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According to recent reports from the WHO, noma (or cancrum oris), a hideous, ancient disease primarily affecting children living in poverty in parts of sub-Saharan Africa, is increasing. Noma often starts as an ulcer on the oral mucosa or as ANG and commonly after a bout of measles or other disease. It quickly develops into a massive necrosis, moving from the inside outward, often involving major portions of the face. Early treatment with antibiotics, rehydration, correction of electrolytic imbalances, and administering nutritional supplements will halt the disease. The high mortality rate, however, indicates that many children are not given care or brought for care in time. Surviving victims often display severe facial deformities that demand extensive reconstructive surgery. Current research has elucidated parts of the pathogenesis of noma. The WHO started the international Action Network Against Noma in 1992, with its official launch on the World Health Day in 1994: a five-point action plan was presented and current work follows that plan.  相似文献   

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Lemierre's syndrome is the clinical presentation characterized by oropharyngeal or tonsillar infection, anaerobic septicaemia often with distant septic emboli, and clinical or radiological evidence of thrombosis of the internal jugular vein. We report a case of Lemierre's syndrome in a 44‐year‐old type II diabetic male. This case is unique for two reasons. Firstly, we believe it is the first reported iatrogenic case following a routine dental procedure. Secondly, the internal jugular vein thrombosis was found to occur on the contralateral side to the primary infection.  相似文献   

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Lemierre's syndrome is characterized by thrombophlebitis in the internal jugular vein after an infection in the area of the head or neck, mostly in the form of pharyngitis and/or tonsillitis. It may also result from less common conditions, such as odontogenic infections, but this condition has not often been reported in the dental literature. The syndrome's main etiological agent is Fusobacterium necrophorum, and it most commonly occurs in young adults. This study reports the clinical case of a 34‐year‐old female patient of poor socioeconomic status with a history of pericoronitis, who reported having a chest pain that radiated to the upper limbs, along with dyspnea. The computed tomography of her neck provided evidence of an acute thrombus in the right internal jugular vein. The treatment comprised antibiotic and anticoagulant therapy in addition to the extraction of her third molar and some residual roots. This report highlights the perils of systemic complications through dental infection, including the risk of death.  相似文献   

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Background

The authors systematically reviewed the scientific evidence of an association between periodontal disease and Down syndrome (DS).

Types of Studies Reviewed

In this systematic review, the authors included observational studies in which the investigators assessed the prevalence, incidence, or experience of periodontal disease in patients with DS compared with that in healthy patients. The authors used the Population, Exposure, Comparison, Outcome structure. The population was patients of any age, the exposure was the presence of DS, the comparison was the absence of DS, and the outcome was the presence of periodontal disease. The authors conducted an electronic search in 5 databases through March 2017. Two independent reviewers assessed the risk of bias by using the Fowkes and Fulton scale. The authors performed a meta-analysis to compare periodontal disease among patients with DS and those without DS. The authors calculated a summary effect measure—standard mean difference—when evaluating the means of the oral hygiene index. The authors assessed the strength of evidence from the selected studies by using a modified Grading of Recommendations Assessment, Development and Evaluation system.

Results

The authors included 23 case-control studies in the systematic review and submitted 3 to meta-analysis. In the qualitative analysis, results from most studies showed that the prevalence of some periodontal parameters was higher among patients with DS than among those without DS. Evaluations of the Fowkes and Fulton scale point to many methodological problems in the studies evaluated. Results of the meta-analysis revealed no differences between groups with regard to the oral hygiene index (standard mean difference, 0.05; 95% confidence interval, ?0.55 to 0.65; I2 = 0.0%).

Conclusions and Practical Implications

Further research is required, in particular well-designed studies that avoid the deficiencies identified in the studies in this review.  相似文献   

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One of the greatest figures in the development of the dental profession to the high status it enjoys today is all but forgotten. Jonathan Taft was dean of the second dental school in the world and wrote the most important clinical textbook of his time, one that was reprinted in many editions over a quarter of a century. Later appointed dean of the new University of Michigan Dental School, he instituted innovations in admission requirements and course of study that were copied by all subsequent schools and are the standards adhered to today.The editor of one of the most important dental journals for 44 years, a record unmatched to this day, he set the standards for modern dental periodical literature that have done so much to elevate dentistry that today it stands on a par with medicine as a truly science-based profession. He served dentistry in many capacities: president of the American Dental Association, founder of the National Association of Dental Faculties, and founder of the National Association of Dental Examiners. Over his lifetime, he published almost 200 professional papers and probably attended and lectured at more dental meetings than anyone of his day and since. His memory should be resurrected, and the profession must be made aware of the great debt it owes to this intrepid fighter for a better dental profession.  相似文献   

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