柴胡疏肝散加减治疗萎缩性胃炎28例疗效分析

目的探讨柴胡疏肝散加减治疗萎缩性胃炎的疗效。方法将确诊的病例随机分为2组,治疗组与对照组各28例。治疗组给予中药柴胡疏肝散加减。对照组用维酶素片每次1g,每日3次;阿莫西林胶囊每次0.5g,每日3次。结果治疗组治疗2周内胃脘胀满疼痛等症状均明显好转,对照组治疗2周内胃脘胀满疼痛等症状明显好转20例,有8例仍有胃脘胀满疼痛等症状,治疗组与对照组疗效比较有统计学意义(p<0.01)。结论中药柴胡疏肝散加减治疗治疗萎缩性胃炎有满意的疗效。     

柴胡疏肝散加减治疗慢性萎缩性胃炎68例

目的 观察柴胡疏肝散加减治疗慢性萎缩性胃炎的临床疗效。方法 128例慢性萎缩性胃炎患者随机分为两组，治疗组68例采用柴胡疏肝散随证加减，对照组60例口服吗丁啉、猴头菌片。结果 治疗组总有效率为97．1％，对照组总有效率为81．7％，两组比较差异有显著性意义（P〈0．01）。结论 柴胡疏肝散加减治疗慢性萎缩性胃炎疗效良好，可改善胃黏膜血液循环，促进病变组织的修复。     

柴胡疏肝散加减合左金丸治疗胆汁反流性胃炎46例

目的 探讨柴胡疏肝散加减合左金丸对胆汁反流性胃炎的作用.方法 将86例胆汁反流性胃炎患者随机划分为治疗组和对照组.治疗组46例给予柴胡疏肝散加减合左金丸治疗,对照组40例给予吗丁啉治疗.结果 治疗组与对照组的总有效率分别为93.48%和77.50%,两组比较,P＜0.05,差异有统计学意义.结论 柴胡疏肝散合左金丸加减...     

柴胡疏肝散治疗肝胃不和型慢性浅表性胃炎52例

目的探讨柴胡疏肝散治疗肝胃不和型慢性浅表性胃炎的临床疗效。方法将患者随机分为两组,治疗组52例予柴胡疏肝散,水煎服,日一剂;对照组49例予口服奥美拉唑20mg,每日1次,吗丁啉片10mg,每日3次,四周为1个疗程,2个疗程后观察其治疗前后临床症状和胃镜的变化。结果在改善肝胃不和型慢性浅表性胃炎患者的临床症状和胃镜表现上,两组比较,差异有显著性意义(p<0.05),治疗组疗效优于对照组。结论柴胡疏肝散对肝胃不和型慢性浅表性胃炎有较好临床疗效。     

柴胡疏肝散加减治疗胆汁反流性胃炎

目的观察柴胡疏肝散加减治疗胆汁反流性胃炎的临床疗效。方法选择2008年9月—2011年9月收治的胆汁反流性胃炎患者87例,均给予柴胡疏肝散加减治疗。结果临床治愈75例,有效10例,无效2例,总有效率97.7%。结论柴胡疏肝散加减治疗胆汁反流性胃炎有较好疗效,值得临床应用。     

柴胡疏肝散联合穴位埋针治疗肝胃气滞型胃痛的临床观察

目的 探究柴胡疏肝散联合穴位埋针在肝胃气滞型胃痛中的临床作用。方法 选取医院2019年11月-2021年3月收治的肝胃气滞型胃痛患者80例,采用随机数字表法结合组间性别、年龄、病程具有可比性的原则,分为对照组和观察组各40例。对照组给予柴胡疏肝散治疗,观察组给予柴胡疏肝散联合穴位埋针治疗,对两组患者的疗效、中医症状积分、生活质量进行对比。结果 观察组的治疗总有效率为97.5%,高于对照组的77.5%,差异有统计学意义（P<0.05）。治疗后观察组中医症状积分（泛酸、嗳气、胁肋胀痛、胃脘疼痛、烦躁易怒、胃脘胀满）均低于对照组,差异有统计学意义（P<0.05）;且观察组生活质量各维度（物质生活、生理功能、社会关系、心理状态）评分均高于对照组,差异有统计学意义（P<0.05）。结论 应用柴胡疏肝散联合穴位埋针对肝胃气滞型胃痛进行治疗,能够有效缓解患者的症状,提升患者生活质量,疗效显著。     

胆汁反流性胃炎应用柴胡疏肝散加减治疗临床疗效评价

目的:观察胆汁反流性胃炎采取柴胡疏肝散加减诊治的临床效果。方法:选自2018年5月到2019年5月这一阶段本科室收诊的76例伴有胆汁反流性胃炎症状患者实施研究,依照随机数表法原则分为常规组(n=38)和实验组(n=38),常规组运用常规治疗,实验组采取柴胡疏肝散加减诊治,比较两组临床效果。结果:实验组治疗总效率97.67%升高效果比常规组81.58%更加明显,(P=0.0249,X~2=5.0294)。结论:胆汁反流性胃炎采取柴胡疏肝散加减诊治临床效果明确,可缓解症状,具有应用价值。     

中西医治疗原发性胆汁返流性胃炎90例临床观察

目的　观察中西医治疗原发性胆汁返流性胃炎 90例的疗效 ,并与单纯应用西药的对照组 45例做对比观察。方法　两组均予莫沙必利片 ,铝碳酸镁片及Hp感染加三联药 (奥美拉唑胶囊 +克拉霉素片 +阿莫西林胶囊 )治疗的基础上 ,治疗组加用柴胡疏肝散加减治疗 ,疗程为 1个月。结果　两组在临床症状 ,胆汁返流 ,Hp根除率方面 ,治疗组总有效率优于对照组 (P <0 0 1)。结论　中西医结合是治疗原发性胆汁返流性胃炎较好的方法 ,其原因可能是柴胡疏肝加减方中 ,经临床实验证明具有调节胃肠功能 ,杀灭或抑制Hp及保护胃黏膜作用的中药与西药联用 ,从而使疗效提高     

慢性萎缩性胃炎从瘀论治的临床疗效分析

目的探讨慢性萎缩性胃炎从瘀论治的临床疗效。方法将74例慢性萎缩性胃炎患者随机方法分为治疗组(38例)与对照组(36例),对照组根据中医辨证分型为肝胃不和型、湿热内蕴型、脾胃虚寒型及胃阴亏虚型,分别予以柴胡疏肝散、温胆汤、黄芪建中汤及益胃汤治疗,治疗组在对照组基础上同时加服丹参饮合失笑散,比较两组患者的临床治疗效果以及临床症状消失时间。结果治疗组的总有效率显著高于对照组,临床症状消失时间显著短于对照组,差异均具有统计学意义(P<0.05)。结论从瘀论治慢性萎缩性胃炎较单纯中医辨证治疗疗效显著,能够快速缓解临床症状,可推广应用。     

柴胡疏肝散加减治疗胃痛的临床观察

目的:观察柴胡疏肝散加减对于胃痛的临床治疗价值。方法:2012年3月-2014年9月于我院住院收治的胃痛患者72例,随机分为柴胡疏肝散组(31例)和对照组(31例),观察分析柴胡疏肝散组与对照组临床疗效及复发率。结果:柴胡疏肝散组的临床治疗有效率显著高于对照组(p<0.05);柴胡疏肝散3个月的复发率及6个月复发率均显著低于对照组(p<0.05)。结论:柴胡疏肝散能够调理阴阳,顺气升降,补与泻双管齐下,合理配伍,能够有效地应用于胃痛的临床治疗。     

Calcium intake in the elderly: validation of a dietary questionnaire

Epidemiological studies of calcium and osteoporosis have been hampered by the lack of a suitable tool for assessing calcium intake. This report describes a new frequency and amount questionnaire for measuring present and past calcium intake in the elderly. The validity of the questionnaire was tested against two commonly used standards of dietary assessment, five-day duplicate diets and seven-day weighed dietary inventories. The resulting correlation coefficients were, respectively, r = 0.76 and r = 0.69, while that for repeatability was r = 0.84. Furthermore, the questionnaire categorized subjects into thirds of the distribution of intake with almost no gross misclassification. It is suggested that the present findings may be extended to the majority of normal, healthy elderly subjects, implying wide application for the questionnaire in the assessment of calcium intake in the elderly.     

The occurrence of antimicrobial substances in toilet,sink and shower drainpipes of clinical units: A neglected source of antibiotic residues

Antibiotics represent one of the most important drug groups used in the management of bacterial infections in humans and animals. Due to the increasing problem of antibiotic resistance, assurance of the antibacterial effectiveness of these substances has moved into the focus of public health. The reduction in antibiotic residues in wastewater and the environment may play a decisive role in the development of increasing rates of antibiotic resistance. The present study examines the wastewater of 31 patient rooms of various German clinics for possible residues of antibiotics, as well as the wastewater of five private households as a reference.To the best of our knowledge, this study shows for the first time that in hospitals with high antibiotic consumption rates, residues of these drugs can be regularly detected in toilets, sink siphons and shower drains at concentrations ranging from 0.02?μg·L^?1 to a maximum of 79?mg·L^?1. After complete flushing of the wastewater siphons, antibiotics are no longer detectable, but after temporal stagnation, the concentration of the active substances in the water phases of respective siphons increases again, suggesting that antibiotics persist through the washing process in biofilms. This study demonstrates that clinical wastewater systems offer further possibilities for the optimization of antibiotic resistance surveillance.     

Self-reported health problems among Swedish miners one year after unemployment

Unemployment is considered to be a public health concern sincedeterioration in the health of the unemployed is often anticipated.However, for some groups, such as miners, unemployment mightimprove health due to a cessation of potentially harmful occupationalexposures. This study evaluates the health of 79 miners in oneSwedish iron-ore mine, and 226 age-matched controls from thegeneral population, during one year after the closure of themine. The participants received a questionnaire regarding medicalhistory and subjective symptoms at the beginning of the studyperiod, and after one year. Statistically significant negativeeffects on self-reported health attributable to unemploymentwere not found, although neuropsychiatric symptoms were morecommon among the unemployed miners. The miners reported a statisticallysignificant improvement in grip force (p=0.031). They had asignificantly higher prevalence of symptoms associated withmining related exposures when compared with the population controls;pain in the upper extremities [relative risk (RR)=2.27, 95%confidence interval (Cl)=1.44–3.59), back pain (RR=1.84;Cl=1.237–2.75), vasospastic disease of the fingers (RR=2.05;Cl=1.18–3.57) and obstructive respiratory symptoms (attacksof dyspnea and wheezing: RR=3.67; Cl=1.167–11.6).     

Excès de cas humains et animaux de tularémie en France au cours de l’hiver 2007–2008 : émergence ou phénomène isolé ?

Context

Tularemia is a zoonosis affecting humans and hares in France. We describe the results of surveillance in both species, in 2007 and 2008.

Methods

Human tularemia cases are mandatorily notifiable in France since 2003. In hares, surveillance relies on volunteer hunter associations in all districts of the country. Data from mandatory reports and volunteer surveillance in 2007/2008 were analyzed and compared with previous results.

Results

In 2007/2008, 144 cases were reported in humans and 117 cases in hares. This was a 100% increase compared to previous years. Human cases differed from those of previous years only by the frequency of contact with breeding animals. Human cases without any documented risk exposure were also more frequent.

Conclusion

An increase of tularemia cases occurred in 2007/2008 in both species. Complementary studies are needed to identify the species reservoir in France to understand the causes of this peak of cases.     

Occupational health hazards in mining: an overview

This review article outlines the physical, chemical, biological, ergonomic and psychosocial occupational health hazards of mining and associated metallurgical processes. Mining remains an important industrial sector in many parts of the world and although substantial progress has been made in the control of occupational health hazards, there remains room for further risk reduction. This applies particularly to traumatic injury hazards, ergonomic hazards and noise. Vigilance is also required to ensure exposures to coal dust and crystalline silica remain effectively controlled.     

Manufacture and use of nanomaterials: current status in the UK and global trends

This paper provides an overview of the production and use of nanomaterials (NMs), particularly in the UK. Currently, relatively few companies in the UK are identifiable as NM manufacturers, the main emphasis being the bulk markets in metals and metal oxides, and some niche markets such as carbon nanotubes and quantum dots. NM manufacturing in the UK does not reflect the global emphasis on fullerenes, nanotubes and fibres. Some assumptions have been made about the types of NM that are likely to be imported into the UK, which currently include fullerenes, modified fullerenes and other carbon-based NMs including nanotubes. Many university departments, spin-offs and private companies have developed processes for the manufacture of NMs but may only be producing small quantities for research and development (R&D) purposes. However, some have the potential to scale up to produce large quantities. The nanotechnology industry in the UK has strong R&D backup from universities and related institutions. This review has covered R&D trends at such institutions, and appropriate information has been added to a searchable database. While several companies are including NMs in their products, only a few (e.g. manufacturers of paints, coatings, cosmetics, catalysts, polymer composites) are using nanoparticles (NPs) in any significant quantities. However, this situation is likely to change rapidly. There is a need to collect more information about exposure to NPs in both manufacturing and user scenarios. As the market grows, and as manufacturers switch from the micro- to the nanoscale, the potential for exposure will increase. More research is required to quantify any risks to workers and consumers.     

深圳公立医院管理体制改革制度设计

深圳公立医院管理体制改革实行政事分开、管办分开,在理事会架构下按法定机构模式组建市医管中心,落实公立医院运营管理自主权.作者从当前公立医院管理体制的弊端入手,介绍了深圳市进行公立医院管理体制改革的基本思路及改革方案设计的主要举措,深入剖析了的改革方案的特点,并对改革效果进行了预测.     

Effects of nitrogen dioxide on red blood cells of rats: Changes in components of red cell membranes during in vivo exposure to NO2

Red cell membranes, prepared from red blood cells of rats exposed to 4, 10, or 20 ppm nitrogen dioxide (NO₂) for 1 to 10 days, were examined for evidence of changes in membrane components. Appreciable changes were not found in contents of phospholipid and cholesterol during exposure to 10 ppm NO₂. By contrast, protein content altered with the time of exposure. Moreover, changes in protein composition were observed by employing sodium dodecyl sulfate — polyacrylamide gel electrophoresis. Twenty-four-hour exposure to NO₂ at the concentration above 10 ppm resulted in a marked increase in the percentage of lysophosphatidylethanolamine (LysoPE) to the total phospholipids. The prolonged exposure to 10 ppm NO₂ gave rise to a further increase in LysoPE, whereas the percentage of phosphatidylethanolamine (PE) showed a gradual decrease. A 1-day exposure to 4.0 ppm NO₂ also caused an increase in sialic acid content and decreases in those of PE and hexose. In addition to contents of these components the percentage of LysoPE increased 5 days after exposure and the elevated values were maintained up to the end of exposure period. These results demonstrate that red blood cells in circulation exhibit different membrane properties in terms of lipid and carbohydrate composition during 10 days of exposure to 4.0 ppm NO₂.     

Investigating clusters in the workplace and beyond

Clusters of disease are common and occur in the workplace and in the general community. They often arouse considerable concern among the population. Investigations have sometimes lead to exciting new knowledge, but in general the investigation of clusters is difficult and often unrewarding, especially for community clusters. In the workplace, investigations are more likely to find associations and even new causes, but still many clusters remain enigmatic. Despite this, there are many reasons for investigating clusters, including allaying community concern and identifying uncontrolled exposures. A structure for investigating clusters in the workplace is suggested.