神经外科患者腰椎穿刺术后最佳卧床时间的循证实践

目的 探讨基于最佳证据的缩短神经外科腰椎穿刺术后卧床休息时间方案的临床实践并评价其效果。方法 采用JBI证据应用模式,检索关于腰椎穿刺术后卧床的相关证据,采用JBI证据预分级及证据推荐级别系统（2014版）进行证据等级及推荐级别的划分,并运用FAME结构从可行性、适宜性、临床意义和有效性4个方面对证据进行评价。将采纳的证据转化为临床审查指标,通过查看护理记录、现场审查和问卷法的方式收集资料。比较证据应用前后腰椎穿刺术后患者的舒适度、头痛和腰背部疼痛率、压疮风险及护士知晓率。结果 证据应用后,腰椎穿刺术后患者舒适度高于证据应用前（P<0.001）;术后头痛及腰背部疼痛率无统计学差异（P>0.05）;压疮风险较证据应用前降低（P=0.005）;6项审查指标中,指标1~2在证据应用前执行率已是100%,其余4项指标证据应用后执行率高于证据应用前,差异均有统计学意义（P<0.001）。结论 将基于循证的最佳证据应用于临床实践,缩短神经外科患者腰椎穿刺术后卧床休息时间,可降低患者不适感,减少并发症的发生,从而提升临床护理质量。     

Prevention and management of post-lumbar puncture headache in pediatric oncology patients.

Pediatric oncology patients are at risk for developing a headache after they undergo a lumbar puncture for diagnostic or therapeutic purposes. These headaches are likely due to leakage of cerebrospinal fluid at the puncture site. While usually mild and self-limited, some headaches may be persistent and severe, adding to the distress of these young patients. In the past 10 years, refinements in lumbar needle size and shape as well as procedural techniques have reduced the tissue trauma that predisposes patients to headache. A number of interventions, such as bed rest, hydration, caffeine administration, and epidural blood patching, have been suggested to prevent and relieve the headaches that follow lumbar punctures. This article outlines the pathophysiology and incidence of headaches related to lumbar punctures in the pediatric oncology setting and reviews the evidence from research trials to suggest which interventions clinicians should adopt into their practice to minimize this complication of lumbar punctures.     

Effect of 24-Hour Bed Rest versus Early Ambulation on Headache after Spinal Anesthesia: Systematic Review and Meta-analysis

Objectives: We performed a systematic review of the evidence for the effectiveness of bed rest after dural puncture to update current evidence on the topic. Design: The design was a systematic review and meta-analysis. Data Sources: We searched 10 electronic databases in English (Medline, CINAHL, EMBASE, and the Cochrane Controlled Trial Register) and Korean (KISS, KMBASE, NDSL, and RISS) using the terms “post–dural puncture headache,” “spinal anesthesia,” “epidural anesthesia,” and “bed rest” to identify reports discussing the effectiveness of bed rest in preventing post–dural puncture headache (PDPH) after spinal anesthesia from 1980 to 2014. Review/Analysis Methods: Original studies such as randomized and nonrandomized controlled trials, where participants were allocated to an intervention or control group, were included. A total of eight studies that met the inclusion criteria were independently reviewed and encoded by two review authors. To ensure the quality of the eight studies, levels of risk of bias were assessed by two different researchers. The main outcome was the prevalence of PDPH. Results: The included studies indicated that PDPH prevalence did not differ between the group assigned to 24 hours of bed rest and the group assigned to early ambulation. In subgroup analysis, the effect size of clinical factors (severity of headache, day of onset, and needle gauge) and the study characteristics (language and sample size) did not differ between groups. Conclusion: This meta-analysis of studies suggested that long-term bed rest after spinal anesthesia may not be effective in preventing PDPH.     

Significant reduction in post-lumbar puncture headache using an atraumatic needle. A double-blind, controlled clinical trial

A characteristic headache occurs in about 36–55% of patients after lumbar puncture, and many of these patients need bed rest for one or more days to get relief. In a double-blind randomized trial we compared a new 22-gauge atraumatic puncture needle with the most widely used 20-gauge "conventional" needle. In 49 patients randomized to the atraumatic needle, post-lumbar puncture headache occurred in 6%, whereas in the 50 patients randomized to the conventional needle this occurred in 32% ( p =0.001). On the basis of these results we recommend use of the atraumatic needle in order to diminish the frequency of post-lumbar puncture headache.     

儿童腰椎穿刺术后两种体位的对比研究

目的:探讨儿童腰椎穿刺术后两种卧位的舒适性及并发症发生情况。方法:将230例行腰椎穿刺术患儿随机分为观察组和对照组各115例,观察组术后交替采取去枕平卧位和平头侧卧位,对照组术后去枕平卧4~6h,观察术后头痛、腰背痛、脑疝等并发症发生情况。结果:两组患儿头痛、脑疝发生情况比较无显著性差异,观察组术后腰背疼痛的发生率明显低于对照组(P<0.01)。结论:腰椎穿刺术后交替采取去枕平卧与平头侧卧位,不仅具有传统卧位使头痛发生率低的优点,而且可减少腰背疼痛的发生率,提高患儿舒适度。     

SECONDARY HEADACHES

Murata Y, Yamagata M, Ogata S, Shimizu K, Ikeda Y, Hirayama J, Yamada H. The influence of early ambulation and other factors on headache after lumbar myelography. J Bone Joint Surg Br. 2003;85:531-534.
In order to determine the influence of early ambulation and other factors on headaches occurring after lumbar myelography we randomised 207 patients (127 men and 80 women) into two groups. Following the investigation, we allowed the 101 patients (65 men and 36 women) in group A to sit or stand freely, while we confined the 106 patients (62 men and 44 women) in group B to bed for 20 hours. The nine patients in group B who could not maintain bed rest were excluded. There was no significant difference between the two groups as regards the prevalence of spinal headache (8.9% in group A v 14.4% in group B). Patients who reported headaches, however, were significantly more likely to be women (18.7%) than men (73%), be younger (mean age 45 years v 56 years), have a higher cerebrospinal pressure before removal of fluid (mean values 172 v 137 mm H2O) and a lower systolic (mean values 120 v 134 mmHg) and diastolic blood pressure. We conclude that, although other factors may be associated with headaches, late ambulation is not effective in preventing spinal headaches after lumbar myelography.
Comment: The only proven way to prevent spinal headache after lumbar puncture that I have ever read is to use special blunt-end needles such as Sprotte needles, which need to be special ordered, but which markedly reduce this complication. SJT     

连续腰椎穿刺引流在动脉瘤性蛛网膜下腔出血栓塞术后的作用

目的探讨连续腰椎穿刺引流对动脉瘤性蛛网膜下腔出血（a SAH）患者血管栓塞治疗后的作用。方法 42例a SAH患者接受颅内动脉栓塞治疗后,根据是否采取连续腰椎穿刺分为观察组20人和对照组22人。观察2组患者迟发性缺血性神经功能缺陷（DIDN）、头痛缓解和Rankin评分差异。结果观察组患者头痛缓解天数短于对照组（P〈0.05）;治疗期内,观察组患者DIDN发生率低于对照组（P〈00.05）,14 d时Rankin评分低于对照组（P〈0.05）。结论 a SAH患者栓塞治疗后行早期连续腰椎穿刺引流,能降低DIND发生风险,促进神经和认知功能早期恢复。     

Ambulation after femoral sheath removal in percutaneous coronary intervention: a prospective comparison of early vs. late ambulation

Aim and objectives. To investigate if ambulation four hours after sheath removal can replace ambulation 10 hours or more after sheath removal with regard to puncture site complications after percutaneous coronary interventions and to examine patient comfort in both groups. Background. Early ambulation after percutaneous coronary intervention may facilitate earlier hospital discharge. Whether this approach is safe, is unknown. Design. A non‐randomised comparative study. Methods. Percutaneous coronary intervention was performed by femoral approach. Registered nurses of the ward removed the sheath and haemostasis was achieved by manual compression. After bed rest with a compression bandage for four hours, the patients in the early ambulation group were ambulated. The patients in the control group stayed in bed till the next morning. Primary study endpoint was the composition of puncture site complications: haematoma, bleeding, false aneurysm and arteriovenous fistula. Secondary endpoints were occurrence of vasovagal collapse after mobilisation, back pain and problems with voiding. Results. In the early ambulation group (n = 329) the total number of complications was nine (2·7%), vs. six (3·0%) in the control group (n = 202). The complication rate in the early ambulation group is not increased compared to the control group (test for non‐inferiority p = 0·002). Hence non‐inferiority is accepted and practical equivalence shown. There were no statistically significant differences concerning patient comfort between the groups. Conclusions. Early ambulation four hours after femoral sheath removal is feasible and safe. The incidence of puncture site complications in the early ambulation group is not increased in comparison with the group with prolonged bed rest. Relevance to clinical practice. Patients could possibly be discharged earlier after percutaneous coronary intervention, allowing percutaneous coronary intervention in an ambulant setting. Further research should confirm these findings and extend the research to the effect of various closure devices in early ambulation and on patients’ well‐being.     

Comparison of post-dural puncture headache and low back pain between 23 and 25 gauge Quincke spinal needles in patients over 60 years: randomized, double-blind controlled trial

Background

Even though the use of a 25 gauge or smaller Quincke needle is recommended for spinal anesthesia to reduce post-dural puncture headache in Korea, lumbar puncture in older patients using a 25 gauge or smaller Quincke needle can be difficult. However, most previous studies concerning post-dural puncture headache have chosen children, parturients, and young adults as study participants.

Objectives

The study compared post-dural puncture headache, post-operative back pain, and the number of lumbar puncture attempts using a 23 or 25 gauge Quincke needle for spinal anesthesia of Korean patients >60-years-of-age.

Design

Randomized, double-blinded controlled trial.

Participants

The 53 participants who underwent orthopedic surgery under spinal anesthesia were recruited by informed notices from December 2006 through August 2007 at a 200-bed general hospital located in Kyunggido. Inclusion criteria were an age >60 years, ASA I–II, and administration of patient controlled analgesia for the first 48 h post-operatively.

Methods

The 53 patients were randomly allocated to either the experimental (23 gauge Quincke needle) or control group (25 gauge Quincke needle). All patients had 24 h bed rest post-operatively. Post-dural puncture headache was assessed by the Dittmann Scale and post-operative back pain was assessed by a visual analogue scale at 24, 48, and 72 h post-operatively. The statistical methods included the Mann–Whitney U-test and Spearman correlation.

Results

There were no differences in post-dural puncture headache, and post-operative back pain at 24, 48, and 72 h post-operatively, and no differences in the number of lumbar punctures, with the 23 and 25 gauge Quincke needle. Forty-eight hour post-operative back pain was positively associated with the number of lumbar punctures (p = .036) and age (p = .040). There were no statistically significant associations among post-dural puncture headache, the number of lumbar punctures, and 48 h post-operative back pain. Pre-operative back pain was positively associated with 48 h post-operative back pain (p < .001).

Conclusions

The choice of a 23 or 25 gauge Quincke needle for spinal anesthesia has no significant influence on post-dural puncture headache and post-operative back pain for Korean patients greater than 60-years-of-age. The 23 gauge Quincke needle is an option for lumbar punctures in this patient population.     

Spontaneous intracranial hypotension--a case report

Positional or orthostatic headache symptoms secondary to intracranial hypotension are usually seen as complications in patients after medical procedures, such as lumbar puncture. We describe a case of spontaneous intracranial hypotension (SIH) in a 43-year-old man without a previous history of headaches. He presented to the Emergency Department (ED) with a new-onset orthostatic headache without any history of recent medical procedure, such as lumbar puncture (LP). The ED evaluation included a normal neurologic examination and normal computed tomography (CT) scan of the brain. An LP showed low opening pressure, elevated protein, 46 RBCs and one lymphocyte. Subsequent evaluation with radionuclide cisternography confirmed a cerebrospinal fluid (CSF) leak in the area of the upper thoracic spine, and treatment with an epidural blood patch dramatically improved his symptoms. SIH is due to CSF leakage, usually in the area of the cervical or upper thoracic spine, often without a clear etiology. Conservative medical management including bed rest, oral hydration and caffeine intake is the usual first line treatment. An epidural blood patch is often a dramatically effective treatment that can be done once the presence and location of the leak is identified. Although mostly benign, this condition occasionally can be associated with the formation of clinically significant subdural fluid collections or hematomas. SIH is an increasingly recognized cause of headache.     

Usefulness of electrophysiology and neuroimaging in the evaluation of headache

First time experienced severe headache combined with fever or meningism requires immediate evaluation by computer tomography (CT) to exclude subarachnoidal or cerebral hemorrhage, hydrocephalus or a tumor. If CT is normal,lumbar puncture must be performed to exclude meningitis and meningoencephalitis. Chronic or chronic recurrent headache without focal neurological deficits does not require EEG or CT. CT must be performed if the headache characteristics change or if the headache is combined with neurological deficits.     

An MRI Study of Lumbar Puncture Headaches

We studied 11 patients undergoing a routine lumbar puncture to determine if there were cerebrospinal fluid leaks at the puncture site and whether the maximum volume of leakage correlates with a lumbar puncture headache. Patients completed a headache questionnaire before and after the lumbar puncture. Limited magnetic resonance imaging of the lumbar spine was obtained 8 to 36 hours after the lumbar puncture and two patients also had later imaging. In a blinded fashion, the largest diameter of cerebrospinal fluid leakage into the paraspinous area was determined from T2 weighted magnetic resonance images and the maximum possible fluid volume was calculated. Six patients had a small cerebrospinal fluid leakage (< 10 mL), two had a medium leakage (10 to 110 mL), and three had a large leakage (> 110 mL). The volume of cerebrospinal fluid leakage did not corre late with occurrence of a lumbar puncture headache. The study demonstrates that cerebrospinal fluid usually leaks into the paraspinous area after a lumbar puncture, but the volume of escaped fluid does not correlate with a lumbar puncture headache.     

Changes in cerebral haemodynamics in cases of post-lumbar puncture headache: a prospective transcranial Doppler ultrasound study

We used transcranial Doppler ultrasonography in 45 patients to investigate if changes in haemodynamics in the major arteries of the brain base occurred after lumbar puncture and whether or not patients with or without post-lumbar puncture headache differ with respect to their cerebral haemodynamic parameters before and after lumbar puncture. Before lumbar puncture, patients with post-lumbar puncture headache differed from patients without post-lumbar puncture headache in that they showed significantly higher flow velocities and significant asymmetry of flow velocities with lateralization to the right (p less than or equal to 0.05). Patients without post-lumbar puncture headache, on the other hand, showed non-significant flow velocity lateralization to the left. Forty-eight hours after lumbar puncture, both groups demonstrated symmetrical flow velocities. In addition, only patients with post-lumbar puncture headache showed a significant reduction in the flow velocity of the right middle cerebral artery (p less than or equal to 0.05). These findings suggest that it is not only absolute flow velocity that plays a part in the event of headache, the interhemispheric relation of cerebral haemodynamics also plays a fundamental role.     

Impact of pseudotumor cerebri (idiopathic intracranial hypertension) in pregnancy: a case report

This case report reviews anesthetic management and medical considerations for a pregnant patient with a history of pseudotumor cerebri (PTC). The 24-year-old woman, gravida 2, paragravida 0, spontaneous abortion 1, was in active labor at an estimated 38 weeks' gestation and had been given a diagnosis of PTC 4 years earlier. This patient first experienced global headaches and blurred vision at age 20 years. At the time of onset of her headache symptoms, she underwent a full diagnostic workup and detailed neurologic examination, including magnetic resonance imaging (MRI) of the brain and a lumbar puncture. The MRI was normal. Her lumbar puncture showed elevated cerebral spinal fluid (CSF) pressures and normal CSF composition. The patient's initial symptoms of headache and blurred vision were managed with medication and serial lumbar punctures. The patient was free of PTC symptoms on admission for labor. A lumbar epidural was placed for labor analgesia. The patient delivered a healthy infant after approximately 10.5 hours of patient-controlled epidural analgesia.     

Persistent Post-DuraI-Puncture Headache Treated With Epidural Infusion of Dextran

SYNOPSIS
A retrospective review was done on medical records of 13 patients with persistent post-dural-puncture headaches after one or more epidural blood patches. Headache occurred in nine patients with post-laminectomy syndrome after "wet taps" while performing epidural blocks. In two patients post-dural-puncture headache appeared after long term implanted intrathecal catheters were removed. In two other cases headache developed after spinal anesthesia. Treatment included bed rest, intravenous hydration and at least one epidural blood patch; three patients were given 60 milliliters of epidural saline, without success. Eight epidural catheters were inserted through the lumbar access and five through the caudal approach. Initially, a bolus of 20 milliliters of dextran-40 was given followed by an infusion of 3 mL/hr, until 12 hours after the head pain and any other related symptoms subsided. In all patients the headache disappeared within 20 hours after initiating therapy (9.55 mean hours, SD ± 0.79). In five patients headache ceased in less than five hours. Nausea and photo-phobia subsided earlier. Patients with post-dural-puncture headache resistant to other treatments, including at least one epidural blood patch, were successfully treated by a bolus followed by continuous epidural infusion of dextran-40.     

脑血管造影术后不同卧床时间与制动方法的对比研究

目的：探讨脑血管造影术后卧床和患肢制动的最佳时间。方法：将120例行脑血管造影的住院患者分为缩短卧床时间组（观察组）和常规卧床时间组（对照组），分别按卧床12h和24h两种不同时间、不同制动方式进行术后指导。结果：观察组术后腰背疼痛、尿潴留等并发症发生率显著低于对照组（P〈0．01或P〈0．05）。结论：脑血管造影术后宜采用沙袋压迫局部4～6h，6h后患肢可以左右移动，小腿自由曲伸或取健侧卧位，12h后即可下床行走。     

Use of atraumatic spinal needles among neurologists in the United States

OBJECTIVE: To evaluate atraumatic spinal needle use among US neurologists. BACKGROUND: Postdural puncture headache following lumbar puncture may be dramatically reduced through the use of atraumatic pencil-point spinal needles. It was hypothesized that atraumatic spinal needles are rarely used by members of specialties outside of anesthesiology. To determine the extent to which atraumatic spinal needles are currently being used for lumbar puncture in the United States, American neurologists (one group of physicians who regularly perform lumbar punctures) were surveyed. METHODS: A questionnaire was mailed to all 7798 members of the American Academy of Neurology listed in the membership directory. The questionnaire included items pertaining to age, practice setting, knowledge of pencil-point (atraumatic) spinal needles, and lumbar puncture practices. RESULTS: Only a fraction (2%) of the neurologists surveyed routinely use atraumatic spinal needles. Almost half of the responding neurologists reported having no knowledge of pencil-point spinal needles. Among those who did have knowledge of these new spinal needles, the most common reasons given for not using them were nonavailability and expense. CONCLUSIONS: Atraumatic spinal needles for lumbar puncture have been shown to dramatically decrease the risk of postdural puncture headache. Although the use of these needles is standard practice among anesthesiologists, they have not been adopted by other medical specialties. This may lead to unnecessary morbidity among patients undergoing lumbar puncture.     

Post-lumbar-puncture headache: The significance of body posture

In this single-blind, randomized study of post-lumbar-puncture headache (PPH) in 300 neurologic inpatients the significance of body posture after lumbar puncture (LP) was evaluated. Immediate mobilization was compared with bed rest for 6 h (3 h prone followed by 3 h supine posture). Contrary to the widely held belief, this investigation did not show significant differences between recumbent and ambulant patients as to frequency of PPH in the total material (39% versus 35%) or when men (31% versus 29%) and women (48% versus 41%) were evaluated separately. Headache associated with nausea was significantly more frequent in the recumbent than in the ambulant patients both in the total material (23% versus 13%) and in women (35% versus 16%). Thus, immediate mobilization seems to be preferable after LP.     

Hypersensitivity to Substance P in the Etiology of Postlumbar Puncture Headache

Objective.-Postlumbar puncture headache may represent a model which could be used to test the hypothesis that headache pain is caused by the release of substance P in patients who are predisposed to headache due to hypersensitivity to substance P.
Methods.-We measured substance P in CSF and plasma in 37 patients undergoing diagnostic lumbar puncture. In 9 patients, plasma samples were obtained before lumbar puncture, in 28 patients plasma was obtained after lumbar puncture. Patients were followed up by telephone to determine if they developed postlumbar puncture headache. Patients were also asked about a history of chronic or recurrent headaches. Substance P was determined by radioimmunoassay.
Results.-The mean plasma substance P levels obtained before lumbar puncture was 1.0 ± 0.1 pg/mL and 1.3 ± 1.2 after lumbar puncture (P<0.0005). The mean plasma substance P levels in subjects who developed postlumbar puncture headache was 0.6 ± 0.6 pg/mL compared with 1.4 ± 1.5 in subjects who remained headache-free ( P <0.05). The mean CSF substance P levels in subjects who developed postlumbar puncture headache was 0.7 ± 0.5 pg/mL compared with 1.2 ± 0.8 in subjects who remained headache-free ( P <0.05). There were no significant differences in substance P levels between chronic headache sufferers and nonheadache subjects.
Conclusions.-Postlumbar puncture headache may be mediated by the release of substance P triggered by lumbar puncture, in patients predisposed to headache by a hypersensitivity to substance P. Hypersensitivity to substance P may also represent a mechanism for headache pain in other headache disorders.     

Diagnostic lumbar puncture. Comparative study between 22–gauge pencil point and sharp bevel needle

Post-lumbar puncture headache is a frequent clinical problem. Needle design is expected to reduce post-puncture headache. In this study, we compared two different lumbar puncture needle designs in diagnostic lumbar puncture and analysed post-dural puncture headache (PDPH) and social and economical harm associated with the diagnostic lumbar puncture procedure. This prospective, controlled study consisted of 80 consecutive adult patients requiring elective diagnostic lumbar puncture due to various neurological symptoms. Lumbar puncture was completed either with Spinocan 22 G sharp bevel needle or Whitacre 22G pencil point needle. Patients were asked about previous headache symptoms and pain provoked by puncture. One week after the lumbar puncture all patients were interviewed by telephone and occurrence and type of headache, headache intensity, medication and frequency of impairment in activities of daily living were asked. Need for epidural blood patch was also recorded. Thirty-three of 78 (42%) patients experienced headache after diagnostic lumbar puncture and in 26 (33%) the headache could be classified as PDPH. There were no statistically significant differences between needle types in the frequency of common headache, PDPH, puncture pain intensity, need for epidural blood patch or sick leave. Also, there were no other complications except local back pain or headache. In this study, the needle design did not affect the frequency of PDPH. Also, PDPH was common, occurring in 33% cases and caused a considerable amount of disturbance in daily activities. Seeking help for this condition was insufficient and only part of these PDPH patients were treated with epidural blood patch.