幽门螺杆菌感染与儿童哮喘发病的相关性分析

目的 探讨幽门螺杆菌(H.pylori)感染与哮喘发病的影响,分析H.pylori感染对免疫功能指标、辅助性T细胞1(Th1)/辅助性T细胞2(Th2)和辅助性T细胞17(Th17)/调节T细胞(Treg)平衡的影响。方法 收集2020年1月至2021年12月,在南阳市第一人民医院接受治疗的哮喘病儿(哮喘组)142例,及健康儿童(对照组)120例。采用14C呼气试验检测H.pylori感染情况,比较哮喘组和对照组中H.pylori阳性率。哮喘病儿根据是否合并H.pylori感染,分为H.pylori阴性组和H.pylori阳性组,比较两组间免疫功能指标、Th1/Th2及Th17/Treg。结果 哮喘组H.pylori阳性率10.6%显著低于对照组32.5%(χ²=19.13,P<0.001)。轻度哮喘组、中度哮喘组和重度哮喘组H.pylori阳性率分别为22.2%(10/45)、6.6%(4/61)和2.8%(1/36),三组间比较均差异有统计学意义(χ²=9.82,P=0.007),且重度哮喘组H.pylori阳性率低于轻度哮喘组(χ...     

老年人胃黄色瘤与幽门螺杆菌感染的相关性分析

目的 了解老年慢性胃炎患者黄色瘤与幽门螺杆菌(Hp)感染之间的相关关系.方法 对2010年1月至2011年12月在该院接受胃镜检查的60岁以上的慢性胃炎患者499例根据病理结果分为黄色瘤组186例和非黄色瘤组313例,分别观察两组患者胃黏膜Hp感染、中性粒细胞浸润、腺体萎缩、淋巴滤泡等病理表现.结果 黄色瘤组与非黄色瘤组比较,Hp感染率(52.7％、37.3％)、中性粒细胞浸润率(35.5％、24.0％)、腺体萎缩率(36.6％、3.5％)均明显升高(x210.677、7.641、95.606,P＜0.01)；两组淋巴滤泡检出率(21.0％、20.8％)比较,差异无统计学意义(x2=0.003,P=0.957).Hp 感染者中性粒细胞浸润(45.8％)、淋巴滤泡检出率(42.6％)均高于Hp阴性者(14.8％、4.2％),差异均有统计学意义(P=0.000).结论 胃黄色瘤与Hp感染、中性粒细胞浸润、腺体萎缩相关,淋巴滤泡形成与Hp感染密切相关,应加强对老年慢性胃炎患者Hp的根治.     

幽门螺杆菌感染与胃食管反流的关系

目的探讨胃食管反流病(GRED)与幽门螺杆菌(Hp)的关系。方法确诊的胃食管反流病患者60例及浅表糜烂性胃炎患者63例(对照组),均行幽门螺杆菌检测,再将60例GERD患者分为2组,25例常规三联抗HP治疗,为HP根除组,另外35例作为Hp持续感染组。随访1年。结果 60例GERD患者Hp感染率为58.3%,对照组Hp感染率82.5%,GERD患者Hp感染率低于对照组,差异有统计学意义(P0.05)。Hp根除组GERD复发率高于Hp持续感染组,差异有统计学意义(P0.05)。对照组Hp根除后GERD的发病率为25.5%。结论 Hp感染可能在GERD的发病过程中起保护作用。     

Treatment of Helicobacter pylori infection in children

The majority of Helicobacter pylori (H. pylori) infections appear to be acquired during childhood. Despite this fact, the natural history of H. pylori infection in children, such as the mode of acquisition, the clinical symptoms and signs of infection and the appropriate treatment, is poorly understood. There is no consensus regarding which children with H. pylori infection deserve treatment nor is there agreement on the appropriate treatment regimen. This stems from the lack of controlled studies into H. pylori infection during childhood. For example, there have been no controlled studies to determine effective treatment of H. pylori infection in children. Although published guidelines for the treatment of childhood H. pylori infection do not currently exist, there is reasonable evidence to support treatment in children with gastric or duodenal ulcer, gastric MALT (mucosa-associated lymphoid tissue) lymphoma and atrophic gastritis. There is no strong evidence to recommend treatment of children with H. pylori infection and recurrent abdominal pain, asymptomatic infection, children in chronic care facilities and children who have a family member with H. pylori infection. Current evidence suggests that single and dual therapy regimens for H. pylori infection in children are not effective. Triple therapy , generally the combination of 2 antibiotics and a proton pump inhibitor, given two times daily for 2 weeks appears to offer the best current treatment.     

Helicobacter pylori infection in children: management and pharmacotherapy

Helicobacter pylori infection is mainly acquired during childhood: it is recognised as a cause of gastritis and peptic ulcer and it has been classified as a group A carcinogen by the World Health Organisation. The exact mode of transmission is as yet unknown. The aim of this review was to analyse the literature about H. pylori infection in paediatric patients. The large diffusion of H. pylori infection in paediatric patients, the absence of a specific clinical feature, the new non-invasive methods for diagnosis and follow-up, which are still not validated and the different therapeutic schedules have led to the necessity of determining the real clinical outcome in affected children and adolescents. The scope of the review was to identify better eradication therapy and the most important factors in treatment failure. The international literature has shown the importance of culture, antibiograms, the compliance of families and patients and the use of probiotics during triple eradication therapy. The review paid attention to the management, diagnostic techniques and therapy of this infection in paediatric patients.     

幽门螺杆菌感染与儿童过敏性紫癜相关性研究

目的探讨幽门螺杆菌感染与儿童过敏性紫癜相关性情况。方法选取我院2015年6月～2017年6月收治的30例过敏性紫癜儿童作为观察组,同期门诊健康体检56例儿童作为对照组,以~(13)C尿素呼气试验阳性作为判定幽门螺杆菌是否发生感染的标准,依据治疗措施不同再将观察组~(13)C尿素呼气试验阳性儿童分为治疗A组(常规性的治疗)10例和治疗B组11例(抗幽门螺杆菌感染治疗)。结果观察组儿童幽门螺杆菌感染发生率高于对照组,治疗B组幽门螺杆菌感染患儿临床治疗总有效率高于治疗A组,复发率低于治疗A组,差异有统计学意义(P<0.05)。结论幽门螺杆菌感染与儿童过敏性紫癜存在一定的相关性,进行抗幽门螺杆菌感染治疗,可以提高儿童过敏性紫癜临床效果,值得推广应用。     

Helicobacter pylori infection in children: management and pharmacotherapy

Helicobacter pylori infection is mainly acquired during childhood: it is recognised as a cause of gastritis and peptic ulcer and it has been classified as a group A carcinogen by the World Health Organisation. The exact mode of transmission is as yet unknown. The aim of this review was to analyse the literature about H. pylori infection in paediatric patients. The large diffusion of H. pylori infection in paediatric patients, the absence of a specific clinical feature, the new non-invasive methods for diagnosis and follow-up, which are still not validated and the different therapeutic schedules have led to the necessity of determining the real clinical outcome in affected children and adolescents. The scope of the review was to identify better eradication therapy and the most important factors in treatment failure. The international literature has shown the importance of culture, antibiograms, the compliance of families and patients and the use of probiotics during triple eradication therapy. The review paid attention to the management, diagnostic techniques and therapy of this infection in paediatric patients.     

肝硬化患者幽门螺杆菌感染与血清肌钙蛋白T的关系

目的：探讨肝硬化患者幽门螺杆菌（HP）感染与血清肌钙蛋白T（cTNT）的关系。方法：乙肝后硬化患者140例，经检测HP后分HP阴性和阳性组，并设正常对照组，分别测定各组的cTNT；对于HP阳性病例根治HP后再次测定cTNT,并与根治前进行比较；同时，将HP阳性病例分为大量感染组、中量感染组及少量感染组，分别比较各组的cTNT；另外，对于HP阴性和阳性组病例，根据肝功能Child分级进行分组，分别比较各组的cTNT。结果：HP阳性组cTNT明显高于HP阴性组和对照组（P＜0．01），HP阴性组明显高于对照组（P＜0．05），HP根治后cTNT显著下降（P＜0．01）；大量感染组明显高于中量及少量感染组（P＜0．01－0．05）；中量感染组亦明显高于少量感染组（P＜0．01）；HP阳性组中肝功能Child C、B级组明显高于A级组（P＜0．01）C级组又明显高于B级组（P＜0．05），而HP阴性组中各组之间差异无显著意义（P＞0．05）。结论：HP感染使肝硬化患者血cTNT升高，易于并发心肌损害，根治HP有利于防治该并发症。     

有上消化道症状患者幽门螺杆菌感染情况分析及其与胃癌前病变的关系

目的 分析幽门螺杆菌(Hp)感染与胃癌前病变、胃癌的关系.方法 对6年中门诊胃镜检查的106780例患者进行快速尿素酶试验检测Hp,并结合活检病理报告,对Hp感染与年龄、胃癌前病变、胃癌进行回顾性统计分析.结果 Hp感染率由2006年的36.3％降至2011年的24.2％.20-29岁组Hp感染率为34.9％,明显高于40-49岁组的31.4％、50-59岁组的28.5％和＞60岁组的24.8％(P＜0.05).6年中,Hp感染患者中肠化生、胃癌发生率均明显下降(P＜0.05),高级别上皮内瘤变发生率明显上升(P＜0.05).肠化生、上皮内瘤变、胃癌患者中Hp感染率均显著下降(P＜0.05).结论 6年间胃镜检查患者中Hp感染率逐年下降,Hp感染在青中年中居多,胃癌前病变及胃癌患者的Hp感染率下降.     

幽门螺杆菌感染与儿童感染胃炎的关系探讨

目的 进一步探讨幽门螺杆菌(H·pylori)感染在儿童中发病率以及家庭中的传播关系.方法 将我院2000年1月至2005年12月87例儿童胃炎,其中住院20例,门诊67例,做胃镜检查,并做病理学检查,胃黏膜H·pylori的检测.H·pylori阳性44例,H·pylori阴性43例.结果 表明H·pylori感染与儿童胃炎有密切的关系,H·pylori阳性家庭中的感染率为77.3%,H·pylori阴性家庭中的感染率44.2%,有显著差异性(P＜0.01).胃镜检查显示慢性浅表性胃炎52.87%,十二指肠球部溃疡19.54%,病理学检查显示慢性浅表性胃炎在H·pylori阳性组轻度占23%,中度50%,在H·pylori阴性组轻度占70%,中度占23%,两组比较有显著差异性(P＜0.01).结论 H·pylori感染呈现明显家庭群聚现象.胃黏膜病理变化H·pylori阳性组比H·pylori阴性组严重.     

Relationship between gastric mucosal IL-8 levels and histological gastritis in patients with Helicobacter pylori infection

To determine the role of host immune responses in H. pylori infection, we examined the relationship between gastric mucosal IL-8 levels and histological gastritis in patients with H. pylori infection. Biopsy tissue obtained from 99 patients were homogenizedand mucosal IL-8 levels measured by ELISA. The gastric mucosal IL-8 levels in both the antrum and corpus were higher in patients with H. pylori than in H. pyloi negativepatients. IL-8 levels in the corpus but not the antrum correlated with the severity of the atrophy. The IL-1B polymorphism had no influence on the degree of IL-8 production. These findings indicate that IL-8 production is independent of IL-1B polymorphisms and IL-8 may play an important role in the development of atrophic gastritis.     

Ghrelin与儿童肥胖关系

目的 探讨新发现的促生长激素释放多肽ghrelin与儿童肥胖的关系.方法 采用ELISA方法测定肥胖组8例儿童和正常对照组12例儿童的血清ghrelin水平,同时测定各组儿童的血清胆固醇、甘油三酯,研究其相关性.结果 肥胖组儿童ghrelin(39.55±21.42) ng/ml,正常对照组儿童为(10.80±5.98) ng/ml( P＜0.01);肥胖组ghrelin水平与甘油三酯呈负相关(P＜0.05).结论 肥胖儿童空腹血清ghrelin水平显著升高,ghrelin可能与儿童肥胖的发生有关.     

胃癌组织中幽门螺旋杆菌感染与Cox-2及Tiaml表达的关系研究

目的:通过分析不同病理类型组织胃癌中幽门螺旋杆菌的感染情况、病灶组织中环氧合酶2(Cox-2)及T淋巴瘤侵袭转移因子(Tiaml)的表达情况,探讨在各类型胃癌的病理组织中幽门螺旋杆菌感染与Cox-2,Tiaml表达的相关性。方法:选择90例不同病理类型胃癌患者作为研究组,并将22例健康志愿者作为对照组。用HE染色法及乳胶凝集试验检测血中抗Hp Ig G抗体的方法评估Hp的感染情况,原位聚合酶链反应(PCR)技术及免疫组织化学技术检测病灶组织中Cox-2,Tiaml的蛋白表达情况。用多元线性回归分析,得出Hp及Cox-2,Timal的相关性。结果:病灶组织中Cox-2及Timal的蛋白表达量值随着Hp抗体浓度的升高而增加,二者具有正相关性。结论:Hp与Cox-2,Timal蛋白表达量成正相关性,通过检测血清Hp抗体,Cox-2,Timal的表达,可为临床胃癌的诊断提供参考。     

儿童幽门螺杆菌感染与缺铁性贫血相关性探讨

目的探讨儿童幽门螺杆菌感染与缺铁性贫血（IDA）的相关性。方法以因慢性腹痛而行胃检查及Hp检测的69例患儿为观察对象,根据检查结果分为Hp阳性慢性胃炎组、Hp阴性慢性胃炎组及Hp阳性胃部镜下无损害组3组,所有病例均检测血红蛋白（Hb）、平均红细胞体积（MCV）、血清铁（SI）、血清铁蛋白（SF）、总铁结合力（TIBC）等IDA指标。比较三组之间的IDA指标和IDA伴发率。结果Hp阴性慢性胃炎组的IDA指标分别与Hp阳性慢性胃炎组、Hp阳性胃部镜下无损害组比较,差异均有统计学意义（P〈0.01,P〈0.05）,而Hp阳性慢性胃炎组的IDA指标与Hp阳性胃部镜下无损害组之间比较,则差异无统计学意义（P〉0.05）。Hp阴性慢性胃炎组的IDA伴发率均低于Hp阳性慢性胃炎组和Hp阳性胃部镜下无损害组（P〈0.05）,Hp阳性慢性胃炎组与Hp阳性胃部镜下无损害组之间的IDA伴发率比较差异无统计学意义（P〉0.05）。结论儿童幽门螺杆菌感染与缺铁性贫血两者之间的相关性有统计学意义,且较慢性胃炎与缺铁性贫血的关系更为密切。     

Gastric MALT-lymphoma and Helicobacter pylori infection

The presence of lymphoid tissue in the gastric mucosa is virtually pathognomonic of Helicobacter pylori infection. This lymphoid tissue has mucosa–associated lymphoid tissue (MALT) characteristics suggesting that H. pylori infection may represent a stimulus for the growth of gastric MALT lymphoma. H. pylori can be detected in more than 90% of patients with low–grade gastric MALT lymphoma supporting the aetiological role of the organism. The strongest evidence for the significance of H. pylori in the pathogenesis of low aetological–grade gastric MALT lymphoma is provided by clinical studies showing that cure of H. pylori infection is followed by a complete regression of these tumours in most patients. This paper reviews the current knowledge about antibacterial treatment of low–grade gastric MALT lymphoma, and immunological and molecular aspects in the pathogenesis of the disease.