The response of prototype plane-parallel ionization chambers in small megavoltage x-ray fields

Accurate small-field dosimetry has become important with the use of multiple small fields in modern radiotherapy treatments such as IMRT and stereotactic radiosurgery. In this study, we investigate the response of a set of prototype plane-parallel ionization chambers, based upon the Exradin T11 chamber, with active volume diameters of 2, 4, 10, and 20 mm, exposed to 6 MV stereotactic radiotherapy x-ray fields. Our goal was to assess their usefulness for accurate small x-ray field dose measurements. The relative ionization response was measured in circular fields (0.5 to 4 cm diameter) as compared to a 10 x 10 cm2 reference field. A large discrepancy (approximately 40%) was found between the relative response in the smallest plane-parallel chamber and other small volume dosimeters (radiochromic film, micro-metal-oxide-semiconductor field-effect transistor and diode) used for comparison. Monte Carlo BEAMnrc simulations were used to simulate the experimental setup in order to investigate the cause of the under-response and to calculate appropriate correction factors that could be applied to experimental measurements. It was found that in small fields, the air cavity of these custom-made research chambers perturbed the secondary electron fluence profile significantly, resulting in decreased fluence within the active volume, which in turn produces a chamber under-response. It is demonstrated that a large correction to the p(fl) correction factor would be required to improve dosimetric accuracy in small fields, and that these factors could be derived using Monte Carlo simulations.     

Some unexpected behaviours of PTW/Nucletron well-type ionization chambers

Some unexpected behaviours of PTW/Nucletron well-type ionization chambers have been discovered. A significant undesired detection volume is present in the region surrounding the electrical terminals. A finite-element code has been used to compute electrical fields in this region, and it showed that the magnitude of the undesired volume was dependent on the electrical connector type. An experimental confirmation of this assumption has been obtained. A source activity dependence of the calibration coefficients has also been revealed. A set of recommendations for the optimal use of this detector is proposed.     

Polarity effect in plane-parallel ionization chambers using air or a dielectric liquid as ionization medium.

A plane-parallel ionization chamber having a sensitive volume of 2 mm3 and using the dielectric liquid tetramethylsilane as the sensitive medium instead of air is described. In the design of the chamber special attention was given to the factors that can cause unwanted currents in the cable, stem, or the chamber dielectric material. The chamber has been tested with respect to the polarity effect in regions of radiation fields where ordinary plane-parallel ionization chambers will often fail. These regions are the build-up region in photon fields, and the region close to the practical range for electrons where nonelectronic equilibrium is significant. Experimental results show that, despite the extremely small ionization volume in the liquid ionization chamber, the polarity effect never exceeds a few tenths of a percent in field positions where well-known commercially available chambers with much less spatial resolution designed for measurements in radiation therapy fields can show polarity effects of 5% to 30%. The origin of spurious currents and how they must be minimized in the design of either a liquid- or gas-filled ionization chamber is discussed.     

Polarity effect of plane-parallel ionization chambers in electron radiation

Although plane-parallel ionization chambers have been in use for some time, there is still much to be learned about their performance characteristics. This work is concerned with the polarity effect in electron beams about which there is little published data. The investigations involved several popular ionization chambers; the PTW Markus chamber, the NACP chamber and its Calcam version, the Vinten-631 chamber, and the NE 2571 (Farmer-type) thimble chamber. The chambers were irradiated in electron beams of nominal energies between 4 MeV and 18 MeV. It was found in this study that the NACP, Markus and Vinten chambers require a correction of the order of 0.2% in the energy range between 4.5 MeV and 18 MeV. The overall behaviour of the Calcam chamber was similar with the exception of energies below 4 MeV. The depth dependence of the polarity effect seemed closely related to the mean beam energy at the depth of measurement. There is some evidence that the effect is also dependent on the angular spread of the electron beam and its spectrum. The authors considered how best to quantify the polarity effect practically, and propose that it should be expressed as a correction factor to be applied to readings with one particular chamber bias.     

Dosimetry using plane-parallel ionization chambers in a 75 MeV clinical proton beam

Reference ionization chamber dosimetry in clinical proton beams is generally performed with cylindrical ionization chambers. However, when the measurement is performed in the presence of a large depth dose gradient or in a narrow spread out Bragg peak (SOBP), it could be advisable to use a plane-parallel chamber. Few recommendations and studies have been devoted to this subject. In this paper, experimental information on perturbation correction factors for four plane-parallel ionization chamber types in proton beams is presented. The experiments were performed in 75 MeV modulated and non-modulated proton beams. Monte Carlo calculations have been performed to support the conclusions of the experimental work. Overall, we were not able to find experimental evidence for significant differences between the secondary electron perturbation correction factors for plane-parallel chambers and those for a cylindrical NE2571. We found experimental ratios of perturbation correction factors that did not differ by more than 0.6% from unity for a Roos and two NACP02 chambers, and by not more than 1.2% for a Calcam-2 and two Markus chambers. Monte Carlo simulations result in corrections that are limited to 0.6% in absolute value, but given the overall uncertainties of the measurements, the deviations of the correction factors from unity could not be resolved from the experimental results. The results of the simulations thus support the experimental conclusion that perturbation correction factors for the set of plane-parallel chambers in both proton beams (relative to NE2571) do not deviate from unity by more than 1.2%. This confirms, within the experimental uncertainties, the assumption that the overall perturbation correction factor for a plane-parallel chamber in a low-energy proton beam is unity, made in IAEA TRS-398 and other dosimetry protocols. Given the large uncertainties of the gradient correction factors to be applied when using a cylindrical ionization chamber in a narrow SOBP or in the presence of a strong depth dose gradient, the level of agreement between plane-parallel and cylindrical ionization chambers observed in this study shows that plane-parallel chambers are a reliable alternative for reference dosimetry in low-energy proton beams.     

Measurement of dose in the buildup region using fixed-separation plane-parallel ionization chambers

Accurate measurement of dose at the surface of a phantom and in the buildup region is a difficult task but one that is important for the proper treatment of patients. The instruments of choice for these measurements are extrapolation chambers but few institutions have these instruments at their disposal. As a result, fixed-separation plane-parallel ionization chambers are most commonly used for this purpose. Recent papers have re-emphasized the inaccuracies in the measurement of dose in the buildup region of normally incident photon beams when using fixed-separation plane-parallel ionization chambers. Data for Co-60, 6-, 10-, 18-, and 24-MV photon beams are presented that show the magnitude of this over response in the buildup region for several commercially available plane-parallel ionization chambers versus results obtained using both an extrapolation chamber and LiF thermoluminescent detectors. Differences in the percent depth dose at the surface of a phantom of greater than 19% were found for one of the chambers. All chambers over responded in the buildup region to some degree based upon their internal dimensions. The appropriateness of published corrections for these chambers is evaluated and guidelines for the accurate measurement of dose in the buildup region are presented.     

An investigation of the response of a simple design of plane-parallel chamber

This paper reports the experimental investigation of a simple design of plane-parallel electron chamber, which has very thin layers of copper (0.018 or 0.035 mm) as conducting material. Measurements comparing the prototype chambers with other ionization chambers (PTW/Markus, NACP) have been carried out, both in a 60Co gamma-ray beam and in high-energy electron beams. The results show that the Ce factors (proportional to the product of water/air stopping-power ratio and perturbation factor) for converting the in-phantom air-kerma-calibrated chamber reading to the absorbed dose to water are nearly constant for incident electron energies between 4 and 11 MeV for prototype chambers with 0.018 mm thick copper layers and between 4 and 15 MeV for chambers with 0.035 mm thick copper layers. Other aspects concerning these prototype chambers, such as polarity effect, cable effect, collecting efficiency and angular response, have also been studied and the results are presented in this paper.     

On the calibration of plane-parallel ionization chambers for electron beam dosimetry.

The procedure recommended by different dosimetry protocols for the determination of the absorbed dose to air chamber factor, ND,pp, of plane-parallel chambers, comparing absorbed dose determinations in a high-energy electron beam with a reference cylindrical chamber having a known ND,cyl factor, has been investigated. Attention has been focused on the case that the chamber serving as reference has a solid aluminium central electrode. It has been found that using a wide spread Farmer-type chamber (NE 2571), together with recommendations which specifically take into account central electrode corrections for electron beam dosimetry, kcelpcel = pcel-global(IAEA) = 1.008, yields inconsistent results compared with those obtained from a fully homogeneous ionization chamber; for the NE 2571 chamber, a value kcelpcel = pcel-global(IAEA) congruent to 1.0 has been obtained. Analytical calculations of kmkatt for Farmer-type cylindrical chambers and experimental determinations of the product kmkattkcelpcel in electron beams agree within experimental uncertainties, with no evidence of statistical significance for the commonly used assumption pcel = 1, which yields a 0.8% correction (due to kcel only) for the effect of the NE 2571 aluminium electrode in electron beam dosimetry. The use of a 'NACP-chamber' specific factor (kpp or kmkatt) to obtain ND,pp from NK,pp in NACP plane-parallel chambers has been found unsatisfactory, and direct experimental determinations of ND,pp are recommended instead. It is suggested that Standard Dosimetry Laboratories provide ND,pp calibration factors in 60Co beams.     

Monte Carlo-based treatment planning for a spoiler system with experimental validation using plane-parallel ionization chambers

A beam spoiler is often used to increase the build-up dose near the surface for treatment of superficial treatment areas. Photon-beam spoilers produce a large amount of contaminant electrons, conditions for which standard, commercial treatment-planning system dose-calculation algorithms are inadequate for producing accurate dose calculations. In this study, we implemented a Monte Carlo (MC) dose-calculation algorithm for this spoiler system. With and without a spoiler of 1 cm Lucite, depth doses and transverse profiles in the build-up region were measured for field sizes of 5 x 5 cm2 and 10 x 10 cm2 at the spoiler-to-surface distances (STSDs) of 6, 10 and 15 cm. An Attix chamber and a Markus chamber were used for depth doses, whereas a diode detector was used for transverse profiles. An MC simulation using BEAM/DOSXYZ was used to compare the calculated and the measured data. The MC calculations agreed with the Attix chamber measurements within 2% for all STSDs and field sizes, whereas the Markus data--even with corrections made-showed a discrepancy of about 3.5% with a maximum difference of 7.3% for a field size of 10 x 10 cm2 at an STSD of 6 cm. The MC treatment-planning system was successfully applied to a head-and-neck case using 6 MV photon beams with a beam spoiler.     

Validation of a Monte Carlo model of a NACP-02 plane-parallel ionization chamber model using electron backscatter experiments

The accuracy of Monte Carlo (MC) simulation results relies on validating the MC models used in the calculations. In this work, a MC model for the NACP-02 plane-parallel ionization chamber was built and validated against megavoltage electron backscatter experiments using materials of water, graphite, aluminium and copper. Electron energies ranged between 6-18 MeV and the chamber's air cavity was at the depth of maximum dose, z(max). A chamber model based on manufacturer's specifications resulted in systematic discrepancies of several percents between measured and simulated backscatter factors. Tuning of the MC chamber model against backscatter factors to improve agreement increased the chamber's front window mass thickness by 35% over the reported value of 104 mg cm(-2) in the IAEA's TRS-398 absorbed dose protocol. The large increase in chamber window mass thickness was verified by measurements on a disassembled NACP-02 chamber. The new backscatter factor results based on the tuned MC NACP-02 chamber model matched the experimental results within 1-2 standard deviations. We conclude therefore that for MC simulations near z(max), tuning of the NACP-02 chamber model against experimental backscatter measurements is an acceptable method for validating the chamber model.     

Wall correction factors for calibration of plane-parallel ionization chambers with high-energy photon beams

Most dosimetry protocols recommend that calibration of plane-parallel ionization chambers be performed in an electron beam of sufficiently high energy by comparison with cylindrical chambers. For various plane-parallel chambers, the 1997 IAEA TRS-381 protocol includes an overall perturbation factor pQ for electron beams, a wall correction factor p(wall) for a 60Co beam and the product of two wall corrections k(att)k(m) for 60Co in-air calibration. The recommended values of p(wall) for plane-parallel chambers, however, are limited to certain phantom materials and a 60Co beam, and are not given for other phantom materials and x-ray beams. In this work, the p(wall) values of the commercially available NACP, PTW/Markus and PTW/Roos plane-parallel chambers in a solid water phantom have been determined with 60Co and 4 and 10 MV photon beams. The k(att)k(m) values for the NACP and PTW/Markus chambers have also been obtained. The wall correction factors p(wall) and k(att)k(m) have been determined by intercomparison with a calibrated Farmer chamber. The average value of p(wall) for these plane-parallel chambers was 1.005 +/- 0.1% (1 SD) for 60Co beams and 1.007 +/- 0.2% (1 SD) for both 4 MV and 10 MV photons. The k(att)k(m) values for the NACP and PTW/Markus chambers were about 1.5% lower than other published data.     

Monte Carlo calculations of correction factors for plane-parallel ionization chambers in clinical electron dosimetry

Recent standard dosimetry protocols recommend that plane-parallel ionization chambers be used in the measurements of depth-dose distributions or the calibration of low-energy electron beams with beam quality R50 <4 g/cm2. In electron dosimetry protocols with the plane-parallel chambers, the wall correction factor, Pwall, in water is assumed to be unity and the replacement correction factor, Prepl, is taken to be unity for well-guarded plane-parallel chambers, at all measurement depths. This study calculated Pwall and Prepl for NACP-02, Markus, and Roos plane-parallel chambers in clinical electron dosimetry using the EGSnrc Monte Carlo code system. The Pwall values for the plane-parallel chambers increased rapidly as a function of depth in water, especially at lower energy. The value around R50 for NACP-02 was about 10% greater than unity at 4 MeV. The effect was smaller for higher electron energies. Similarly, Prepl values with depth increased drastically at the region with the steep dose gradient for lower energy. For Markus Prepl departed more than 10% from unity close to R50 due to the narrow guard ring width. Prepl for NACP-02 and Roos was close to unity in the plateau region of depth-dose curves that includes a reference depth, dref. It was also found that the ratio of the dose to water and the dose to the sensitive volume in the air cavity for the plane-parallel chambers, Dw/[Dair]pp, at d(ref) differs significantly from that assumed by electron dosimetry protocols.     

Influence of type 2 diabetes on the inflammatory response in rats

OBJECTIVES AND DESIGN: To verify whether the inflammatory responses in animals with type 2 diabetes are altered to an extent similar to that in type 1 diabetes. MATERIALS: Male newborn (2 days old) Wistar rats were made diabetic by streptozotocin (160 mg/kg, i.p.) and used 8-10 weeks later (10 rats/group). METHODS: The inflammatory responses were evaluated using paw edema (induced by local injection of carrageenan or dextran), pleurisy (by pleural injection of carrageenan), increases in vascular permeability (induced by intradermal injection of histamine, serotonin and bradykinin) and leukocyte counts in peripheral blood and pleural exudate. RESULTS: Diabetic animals showed reduced inflammatory responses to carrageenan but not to dextran. The increase in vascular permeability induced by serotonin and bradykinin was reduced whereas that to histamine was not altered in diabetic compared to control rats. Although the pleural exudate was reduced, leukocyte counts were similar in diabetic and control rats. Insulin (2 IU, 4 h before), though effective in reducing blood sugar levels, did not restore the altered responses in diabetic rats. In contrast to that in rats with type 1 diabetes, in rats with type 2 diabetes, removal of the adrenal glands restored the reduced inflammatory responses. CONCLUSIONS: Insulin resistance in type 2 diabetic rats led to reduced inflammatory responses, which were partially corrected by adrenalectomy.     

The effect of wall thickness on the response of a spherical ionization chamber

Air-filled ionization chambers are used widely for radiation dosimetry. For some applications it is important to know the effect on the chamber response of photon attenuation and scattering in the chamber walls. Traditionally, the wall effect is determined by measuring the chamber response as a function of wall thickness and extrapolating linearly to zero thickness. We have constructed a spherical graphite chamber with variable wall thickness. The change in the chamber response with wall thickness has been measured in a 137Cs gamma-ray beam. Our data show that the change in response is not linear with wall thickness, in agreement with the theoretical prediction of Bielajew (1990 Med. Phys. 17 583-7). A linear versus non-linear extrapolation of the measured data to zero wall thickness leads to a difference of almost 1% in the estimate of the wall correction factor, Kw. The value of Kw obtained using the non-linear extrapolation is in good agreement with the result obtained using Monte Carlo techniques.     

Influence of phantom material and phantom size on radiographic film response in therapy photon beams

The energy dependence of radiographic film can introduce dosimetric errors when evaluating photon beams. The variation of the film response, which is attributed to the changing photon spectrum with depth and field size, has been the subject of numerous publications in recent years. However, these data show large unexplained differences in the magnitude of this variation among independent studies. To try to resolve this inconsistency, this study assesses the dependence of radiographic film response on phantom material and phantom size using film measurements and Monte Carlo calculations. The relative dose measured with film exposed to 6 MV x rays in various phantoms (polystyrene, acrylic, Solid Water, and water; the lateral phantom dimensions vary from 25 to 50 cm square; backscatter thickness varies from 10 to 30 cm) is compared with ion chamber measurements in water. Ranges of field size (5 x 5 to 40 x 40 cm2) and depth (dmax to 20 cm) are studied. For similar phantom and beam configurations, Monte Carlo techniques generate photon fluence spectra from which the relative film response is known from an earlier study. Results from film response measurements agree with those derived from Monte Carlo calculations within 3%. For small fields (< or = 10 x 10 cm2) and shallow depths (< or = 10 cm) the film response variation is small, less than 4%, for all phantoms. However, for larger field sizes and depths, the phantom material and phantom size have a greater influence on the magnitude of the film response. The variation of film response, over the ranges of field sizes and depths studied, is 50% in polystyrene compared with 30% in water. Film responses in Solid Water and water phantoms are similar; acrylic is between water and polystyrene. In polystyrene the variation of film response for a 50 cm square phantom is nearly twice that observed in a 25 cm square phantom. This study shows that differences in the configuration of the phantoms used for film dosimetry can explain much of the inconsistency for film response reported in the literature.     

Receptive field size and response latency are correlated within the cat visual thalamus

Each point in visual space is encoded at the level of the thalamus by a group of neighboring cells with overlapping receptive fields. Here we show that the receptive fields of these cells differ in size and response latency but not at random. We have found that in the cat lateral geniculate nucleus (LGN) the receptive field size and response latency of neighboring neurons are significantly correlated: the larger the receptive field, the faster the response to visual stimuli. This correlation is widespread in LGN. It is found in groups of cells belonging to the same type (e.g., Y cells), and of different types (i.e., X and Y), within a specific layer or across different layers. These results indicate that the inputs from the multiple geniculate afferents that converge onto a cortical cell (approximately 30) are likely to arrive in a sequence determined by the receptive field size of the geniculate afferents. Recent studies have shown that the peak of the spatial frequency tuning of a cortical cell shifts toward higher frequencies as the response progresses in time. Our results are consistent with the idea that these shifts in spatial frequency tuning arise from differences in the response time course of the thalamic inputs.     

Influence of prevaccination immunity on the human B-lymphocyte response to a Haemophilus influenzae type b conjugate vaccine.

The purpose of this study was to investigate whether preexisting immunity to components of a polysaccharide-protein conjugate influences the B-lymphocyte response to vaccination with the conjugate. Thirty-two healthy adults were vaccinated once or twice with a conjugate (PRP-D) consisting of Haemophilus influenzae type b capsular polysaccharide (PRP) and diphtheria toxoid (DT), and the response was related to the prevaccination levels of PRP and DT antibodies. Positive correlations were found between increases in plasma PRP (median, 32.0 micrograms/ml) and DT (1.14 IU/ml) antibodies and numbers of circulating PRP and DT antibody-secreting cells (AbSC) (postvaccination days 6 to 9). The B-cell responses (antibody response and AbSC) to both PRP and DT correlated positively with prevaccination levels of anti-DT. DT AbSC appeared earlier (peak, day 7) than PRP AbSC (peak, day 8). Individuals whose PRP AbSC peaked early (day 7) had higher prevaccination anti-DT levels than those who peaked later (P less than 0.05). In contrast, the prevaccination levels of anti-PRP did not correlate significantly with the magnitude of the antibody or AbSC response and did not affect the kinetics of the AbSC. Following revaccination with PRP-D, small increases in the level of PRP antibodies (median, 2.9 micrograms/ml; n = 11) were found; no significant increase in the level of DT antibodies was seen. The numbers of PRP AbSC were lower (P = 0.04) and peaked earlier (day 7) than after the first vaccination. The isotype pattern of PRP AbSC, which was dominated by immunoglobulin A (IgA) after the first vaccination, now showed a more equal distribution between IgG and IgA AbSC. It is concluded that after immunization with PRP-D both the magnitude and the kinetics of the antipolysaccharide B-cell response are influenced by prevaccination immunity to the carrier molecule.     

Effect of a modulated electromagnetic field on self-stimulation response in rats

The effect of an electromagnetic field (EMF) with different frequencies of modulation (2, 7, and 50 Hz) on the self-stimulation response was studied in rats. Exposure to an EMF of 2 Hz caused a primary increase in frequency of the self-stimulation response, followed by depression. Exposure to an EMF of 7 Hz initially did not change the intensity of self-stimulation, but later led to a gradual decrease in its frequency. EMF with modulation of 50 Hz suppressed the self-stimulation response virtually immediately. The changes observed in the self-stimulation response were independent of the location of the stimulating electrodes and were determined by the frequency of modulation of the EMF.P. K. Anokhin Institute of Normal Physiology, Academy of Medical Sciences of the USSR, Moscow. (Presented by Academician of the Academy of Medical Sciences of the USSR N. A. Fedorov.) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 82, No. 10, pp. 1163–1165, October, 1976.