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1.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1996,121(1):22-25
Lipid peroxidation and the antioxidant system of the heart, liver, and brain are studied in adult male Wistar rats with high
and low resistance to hypoxia tested by “raising” to an altitude of 11.5 km and in intact outbred rats. These parameters are
found to be the same in the brain of low- and high-resistance rats, while the brain content of lipid peroxidation products
is higher in both groups of Wistar rats compared with outbred rats. The heart and liver parameters are coupled to the resistance
to hypoxia. Antioxidant activity prevails over lipid peroxidation in the hearts and livers of high-resistance rats, confirming
that oxidation plays a major role in the damaging and lethal effects of acute hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
1, pp 26–29, January, 1996
Presented by A. I. Archakov, Member of the Russian Academy of Medical Sciences 相似文献
2.
In contrast to short-term exposure, prolonged exposure to ethanol in the anternatal period is found to inhibit lipid peroxidation
in the brain and liver of rats. Activation of the system of antioxidant defense in the brain and liver is observed after both
short-and long-term exposure to ethanol. After short-term ethanol exposure, limontar normalizes lipid peroxidation.
Translated fromByulleten' Eksperimental'noii Biologii i Meditsiny, Vol. 117, N
o
1, pp. 41–44, January, 1994
Presented by M. Ya. Studenikin, Member of the Russian Academy of Medical Sciences 相似文献
3.
M. L. Khachatur'yan V. M. Gukasov P. G. Komarov L. B. Pirogova M. V. Bilenko 《Bulletin of experimental biology and medicine》1995,120(1):733-736
Lipid peroxidation and the antioxidant system of the myocardium of adult male Wistar rats with low and high resistance to
acute hypoxia tested by “raising” to an altitude of 11.5 km are studied in winter and in summer. It is found that the winter
season is a mild stressor inducing changes in the myocardial antioxidant system and lipid peroxidation which are similar to
those observed at the early stages of catecholamine stress in the summer season. In both cases alterations are more pronounced
in low-resistance than in high-resistance rats. In winter, in low-resistance rats the intensity of lipid peroxidation and
the activity of the antioxidant system are lower, while the ratio of their parameters (chemiluminescence data) is higher.
At the same time, the levels of thiobarbituric acid-reactive substances are higher in winter in both groups. The relationship
between the studied parameters and the resistance of rats to hypoxia is more obvious in winter than in summer, i.e., it is
season-dependent and is also more pronounced in catecholamine stress.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, Nolo 7, pp. 87–90, July, 1995
Presented by N. A. Agadzhanyan, Member of the Russian Academy of Medical Sciences 相似文献
4.
K. N. Kontorshchikova T. I. Solov'eva 《Bulletin of experimental biology and medicine》1996,121(2):148-150
Clinical death of outbred albino rats ensues after rapid blood loss due to a cut in the coronary coronary artery. Five minutes
later, the isolated heart is perfused with ozonized Krebs-Henseleit solution. The activity of the antioxidant system in the
heart is increased compared with that during routine oxygenation. The intensity of lipid peroxidation assessed by the intensity
of chemiluminescence and the amount of lipid peroxidation products is significantly decreased during ozonization.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, № 2, pp. 161–163, February, 1996
Presented by B. A. Korolev, Member of the Russian Academy of Medical sciences 相似文献
5.
T. G. Sazontova Yu. V. Arkhipenko F. Z. Meerson 《Bulletin of experimental biology and medicine》1995,120(1):687-690
The relationship between the level of accumulation of lipid peroxidation products and the status of the Ca2+-transporting system in the sarcoplasmic reticulum of the rat myocardium is studied against the background of two cardioprotective
factors, namely adaptation to periodic hypoxia and a diet enriched in polyunsaturated fatty acids of the ω-3 class. It is
shown that the diet leads to an increase of level of lipid peroxidation products by 1.8 times in the heart and by 19 times
in the liver, whereas a adaptation has no effect on the level of lipid peroxidation products in either of these organs. At
the same time, the combined action of both factors considerably enhances the resistance of the myocardial Ca2+-transporting system to free radical-induced oxidation. Inin vitro experiments it is shown that adaptation to periodic hypoxia results in a more than twofold deceleration of Ca2+ transport inhibition during the oxidation induction by the Fe2+/ascorbate system; the diet causes a 3.5-fold deceleration of such inhibition. The results show that the accumulation of a
high level of lipid peroxidation products is not always followed by damage to the Ca2+-transporting system in the myocardial sarcoplasmic reticulum.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
7, pp. 42–45, July, 1995
Presented by G. N. Kryzhanovskii, Member of the Russian Academy of Medical Sciences 相似文献
6.
A. M. Dudchenko L. D. Luk'yanova 《Bulletin of experimental biology and medicine》1995,120(6):1193-1195
After a prolonged (for 30 days) adaptation of rats to intermittent hypoxia, their brains contained lowered levels of mitochondrial
cytochromes, despite an increase in the number of mitochondria in the brain tissue mass, along with similar levels of high-energy
compounds and more protein as compaired to the brains of unadapted controls. A mitochondrial population with novel properties
presumably emerged in the brain. These effects were all more strongly marked in rats with an initially low resistance to hypoxia.
In the liver of hypoxiaadapted animals, unlike in their brain, cytochrome levels in the mitochondrial and microsomal redox
chains were lowered and the biogenesis of mitochondria was much less intensive.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
12, pp. 576–579, December, 1995 相似文献
7.
Newborn rats were born of females exposed to high-altitude hypoxia. Pregnant females were injected i.p. either nonopiate leu-enkephalin
analog or hydra peptide morphogen 10 μg/kg 30 min prior to being placed in a pressure chamber. Prenatal hypoxia causes the
inhibition of the proliferative processes in tracheal epithelium and activation of lipid peroxidation (LPO) in lungs of newborn
rats. The administration of nonopiate leu-enkephalin analog prevents the development of posthypoxic alterations in newborn
rats. The administration of hydra peptide morphogen inhibits the proliferation of tracheal epithelium and lowers the activity
of the antioxidant defense of the lungs in newborn rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 535–537, May, 1994
Presented by Yu. A. Romanov, Member of the Russian Academy of Medical Sciences 相似文献
8.
S. K. Soodaeva E. A. Ostrakhovich A. V. Kozlov B. T. Velichkovskii 《Bulletin of experimental biology and medicine》1994,118(2):834-836
The iron content, the state of the serum antioxidant system, and their relationship with the changes in lipid peroxidation
in rat liver and lungs at the early stages of chrysotile-asbestos action, and the effect of the naturally occurring flavonoid
rutin are studied. Intensification of lipid peroxidation in the liver and lungs and an increase in the oxyproline content,
which correlates with the rise in serum antioxidant activity, are observed four weeks after a single intratracheal administration
of 50 mg asbestos. The total serum iron content remains unchanged. Rutin has a pronounced anti-asbestos effect, inhibits the
early stages of fibrosis, and facilitates normalization of the antioxidant system imbalance induced by asbestos.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N
o
8 pp. 145–147, August, 1994 相似文献
9.
A study of kinetic parameters of brain respiratory enzymes revealed that the maximal velocity and the Michaelis apparent constant
for NADH-cytochrome C-reductase are significantly lower in low-resistant rats than in rats with a high resistance to hypoxia.
Adaptation to periodic hypoxia increases total resistance only in low-resistant rats. It is accompanied by an increase in
the values of kinetics parameters for NADH-cytochrome C-reductase and cytochrome oxidase. Kinetic parameters for these enzymes
in the brain of high-resistant rats are either unaltered or even decreased. It is suggested that the first enzymatic complex
of the respiratory chain is one of the limiting or regulating links in energy metabolism determining the brain's resistance
to hypoxia.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 252–255, March, 1996. 相似文献
10.
Protective effects of trimetazidine in acute hypoxia 总被引:1,自引:0,他引:1
A. V. Smirnov I. Krivoruchko I. B. Zarubina O. P. Mironova 《Bulletin of experimental biology and medicine》1998,125(4):361-363
Trimetazidine improves resistance to acute hypobaric hypoxia. Intraperitoneal injection of this preparation in an optimal
protective dose (25 mg/kg) to rats prevents serious disturbances of energy metabolism and activation of lipid peroxidation
in the brain, heart, and liver.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 4, pp. 410–412, April, 1998 相似文献
11.
V. V. Malyshev L. S. Vasil'eva S. B. Belogorov T. V. Nefedova 《Bulletin of experimental biology and medicine》1995,119(6):567-570
Preadaptation of rats to altitude hypoxia results in reduced activation of lipid peroxidation during subsequent stress, inflammation,
or both, as compared to hypoxiaunadapted animals, with the result that secondary changes in organs and tissues of adapted
rats are much less pronounced and conditions are created for alleviating the acute inflammation and the stress reaction.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 119, N
o
6, pp. 590–593, June, 1995
Presented by E. D. Gol'dberg, Member of the Russian Academy of Medical Sciences 相似文献
12.
V. D. Slepushkin N. N. Mikhailova I. V. Egorov A. V. Kiseleva 《Bulletin of experimental biology and medicine》1999,127(4):350-354
Effect of melatonin on antioxidant activity and lipid peroxidation in blood, heart, liver, and brain was studied in rats exposed
to traumatic shock. Melatonin exerted a potent modulatory effect on antioxidant enzyme activity. Its efficacy depended on
organ sensitivity to oxygen deficiency under conditions of traumatic shock.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 127, No. 4, pp. 387–391, April, 1999. 相似文献
13.
M. L. Kuklei S. L. Stvolinskii A. A. Boldyrev I. V. Gannushkina 《Bulletin of experimental biology and medicine》1994,118(4):1085-1087
It is found for each of the rat brain regions studied (cerebral cortex, subjacent white substance, and brainstem) that both
the initial levels of 2-thiobarbituric acid-reactive products and the rates of their increment are highest in rats resistant
to emotional stress and lowest in stress-prone rats, and that the rates at which lipid peroxidation products accumulate are
highest in the brainstem and lowest in the white substance. A correlation is presumed to exist between individual resistance
to cerebral ischemia and the rate of lipid peroxidation in particular brain regions of healthy rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, № 10, pp. 384–387, October, 1994 相似文献
14.
A. A. Vishnevskii G. A. Zakhrov V. M. Yakovlev G. I. Gorokhova L. S. Kostyuchenko 《Bulletin of experimental biology and medicine》1995,120(2):779-781
Vascular spasm, hypertrophy of cardiac muscle cells, and necrotic changes in the myocardial tissue of rats administered norepinephrine
in incremental doses over 14 days were accompanied by a considerable activation of lipid peroxidation and a weakening of antioxidant
defense during the first 7 days of exposure to this injurious agent. On day 14, despite the greatly increased load of norepinephrine,
the concentrations of lipid peroxidation products and the activity of antioxidant enzymes deviated from their control values
to a lesser extent than on day 7. A similar change was shown by the concentration of brain tissue phosphatidylinositol-4,5-diphosphate,
a source of second messengers, suggesting that the phosphoinositide system of second messengers is involved in the mechanisms
whereby the destructive effects of norepinephrine are mitigated.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 120, N
o
8, pp. 137–139, August, 1995
Presented by I. P. Ashmarin, Member of the Russian Academy of Medical Sciences 相似文献
15.
N. G. Kolosova N. A. Solov'eva I. G. Shabalina R. I. Salganik 《Bulletin of experimental biology and medicine》1996,121(3):259-261
It is shown that at the age of 2–3 months S rats with genetically determined hyperproduction of free radicals have the same
content of tocopherol in the heart, epididymal fat, adrenals, liver, and liver mitochondria as Wistar rats but a lower content
of plasma tocopherol. At 10–12 months, the tocopherol content in all studied tissues and organs, except the liver, is higher
than in young S rats and age-matched Wistar rats. This is regarded as a compensatory response facilitating the stabilization
of LPO under conditions of increased free radical formation.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 121, N
o
3, pp. 282–284, March, 1996 相似文献
16.
I. M. Solopaeva K. N. Kontorshchikova 《Bulletin of experimental biology and medicine》1994,117(6):571-573
A study is performed of the effect of chorionic gonadotropin on lipid peroxidation in the liver and myocardium of white rats
injected subcutaneously with tetrachloromethane for a long time. Chorionic gonadotropin is shown to reduce the content of
diene conjugates and Schiff bases, which suggests an antioxidant effect of the hormone.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
6, pp. 572–573, June, 1994
Presented by Yu. A. Romanov. Member of the Russian Academy of Medical Sciences. 相似文献
17.
Gorbenko NI Poltorak VV Gladkikh AI Ivanova OV 《Bulletin of experimental biology and medicine》2000,130(7):647-648
The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration
of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral
tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation
products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably
due to its antioxidant properties.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 42–44, July, 2000 相似文献
18.
N. I. Gorbenko V. V. Poltorak A. I. Gladkikh O. V. Ivanova 《Bulletin of experimental biology and medicine》2000,130(1):647-648
The effects of new antioxidant fensuccinal on dexamethasone-induced insulin resistance in rats were studied. Oral administration
of fensuccinal in a dose of 25 mg/kg for 2 weeks prevented basal hyperinsulinemia and insulin insensitivity of peripheral
tissues. Fensuccinal also attenuated oxidative stress by decreasing the concentrations of primary and secondary lipid peroxidation
products in liver homogenates. The ability of fensuccinal to prevent dexamethasone-induced insulin resistance is probably
due to its antioxidant properties.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 130, No. 7, pp. 42–44, July, 2000 相似文献
19.
Newborn rats euthanized 24 h after birth were examined. The rats were born to females exposed to chronic hypobaric hypoxia
on days 14–19 of gestation. The index of nuclei labeled with3H-thymidine in the tracheal epithelium of newborn rats exposed to prenatal hypoxia was 3 times lower than in the control.
The LPO level was higher in posthypoxic animals than in intact rats. Prenatal hypoxia led to the suppression of antioxidant
defense in the lungs of newborn rats.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 117, N
o
5, pp. 531–533, May, 1994 相似文献
20.
U. R. Farkhutdinov R. R. Farkhutdinov 《Bulletin of experimental biology and medicine》2000,129(3):219-222
Lipid peroxidation in the lungs and plasma of albino rats was studied under normal conditions and during experimental pneumonia.
In intact rats the content of lipid peroxidation products and the rate of their accumulation in lung homogenate is lower than
in homogenates of other organs. Bivalent iron ions added to blood plasma did not induce chemiluminescence characteristic of
lipid peroxidation. Experimental pneumonia intensifies production of active oxygen forms by alveolar macrophages and blood
neutrophils and increases the content of lipid peroxidation products in lung homogenate. Combined application of antibiotics
and antioxidant (vitamin E) during experimental pneumonia promotes normalization of free-radical oxidation and diminishes
morphological alterations in the lungs.
Translated fromByulleten' Eksperimental'noi Biologii i Medistiny, Vol. 129, No. 3, pp. 260–264, March, 2000 相似文献