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Step‐by‐step StentBoost‐guided small vessel stenting using the self‐expandable sparrow stent‐in‐wire
Pierfrancesco Agostoni MD Stefan Verheye MD PhD 《Catheterization and cardiovascular interventions》2009,73(1):78-83
A 56 year‐old woman underwent percutaneous coronary intervention for a lesion in a small mid‐left anterior descending coronary artery (reference vessel diameter by quantitative coronary angiography: 2.11 mm) with a novel drug‐eluting stent specifically designed for small vessels, the CardioMind Sparrow stent delivery system. This is a self‐expandable sirolimus‐eluting nitinol stent directly mounted into a 0.014‐inch coronary guidewire. The stent has a very thin strut thickness (67 micron), limiting its radiopacity. A specific X‐ray stent‐enhancing visualization technique, “StentBoost”, allowed clear visualization and understanding of the steps needed for an appropriate release and deployment of the aforementioned stent. © 2008 Wiley‐Liss, Inc. 相似文献
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Sida Niu Feng Li Dun‐Xian Tan Lirong Zhang Jeffrey R. Idle Frank J. Gonzalez Xiaochao Ma 《Journal of pineal research》2010,49(2):106-114
Abstract: The interactions of melatonin, a potent endogenous antioxidant, with reactive oxygen species generate several products that include N1‐acetyl‐N2‐formyl‐5‐methoxykynuramine (AFMK) and N1‐acetyl‐5‐methoxy‐kynuramine (AMK). The physiological or pathological significance of AFMK/AMK formation during the process of melatonin metabolism in mammals has not been clarified. Using a metabolomic approach in the current study, the AFMK/AMK pathway was thoroughly investigated both in mice and humans. Unexpectedly, AFMK and AMK were not identified in the urine of humans nor in the urine, feces or tissues (including liver, brain, and eyes) in mice under the current experimental conditions. Metabolomic analysis did identify novel metabolites of AMK, i.e. hydroxy‐AMK and glucuronide‐conjugated hydroxy‐AMK. These two newly identified metabolites were, however, not found in the urine of humans. In addition, oxidative stress induced by acetaminophen in the mouse model did not boost AFMK/AMK formation. These data suggest that AFMK/AMK formation is not a significant pathway of melatonin disposition in mice, even under conditions of oxidative stress. 相似文献
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Doxorubicin is a common chemotherapeutic anticancer drug. Its use is associated with adverse effects including cardiotoxicity. Several therapeutics interventions have been attempted to reduce the toxicity and to improve the efficacy of the drug. However, on phytochemicals very few investigations have been made. In the present study we have evaluated the potential of a cardenolide, periplogenin, isolated from the leaves of Aegle marmelos in protecting the doxorubicin induced cardiotoxicity and lipid peroxidation (LPO) in rats. Doxorubicin induced cardiac and hepatotoxicity were characterized by marked biochemical changes including an increase in serum creatine kinase–MB (CK–MB), glutamate‐pyruvate transaminase (SGPT), and tissue LPO, with a decrease in superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). It also increased the levels of different serum lipids, but decreased the amount of high‐density lipoprotein (HDL). Cotherapy of the test cardenolide and doxorubicin for 4 weeks reversed all these adverse effects. However, out of three different concentrations (12.5, 25, and 50 mg/kg p.o.) of the test periplogenin, 25 mg/kg appeared to be most effective. When its efficacy was compared with that of vitamin E (α‐tocopherol) the isolated compound exhibited a better therapeutic potential. The isolated periplogenin from the leaves of A. marmelos could potentially inhibit doxorubicin‐induced cardiovascular problems in rats. However, its moderate dose was found to be most effective. 相似文献
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Hochang B. Lee MD 《Journal of the American Geriatrics Society》2013,61(10):1810-1811
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Safety and efficacy profile of bioresorbable‐polylactide‐polymer‐biolimus‐A9‐eluting stents versus durable‐polymer‐everolimus‐ and zotarolimus‐eluting stents in patients with acute coronary syndrome
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Milosz Jaguszewski MD PhD Manuela Dörig Antonio H. Frangieh MD Jelena‐Rima Ghadri MD Victoria Lucia Cammann Johanna Diekmann L. Christian Napp MD Fabrizio D'Ascenzo MD Yoichi Imori MD Slayman Obeid MD Willibald Maier MD Thomas F. Lüscher MD Christian Templin MD PhD 《Catheterization and cardiovascular interventions》2016,88(6):E173-E182
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Joanna Ghobrial Brian Reemtsen Daniel S. Levi Jamil Aboulhosn 《Catheterization and cardiovascular interventions》2019,93(6):1165-1169
Transcatheter valve replacement offers a safe and effective alternative to traditional surgical techniques in patients with congenital heart disease, especially those at high surgical risk. The most common causes of morbidity and mortality in patients with D‐transposition of the great arteries status post Senning or Mustard repair is severe tricuspid valve (TV) regurgitation. Replacement of the systemic TV may be useful in those without severe systemic ventricular dysfunction. We present a case of a patient with D‐loop transposition of the great arteries status post Mustard repair and TV ring placement with subsequent severe systemic TV regurgitation, at high surgical risk, who underwent a transcatheter valve replacement via a trans‐apical approach using an Edwards Sapien XT valve. 相似文献
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Jennifer E. Vaughn Ted Gooley Richard T. Maziarz Michael A. Pulsipher Smita Bhatia David G. Maloney Brenda M. Sandmaier Mary E. Flowers Rainer Storb Mohamed L. Sorror 《British journal of haematology》2015,171(3):411-416
The Haematopoietic Cell Transplantation‐Comorbidity Index (HCT‐CI) was designed as a predictor of non‐relapse mortality after HCT. Chronic graft‐versus‐host disease (GVHD) contributes to mortality after HCT. Here, we investigated whether the HCT‐CI could predict development of chronic GVHD or post‐chronic GVHD mortality. We retrospectively analysed data from 2909 patients treated with allogeneic HCT for malignant and non‐malignant haematological conditions at four institutions. In Cox regression models adjusted for potential confounders, increasing HCT‐CI was not statistically significantly associated with the development of chronic GVHD [hazard ratio (HR) = 1·02, P = 0·34]. Yet, the index was associated with an increased risk of non‐relapse mortality (HR = 1·29, P < 0·0001) as well as overall mortality (HR = 1·25, P < 0·001) following the development of chronic GVHD. The association between HCT‐CI and post‐chronic GVHD mortality was similar regardless of donor type or stem cell source. HCT‐CI scores could be incorporated in the design of clinical trials for treatment of chronic GVHD. 相似文献