Pulmonary sequestration with high levels of tumor markers tending to be misdiagnosed as lung cancer

A 62-year-old man with hemoptysis and an abnormal shadow on chest roentgenogram was diagnosed as having anomalous systemic arterial supply to the normal basal segment of the left lower lobe. The preoperative serum carbohydrate antigen 19–9 and carcinoembryonic antigen levels were 73.8 units/ml and 10.8 ng/ml, respectively. Histopathological examination confirmed that the lesion was an intralobar pulmonary sequestration without air connection. There was no malignant finding in the resected specimen. The serum values of tumor markers returned to their approximate normal ranges after lower lobectomy.     

Liver hamartoma in an adult: Report of a rare case

Liver hamartoma is a rare type of benign tumor which usually occurs in the first few years of life. Although it is the second most common benign tumor in childhood, only about 100 cases have been reported in the English literature. Thus, it is extremely rare to encounter liver hamartoma in adults. This report details the clinical presentation and surgical management of a 24-year-old woman with a rapidly growing liver hamartoma. A right hepatic lobectomy was successfully performed and the patient was discharged in good health on the 10th postoperative day.     

Synchronous growth of triple lung cancer

The case of a 75-year-old man with three synchronous carcinomas of the lung (large cell carcinoma, adenocarcinoma, and small cell carcinoma) is reported. This is the eighth well-documented case report in the literature; however, our case is the first to be reported with the newly described histological combination.     

The use of transbronchial lung biopsy to establish a diagnosis of benign clear cell tumor of the lung: Report of a case

(Received for publication on Mar. 27, 1997; accepted on Sept. 2, 1997)     

肺血管成形术在肺癌手术中的应用

目的　评价肺血管成形术在肺癌外科治疗中的临床疗效。方法　将 12 5例肺血管受累的肺癌患者 ,分为两组 :肺血管成形组 94例 ,非成形组 3 1例。比较两组间术后并发症、肺功能状态以及生存率。结果　肺血管成形组手术时间较非成形组长 ,但术后并发症两组类似 ,且成形组的术后呼吸衰竭发生率较非成形组为低 (P <0 .0 5 )。术后 1、3年生存率以及术后 1年肺通气功能 ,肺血管成形组明显优于非成形组 ,差异有显著性。结论　肺血管成形术能提高中晚期肺癌的手术切除率 ,降低全肺切除和姑息手术的比率 ,使患者的术后生存率和生活质量均得到明显改善 ,应在临床上常规应用。     

Mesenchymal hamartoma of the liver

Mesenchymal hamartoma of the liver is the second most common benign liver tumor of childhood. Ultrasonography demonstrates a cystic lesion that may be very large. Computed tomographic scan will further establish the location and its relationship to vascular anatomy. Most will be amenable to gross total resection with clear margins. To illustrate the radiological and gross operative features, we present a 9-month-old male infant with a mesenchymal hamartoma with classic features.     

Retrorectal cystic hamartoma: A case report

Retrorectal tumors are a rare group of tumors that can be of benign or malignant origin, the differential diagnosis concerns all retrorectal tumors. We report a case of a huge retrorectal cystic hamartoma in which surgical excision was performed.A 58 years-old female presented with a low back pain and constipation. Digital rectal examination found a renitent cystic mass compressing the posterior wall of the rectum. Colonoscopy showed a tumor compressing the rectum. Magnetic resonance imaging (MRI) scan showed a presacral cystic formation. Surgical resection using laparotomy was performed. The patient made a full recovery and was released eight days after the surgery. Histological examination of the mass revealed a retrorectal cystic hamartoma.     

Mesenchymal hamartoma of the liver: a systematic review

Mesenchymal hamartoma of the liver is the second commonest benign liver tumor in children, yet its biology and pathogenesis are poorly understood. Cytogenetic studies have suggested that the tumor may be a neoplasm rather than a hamartoma. Typically, it presents as a large benign multicystic liver mass in a child younger than 3 years amenable to complete resection. However, its imaging characteristics are variable, ranging from a few large cysts to a solid mass occupying one or both lobes of the liver. In addition, the tumor occasionally contains angiomatous elements or is multifocal. Most tumors gradually increase in size, some reaching enormous proportions, which can make surgery challenging. Paradoxically, a few undergo incomplete spontaneous regression and, on rare occasions, others have shown malignant transformation to undifferentiated (embryonal) sarcoma. These unusual pathological and biological features must be taken into account when considering the management of affected individuals.     

Hepatic mesenchymal hamartoma causing heart failure in the neonate

This is the first report of an hepatic mesenchymal hamartoma causing congestive heart failure in an infant. These benign tumors usually present as a bulky abdominal mass but rarely can present with congestive failure when the angiomatous component is prominent.     

Giant cystic chondroid hamartoma of the lung

Pulmonary hamartoma composed of an abnormal mixture of mesenchymal elements is the most common benign neoplasm in the lung. Pulmonary hamartoma larger than 10 cm and the cystic variant are also very rare.We describe an asymptomatic 11-year-old boy with a huge mass in the right hemithorax. Chest computed tomography revealed a heterogeneous mass filling the middle and the lower lobes of the right lung. The patient underwent thoracotomy and resection of the lesion. Gross examination of the surgical specimen showed a well-circumscribed, encapsulated, lobulated, and bluish-white mass, measuring 18 × 16 × 8 cm. Multilocular cystic spaces with intervening lobulated fragments of cartilaginous tissue and adipose tissue were seen. Microscopically, the solid component was composed of cartilage and adipose tissue. Cystic areas and cleft-like spaces were lined by ciliated columnar epithelium.We believe this is the first case of ‘giant cystic chondroid hamartoma of the lung’ described in childhood. We suggest that giant cystic pulmonary hamartoma should be included in the differential diagnosis of large intrathoracic masses in children.     

Fibrous hamartoma of infancy

Fibrous hamartoma of infancy is a rare benign soft tissue tumor that usually occurs within the first 2 years of life. We report 3 cases of fibrous hamartoma of infancy seen over a 10-year period. Treatment is curative by local excision with a low local recurrence rate. Fibrous hamartoma of infancy should be considered in the differential diagnosis of soft tissue masses in children because it is always benign and subject to nonaggressive treatment.     

Clinical impact of concomitant surgical diagnosis and subsequent lobectomy for preoperatively undiagnosed lung cancer

Objective We conducted a retrospective study of the clinical impact of a concomitant diagnostic and therapeutic procedure for patients with histologically unproven pulmonary nodules.Methods: Between January 2001 and December 2003, we performed 150 consecutive surgical biopsy procedures for histologically indeterminate pulmonary nodules. We compared the clinical impact of the concomitant diagnostic wedge resection followed by lobectomy (U group, n=50) with that of a scheduled standard lobectomy in those with preoperatively proven clinical stage I lung cancer during the same period (C group, n=60).Results: There were no significant differences in dichotomous variables, whereas we found significant differences in tumor size, operative time and blood loss between the 2 groups. Complication developed in 9 in the U group and 3 in the C group (p=0.030). Hospital mortality was 2% in the U group and 0% in the C group (p=0.11).Conclusion: Morbidity and mortality following a concomitant diagnostic and therapeutic procedure in patients with preoperatively undiagnosed lung cancer was acceptable, however, staged operations should be indicated for patients with considerable co-morbidity. (Jpn J Thorac Cardiovasc Surg 2006; 54:187-192)     

Completion pneumonectomy for recurrent or second primary lung cancer

OBJECTIVE: We studied 8 patients undergoing completion pneumonectomy for recurrent or second primary lung cancer. METHODS: Subjects were men who averaged 62 years of age. Of these 6 had p-stage I, and 2 p-stage II disease at initial operation. At the second operation, we diagnosed 3 with second primary lung cancer and 5 with recurrent lung cancer. We predicted postoperative pulmonary function by calculating the predicted forced expiratory volume in 1.0 second (FEV1.0) from residual numbers of subsegments after completion pneumonectomy. All predicted FEV1.0 in our 8 cases ranged from 544 to 926 (773 +/- 144) ml/m2. RESULTS: Six patients experienced postoperative complications and morbidity was 75%. One patient undergoing completion sleeve pneumonectomy after radiation therapy for local carina recurrence died on 7th postoperative day due to anastomotic dehiscence and pneumonia. Overall operative mortality was 12.5% (1/8). Four remain alive and actuarial 5-year survival was 37.5%. CONCLUSIONS: Careful consideration is needed in determining operative indications for completion pneumonectomy for patients after radiation therapy. Patients with recurrent squamous cell carcinoma who have p-stage I disease at initial operation and those with second primary lung cancer and p-stage I or II disease can expect relatively a long-term survival, and we concluded that completion pneumonectomy could be conducted in these cases with a satisfactory prognosis.     

Aortic valve lipomatous hamartoma in a young woman

We present a rare case of lipomatous hamartoma of the aortic valve. A 17-year-old woman was admitted with cardiac murmur. Echocardiography demonstrated severe aortic regurgitation and a highly echoic mass on the right cusp of the aortic valve. Surgery was performed with a differential diagnosis of chronic infective endocarditis or aortic valve tumor. At operation, a yellowish bead-shaped tumor was detected on the right cusp of the aortic valve, and aortic valve replacement was performed. Histopathological examination confirmed a lipomatous hamartoma. To the best of our knowledge, this is the first reported case of a lipomatous hamartoma located on the aortic valve.     

自体材料替代肺动脉在肺癌外科治疗中的应用

目的评价自体材料替代肺动脉在肺癌外科治疗中的价值。方法将104例肺血管受累的肺癌患者分为两组．自体材料替代肺动脉成形术组42例,常规肺动脉成形组62例。比较两组间术后并发症、肺功能状态以及生存率。结果两组在术后并发症、术后1年存活患者肺功能状态上无明显差异,而自体材料组术后1年生存率明显优于常规组,术后3年生存率两组无明显差异。结论自体材料替代肺动脉成形术临床疗效满意,值得推广应用。     

肺叶切除并肺动脉重建术治疗中心型肺癌42例体会

目的总结应用肺叶切除并肺动脉重建术治疗中心型肺癌的经验。方法回顾性分析自1995年9月至2006年8月,我院采用肺叶切除肺动脉重建术治疗中心型肺癌42例,其中24例肺动脉楔形切除后10例直接对拢缝合,14例用自体心包片修补;18例行肺动脉段袖式切除后6例直接吻合,5例用自体奇静脉移植,7例用自体心包片作成人工管道间置,恢复血管的连续性;同期有19例施行支气管成形术;术后有29例接受化疗,8例接受放疗。结果术后无死亡病例,并发肺炎7例,轻度肺不张4例,支气管残端漏1例,经治疗后均获痊愈。余者恢复良好,均顺利出院。结论肺叶切除肺动脉重建术治疗中心型肺癌能提高肺癌切除率,扩大手术适应证,最大限度保存患者的肺功能,是一种安全有效的手术方法。     

Torsion of a mesenchymal hamartoma of the liver in a 1-year-old boy

We report a case of a one-year-old boy who was referred to our clinic suspected of having acute abdomen. On physical examination, the abdomen was soft, diffusely tender with weak peristalsis. Ultrasonography and MRI of the right hemiabdomen demonstrated a well-defined, solid, expansive formation with slightly lobulated contours and an interspersed inhomogeneous structure with overall dimensions of 59?×?45?×?50?mm. After midline laparotomy was performed, a cystic tumor was found, twisted around a pedicle which was arising from the falciform ligament and it measured 5–6?cm in diameter. The tumor appeared to be necrotic. The mass was ligated and extirpated on the pedicle and sent for histopathological analysis. After the surgery, the boy was hemodynamically stable, without respiratory complications and all laboratory findings were within normal limits. Histopathological analysis showed that the tumor was composed of mesenchymal stroma with sparse glimpses of hepatocytes and bile ducts with partly cystic changes lined by orderly epithelium. Given the clinical data, histology and immunohistochemistry analysis (alpha-fetoprotein, CK8/18, hepatocyte, desmin and CD31) a diagnosis of a twisted mesenchymal hamartoma of the liver was made.     

呼吸功能训练对肺癌患者术后肺功能的影响

目的通过探讨呼吸功能训练对肺癌患者术后肺功能的影响。方法将80例肺癌术后患者分为观察组、对照组,每组40例。对照组采用传统的常规护理,观察组在对照组的基础上,采取在围手术期对患者呼吸功能训练的护理干预,入院后第一天及术后第一周对肺功能的测定。结果术前两组血气指标、肺功能指标等无明显差异(P0.05);术后一周观察组血氧饱和度、氧分压、FEV1%、FEV1\FVC%指标值均优于对照组,差异具有统计学意义(P0.05)。观察组肺功能质量均好于对照组,并且患者对术后的生活质量期望值明显提高。结论肺癌术后在常规护理基础上进行呼吸功能训练可提高肺癌患者术后的呼吸功能,促进肺功能的恢复。     

Perioperative rehabilitation and physiotherapy for lung cancer patients with chronic obstructive pulmonary disease

Objective: The purpose of this study was to investigate the impact of pulmonary rehabilitation on surgical morbidity and lung function in lung cancer patients with chronic obstructive pulmonary disease (COPD). Methods: Prospectively, 22 lung cancer patients with COPD who underwent lobectomy between 2000 and 2003 were enrolled for this study as a rehabilitation group (Rehab. Group). The criteria of COPD were preoperative forced expiratory volume in 1 second (FEVl)/forced vital capacity (FVC) ≦70% and more than 50% of low attenuation area in a computed tomography. Preoperatively patients performed aggressive pulmonary exercise for two weeks and received chest physiotherapy postoperatively. As a historical control, 60 patients with lung cancer who fulfilled the same criteria but did not receive rehabilitation between 1995 and 1999 (control group) were entered in this study. Results: Patient backgrounds were all equivalent between the two groups. However, FEV1 and FEV1/FVC were significantly lower in the Rehab. Group (p<0.05). Prolonged oxygen supplement and tracheostomy tended to be more frequent in the control group. The ratio of actual postoperative to predicted postoperative FEV1 was significantly better in the Rehab. Group (p=0.047). Furthermore, postoperative hospital stay was significantly longer in the control group (p=0.0003). Conclusion: Despite lower FEV1 and FEV1/FVC in the Rehab. Group, postoperative pulmonary complications and long hospital stay could be effectively prevented and FEV1 was well preserved by rehabilitation and physiotherapy.     

支气管袖式肺叶切除肺动脉成形术治疗中心型肺癌

目的 总结支气管袖式肺叶切除、肺动脉成形术治疗中心型肺癌的临床经验.方法 回顾分析1989年5月至2009年5月收治的52例中心型肺癌患者,其中38例行支气管环状切除成形及支气管袖式肺叶切除术;12例行支气管肺动脉双袖式肺叶切除术;2例行气管隆突及半隆突切除重建合并肺叶切除术.结果 本组术后死亡1例,发生手术并发症5例...