不同血型精神分裂症患者暗示性的对比分析

目的了解不同血型精神分裂症患者在暗示性方面的差异.方法以住院精神分裂症患者为研究对象,用临床常规的正反定型法检测ABO血型,依照唐安平的暗示性测查方法测查其暗示性,同时调查其可能的相关因素.结果不同血型的精神分裂症患者在暗示性的各单项分值间存在差异(P值均＜0.05或0.01),在条件Logistic回归分析中,有嗅觉暗示性、听觉暗示性以正相关和负相关分别进入O型和AB型方程(其偏回归系数分别为0.248,-0.581,P值均＜0.01).结论不同血型精神分裂症患者间暗示性的差异间接表明了在精神分裂症患者中其接受暗示,尤其是某单项暗示的程度强弱与个体的生物学基础是分不开的.     

不同血型抑郁症患者的暗示性研究

目的了解不同血型抑郁症患者在暗示性方面的差异。方法以住院抑郁症患者为研究对象,用临床常规的正反定型法检测ABO血型,依照唐安平的暗示性测查方法,测查其暗示性,同时调查其可能的相关因素。结果不同血型的抑郁症患者在暗示性的各单项分值间存在差异,在条件Logistic回归分析中有视觉暗示性、触觉暗示性,以正相关和负相关分别进入O型和AB型方程。结论不同血型抑郁症患者间暗示性的差异间接表明了在抑郁症患者中其接受暗示,尤其是某单项暗示的程度强弱,与个体的生物学基础是分不开的。     

喹硫平治疗对首发精神分裂症认知功能的影响

目的 探讨喹硫平治疗对首发精神分裂症患者认知功能的影响.方法 选择符合国际疾病分类第十版(ICD-10)诊断标准的首发精神分裂症住院病人90例,详细收集临床资料.均使用喹硫平治疗,分别在基线时及治疗12周末对患者进行阳性和阴性症状量表(PANSS)评定临床症状,威斯康星卡片分类(WCST)、重复性神经心理测查系统(RBANS)检测认知功能.对患者在治疗前和治疗后的临床症状、认知功能的变化值进行比较.分析首发精神分裂症患者基线时的临床症状与认知损害是否相关,以及通过喹硫平治疗是否可以改善首发精神分裂症患者的认知损害.结果 基线时患者的临床症状与认知损害存在明显相关(P均<0.05).经过12周的喹硫平治疗后,临床症状有显著的改善(P均<0.01);患者12周末与基线相比RBANS测验总分及部分因子分与基线评分相比较有显著提高,差异有统计学意义(P均<0.05);WCST中部分因子分均较基线明显改善,差异有统计学意义(P均<0.01).结论 喹硫平具有改善首发精神分裂症认知功能的作用.     

Ⅰ型、Ⅱ型精神分裂症患者认知功能比较

目的:比较Ⅰ型、Ⅱ型精神分裂症认知功能状况及疗效。方法:选取连续入院符合入组标准要求患者60例,根据其临床表现将其划分为Ⅰ型组、Ⅱ型组。在入院时及治疗6周后分别予以PANSS、SCoRS进行评定。结果:入院时两组精神分裂症患者PANSS评分总分组间比较无明显差异(t=1.9718,P=0.0544)。治疗6周后,两组患者症状均有显著改善,两组患者PANSS总分分别与入院时比较均有统计学显著差异(P<0.01)。组间PANSS评分总分比较存在统计学差异(t=2.1022,P=0.0408),Ⅰ型组患者疗效优于Ⅱ型组。入院时两组精神分裂症患者之间SCoRS未发现统计学差异,经6周治疗后两组患者认知功能评定均有不同程度改善,两组之间SCoRS未发现统计学差异;PANSS减分与SCoRS减分之间相关性分析提示Ⅰ型组为0.227,P<0.01;Ⅱ型组为0.341,P<0.01。结论:Ⅰ型精神分裂症和Ⅱ型精神分裂症患者均存在认知功能损害,经抗精神病治疗后,患者精神症状均有显著改善,Ⅰ型组优于Ⅱ型组。入院时患者认知功能均有不同程度改善,但两者之间无明显统计学差异,精神分裂症认知功能改善似乎与阴性症状改善之间关系更密切。     

暗示性护理对精神分裂症急性期的作用

目的：探讨暗示性心理护理对急性期精神分裂症患者的作用。方法：将70例精神分裂症患者，分为观察组和对照组，观察组采用暗示性心理护理，对照组采用常规护理，2组均采用BPRS和N-BPRS量表进行评定。结果：入组时2组BPRS和N-BPRS总分无显著差异，P＞0.05；在实施暗示性心理护理之后，2组的BPRS和N-BPRS总分有显著差异，P均＜0.05。结论：暗示性心理护理能显著提高急性期暗示性高的精神分裂症患者的康复效果。     

Ⅰ型、Ⅱ型精神分裂症患者认知功能比较简

目的：比较Ⅰ型、Ⅱ型精神分裂症认知功能状况及疗效.方法：选取连续入院符合入组标准要求患者60例,根据其临床表现将其划分为Ⅰ型组、Ⅱ型组.在入院时及治疗6周后分别予以PANSS、SCoRS进行评定.结果：入院时两组精神分裂症患者PANSS评分总分组间比较无明显差异（t=1.9718,P=0.0544）.治疗6周后,两组患者症状均有显著改善,两组患者PANSS总分分别与入院时比较均有统计学显著差异（P＜0.01）.组间PANSS评分总分比较存在统计学差异（t=2.1022,P=0.0408）,Ⅰ型组患者疗效优于Ⅱ型组.入院时两组精神分裂症患者之间SCoRS未发现统计学差异,经6周治疗后两组患者认知功能评定均有不同程度改善,两组之间SCoRS未发现统计学差异;重PANSS减分与SCoRS减分之间相关性分析提示Ⅰ型组为0.227,P＜0.01;Ⅱ型组为0.341,P＜0.01.结论：Ⅰ型精神分裂症和Ⅱ型精神分裂症患者均存在认知功能损害,经抗精神病治疗后,患者精神症状均有显著改善,Ⅰ型组优于Ⅱ型组.入院时患者认知功能均有不同程度改善,但两者之间无明显统计学差异,精神分裂症认知功能改善似乎与阴性症状改善之间关系更密切.     

无抽搐电休克治疗对患者认知功能的影响

目的:研究无抽搐电休克治疗(MECT)对精神分裂症患者认知功能的影响。方法:将符合入组条件的51例精神分裂症患者按入院顺序依次分为MECT组和非MECT组,MECT组采用MECT治疗,非MECT组采用常规非典型抗精神病药物治疗,在治疗前和治疗结束进行阳性与阴性症状量表(PANSS)、1个月后作认知功能检查评估变化情况。结果:两组患者经PANSS评分,其治疗后基础评分均明显低于治疗前,比较差异均有统计学意义(P0.01)。而MECT组的阳性症状分和PANSS总分均明显低于非MECT组,差异均有统计学意义(P0.05),两组治疗前后经WCST、CPT、WAIS-RC等认知功能测查,其组内与组间比较差异均无统计学意义(P0.05)。结论:MECT对精神分裂症治疗安全有效,对患者认知功能无明显影响。     

精神分裂症与神经症的反应时间比较

目的探讨精神分裂症和神经症患者反应时间(RT)的特点. 方法应用美国CA-1000型电生理仪以及短音和视觉刺激,测查62例精神分裂症、54例神经症和67名正常对照组的反应时间. 结果精神分裂症组、神经症组及正常对照组的听反应时间和视反应时间两两比较均有非常显著差异(P＜0.01).上述三组第二轮听反应时间与命令信号后负电位(PINV)变化表现为同一趋势,即听反应时间延迟,PINV随之延长. 结论反应时间可辅助精神分裂症患者和神经症患者的认知功能评定.     

精神分裂症患者MMPI的比较分析

目的:探讨MMPI在精神分裂症患者中的应用意义。方法:对50例精神分裂症患者在治疗前、后进行MMPI测查,并对结果进行比较分析。结果:MMPI在精神分裂症患者治疗后,其F、Pa、Sc量表分明显下降,D分明显增高,且差异有统计学意义(P<0.05或P<0.01)。结论:精神分裂症患者MMPI的测查结果是一个动态的变化,发病期的结果并非患者的人格特征,它反映了患者的病态心理活动;测查结果也能反映出患者病情的缓解程度。     

精神分裂症患者脑皮层兴奋性的对照研究

目的 了解精神分裂症患者的运动阈值(MT)与正常人的差异,以探讨精神分裂症患者的皮层兴奋性变化.方法 采用单脉冲经颅磁刺激(sTMS)检测均为右利手的48例精神分裂症患者和48例正常对照的MT值.结果 精神分裂症患者的MT值为左侧(47.01±9.14)高于右侧(44.59±10.54),差异有显著性(P＜0.05);而正常对照的MT值为左侧(41.79±7.65)低于右侧(44.63±7.96),差异有非常显著性(P＜0.01);精神分裂症患者左侧的MT值显著高于正常对照(P＜0.05),而右侧的MT值与正常对照差异无显著性(P＞0.05).结论 精神分裂症患者的皮层兴奋性与正常对照存在差异,具体表现为患者左、右两侧皮层兴奋性的不对称性与正常对照呈相反表现;精神分裂症患者左侧大脑皮层的兴奋性明显降低.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Electro-Acupuncture Combined with the Trigger Point Needle-Embedding for Treatment of Primary Trigeminal Neuralgia in 31 Cases

In recent years, the author of this essay has applied electro-acupuncture combined with the trigger point needle-embedding for treatment of primary trigeminal neuralgia in 31 cases, yielding satis- factory results as reported in the following.     

Investigation of Matrix Metalloproteinase -1, 2 and tissue inhibitor of matrix metalloproteinases-1 in Endometriosis

Objective： To explore the role of matrix metalloproteinase-1,2 （MMP-1, MMP-2） and tissue inhibitor of matrix metalloproteinases-1 （TIMP-1） in endometriosis. Methods： The eutopic and ectopic endometria from 40 subjects suffering from endometriosis and regular.endometria from 40 subjects （excluding endometriosis） were collected and examined by in situ hybridization technology and western blot assay. Results： Both expressions of MMP-1 and -2 were stronger in ectopic endometrium and eutopic endometrium than in normal endometrium. On the contrary, the expression of TIMP-1 in ectopic endometrium and eutopic endometrium was lower. The differences were significant （P 〈 0.01 ）. Moreover, there was no relationship among the expressions of MMP-1, 2 and TIMP-1 in ectopic endometrium. Conclusion： The expressions of MMP-1, 2 and TIMP-1 lose balance and lack of periodic changes in ectopic endometrium , which explains the biological invasive behavior of endometriosis. It was suggested-that regulating the balance between the MMPs and TIMP-1 should be an ideal therapeutic target to endometriosis.     

Shi Da-zhuo (史大卓) —An outstanding cardiologist of integrative medicine

Prof. SHI Da-zhuo, Ph.D., male, was born on March 20, 1960. Prof. SHI entered the Ph.D. program in 1990 at the China Academy of Chinese Medical Sciences under the supervision of Prof. CHEN Ke-ji, majoring in the treatment of cardiovascular diseases. After receiving his Ph.D. degree in 1993, Prof. SHI started working at the Cardiovascular Center in Xiyuan Hospital affiliated to China Academy of Chinese Medical sciences.     

Persist in and Carry Forward the Integrative Medical Research——Speech at the 6th National General Congress of Chinese Association of Integrative Medicine by Academician CHEN Zhu,Minister of Ministry of Health

The 6th National General Congress of Chinese Association of Integrative Medicine （CALM） was convened at 19-20, April 2008 in Beijing. Academician CHEN Zhu, the minister of Ministry of Health indicated at the congress that the integration of Chinese and Western medicine is very well in keeping with the situation of our country and the general rule of development in medical science; and as a good integration of Chinese medicine and Western medicine, it is mutually beneficial and advantageous to both of them. Seeing the creativity shown in integrative medical investigation in theoretic and methodological sides, we should and must persist in and develop it.