溃疡性结肠炎活动期肠系膜血管数字减影血管造影研究北大核心CSCD

目的研究溃疡性结肠炎患者肠系膜血管数字减影血管造影(DSA)的表现。方法 2012年4月—11月对52例溃疡性结肠炎活动期患者,在行经肠系膜动脉药物灌注治疗前先行肠系膜上、下动脉造影,了解患者肠系膜动脉的血管特点,尤其是病变区域的血管变化。按不同肠段对血管造影诊断灵敏度和特异度进行评价。结果造影显示,52例患者均出现血管异常变化,主要表现为肠系膜动脉增粗47例(90.4%),毛细血管像出现肠壁浓染51例(98.1%),静脉像可见静脉回流浓集49例(94.2%),直动脉迂曲紊乱50例(96.2%),以及边缘动脉迂曲8例(15.4%)。血管造影对活动期溃疡性结肠炎灵敏度较高,而特异度相对较低。结论溃疡性结肠炎患者的病变区域血管会发生异常变化,DSA可较为敏感的发现这些变化,从而为诊断治疗提供参考。     

急性非闭塞性肠系膜血管缺血的诊断和介入治疗

目的探讨选择性肠系膜上动脉造影,经肠系膜上动脉持续灌注罂粟碱在诊断和治疗急性非闭塞性肠系膜血管缺血(NOMI)的价值。方法回顾分析从1999年8月到2005年3月经选择性肠系膜上动脉造影确诊,并行介入诊疗的18例NOMI。明确NOMI诊断后即行经导管肠系膜上动脉灌注罂粟碱治疗。结果本组18例NOMI中15例患者治愈;3例有效,介入治疗后腹痛减轻,但仍有局限性的腹膜刺激征,转外科行肠切除治愈;1例10d后死于严重肺部感染导致的呼吸衰竭。结论选择性肠系膜上动脉造影持续经导管肠系膜上动脉灌注罂粟碱是NOMI有效的诊断和治疗方法。     

症状性内脏动脉夹层影像学诊断和介入治疗

目的：总结症状性内脏动脉夹层(SAD)影像学诊断和介入治疗经验。方法回顾中国医科大学附属第一医院2006年6月至2014年3月收治的21例症状性SAD患者的诊断和治疗方法,并结合相关文献进行分析。结果腹部增强CT和CTA检查显示15例为肠系膜上动脉夹层,5例腹腔干动脉夹层,1例脾动脉夹层。5例保守治疗患者中1例并发肝动脉血栓形成。16例血管腔内支架植入术(ESP)治疗患者中2例行ESP联合肠切除术,2例行置管溶栓联合ESP治疗;围手术期均未发生严重并发症。全部患者随访2~74个月,平均19.1个月。 ESP治疗患者腹部疼痛及血便症状明显缓解或消失,无腹痛复发;CTA显示支架内血流通畅,位置良好,无管腔狭窄及血栓形成。1例肠系膜上动脉夹层患者术后3个月因脑卒中死亡。结论症状性SAD应早期诊断、早期治疗。CTA检查能确诊大多数病变,但要注意不典型表现;ESP术是一种微创、安全有效的治疗方法。     

介入性动脉灌注治疗胃癌术后癌性肠梗阻

目的 探讨胃癌术后腹腔转移癌性肠梗阻介入性动脉灌注化疗的疗效.方法 47例胃癌术后癌性不完全肠梗阻患者,经右侧股动脉插入血管鞘和导管、导丝,分别将导管插入腹腔动脉、肠系膜上动脉、肠系膜下动脉和双侧髂内动脉注入化疗药物,采用药物为DDP 60 mg,羟基喜树碱15 mg,5-Fu 1.0 g,化疗周期为每月动脉灌注介入化疗1次.本组病例至少灌注1次,最多13次.结果 灌注介入化疗后有效率18/47(38%),介入化疗后生存时间35 d～13个月,平均生存时间4.7个月.结论 介入灌注化疗能在短期内明显缓解癌性肠梗阻症状,延长生存时间.     

股骨头缺血坏死中西药联合溶栓的介入治疗

目的:应用导管经旋股内、外侧动脉,闭孔动脉灌注治疗股骨头坏死的临床研究。方法:采用seldinger’s穿刺超选择灌注溶通术,对66例股骨头坏死患者经旋股内、外侧动脉,闭孔动脉灌注溶通药物。结果:介入治疗后66例患者临床症状明显改善,髋关节疼痛、功能障碍等得到缓解或消失。治疗后X线片示坏死骨质均有不同程度吸收,新骨形成及修复。结论:介入插管中西药物联合灌注治疗股骨头缺血坏死具有较好的临床应用价值。     

中西结合治疗溃疡性结肠炎临床分析

目的：探讨溃疡性结肠炎的临床特点及治疗方法。方法：回顾分析本院2000-03～2009-11收治的36例溃疡性结肠炎患者的临床资料。结果：溃疡性结肠炎以腹痛、腹泻、粘液血便为主要临床症状。治疗以内科中西结合治疗为主,辅以外科手术。结论：掌握溃疡性结肠炎分期,分级,分段治疗的原则加中药保留灌肠,明显提高了治疗效果,降低了复发率。     

经皮腔内球囊扩张联合动脉内灌注药物治疗慢性下肢缺血

目的临床观察球囊扩张联合动脉内灌注药物治疗慢性下肢缺血的近期疗效。方法慢性下肢缺血患者21例,采用经股或腋动脉入路,先用球囊扩张闭塞段血管,然后经导管向动脉内灌注尿激酶、前列腺素E1、银杏叶注射液。胫腓动脉闭塞的部分患者保留血管鞘,经鞘灌注上述药物,每日1次,共5～7 d。术后观察患肢缺血症状、皮肤溃疡和趾端坏疽的改善情况。结果21例中20例成功实现经皮经腔球囊扩张和动脉内灌注药物治疗,技术成功率95.2%。无严重并发症。其中5例患者术后保留血管鞘,灌注药物5～7 d后复查造影,显示经球囊扩张后血管腔保持通畅。术后20例患者均出现诸如患肢皮温升高、间歇性跛行消失、静息痛减轻或消失等临床症状改善情况;随访2～7个月,4例皮肤溃疡愈合,2例坏死足趾脱落,创面愈合,已坏疽的足趾均变干燥,坏死范围停止扩大,未出现需截肢现象。结论经皮腔内球囊扩张联合动脉内灌注尿激酶、前列腺素E1、银杏叶注射液治疗慢性下肢缺血安全有效,能够改善肢体缺血症状,促进溃疡愈合,阻止病变发展;保留血管鞘连续灌注药物有助于保持扩张后的血管通畅。     

中药保留灌肠治疗溃疡性结肠炎42例疗效观察

目的：探讨采用中药汤剂保留灌肠治疗溃疡性结肠炎的临床疗效。方法：将2008-01～2009-04期间我院收治的42例溃疡性结肠炎患者的资料进行回顾性的分析。结果：42例溃疡性结肠炎患者中显效36例,占85.72%;好转6例,占14.28%。脓血便3 d内消失34例,7 d内消失6例,7 d后消失2例。所有病例均无明显不良反应。结论：中药保留灌肠治疗溃疡性结肠炎,简便安全,疗效明显,值得临床推广。     

动脉硬化性闭塞症动脉内药物灌注治疗——附3例报道

目的:探讨动脉内中西药物灌注治疗对于老年性动脉硬化闭塞症患者的效果。方法:3例男性老年性动脉硬化患者,经对侧股动脉穿刺插管,灌注罂粟碱30mg,葛根素300mg,尿激酶40万单位,盐酸山莨菪碱10mg,川芎嗪240mg,上述药物用低分子右旋糖酐210ml和生理盐水210ml稀释后经导管缓慢注入。有下肢感染者注入抗生素。导管保留1周,期间灌注相同药物,1次/d。结果:1周后造影复查缺血下肢血供均有改善,溃疡愈合,避免了截肢。随访患侧下肢缺血症状消失,皮温恢复正常,疼痛消失,达到了临床痊愈。结论:动脉内中西药物灌注治疗对于老年性动脉硬化闭塞症患者是一种有效的方法。     

肠系膜下动脉在晚期卵巢癌及其术后复发介入治疗中的价值

目的 探讨肠系膜下动脉在晚期卵巢癌及其术后复发患者介入治疗中的价值.方法 对34例晚期卵巢癌及术后复发患者(其中晚期22例,术后复发12例)在行常规双侧髂内动脉和(或)子宫动脉化疗和(或)栓塞后,对肠系膜下动脉参与供血者行灌注化疗,并观察其疗效.结果 本组病例中,共有26例肠系膜下动脉参与肿瘤供血.灌注化疗后3周随访CT见肿块皆有不同程度缩小.1例另行栓塞治疗,未出现肠坏死等并发症;其中卵巢癌术后复发者肠系膜下动脉有异常供血占90.9%(20/22),而晚期者则占50.0%(6/12),2组间差异有统计学意义(X2=7.2,P=0.007);卵巢癌FIGO分期Ⅲ期占61.5%(8/13),Ⅳ期占85.7%(18/21),2组间差异无统计学意义(X2=2.608,P=0.16).结论 在晚期卵巢癌,尤其是术后复发患者的血管内介入治疗中,肠系膜下动脉常参与肿瘤的血供,故常规仅行双侧髂内动脉和(或)子宫动脉介人治疗往往疗效不佳.因此对此类患者行血管内介入治疗时,常规探查肠系膜下动脉并进行灌注化疗,具有重要的临床价值.     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.     

Bronchial stump fistula :treatment with covered retrievable hinged metallic stents-preliminary clinical experience

Objective To evaluate the preliminaily clinical efficacy and retrievability of a retrievable hinged covered metallic stent in the treatment of the bronchial stump fistula （BSF）. Methods Between April 2003 and March 2005, 8 patients with bronchial stump fistula after pneumonectomy or lobectomy were treated with two types （A and B） of retrievable hinged covered metallic stents. Type A stent was placed in 6 patients and type B in 2 under fluoroscopic guidance. The stent was removed with a retrieval set when BSF was healed or complications occurred. Results Stent placement in the bronchial tree was technically successful in all patients, without procedure-related complications. Immediate closure of the BSF was achieved in all patients after the procedure. Stents were removed from all patients but one. Removal of the stents was difficult in two patients due to tissue hyperplasia. Patients were followed up for 6 - 21 months. Placement of the stents remained stable in all patients except one due to severe cough. Permanent closure of BSF was achieved in 7 （87.5%） of 8 patients. Conclusion Use of a retrievable hinged covered expandable metallic stent is a simple, safe, and effective procedure for closure of the BSF. Retrieval of the stent seems to be feasible. （J Intervent Radiol, 2007, 16： 253-257）     

Prevalence and severity of hip and groin pain in sub‐elite male football: a cross‐sectional cohort study of 695 players

The purpose of this study was twofold: (a) to investigate the prevalence of hip and groin pain in sub‐elite male adult football in Denmark and (b) to explore the association between prevalence and duration of hip and groin pain in the previous season with the Copenhagen Hip and Groin Outcome Score (HAGOS) in the beginning of the new season. In total 695 respondents from 40 teams (Division 1–4) were included. Players completed in the beginning of the new season (July–Sept 2011) a self‐reported paper questionnaire on hip and/or groin pain during the previous season and HAGOS. In total 49% (95% CI: 45–52%) reported hip and/or groin pain during the previous season. Of these, 31% (95% CI: 26–36%) reported pain for >6 weeks. Players with the longest duration of pain during the previous season had the lowest HAGOS scores, when assessed at the beginning of the new season, P < 0.001. This study documents that half of sub‐elite male adult football players report pain in the hip and/or groin during a football season. The football players with the longest duration of pain in previous season displayed the lowest HAGOS scores in the beginning of the new season.