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1.
Jong Suk Park Min Ho Cho Ji Sun Nam Chul Woo Ahn Bong Soo Cha Eun Jig Lee Sung Kil Lim Kyung Rae Kim Hyun Chul Lee 《Acta diabetologica》2010,47(2):113-118
The inflammatory marker, C-reactive protein (CRP) is associated with long-term cardiovascular events. The aim of the study
was to investigate the factors contributing to serum CRP, assess the relationship between CRP level and the parameters of
visceral obesity, and examine the association between leptin and CRP level in type 2 diabetic patients. 150 patients with
type 2 diabetes were enrolled. These patients were recently diagnosed (≤3 years) with type 2 diabetes and were drug naive
or taking sulfonylureas only. BMI, WC, and serum concentration of CRP, glycosylated hemoglobin (HbA1c), glucose, lipids, plasminogen
activator-1 (PAI-1) and leptin were measured. Insulin resistance was estimated by the insulin resistance index of homeostasis
model assessment (HOMA-IR). We measured the carotid intima-media thickness (IMT). Fat mass assessed by dual-energy X-ray absorptionmetry
and abdominal fat distribution was determined by CT scan. Serum concentration of CRP was significantly correlated with BMI
(γ = 0.257, P < 0.01), WC (γ = 0.293, P < 0.01), fat mass (γ = 0.213, P < 0.01), total adipose tissue (γ = 0.263, P < 0.01), visceral adipose tissue (γ = 0.296, P < 0.01), insulin (γ = 0.189, P = 0.047), PAI-1 (γ = 0.206, P < 0.01), leptin (γ = 0.322, P < 0.01), mean IMT (γ = 0.132, P = 0.042), and HOMA-IR (γ = 0.172, P = 0.045). After adjustment for age and gender, multiple regression analysis showed that serum CRP was significantly associated
with leptin (β = 0.326, P = 0.01) and visceral adipose tissue (β = 0.265, P = 0.035). In conclusion, serum CRP level is significantly associated with obesity, especially the visceral adipose tissue,
and serum leptin is another important independent factor associated with CRP in Korean type 2 diabetic patients. 相似文献
2.
Tomonori Sugiura Yasuaki Dohi Yasuyuki Takagi Takashi Yokochi Naofumi Yoshikane Kenji Suzuki Takamasa Tomiishi Takashi Nagami Mitsunori Iwase Hiroyuki Takase Yoshihiro Seo Nobuyuki Ohte 《Journal of atherosclerosis and thrombosis》2022,29(1):11
Aims: Small arteries can be visualized in the ocular fundus, and findings of retinopathy based on Scheie classification are often applied to evaluate the impact of hypertension and atherosclerosis. However, the relationship between damage in the large and small arteries has not been investigated sufficiently, especially in the early stages. The present study investigated possible associations between large artery atherosclerosis and small artery retinopathy in untreated middle-aged individuals. Methods: Untreated middle-aged workers undergoing periodic health check-ups ( n =7,730, 45±8 years) were enrolled in this study. The absence or presence and extent of retinopathy were characterized by ophthalmologists as hypertensive (H0-4) and atherosclerotic grades (S0-4) based on Scheie classification. Large artery atherosclerosis was examined based on functional assessment of the cardio-ankle vascular index (CAVI) and morphological assessment of the carotid intima-media thickness (IMT) by ultrasound. Results: We found significant differences in CAVI and carotid IMT between individuals with and without hypertensive or atherosclerotic retinopathy. Multivariable regression analysis showed that the presence of hypertensive and atherosclerotic retinopathy was significantly associated with CAVI and carotid IMT. Logistic regression analysis with the endpoint of a hypertensive or atherosclerotic lesion revealed that CAVI and carotid IMT are independent determinants of retinopathy. Conclusions: CAVI and carotid IMT were significantly associated with the presence of retinopathy based on Scheie classification in untreated middle-aged subjects, implying that atherosclerotic examination in large arteries could reveal early-stage small artery retinopathy. 相似文献
3.
Effects of age on the relationship between cardio-ankle vascular index and atherosclerotic progression in patients with type 2 diabetes mellitus 总被引:2,自引:0,他引:2
Wakabayashi I Masuda H 《Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics》2006,43(2):217-221
AIM: A new indicator of arterial stiffness, cardio-ankle vascular index (CAVI), has recently been developed, instead of conventional pulse wave velocity. CAVI is proposed as a blood pressure-independent indicator of atherosclerosis, however, there have been few studies on the association of CAVI with atherosclerosis. The purpose of this study was to investigate effects of age on the relationship between CAVI and atherosclerotic risk in patients with diabetes mellitus. METHODS: The relationship between CAVI and atherosclerotic risk was investigated in 105 subjects with type 2 diabetes mellitus (mean age, 65.1 years old). The mean intima-media thickness (IMT) of the carotid artery was used as an indicator of atherosclerotic progression. RESULTS: In 55.2% of the subjects, CAVI was abnormally high (> or =9.0). In simple regression analysis, CAVI showed significant correlations with age, duration of diabetes and IMT. In logistic regression analysis, crude odds of abnormally high values of CAVI were significant for highest versus lowest tertile groups of mean arterial pressure (MAP) and IMT. Age-and sex-adjusted odds of abnormally high values of CAVI were significant for highest versus lowest tertile groups of mean arterial pressure (MAP) and serum total cholesterol. In multiple regression analysis, CAVI showed significant correlation with IMT independently of MAP but not independently of age, while the significant correlation of ankle-brachial pressure index (ABPI) with IMT was independent of age, sex and MAP. CONCLUSIONS: CAVI reflects atherosclerotic risk and the relationship between CAVI and atherosclerotic progression is strongly confounded by age. Thus, age should be taken into account when CAVI is used as an indicator of atherosclerotic progression. 相似文献
4.
Bilginer Y Ozaltin F Basaran C Duzova A Besbas N Topaloglu R Ozen S Bakkaloglu A 《Rheumatology international》2008,28(12):1211-1216
The aim of the present study was to determine whether intima-media thickness (IMT) of the common (CCA) and internal carotid
arteries (ICA) was increased due to chronic inflammation occurring in familial Mediterranean fever (FMF) patients compared
to healthy controls. Erythrocyte sedimentation rate (ESR), serum C-reactive protein (CRP), serum amyloid A protein (SAA),
lipid profile and homocysteine levels were examined in 70 FMF patients [median age 14 years (range 4–24)] in an attack free
period and in 50 healthy controls [median age 14 years (range 4–18)]. All the patients were homozygous or compound heterozygous
for MEFV mutations. IMT of both CCA and ICA was evaluated with a high resolution B-mode ultrasonography. ESR, CRP, fibrinogen
and SAA levels were significantly higher in FMF patients as compared to healthy controls (P < 0.05). Intima media thickness of the common carotid artery was found to be significantly higher in FMF patients when compared
to those in healthy controls [0.37 mm (0.26–0.61) vs. 0.28 mm (0.21–0.35), P < 0.001]. The median ICA-IMT was significantly increased in the patients when compared to those in the controls [0.25 mm
(0.18–0.44) vs. 0.22 mm (0.10–0.26), P < 0.001]. A positive correlation between CCA-IMT and SAA levels (r = 0.24, P = 0.04) was found while ICA-IMT positively correlated with ESR (r = 0.31, P = 0.008) and fibrinogen levels (r = 0.30, P = 0.012). Intima media thickness, an early predictor of atherosclerosis, may be associated with subclinical inflammation
in children with FMF. Further studies will enlighten whether these patients will be predisposed more to coronary artery disease.
Yelda Bilginer and Fatih Ozaltin contributed equally to this work. 相似文献
5.
Mineoka Y Fukui M Tanaka M Tomiyasu K Akabame S Nakano K Yamazaki M Hasegawa G Oda Y Nakamura N 《Heart and vessels》2012,27(2):160-165
Early detection of atherosclerosis is important for patients with type 2 diabetes mellitus because cardiovascular disease
(CVD) is a main cause of death in these people. In this study, we investigated the relationship between an arterial stiffness
parameter called cardio-ankle vascular index (CAVI) and coronary artery calcification (CAC). We performed a cross-sectional
study in 371 type 2 diabetic patients with clinical suspicion of coronary heart disease (CHD). We evaluated the relationships
between CAVI and CAC score determined by multislice computed tomography as well as major cardiovascular risk factors, including
age, body mass index, hemoglobinA1c and the Framingham CHD risk score. CAVI was correlated with age (r = 0.301, p < 0.0001), uric acid (r = 0.236, p < 0.0001), estimated glomerular filtration rate (r = −0.145, p = 0.0166), CHD risk score (r = 0.327, p < 0.0001) and log (CAC + 1) (r = 0.303, p < 0.0001). The area under the receiver operating characteristic curve for CAVI was higher than that of CHD risk score in
predicting CAC >0, CAC >100, CAC >400, or CAC >1000. CAVI is positively correlated with CAC, and is considered to be a useful
method to detect CAC. 相似文献
6.
Tomoyuki Kabutoya Satoshi Hoshide Takeshi Fujiwara Keita Negishi Masafumi Nishizawa Mitsuyoshi Yamamoto Kayo Yamagiwa Akihiro Kawashima Tetsuro Yoshida Jun Nakazato Yoshio Matsui Hiromitsu Sekizuka Hideyasu Abe Yasuhisa Abe Yumiko Fujita Kei Sato Keisuke Narita Norihiro Tsuchiya Yoshiaki Kubota Toshikazu Hashizume Kazuomi Kario 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(7):1208-1215
The value of the cardio‐ankle vascular index (CAVI) increases with age. All large‐scale studies of the CAVI have investigated patients <80 years old. Thus, the clinical characteristics of high CAVI in patients aged 80 or more remain unclear. Therefore, we investigated (1) the CAVI in very elderly patients and (2) the determinants of a high CAVI in high‐risk patients, including very elderly patients. The Cardiovascular Prognostic Coupling Study in Japan (Coupling Registry) is a prospective observational study of Japanese outpatients with any cardiovascular risk factors. We enrolled 5109 patients from 30 institutions (average age 68.7 ± 11.4 years, 52.4% males). We investigated the determinants of the CAVI by separating the patients into three groups: 970 middle‐aged (<60 years), 3252 elderly (60‐79 years), and 887 very elderly (≥80 years) patients. The CAVI values of the males were significantly higher those of the females in all age groups (<60 years: 7.81 ± 1.11 vs. 7.38 ± 0.99, P < .001; 60‐79 years: 9.20 ± 1.29 vs. 8.66 ± 1.07, P < .001; ≥80 years: 10.26 ± 1.39 vs. 9.51 ± 1.12, P < .001). In all age groups, the CAVI of the patients with diabetes/glucose tolerance disorder was higher than that of the patients without diabetes/glucose tolerance disorder (<60 years: 7.82 ± 1.22 vs 7.58 ± 1.03, P = .002; 60‐79 years: 9.23 ± 1.20 vs 8.78 ± 1.19, P < .001; ≥80 years: 10.04 ± 1.24 vs 9.75 ± 1.32, P = .002). The determinants of the CAVI in these very elderly patients were age, male sex, low BMI, and mean blood pressure. Diabetes/glucose tolerance disorder and glucose were independently associated with the CAVI in the patients aged <60 years and 60‐79 years, but not in those aged ≥80 years after adjusting for other covariates. 相似文献
7.
Cilostazol, a phosphodiesterase III inhibitor, is known to have anti-proliferative activity. We investigated the effects of
cilostazol 200 mg, in addition to aspirin 100 mg and clopidogrel 75 mg, on carotid intima-media thickness (IMT) progression
during a 2-year follow-up period in patients with acute coronary syndrome (ACS) requiring stent implantation. Patients with
ACS (n = 130) were randomly assigned to the cilostazol group (n = 64) or the control group (n = 66). Longitudinal images of left and right carotid IMT were measured at baseline, at 6, 12, and 24 months using a 10-MHz
linear vascular probe. The primary endpoint was to compare the changes in maximum carotid IMT at 2 years. Other parameters
such as inflammatory markers [interleukin (IL)-6, tumor necrosis factor (TNF)-α, C-reactive protein (CRP), and adiponectin]
and bleeding risk were also compared. The carotid IMT showed no significant progression from baseline in the cilostazol group
compared to significant progression in the control group at 12 months (0.78 ± 0.38 and 0.85 ± 0.41 mm, p = 0.034, respectively) and 24 months (0.82 ± 0.41 and 0.96 ± 0.39 mm, p = 0.022, respectively). Major bleeding (p = 1.00), minor bleeding (p = 0.68), and total bleeding rates (p = 0.74) were similar between the two groups during the 2-year follow-up. Decreases from baseline in IL-6 (−2.79 ± 2.83 and
−2.14 ± 3.36 pg/ml, p = 0.010, respectively) and TNF-α (−2.81 ± 1.97 and −2.21 ± 2.68 pg/ml, p = 0.029, respectively) were significantly greater in the cilostazol group than the control group during the follow-up. Cilostazol
treatment, with greater anti-inflammatory effect, inhibited the progression of carotid IMT without increasing the risk of
bleeding in patients with ACS during the 2-year follow-up. 相似文献
8.
目的探讨老年维持性血液透析(HD)患者颈动脉粥样硬化(AS)与C-反应蛋白(CRP)的关系. 方法测定33例老年及同期42例非老年HD患者临床指标、CRP及肱三头肌皮褶厚度(TSF)、上臂围(AC)、上臂肌围(AMC);应用彩色B超测颈动脉内膜-中层厚度(IMT)及粥样硬化斑块情况. 结果老年HD患者AC、AMC、尿素氮(BUN)、血肌酐(Scr)、白蛋白(Alb)均显著低于非老年患者(P<0.05~0.01);而CRP水平、颈动脉平均IMT、斑块阳性率、增厚阳性率显著升高(P<0.05~0.01);HD患者颈动脉平均IMT与CRP、三酰甘油 (TG)、低密度脂蛋白(LDL)、年龄呈正相关,与Alb呈负相关(r=-0.053,P<0.05). 结论老年血液透析患者营养状况差,AS重,改善患者营养状况及微炎症、血脂异常可能减轻患者AS. 相似文献
9.
Kawamoto R Tomita H Inoue A Ohtsuka N Kamitani A 《Journal of atherosclerosis and thrombosis》2006,13(4):175-182
OBJECTIVE: Several cohort studies have shown a link between serum C-reactive protein (CRP) and subsequent cardiovascular disease; however, the role of CRP as an independent risk factor remains controversial. We therefore investigated the association between CRP and sclerotic lesions of common carotid atherosclerosis. PATIENTS AND METHODS: We evaluated sclerotic lesions of common carotid arterial intima-media thickness (IMT) by ultrasonography in 139 men aged 67 +/- 15 years and 201 women aged 75 +/- 10 years. To investigate the relation between CRP and various confounding factors, subjects were divided into four groups based on the quartile of CPR. RESULTS: Carotid IMT values were significantly higher in groups with higher CRP (p = 0.022). To identify the possible CRP level and risk factor interactions for IMT, multiple regression analysis for IMT was performed based on risk factors in subjects with a specific CRP level. It was shown that age, smoking status, systolic blood pressure (SBP) and LDL cholesterol were significantly associated with IMT in subjects in the lower CRP groups (CRP-1 approximately CRP-3), and age, SBP and presence of diabetes mellitus in the highest CRP group (CRP-4). To further investigate whether the interaction between CRP and conventional risk factors could influence IMT, a general linear model demonstrated that interaction between CRP and the presence of diabetes mellitus (F = 4.754 p = 0.030) was significantly associated with IMT, in addition to sex, age, SBP, antihypertensive drug use, LDL cholesterol and HDL cholesterol. CONCLUSIONS: This finding indicates that the association between CRP and IMT significantly differed between subjects with and without diabetes mellitus. 相似文献
10.
Yoshiaki Kubota Daisuke Maebuchi Makoto Takei Yumiko Inui Yuumi Sudo Yukinori Ikegami Jun Fuse Munehisa Sakamoto Yukihiko Momiyama 《Artery Research》2011,5(3):91-96
Introduction
The Cardio-Ankle Vascular Index (CAVI) was established as a parameter of atherosclerosis that does not depend on a subject’s blood pressure, and is now used in many centers. However, it remains unclear whether the CAVI can predict the development and outcome of cardiovascular disease.Methods
CAVI was measured as a parameter of atherosclerosis in 400 patients between January 1 and December 31, 2006. The 400 patients were classified into 3 groups according to the CAVI score: Groups A (CAVI < 9), B (9 ≤ CAVI < 10), and C (CAVI ≥ 10).Result
The cumulative incidences of cardiovascular diseases and stroke were higher in Group C than in Group A and the log-rank test revealed a statistically significant difference between these groups (p < 0.05). A multivariate analysis showed that the hazard ratio of cardiovascular diseases was significantly higher in Group C (hazard ratio, 2.2).In conclusion, CAVI is a useful parameter of atherosclerosis in high-risk patients and is an accurate predictor of patients at a higher risk for cardiovascular diseases. 相似文献11.
Association between percutaneous coronary intervention and long-term C-reactive protein levels in patients with acute coronary syndromes 总被引:1,自引:0,他引:1
Kausik K. Ray Babak Nazer Richard Cairns C. Michael Gibson Christopher P. Cannon 《Journal of thrombosis and thrombolysis》2010,30(1):10-13
C-reactive protein (CRP) is an independent predictor of risk in ACS patients, and it has been previously shown that percutaneous
coronary intervention (PCI) is associated with an early rise in CRP. To assess the long-term relationship between PCI and
CRP, we compared CRP levels at baseline, 30 days, 4 months and 24 months among patients in the Pravastatin or Atorvastatin
Evaluation and Infection Therapy—Thrombolysis in Myocardial Infarction 22 trial who were treated with PCI and those who did
not receive PCI. At study entry, CRP was significantly higher among patients who had undergone PCI (13.2 vs. 9.5 mg/l, P < 0.001). However, by day 30 CRP was significantly lower among patients who had undergone PCI for management of the index
event (1.5 vs. 2.1 mg/l, P < 0.001) and remained lower at 4 months and by end of study (average 2 years after ACS). Using a multivariable model, we
observed that PCI was associated with 8.6% lower CRP level at month 4 (P = 0.05) and 14.2% at approximately 2 years (P = 0.0028). These analyses suggest that although PCI may acutely increase inflammation, it may also serve a role in decreasing
inflammation associated with atherosclerotic plaques via long-term mechanical stabilization. 相似文献
12.
Makoto Goto 《Modern rheumatology / the Japan Rheumatism Association》2010,20(3):238-243
We prospectively compared the anti-inflammatory and antidyslipidemic effects of fenofibrate and statins in rheumatoid arthritis
(RA) patients. Forty-four RA patients [male (M) = 7, female (F) = 37] with dyslipidemia were enrolled in this 6-month study
and randomly allocated to the fenofibrate (2 M + 21 F = 23) or statins (5 M + 16 F = 21) group. We measured blood chemistry
(serum lipid profile, sugar, urate, and γ-glutamyl transpeptidase) and blood pressure 2 h after breakfast. Visual analog scale
(VAS), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and prednisolone (PSL) dosage were also recorded immediately
before and after the study. Fenofibrate, but not statins, significantly decreased serum levels of total cholesterol, low-density
lipoprotein–cholesterol, and triglycerides (all p < 0.05). A significant improvement in VAS was observed in both the fenofibrate group (49.1 ± 24.7 → 14.7 ± 11.2; p < 0.0001) and the statins group (47.4 ± 29.7 → 20.2 ± 16.5; p < 0.001). PSL dosage significantly decreased only in the fenofibrate group (3.58 ± 2.68 → 2.00 ± 2.22 mg/day; p < 0.01). Significant correlation was observed between ∆VAS and ∆CRP in the fenofibrate group (p < 0.05). Fenofibrate showed more anti-inflammatory and antidyslipidemic activity than statins in RA. 相似文献
13.
Daisuke Maebuchi Munehisa Sakamoto Jun Fuse Hiroaki Tanaka Yasuyuki Shiraishi Makoto Takei Yumiko Inui Yuumi Sutoh Yukinori Ikegami Yukihiko Momiyama 《Artery Research》2013,7(1):48-53
ObjectiveChronic kidney disease (CKD) is known to be associated with the incidence and mortality of cardiovascular disease. Therefore, the prevention of CKD may improve the mortality of cardiovascular disease. The risk factors of CKD are variable and multifactorial, similar to atherosclerosis. We hypothesized that the index of atherosclerosis predicts future CKD, and investigated the association between the cardio-ankle vascular index (CAVI), the index of arterial stiffness in part of atherosclerosis, and CKD occurrence in non-CKD patients.MethodsOf the 1000 patients undergoing CAVI in our hospital from 2006 to 2007 without CKD, we followed renal function for 1 or more years in 369 patients. CKD was defined as an estimated glomerular filtration rate of <60 ml/min/1.73 m2.ResultsWe divided our study patients into 4 groups according to their CAVI: <8.0 (n = 85), 8.0–9.0 (n = 75), 9.0–10.0 (n = 112), and ≥10.0 (n = 97), respectively. The differences in serum creatinine between baseline and follow-up were 0.09 ± 0.04, 0.11 ± 0.05, 0.17 ± 0.04 and 0.23 ± 0.04, respectively (the P value for the lowest group versus the highest group was 0.04). The age- and sex-adjusted odds ratios (95% confidential interval, P value versus the lowest group) for the occurrence of CKD were 1.13 (0.58–2.20, P = 0.09), 1.58 (0.85–2.94, P = 0.09), and 2.38 (1.23–4.61, P = 0.02). Even after multivariate adjustment, the relationship remained.ConclusionCAVI was found to be associated with future renal dysfunction, thus suggesting that a CAVI ≥10 may therefore be a risk factor for CKD in Japanese patients. 相似文献
14.
Seockhoon Chung In-Young Yoon Yoon-Kyung Shin Chul Hee Lee Jeong-Whun Kim Hee Jeong Ahn 《Sleep & breathing》2009,13(1):11-17
Introduction Obstructive sleep apnea syndrome (OSAS) is considered to be associated with cardiovascular complications, and atherosclerosis
could mediate this relationship. Cardiovascular risk factors of OSAS still need to be elucidated in elderly patients, since
studies about the association between OSAS and cardiovascular diseases have been done mainly in middle-aged adults. To investigate
whether endothelial dysfunction, as an early marker of atherosclerosis, and inflammatory responses in OSAS were affected by
age, we studied flow-mediated dilatation (FMD) and C-reactive protein (CRP) in elderly and middle-aged patients with OSAS.
Materials and methods This study enrolled 161 male subjects of 117 middle-aged (35–59 years old) and 44 elderly (≥60 years old) patients with OSAS.
After they finished nocturnal polysomnography (NPSG), FMD was measured on the brachial artery and blood samples were obtained
to determine serum CRP levels.
Results and discussion FMD was significantly lower in the elderly patients (p = 0.04), but no difference was observed between two age groups in body mass index (BMI), neck circumference, waist-to-hip
ratio, apnea hypopnea index (AHI), serum CRP level, or NPSG findings related with nocturnal hypoxemia such as average O2 saturation, percentage of time below 90% O2 saturation, and oxygen desaturation index (ODI). From the results of stepwise multiple linear regression analysis, the lowest
oxygen saturation was a significant determinant of FMD (β = 0.25, p < 0.01, adjusted R
2 = 6%), and BMI (β = 0.22, p < 0.05) and waist-to-hip ratio (β = 0.21, p < 0.05) were significant variables to explain CRP (adjusted R
2 = 11%, p < 0.01) in the middle aged patients. In the elderly patients, no variable was significant for predicting FMD, but AHI was
significant determinant of CRP (β = 0.46, p < 0.01, adjusted R
2 = 19%, p < 0.01). In predicting cardiovascular risks of OSAS, both hypoxia and obesity should be considered in the middle-aged group,
whereas nocturnal respiratory disturbances are important in the elderly group. 相似文献
15.
Kunihiro Matsushita Ning Ding Esther D. Kim Matthew Budoff Julio A. Chirinos Bo Fernhall Naomi M. Hamburg Kazuomi Kario Toru Miyoshi Hirofumi Tanaka Raymond Townsend 《Journal of clinical hypertension (Greenwich, Conn.)》2019,21(1):16-24
The cardio‐ankle vascular index (CAVI) is a new measure of arterial stiffness that reflects the stiffness from the ascending aorta to the ankle arteries, and demonstrates little dependence on blood pressure during the evaluation. However, a comprehensive assessment of the association of CAVI with cardiovascular disease (CVD) has not been reported. We performed a systematic review to assess the association between CAVI and CVD. We searched for both prospective and cross‐sectional studies using MEDLINE, Embase, and Cochrane from inception until April 11, 2017. We pooled the results using random‐effects models. Among 1519 records, we identified nine prospective studies (n = 5214) and 17 cross‐sectional eligible studies (n = 7309), with most enrolling high CVD risk populations in Asia. All nine prospective studies investigated composite CVD events as an outcome (498 cases including coronary events and stroke) but modeled CAVI inconsistently. The pooled adjusted hazard ratio for CVD events per 1 standard deviation increment of CAVI in four studies was 1.20 (95% CI: 1.05‐1.36, P = 0.006). Of the 17 cross‐sectional studies, 13 studies compared CAVI values between patients with and without CVD and all reported significantly higher values in those with CVD (pooled mean difference in CAVI values 1.28 [0.86‐1.70], P < 0.001). This systematic review suggests a modest association between CAVI and incident CVD risk, and highlights the need for studies assessing CAVI as a predictor of CVD in the general population and non‐Asian countries. 相似文献
16.
《Journal of the American Society of Hypertension》2014,8(9):637-643
Arterial stiffness is an independent predictor for vascular diseases. Cardio-ankle vascular index (CAVI) is a new index of arterial stiffness. N-terminal pro-brain natriuretic peptide (NT-proBNP) is a strong prognostic marker in advanced stage of coronary heart disease (CHD). In the present study, we investigated the relationship between CAVI and NT-proBNP in hypertension and CHD subjects. Five hundred one subjects (male/female, 209/292) from Vascular Medicine of Peking University Shougang Hospital were divided into four groups: healthy group (n = 186), hypertension group (n = 159), CHD group (n = 45), and hypertension with CHD group (n = 111). CAVI was measured using VS-1000 apparatus. Our results showed that CAVI was significantly higher in hypertension subjects with CHD than in healthy and hypertension group, respectively (8.42 ± 1.51 vs. 7.77 ± 1.19; 8.42 ± 1.51 vs. 7.92 ± 1.11; both P < .05). NT-proBNP was significantly higher in hypertension subjects with CHD than in healthy, hypertension, and CHD group, respectively (422.48 ± 761.60 vs. 174.29 ± 415.48; 422.48 ± 761.60 vs. 196.14 ± 299.16; 422.48 ± 761.60 vs. 209.66 ± 242.66; all P < .05). And after log transformation of NT-proBNP, this phenomenon also exists (2.32 ± 0.47 vs. 2.03 ± 0.40; 2.32 ± 0.47 vs. 2.09 ± 0.44; 2.32 ± 0.47 vs. 2.12 ± 0.42; all P < .05). There was positive correlation between log NT-proBNP and CAVI in the entire study group, healthy group, and nonhealthy group (r = 0.235, P < .001; r = 0.184, P = .023; r = 0.237, P < .001; respectively). Multivariate analysis showed that NT-proBNP was an independent associating factor of CAVI in all subjects (β = 0.150, P = .021). Our present study showed that CAVI and NT-proBNP were significantly higher in hypertension subjects with CHD compared with healthy and hypertension groups. There was significant correlation between NT-proBNP and CAVI, which indicates the relationship between arterial stiffness and biomarkers in vascular-related diseases. 相似文献
17.
Keijiro Nakamura Takanobu Tomaru Shigeo Yamamura Yoh Miyashita Kohji Shirai Hirofumi Noike 《Circulation journal》2008,72(4):598-604
BACKGROUND: Recently, arterial stiffness parameter called cardio-ankle vascular index (CAVI) has been developed. In the current study, using coronary angiographic (CAG) findings, the usefulness of CAVI as a marker of the severity of coronary atherosclerosis was compared with that of carotid atherosclerosis parameters obtained from high-resolution B-mode ultrasonography. METHOD AND RESULT: A total of 109 participants who underwent CAG were enrolled in the current study. They were divided into 4 groups according to the number of stenotic vessels on CAG; no lesion (0VD), 1-vessel (1VD), 2-vessel (2VD) and 3-vessel (3VD) groups. CAVI was significantly higher in 1VD group compared with the 0VD group (p<0.05), and was significantly higher in 2VD and 3VD group compared with the 1VD group. In single regression analysis, CAVI correlated positively with maximum intima-media thickness (IMT) (p<0.01) and plaque score (p<0.0001). A stepwise ordinal logistic regression analysis using mean IMT, maximum IMT, plaque score and CAVI as independent variables identified only CAVI as positively related to the severity of coronary atherosclerosis. The area under the receiver operating characteristic curve defined by CAVI was the greatest. CONCLUSION: CAVI might be more useful for discriminating the probability of coronary atherosclerosis than findings of carotid atherosclerosis by high-resolution B-mode ultrasonography. 相似文献
18.
David Školoudík Michal Bar Daniel Šaňák Petr Bardoň Martin Roubec Kateřina Langová Roman Herzig Petr Kaňovský 《Journal of thrombosis and thrombolysis》2010,29(4):477-482
D-dimers are one of the basic laboratory markers of fibrinolytic system activity. The aim of this prospective study was to
detect changes in D-dimer levels in acute stroke patients as a function of the time of artery recanalization and the therapy
used. During a 12-month period, 80 acute ischemic stroke patients admitted to the hospital within a 6-h time window were consecutively
enrolled in the study. The clinical neurologic examination, brain computed tomography, neurosonologic examination, and biochemical
and hematological blood tests (including D-dimers and fibrinogen) were performed on all patients on admission. The control
examinations of D-dimer and fibrinogen blood levels were performed 3 (optional), 6, and 24 h after stroke onset. The Mann–Whitney
test, Kruskal–Wallis test, ANOVA test, multiple comparison test, and Pearson test were used for statistical evaluation. Application
of intravenous thrombolysis significantly increased the D-dimer levels and decreased the fibrinogen level 6 h after stroke
onset in comparison with patients treated with antiplatelets or anticoagulants (P < 0.01), with normalization of blood levels over a 24 h period. The use of sono-thrombotripsy showed a tendency to increase
the D-dimer levels (P = 0.09) with a significant decrease of the fibrinogen level 6 h after stroke onset (P < 0.05). A significant increase in the D-dimer levels was detected in patients with strokes of cardioembolic and atherothrombotic
etiologies, and patients with occlusion of cervical or large intracranial arteries (P < 0.05). There was no correlation between the changes in D-dimer or fibrinogen levels and age, gender, time to artery recanalization,
risk factors, and the seriousness of neurologic deficits on admission (P > 0.05). D-dimer levels significantly increased during the first 6 h after stroke onset in patients with large artery occlusion
and patients treated using intravenous thrombolysis. However, this increase was independent on the time of artery recanalization
thus cannot be used as its marker. 相似文献
19.
Parasar Ghosh Amresh Kumar Sudeep Kumar Amita Aggarwal Nakul Sinha Ramnath Misra 《Clinical rheumatology》2009,28(11):1259-1265
Patients with systemic lupus erythematosus (SLE), especially Asian Indians, are at increased risk of developing premature
atherosclerosis. To find out the prevalence and predictors of carotid intima-medial thickness (IMT) and brachial artery flow-mediated
dilatation (FMD). Endothelial dysfunction was assessed by FMD in brachial artery and IMT was measured in common carotid artery
in SLE patients and healthy controls. Sixty SLE patients (mean age 31 ± 9 years) and 38 healthy controls (mean age 34 ± 6 years)
were included. The IMT was higher in SLE patients as compared to controls (0.49 ± 0.08 mm vs. 0.39 ± 0.05 mm, p < 0.0001). SLE and damage were independent predictors of abnormal IMT. FMD was impaired in SLE patients compared to controls
(9.97% vs. 18.97%, p < 0.00001). None of the classical cardiovascular risk factors were predictors of FMD or abnormal IMT. Indian patients with
SLE have higher prevalence of subclinical atherosclerosis and endothelial dysfunction. Presence of damage was associated with
abnormal IMT in SLE patients. 相似文献
20.
Miniati M Monti S Bottai M Cocci F Fornai E Lubrano V 《Internal and emergency medicine》2011,6(5):423-430
To establish whether C-reactive protein (CRP) is an independent predictor of all-cause mortality and hospitalization in chronic
obstructive pulmonary disease (COPD), we followed 200 patients with COPD and 201 age- and gender -matched controls for a median
time of 4.2 years (range, 0.2–5.1 years). Airflow obstruction was rated moderate if forced expiratory volume in one second
(FEV1) was 50–69% of the predicted value, or severe if FEV1 was <50%. The CRP level was categorized as low (≤3 mg/L) or high (>3 mg/L). The hazard of death was estimated by a proportional
hazard regression model, using controls with low CRP as the reference category. Fifty subjects died: 41 (21%) among the COPD
and 9 (4%) among the controls (p < 0.0001). The hazard of death in moderate COPD was not significantly higher than in the reference category, independently
of the CRP level. In severe COPD with a low CRP, the hazard of death is 3.4 times higher than in the reference category (p = 0.008); in severe COPD and a high CRP it is 9.6 times higher (p < 0.0001). The rate of hospitalization in COPD patients with a high CRP is 1.9 times higher than in those with a low CRP
[95% confidence interval (CI), 1.2–3.2]. In severe COPD, it is 6.9 times higher than in moderate COPD (95% CI, 3.8–12.7).
A high CRP level is a significant amplifier of the risk of death only in severe COPD. The degree of airflow obstruction is
a strong independent predictor of COPD-related outcomes. 相似文献