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Uzcudun AE Retolaza IR Fernández PB Sánchez Hernández JJ Grande AG García AG Olivar LM De Diego Sastre I Barón MG Bouzas JG 《Head & neck》2002,24(9):830-840
BACKGROUND: Oropharyngeal and hypopharyngeal cancer is increasing all over the world, frequently affecting more and more women and younger individuals and not only the typical 50- to 60-year-old heavy smoker and drinking man. In addition, 5-year overall survival rate remains poor (30% to 40% in most series), despite advances in treatment. Therefore, it is crucial to understand as accurately as possible the risk factors for these malignancies to improve primary prevention. METHODS: We report the results from a case-control study of pharyngeal cancer risk factors conducted in Spain involving 232 consecutive patients who were gender- and age-matched with 232 controls. Data were collected by interviewer-administered personal interview. RESULTS: Our results show that low intake of fruit, fruit juice, uncooked vegetables, dietary fiber-containing foods (legume and cereals), fish, milk, and dairy products is an independent risk factor for pharyngeal cancer and that high consumption of meat and fried foods also increases the risk once data are adjusted for tobacco smoking and alcohol drinking. CONCLUSIONS: Although findings for fruit, juice, and uncooked vegetables are in accordance with those from other authors and can be explained on a biologic basis, the relationship between pharyngeal cancer and dietary excess of saturated fatty acids needs experimental investigation. Findings for milk, dairy products, and fish also warrant more detailed epidemiologic research because of conflicting data reported in the literature and because of the reportedly ambiguous role of retinol in human cancers. No conclusive explanations for the protective effect of dietary fiber-containing foods can be put forward today. Our results are uniquely attributable to oropharyngeal and hypopharyngeal cancers because of the small size of our nasopharyngeal cancer subsample. 相似文献
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Incidence and survival trends of lip,intra-oral cavity and tongue base cancers in south-east England
O Olaleye U Ekrikpo O Lyne J Wiseberg 《Annals of the Royal College of Surgeons of England》2015,97(3):229-234
Background
Oral cavity cancers are on the increase in the UK. Understanding site-specific epidemiological trends is important for cancer control measures.This study demonstrates the changing epidemiological trends in lip, intra-oral cavity and tongue base cancers in south-east England from 1987 to 2006.Aim: Methods
This was a retrospective study using anonymised data obtained from the Thames Cancer Registry (TCR) London. Data were analysed using SPSS v.17 and survival analyses with Kaplan-Meier and Cox regression. Age standardisation of the incidence rates was performed. It was conducted in south-east England, which has an average population of 12 million. The study analysed 9,318 cases (ICD-10 code C00–C06, C14). Kent Research Ethics Committee UK granted ethical approval.Results
Oral cancers were more common in men, with male: female ratio of 1.6:1. Tongue cancers had the highest frequency at 3,088 (33.1%).Incidence varied with each cancer type. Mean incidence (per 1,000,000) ranged from 2.3 (lip cancer) to 13.8 (tongue cancer). There has been a statistically significant increase in incidence for cancers of the tongue base, other parts of tongue, gum and palate (p<0.001).Median survival time varied by sub-site, with lip cancer having the best median survival time (11.09 years) compared with tongue base cancer (2.42 years). Survival analyses showed worse prognosis for men, older age at diagnosis, and presence of synchronous tumours (p<0.001).Conclusion
There is a rising incidence of tongue and tongue base, gum and palate cancers in south-east England with wide variability in survival. Oral cancer awareness and screening programmes should be encouraged. 相似文献5.
The history of urologic lymphadenectomy is rich and diverse. Our current understanding of its use and benefits is a product of the hard work of numerous physicians and scientists from many nations. Standard dissection templates for the various urologic malignancies are based on a complete understanding of the anatomy of the lymphatic system, which has developed immensely since Hippocrates first described the white blood of the lymphatic system while performing an axillary dissection. It is hoped that the next 100 years will bring even greater comprehension of its value and utility. 相似文献
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BackgroundDetected by screening mammography, bilateral breast cancer has a different pathological profile compared to unilateral breast cancer. We investigated the incidence of bilateral interval breast cancers and compared their characteristics with those of unilateral interval breast cancers.MethodsWe included all 468,720 screening mammograms of women who underwent biennial screening mammography in the South of the Netherlands between January 2005 and January 2015. We collected breast imaging reports, biopsy results and surgical reports of all referred women and of all women who presented with interval breast cancer. The tumour with the highest tumour stage (index cancer) was used for comparison with unilateral interval cancers.ResultsA total of 753 interval cancers were detected, of which 24 (3.2%) were bilateral. Among the invasive interval cancers, bilateral cancers more frequently showed a lobular histology than unilateral cancers (37.5% (9/24) vs. 16.1% (111/691), P = .01). There is a trend towards a larger proportion of bilateral than unilateral interval cancers graded 1 (45.8% (11/24) vs. 27.8% (192/691), P = .08). There were no other statistically significant differences in tumour characteristics. Also, the proportion of interval cancers showing significant mammographic abnormalities at the latest screen was comparable for unilateral and bilateral interval cancers (23.0% vs. 25.0%, P = .9).DiscussionBilateral interval cancers comprise a small proportion of all interval cancers. Except of a higher proportion of invasive lobular cancers and a more favourable histological grade of invasive cancers, tumour characteristics are comparable for bilateral and unilateral interval breast cancers. 相似文献
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Hongbo Wei Jiafeng Fang Tufeng Chen Zongheng Zheng Bo Wei Yong Huang Jianglong Huang Haozhong Xu 《JSLS, Journal of the Society of Laparoendoscopic Surgeons》2014,18(2):323-332
Laparoscopy-assisted surgery for either rectal or gastric cancer has been increasingly performed. However, simultaneous laparoscopy-assisted resection for synchronous rectal and gastric cancer is rarely reported in the literature. In our study, 3 cases of patients who received simultaneous laparoscopy-assisted resection for synchronous rectal and gastric cancer were recorded. The results showed that all 3 patients recovered well, with only 253 minutes of mean operation time, 57 mL of intraoperative blood loss, 5 cm of assisted operation incision, 4 days to resume oral intake, 12 days'' postoperative hospital stay, and no complication or mortality. No recurrence or metastasis was found within the follow-up period of 22 months. When performed by surgeons with plentiful experience in laparoscopic technology, simultaneous laparoscopy-assisted resection for synchronous rectal and gastric cancer is safe and feasible, with the benefits of minimal trauma, fast recovery, and better cosmetic results, compared with open surgery. 相似文献
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目的 探讨结肠癌肝转移的外科治疗方法及其病理因素对预后的影响。方法 本组79例结肠癌肝转移患者中共有 2 5例接受原发灶根治术以及肝转移灶切除术或射频消融术。其中 14例进行了原发灶根治术及肝脏转移灶切除术 ,11例进行了肝脏转移灶射频消融术。结果 本组结肠癌肝转移患者术后 1年、3年生存率分别为 84 %、4 8%。分化程度高以及单个转移灶的患者预后较好。肝脏肿瘤切除与肝脏肿瘤射频消融术后患者生存时间无明显差异。结论 结肠癌肝转移患者原发肿瘤的分化程度、肝脏转移灶的数量对预测患者的预后有一定的作用。手术切除及射频消融术对治疗结肠癌肝转移能够达到较为接近的治疗效果。 相似文献
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Fujii T Kaneko T Sugimoto H Okochi O Inoue S Takeda S Nagasaka T Nakao A 《Journal of Hepato-Biliary-Pancreatic Surgery》2004,11(4):280-285
We report a rare case of metachronous double cancer of the biliary tract. At age 59 years, a man had undergone a cholecystectomy and resection of the liver bed for gallbladder cancer pathologically diagnosed as papillary adenocarcinoma, in 1997. Four years later, he was admitted to our hospital with jaundice. At first, we suspected lymph node metastasis of the gallbladder cancer along the common bile duct. But abdominal computed tomography demonstrated circular wall thickness of the common bile duct, so primary bile duct cancer was strongly suspected. Thus, extended right hepatectomy and pancreaticoduodenectomy were performed after right portal vein embolization. The pathological diagnosis of the resected specimen was well-differentiated tubular adenocarcinoma, and this case was clarified to be metachronous double cancer. A review of the literature regarding double cancer of the biliary tract is presented following this case report. We showed that half of 30 cases of double cancer of the biliary tract were not associated with pancreaticobiliary maljunction, including all 6 metachronous cases. 相似文献
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Masakuni Noguchi Shigehiro Tanaka Takayoshi Akiyama Itsuo Miyazaki Takatoshi Michigishi Norihisa Tonami Kin-ichi Hisada Shintaroh Terahata Fujitsugu Matsubara 《Surgery today》1984,14(2):110-117
Clinicopathological studies were carried out on 27 patients with minimal thyroid cancer and 56 with ordinary thyroid cancer
at Kanazawa University, from April, 1979 to December, 1982. There was a significant difference in the rate of preoperative
diagnosis between the minimal and the ordinary cancer groups. Subtotal thyroidectomy with modified neck dissection was usually
performed in both groups. The histological types in minimal cancer group included 16 papillary carcinomas, 7 nonencapsulated
sclerosing carcinomas, one follicular carcinoma, one anaplastic carcinoma with squamous cell metaplasia and two multiple mixed
carcinomas. There was no significant difference in the rates of intrathyroidal and lymph node metastases between the two groups.
While the metastatic lesions of sclerosing carcinoma were localized to the central cervical lymph nodes, the ordinary cancer
in general and the papillary variant of minimal cancer metastasized not only to the central cervical lymph nodes but also
to the ipsilateral and even to the contralateral jugular lymph nodes. 相似文献
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Eriguchi N Aoyagi S Hara M Okuda K Tamae T Fukuda S Hashino K Sato S Fujiki K Furukawa S Jimi A 《Surgery today》2000,30(8):718-721
Pancreatic carcinoma carries a poor prognosis, especially invasive ductal carcinoma of the pancreas. This retrospective study
describes the results of the treatment and prognosis for double cancers in which cancer of the pancreas was associated with
malignancies in other organs in 12 patients who were diagnosed and treated at Kurume University Hospital. The patients included
4 women and 8 men, with an average age of 67 years. Of the 12 tumors, 7 were metachronous pancreatic cancers which occurred
after resections of other organ malignancies. Five patients had synchronous double cancers, one of whom was diagnosed to have
gastric cancer on admission. Two other patients of this group were diagnosed to have lung cancer, while the remaining 2 patients
suffered from colon cancer. By the time pancreatic cancer was diagnosed, gastrectomies had been performed in 7 patients for
either gastric cancer or ulcers. In addition, one patient underwent a hysterectomy for uterine carcinoma and another received
a low anterior resection for rectal carcinoma. Four of 5 patients in the synchronous group had nonresectable tumors and a
palliative bypass operation was performed in 2 of these patients. Six patients who had metachronous double cancers died because
of pancreatic cancer recurrence or metastases. We conclude that the prognosis of double cancers, where cancer of the pancreas
is associated with other organ malignancies, primarily depends on the prognosis of the pancreatic carcinoma, and the present
study suggests the necessity of long-term follow-up examinations for gastrectomy patients in order to make an early diagnosis
of pancreatic cancer.
Received: September 24, 1999 / Accepted: March 24, 2000 相似文献
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Metachronous Triple Cancers of the Sigmoid Colon, Stomach, and Esophagus: Report of a Case 总被引:1,自引:0,他引:1
Iioka Y Tsuchida A Okubo K Ogiso M Ichimiya H Saito K Osaka Y Sato S Aoki T Koyanagi Y 《Surgery today》2000,30(4):368-371
(Received for publication on Feb. 10, 1999; accepted on Nov. 11, 1999) 相似文献
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Laparoscopic surgery has gained wide acceptance for its use in benign gastrointestinal cancer in the past 20 years, while its use in malignant gastrointestinal cancer has been highly controversial until the recent 3-5 years. Several prospective randomized clinical trials have suggested that the long-term outcome of laparoscopic surgery for colon cancer is the same as or better than that of open surgery. As for rectal cancer, whether the principles of total mesorectal excision can be well followed in laparoscopic surgery remains. Most recently, the trial of large number of patients doesn't show any differences upon local recurrence and 3-year survival rate between rectal cancer patients in laparoscopic group and open group. Laparoscopic surgery has been widely accepted as a standard treatment regimen for early gastric cancer in many specialized centers. Meanwhile, the feasibility and effectiveness of laparoscopic D2 lymphadenectomy for gastric cancer has been proved by several scholars. The use of laparoscopic surgery for advanced gastric cancer especially for T3 gastric cancer still remains controversial. The early concern that laparoscopic surgery for malignant cancer might increase tumor dissemination is not confirmed. The system of technical training and occupational qualification, proper selection of patients and adherence to all the principles of cancer clearance will ensure a good result of laparoscopic surgery for malignant gastrointestinal cancer. 相似文献
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Center MM Jemal A Lortet-Tieulent J Ward E Ferlay J Brawley O Bray F 《European urology》2012,61(6):1079-1092
Context
Wide variation exists internationally for prostate cancer (PCa) rates due to differences in detection practices, treatment, and lifestyle and genetic factors.Objective
We present contemporary variations in PCa incidence and mortality patterns across five continents using the most recent data from the International Agency for Research on Cancer.Evidence acquisition
PCa incidence and mortality estimates for 2008 from GLOBOCAN are presented. We also examine recent trends in PCa incidence rates for 40 countries and mortality rates for 53 countries from 1985 and onward via join-point analyses using an augmented version of Cancer Incidence in Five Continents and the World Health Organization mortality database.Evidence synthesis
Estimated PCa incidence rates remain most elevated in the highest resource counties worldwide including North America, Oceania, and western and northern Europe. Mortality rates tend to be higher in less developed regions of the world including parts of South America, the Caribbean, and sub-Saharan Africa. Increasing PCa incidence rates during the most recent decade were observed in 32 of the 40 countries examined, whereas trends tended to stabilize in 8 countries. In contrast, PCa mortality rates decreased in 27 of the 53 countries under study, whereas rates increased in 16 and remained stable in 10 countries.Conclusions
PCa incidence rates increased in nearly all countries considered in this analysis except in a few high-income countries. In contrast, the increase in PCa mortality rates mainly occurred in lower resource settings, with declines largely confined to high-resource countries. 相似文献15.
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《European urology》2019,75(4):637-646
ContextThe recent discovery of the existence of a human genitourinary microbiome has led to the investigation of its role in mediating the pathogenesis of genitourinary malignancies, including bladder, kidney, and prostate cancers. Furthermore, although it is largely recognized that members of the gastrointestinal microbiota are actively involved in drug metabolism, new studies demonstrate additional roles and the potential necessity of the gastrointestinal microbiota in dictating cancer treatment response.ObjectiveTo summarize the current evidence of a mechanistic role for the genitourinary and gastrointestinal microbiome in genitourinary cancer initiation and treatment response.Evidence acquisitionWe conducted a literature search up to October 2018. Search terms included microbiome, microbiota, urinary microbiome, bladder cancer, urothelial carcinoma, renal cell carcinoma, kidney cancer, testicular cancer, and prostate cancer.Evidence synthesisThere is preliminary evidence to implicate the members of the genitourinary microbiota as causative factors or cofactors in genitourinary malignancy. Likewise, the current evidence for gastrointestinal microbes in dictating cancer treatment response is mainly correlative; however, we provide examples where therapeutic agents used for the treatment of genitourinary cancers are affected by the human-associated microbiota, or vice versa. Clinical trials, such as fecal microbiota transplant to increase the efficacy of immunotherapy, are currently underway.ConclusionsThe role of the microbiome in genitourinary cancer is an emerging field that merits further studies. Translating microbiome research into clinical action will require incorporation of microbiome surveillance into ongoing and future clinical trials as well as expansion of studies to include metagenomic sequencing and metabolomics.Patient summaryThis review covers recent evidence that microbial populations that reside in the genitourinary tract—and were previously not known to exist—may influence the development of genitourinary malignancies including bladder, kidney, and prostate cancers. Furthermore, microbial populations that exist at sites outside of the genitourinary tract, such as those that reside in our gut, may influence cancer development and/or treatment response. 相似文献
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Challenges in Interpreting Germline Mutations in BARD1 and ATM in Breast and Ovarian Cancer Patients 下载免费PDF全文
Kimberly DeLeonardis MS Kristin Sedgwick MS Olga Voznesensky MS Ellen Matloff MS Erin Hofstatter MD Steven Balk MD PhD Nadine Tung MD 《The breast journal》2017,23(4):461-464
Next‐generation sequencing promotes identification of mutations in non‐BRCA1/2 genes in hereditary cancer families. The contribution of mutations in moderate penetrance genes to hereditary cancer risk is not well established. Here, we report a family with early onset breast and fallopian tube cancer that was identified as carrying germline mutations in BARD1 and ATM genes. Loss of heterozygosity studies suggest a causative role of the BARD1 mutation in the development of primary peritoneal cancer, but fail to confirm an association between germline ATM mutations and breast cancer development in this family. Complexities in interpreting implications of mutations in moderate‐risk cancer susceptibility genes are discussed. 相似文献
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