Paroxetine-induced reduction of sexual incentive motivation in female rats is not modified by 5-HT<Subscript>1B</Subscript> or 5-HT<Subscript>2C</Subscript> antagonists

Rationale  

Clinical data show that paroxetine causes sexual dysfunction in a substantial proportion of women taking this compound.     

Fe<Subscript>3</Subscript>O<Subscript>4</Subscript>-PEI-RITC Magnetic Nanoparticles with Imaging and Gene Transfer Capability: Development of a Tool for Neural Cell Transplantation Therapies

Purpose  

To develop Fe₃O₄-PEI-RITC magnetic nanoparticles with multimodal MRI-fluorescence imaging and transfection capability, for use in neural cell replacement therapies.     

A Semi-mechanistic Modeling Strategy to Link <Emphasis Type="Italic">In Vitro</Emphasis> and <Emphasis Type="Italic">In Vivo</Emphasis> Drug Release for Modified Release Formulations

Purpose  

To develop a semi-mechanistic model linking in vitro to in vivo drug release.     

A Novel Gastro-Retentive Osmotic Pump Capsule Using Asymmetric Membrane Technology: <Emphasis Type="BoldItalic">In Vitro</Emphasis> and <Emphasis Type="BoldItalic">In Vivo</Emphasis> Evaluation

Purpose  

The purpose of this paper is to develop a novel gastro-retentive osmotic pump capsule using asymmetric membrane technology.     

Phenethyl Isothiocyanate Sensitizes Androgen-Independent Human Prostate Cancer Cells to Docetaxel-Induced Apoptosis <Emphasis Type="Italic">In Vitro</Emphasis> and <Emphasis Type="Italic">In Vivo</Emphasis>

Purpose  

The present study was undertaken to determine efficacy of phenethyl isothiocyanate (PEITC) for sensitization of androgen-independent human prostate cancer cells (AIPC) to Docetaxel-induced apoptosis using cellular and xenograft models.     

Population <Emphasis Type="Italic">In Vitro</Emphasis>-<Emphasis Type="Italic">In Vivo</Emphasis> Correlation Model for Pramipexole Slow-Release Oral Formulations

Purpose  

To establish an in vitro-in vivo level A correlation (IVIVC) for pramipexole slow-release formulations.     

Fast Surface Crystallization of Amorphous Griseofulvin Below <Emphasis Type="Italic">T</Emphasis><Subscript>g</Subscript>

Purpose  

To study crystal growth rates of amorphous griseofulvin (GSF) below its glass transition temperature (T _g) and the effect of surface crystallization on the overall crystallization kinetics of amorphous GSF.     

<Emphasis Type="Italic">Linum usitatissimum</Emphasis> (linseed/flaxseed) fixed oil: antimicrobial activity and efficacy in bovine mastitis

Purpose  

In vitro antimicrobial activity and in vivo therapeutic efficacy of L. usitatissimum (linseed/flaxseed) fixed oil in bovine mastitis were investigated.     

Pharmacokinetic-Pharmacodynamic Modeling of the Inhibitory Effects of Naproxen on the Time-Courses of Inflammatory Pain,Fever, and the <Emphasis Type="Italic">Ex Vivo</Emphasis> Synthesis of TXB<Subscript>2</Subscript> and PGE<Subscript>2</Subscript> in Rats

Purpose  

To quantify and compare the time-course and potency of the analgesic and antipyretic effects of naproxen in conjunction with the inhibition of PGE₂ and TXB₂.     

Evidence of Deep Percutaneous Penetration Associated with Anti-Inflammatory Activity of Topically Applied <Emphasis Type="Italic">Helicteres gardneriana</Emphasis> Extract: A Photoacoustic Spectroscopy Study

Purpose  

To apply the photoacoustic spectroscopy technique to investigate the penetration rate of topically applied Helicteres gardneriana extract used as anti-inflammatory agent.     

<Emphasis Type="Italic">In Vitro</Emphasis> and <Emphasis Type="Italic">In Vivo</Emphasis> Effects of Water Extract of White Cocoa Tea (<Emphasis Type="Italic">Camellia ptilophylla</Emphasis>) Against Human Prostate Cancer

Purpose  

We evaluated the chemotherapeutic effect of water extract of white cocoa tea (WCTE) against human prostate cancer (PCa) in vitro and in vivo.     

Reversal of sibutramine-induced anorexia with a selective 5-HT<Subscript>2C</Subscript> receptor antagonist

Rationale  

The monoamine reuptake inhibitor sibutramine reduces food intake but the receptor subtypes mediating the effects of sibutramine on feeding remain to be clearly identified.     

Multiple Berry Types Prevent <Emphasis Type="Italic">N-</Emphasis>nitrosomethylbenzylamine-Induced Esophageal Cancer in Rats

Purpose  

The present study compared the ability of different berry types to prevent chemically-induced tumorigenesis in the rat esophagus. We also determined if berries influence the levels of inflammatory cytokines in the serum of carcinogen-treated rats.     

Paclitaxel-Loaded,Folic-Acid-Targeted and TAT-Peptide-Conjugated Polymeric Liposomes: <Emphasis Type="Italic">In Vitro</Emphasis> and <Emphasis Type="Italic">In Vivo</Emphasis> Evaluation

Objective  

Folic acid and TAT peptide were conjugated on the octadecyl-quaternized, lysine-modified chitosan-cholesterol polymeric liposomes (FA-TATp-PLs) to investigate their potential feasibility for tumor-targeted drug delivery.     

Fabrication of Cisplatin-Loaded Poly(lactide-<Emphasis Type="Italic">co</Emphasis>-glycolide) Composite Microspheres for Osteosarcoma Treatment

Purpose  

To reduce the toxicity and achieve a sustainable and controllable release of cisplatin (CDDP).     

Methodological Comparison of <Emphasis Type="Italic">In Vitro</Emphasis> Binding Parameter Estimation: Sequential <Emphasis Type="Italic">vs</Emphasis>. Simultaneous Non-linear Regression

Purpose  

Analysis of simulated data was compared using sequential (NLR) and simultaneous non-linear regression (SNLR) to evaluate precision and accuracy of ligand binding parameter estimation.     

Neuropilin-1 Targeting Photosensitization-Induced Early Stages of Thrombosis <Emphasis Type="Italic">via</Emphasis> Tissue Factor Release

Purpose  

This article characterizes the vascular effects following vascular-targeted photodynamic therapy with a photosensitizer which actively targets endothelial cells.     

Folate-PEG-CKK<Subscript>2</Subscript>-DTPA,A Potential Carrier for Lymph-Metastasized Tumor Targeting

Purpose  

A novel conjugate, Folate-PEG-CKK₂-DTPA, was designed and prepared as a carrier for lymphatic metastasized tumor imaging diagnosis and targeting therapy.     

Enhanced Bioavailability of L-Carnitine After Painless Intradermal Delivery <Emphasis Type="BoldItalic">vs.</Emphasis> Oral Administration in Rats

Purpose  

In vitro and in vivo permeation studies were conducted to evaluate the characteristic of percutaneous administration of high hydrophilic drug L-carnitine (LC) by Functional MicroArray (FMA) painless intradermal delivery system.     

PEGylated PAMAM Dendrimer-Doxorubicin Conjugates: <Emphasis Type="BoldItalic">In Vitro</Emphasis> Evaluation and <Emphasis Type="BoldItalic">In Vivo</Emphasis> Tumor Accumulation

Purpose  

To investigate the effects of PEGylation degree and drug conjugation style on the in vitro and in vivo behavior of PEGylated polyamidoamine (PAMAM) dendrimers-based drug delivery system.