10.08%,矮小身材检出率为 4.80%;偏轻体质量检出率为5.57%,正常体质量检出率为 52.50%,超重体质量检出率 17.56%,肥胖体质量检出率为 24.38%;女性儿童中超高身材占比较高,男性儿童中偏矮及矮小身材占比较高( P<0.05);随着年龄增加,学龄儿童三酰甘油( TG)水平呈升高趋势、总胆固醇( TC)及高密度脂蛋白胆固醇( HDL-C)水平呈降低趋势( P<0.05);基于 BMI,四组血尿酸水平随着 BMI增加而升高,且肥胖组血尿酸水平最高( P<0.05);四组 HDL-C水平随着 BMI增加而降低,且肥胖组 HDL-C水平最低( P<0.05);四组其他血脂水平比较,差异无统计学意义( P>0.05);基于 Ht SDS,四组 TG、血尿酸、血红蛋白( Hb)水平随 Ht SDS增加而升高,且矮小组 TG、血尿酸、 Hb水平最低( P<0.05);四组其他身体测量指标水平比较,均差异无统计学意义( P>0.05); Spearman相关性分析显示, TC及 HDL-C与学龄儿童年龄呈负相关, TG与学龄儿童年龄呈正相关(P<0.05); LDL-C、HDL-C、TG及血尿酸与 BMI均呈正相关(P<0.05); TG、血尿酸及 Hb均与 Ht SDS呈负相关( P<0.05)。结论学龄儿童随着年龄增加血脂水平降低,血脂及尿酸水平可能影响学龄儿童身高和体质量,血脂及尿酸水平与体质量具有正相关性,与身高具有负相关性, Hb与身高呈负相关。     

新诊断2型糖尿病伴高尿酸血症与血压及血脂相关性分析

目的 分析新诊断2型糖尿病(T2DM)合并高尿酸血症(HUA)者与血压及脂代谢紊乱的相关性.方法 选取新诊断的T2DM患者170例,根据血尿酸(SUA)水平分为SUA正常组(NUA组)和HUA组,比较两组血脂、肾功能等临床指标的差异.结果 新诊断T2DM患者中合并HUA的患病率为20.0％.HUA组舒张压(DBP)、腰围(wC)、体质量指数(BMI)、血肌酐(Scr)、尿微量白蛋白(UAER)、甘油三酯(TG)均高于NUA组(P＜0.05),而高密度脂蛋白胆固醇(HDL-C)低于NUA组(P＜ 0.05).相关性分析显示,DBP、BMI、WC、TG、HDL-C、Scr及UAER是HUA的影响因素(P＜0.05).结论 新诊断T2DM患者高尿酸血症与高血压、肥胖、血脂异常及肾脏病变相关.     

Prevalence of glucose metabolism abnormalities and cardiovascular co-morbidity in the US elderly adult population

PURPOSE: To estimate the prevalence of glucose metabolism abnormalities, including diabetes, and its associated cardiovascular risk factors and co-morbidity in the US elderly population. METHODS: Cross-sectional analysis of data from the Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994) in adults aged 65 years and more. The 1997 American Diabetes Association (ADA) and the 1998 World Health Organization (WHO) criteria were used to classify the subject's glucose metabolism status. The 2-hour oral glucose tolerance test (OGTT) was performed only among those participants aged 40 to 74 years. RESULTS: The age-adjusted prevalence of diagnosed diabetes was 12.5% (95% CI: 11.4%-13.6%) among US adults aged 65 years or more. According to the ADA definition 40% of men and 28% of women were affected by some degree of glucose metabolism impairment. According to the WHO definition, 55% of men and 50% of women aged 65 to 74 years were affected by glucose metabolism abnormalities. Mexican-Americans were the most affected under both definitions (51% and 77%, respectively). Overall, 72% of elderly diagnosed diabetics had hypertension, 28% had coronary heart disease (CHD), 47% suffered from cardiovascular disease and 80% of them presented known CHD or multiple coronary risk factors, other than age, level of LDL-cholesterol and diabetes. Under both definitions, a trend towards a worsening coronary risk profile with increased glucose metabolism impairment was observed. CONCLUSION: A notable proportion of elderly people is affected by some degree of glucose metabolism impairment which in turn is associated with cardiovascular co-morbidity.     

杭州市老年人群心血管事件发生风险的危险因素及相关预防干预对策研究

目的探讨杭州市老年人群心血管事件发生风险的危险因素,制定预防干预措施对策提供依据。方法选取2015年2月至2019年2月在我院进行健康体检的老年人278例作为研究对象,统计心血管事件发生情况,并收集相关资料,分析心血管事件发生风险的危险因素。结果278例健康体检的老年人中心血管事件高危风险者100例,发生率35.97%;2组性别、婚姻状况、文化程度及人均收入对比,差异无统计学意义(P>0.05);与无心血管事件风险者比较,年龄(≥80岁)、收缩压(异常)、空腹血糖(异常)、总胆固醇(异常)、吸烟、饮酒占比较高,运动习惯占比较低,差异有统计学意义(P<0.05);经Logistic分析,年龄(≥80岁)、收缩压(异常)、空腹血糖(异常)、总胆固醇(异常)、吸烟、饮酒为老年人心血管事件风险发生的危险因素(OR>1,P<0.05);而运动习惯为老年人心血管事件风险发生的保护因素(OR<1,P<0.05)。结论收缩压、年龄、空腹血糖、总胆固醇、吸烟、饮酒及运动习惯为老年人心血管事件风险发生的影响因素,需采取对应干预措施,控制心血管事件发生率。     

唐山市946例煤炭从业人员高尿酸血症患病情况与影响因素分析

目的:了解唐山市煤炭行业从业人员高尿酸血症(HUA)的患病情况和相关危险因素.方法:选取唐山市煤炭行业从业人员946例,询问一般情况、个人生活习惯、家族疾病史等,测定身高、体质量和血压.取空腹肘正中静脉血检测血尿酸、血糖、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C),并对检测结果进行分析.结果:HUA检出率为10.7％,HUA组的体质量指数、TG、TC、SBP、DBP高于非HUA组(P＜0.05).HUA组中男性、肥胖、吸烟、饮酒、高血压家族史、高血压、血脂异常者所占比例大于非HUA组(P＜0.05),多因素分析显示男性、肥胖、血脂异常、高血压是HUA的独立危险因素.结论:煤炭行业从业人员HUA检出率较高,脂质代谢异常、高血压及不良生活习惯是其主要危险因素.     

Risk factors for frequent high alcohol consumption among Swedish secondary-school students

OBJECTIVE: The aim of this study was to analyze the impact and possible causal interrelationships of psychological, psychosocial and socioeconomic factors on frequent high consumption of alcoholic beverages in a Swedish secondary-school student population. METHOD: A cross-sectional study via questionnaire was administered to 1,384 high school students in Trelleborg, Sweden, from 1999 to 2001 (658 boys, 726 girls; response rates, 84.6% in 1999, 89.3% in 2000 and 91.7% in 2001). Logistic regression analyzed the relationship between various risk factors and frequent high alcohol consumption. RESULTS: Interest in trying drugs was the strongest indicator for frequent high alcohol consumption, after adjusting for age, socioeconomic status and psychosocial risk factors (boys: odds ratio (OR) = 3.9, 95% confidence interval (CI): 2.5-6.0; girls: OR = 2.7, 95% CI: 1.8-3.9). This variable also had the highest population-attributable fraction (PAF; boys = 39%, girls = 29%). High purchasing power increased the risk of frequent high alcohol consumption (boys: OR = 2.1, 95% CI: 1.4-3.0; PAF = 25%; girls: OR = 1.6, 95% CI: 1.1-2.3; PAF = 16%). The association between high alcohol consumption and psychosocial factors differed by gender. Participation in organized team sports was associated with increased risk among boys (OR = 3.0, 95% CI: 2.0-4.7; PAF = 32%), but not girls (OR = 1.0, 95% CI: 0.7-1.5; PAF = 0%). Parental acceptance of alcohol consumption was more important for the latter (girls: OR =1.7, 95% CI: 1.2-2.3; PAF = 27%; boys: OR = 1.5, 95% CI: 1.0-2.1; PAF = 21%). CONCLUSIONS: Psychological, psychosocial and socioeconomic elements were independent risk factors for frequent high alcohol consumption. Discrepancies in risk factor patterns between boys and girls suggest alternate approaches be considered in interventiods.     

Impact of ER gene polymorphisms on overweight and obesity in Down Syndrome

The impact of ER XbaI and PvuII α gene polymorphisms on overweight and obesity were studied in 77 subjects with Down Syndrome (DS), of which 32 were children (18 boys, 14 girls), mean age 8.7 ± 2.3 years, and 45 adolescents (28 boys, 17 girls) mean age 14 ± 2.5 years. Their lifestyle was compared to 40 healthy age-matched controls. DS subjects had significant lesser physical activity than controls (p<0.05) and a lower caloric intake than the recommended requirements, which was significantly lesser than controls (p<0.05). Body Mass Index (BMI), Arm Circumference (AC) and Triceps Skinfold Thickness (TST) were significantly higher in DS subjects than controls (p<0.05), while metabolic and cardiovascular parameters were not significantly different between the groups (p>0.05). The frequency of ER genotypes in DS subjects was compared with the healthy controls, finding that there was a high prevalence of XXER genotype in DS subjects. Children and adolescents with DS, lacking ER XbaI site, showed significantly higher BMI and body fat distribution than other XbaI genotypes. The lack of ER XbaI site can indicate added risk of obesity in DS. No differences in metabolic and cardiovascular parameters were observed among ER genotypes. However, childhood obesity is associated with increased cardiovascular risk.     

太原市城乡青春期高血压流行病学调查

目的了解太原市青春期血压水平以及高血压的发生状况,探索青春期原发性高血压的易患因素,为开展成年期心血管疾病的预防提出理论依据。方法采用分层整群随机抽样方法对太原市1 749名13～18岁青春期少年进行身高、体质量、收缩压(SBP)、舒张压(DBP)的测定,并计算体质量指数(BMI),以血压值在其年龄、性别第95百分位以上者为高血压,经进一步体检排除继发性高血压,筛选出原发性高血压者69例,将其作为研究对象,用随机抽样法在所有血压正常青少年中选择69名作为对照,进行1∶1病例对照配对,抽取静脉血查空腹血糖、甘油三酯、胆固醇,并填写统一制定的调查表。对可能影响高血压发生的因素进行Logistic回归分析。结果①城乡间SBP、DBP均值差异有统计学意义,城乡原发性高血压发生率差异无统计学意义。②同性别、不同年龄组间SBP、DBP均值差异无统计学意义,男女之间SBP、DBP差异有统计学意义。③单因素分析显示:BMI升高、高脂血症是青春期原发性高血压的重要危险因素。将SBP和DBP分别进行分析,发现肥胖、高血压家族史、高脂血症是收缩期高血压的危险因素,肥胖、高脂血症是舒张期高血压的危险因素。多因素Logistic回归分析显示:BMI是青春期原发性高血压发病的危险因素。收缩期原发性高血压的危险因素有肥胖、高脂血症、感到入睡困难、高血压家族史;舒张期原发性高血压的危险因素有肥胖、高脂血症。结论肥胖、高脂血症是青春期原发性高血压的重要危险因素,与收缩期及舒张期原发性高血压均有关系,高血压家族史是收缩期高血压的危险因素。     

2型糖尿病患者合并糖尿病性视网膜病变的危险因素meta分析

目的系统评价2型糖尿病患者合并糖尿病性视网膜病变的危险因素。方法计算机检索中国知网、万方数据库, 搜集有关2型糖尿病患者合并糖尿病性视网膜病变的文献, 检索时间为建库至2022年5月1日, 由2名研究员按照预先制定的标准独立筛选病例对照研究文献、质量评价、提取资料后, 评价纳入研究的偏倚风险, 使用Stata 16.0软件进行数据统计分析。结果最终纳入59篇文献, 共27 926例研究对象。暴露因素中三酰甘油(WMD=0.33, 95%CI 0.24～0.45)、低密度脂蛋白胆固醇(WMD=0.30, 95%CI 0.12～0.40)、同型半胱氨酸(WMD=3.89, 95%CI 0.92～6.85)是脂代谢相关的危险因素;糖化血红蛋白(WMD=1.32, 95%CI 1.03～1.61)、空腹血糖(WMD=1.82, 95%CI 1.17～2.47)是糖代谢相关的危险因素;收缩压(WMD=6.45, 95%CI 4.91～8.00)、舒张压(WMD=4.70, 95%CI 3.57～5.84)是血压相关的危险因素;C反应蛋白(WMD=1.34, 95%CI 0.55～3.14)是炎性...     

Association of Fasting Plasma Glucose and Serum Lipids in Type 2 Diabetics

Dyslipidemia is a significant morbidity associated with diabetes and cardiovascular disorders. The present study was undertaken to assess the lipid profile of type 2 diabetic and age-gender matched healthy subjects and its association, if any, with fasting plasma glucose. Clinically diagnosed diabetic subjects were recruited for the study. The fasting plasma glucose and lipid profiles were analyzed for 99 diabetic and 101 healthy volunteers. The blood samples were analyzed for fasting plasma glucose, total cholesterol, triglycerides, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol and very low density lipoprotein-cholesterol. Correlation analysis of lipid profile with fasting plasma glucose and calculation of risk ratio was done. The levels of high density lipoprotein-cholesterol and low density lipoprotein-cholesterol were found to be significantly low in diabetics and subjects with lower low density lipoprotein-cholesterol were on statins. Inspite of lower lipid values, the risk ratio for diabetics was significantly higher. The correlation analysis indicated significant difference in relationship between fasting plasma glucose, lipid parameters and risk ratios in the two groups. Diabetics with lower high density lipoprotein-cholesterol and higher total cholesterol present with a higher risk ratio pointing to need of non-statin high density lipoprotein-raising medications decreasing their predisposition to cardiovascular disorders. The study highlights the altered pattern of correlation of lipid profile with fasting plasma glucose in diabetics and their increased risk of cardiovascular disorders. The dyslipidemia in the form of triglyceridemia and significantly low high density lipoprotein-cholesterol in diabetics point towards the need of non-statin high density lipoprotein-raising medications.     

Hemostatic effects of bezafibrate and ω-3 fatty acids in isolated hypertriglyceridemic patients

This study aimed to compare the effects of ω-3 fatty acids and fibrate treatment on plasma levels and activities of hemostatic risk factors on glucose and lipid metabolism in subjects with isolated hypertriglyceridemia. Seventy-three subjects with elevated triglyceride levels were allocated into one of the following treatment options: bezafibrate (200 mg twice daily), ω-3 fatty acids (1 g twice daily) or placebo. Plasma lipids, glucose homeostasis markers (fasting and 2-h post-glucose load plasma glucose levels and HOMA), as well as plasma levels/activities of fibrinogen, factor VII and PAI-1 were determined at baseline, on the day of randomization, and after 4 and 12 weeks of the treatment. Not only did bezafibrate improve plasma lipids, but it also increased glucose sensitivity and tended to reduce post-glucose loads of plasma glucose. Except for the reduction in plasma triglycerides, ω-3 fatty acids produced no effect on the lipid profile and insulin sensitivity. Both treatment options reduced, to similar extents, plasma levels of fibrinogen and PAI-1 and factor VII coagulant activity. Our study indicates that, although fibrates exhibit more-pronounced metabolic effects than do ω-3 fatty acids, both these treatment options are equipotent in producing a complex beneficial effect on hemostasis in isolated hypertriglyceridemic subjects.