^99Tc^m—MIBI乳房亲肿瘤显像诊断原发性乳腺部及腋淋巴结转移

目的 探讨＾９０Ｔｃ＾ｍ－甲氧基异丁基异腈（ＭＩＢＩ）乳房亲肿瘤显像鉴别诊断乳房肿瘤良恶性及诊断腋淋巴结转移的临床价值。方法 ４６例乳房肿块病人,其中２７例恶性肿瘤,１９例良性病变,在手术前１５ｄ内进行＾９９Ｔｃ＾ｍ－ＭＩＢＩ乳房亲肿瘤显像。病变乳房对侧肘前静脉注射＾９９Ｔｃ＾ｍ－ＭＩＢＩ ７４０ ＭＢｑ后５ｍｉｎ,分别采集俯卧位两侧乳房后斜位图像及仰卧位胸部前位图像。乳房内和（或）腋窝区出现异常     

^99Tc^m—MIBI与^99Tc^m—MDP骨显像诊断骨良恶性病变的比较

目的 对比分析＾９９Ｔｃ＾ｍ－甲氧基异丁基异腈（ＭＩＢＩ）和＾９９Ｔｃ＾ｍ－亚甲基二膦酸盐（ＭＤＰ）对骨良恶性病变的诊断价值和疗效评估。方法 ６１例临床拟诊骨良性病变患者分别进行２项骨显像,其中６例恶性肿瘤患者分别进行化疗前后显像,显像后均经手术,病理检查对比分析。结果 ＾９９Ｔｃ＾ｍ－ＭＩＢＩ显像;７３％恶性肿瘤病灶肉眼见中、高度ＭＩＢＩ浓聚,６０％良性病灶肉眼未见ＭＩＢＩ聚集,恶性病灶部位与对     

^99Tc^m—MIBI在检测乳腺癌中的作用

＾９９Ｔｃ＾ｍ－ＭＩＢＩ（＾９９Ｔｃ＾ｍ－甲氧基异丁基异晴）是第一个经ＦＤＡ（美国食品和药物管理局）批准作为乳腺显像剂的放射性药物。一些前瞻性研究已经显示，＾９９Ｔｃ＾ｍ－ＭＩＢＩ检测乳腺癌的敏感性为８５％，特异性８９％，阳性和阴性预测率分别是８９％和８４％。核素检测乳腺癌有其特殊的临床意义，特别是用于那些不能诊断和诊断有困难的乳腺疾病，评价高危人群，评价对放化疗的反应和检测腋窝转移淋巴结。     

^99mTc—MIBI显像诊断自主功能性甲状腺结节

报告２０例自主功能性甲状腺结节显像的诊断意义，９例＾９９ｍＴｃＯ＾－４显像示正常甲状腺组织完全被抑制的病例，８例＾９９ｍＴｃ－甲氧基异丁基异腈（ＭＩＢＩ）显像正常甲状腺组织显影清晰；１１例正常甲状腺组织不全抑制的病例，＾９９ｍＴｃ－ＭＩＢＩ显像８例显影较＾９９ｍ－ＴｃＯ４显像清晰，３例未见变化。虽然＾９９ｍＴｃ－ＭＩＢＩ显像与ＴＳＨ刺激试验显像的原理不同，但它能使功能受抑制的正常甲状腺组织显像，能     

甲状旁腺显像定位诊断原发性甲状旁腺机能亢进

应用甲状旁腺显像，并经手术及病理确诊１７例原发性甲状旁腺机能亢进患者。我们采用了＾２０１Ｔｌ和＾９９ｍＴｃ－ＭＩＢＩ两种用状旁腺显像剂及＾２０１Ｔｌ／＾９９ｍＴｃＯ＾－４、＾９９ｍＴｃ－ＭＩＢＩ／＾９９ｍＴｃＯ＾－４减影法和＾９９Ｔｃ－ＭＩＢＩ双时相法三种显像方法。１７例的病理结果为１５例甲状旁腺瘤（１例为多发，２个腺瘤），１例癌及１例增生。甲状旁腺显像准确定位１７个腺体，１例假阴性。此例系位于上     

乳腺肿块~(99m) Tc-MIBI双时相显像与X线钼靶对照研究

目的：探讨~(９９ｍ)ＴＣ－ＭＩＢＩ双时相乳腺显像和乳腺钼靶的联合应用对提高患者术前诊断准确性的价值。材料和方法：对疑为乳腺癌的 ３４名患者术前行钼靶检查和~(９９ｍ)Ｔｃ－ ＭＩＢＩ双时相乳腺显像。乳腺钼靶：双乳分别行轴位（头足位）和侧位摄片。乳腺双时相核素显像采用平面显像行正位、双侧斜位、俯卧位时双侧乳腺侧位。所有病例均于两项检查后两星期内行手术获得病理诊断。结果：~(９９ｍ)Ｔｃ－ ＭＩＢＩ乳腺双时相显像示：乳腺的早期和延迟显像一致。恶性病变早期和延迟相的平均Ｔ／Ｎ值分别为１８０±０．６８、１．６４±０．４２,两者Ｐ＞０．０５。~(９９ｍ)Ｔｃ－ＭＩＢＩ乳腺双时相显像敏感性为８８％,特异性为７６％,准确性为８２％。钼靶检查：良性病变诊断的８例中,一例为恶性病变（浸润性导管癌）;病变性质无法确定的１４例中,６例为恶性病变（浸润性导管癌３例,浸润性腺癌２例,鳞癌１例）;恶性病变诊断的１２例中２例为良性病变。钼靶检查病变性质无法确定的１４例中,乳腺双时相显像诊断正确为１２例。结论：~(９９ｍ) Ｔｃ－ＭＩＢＩ乳腺双时相显像和钼靶检查对乳腺肿块的诊断和鉴别诊断中有各自的特点。在临床实践中合理的诊断程序有助于提高诊断准确率,减少不     

乳腺肿物^99mTc—MIBI显像初步临床观察

寻找有效的、无创伤性诊断乳腺癌的方法。方法：对单发、可触及乳腺肿物的７８例患进行了＾９９ｍＴｃ－甲氧基异丁基异腈（ＭＩＢＩ）显像。７８例全部经手术治疗，获得病理结果。结果：７８例中４２例为乳腺癌，其中＾９９ｍＴｃ－ＭＩＢＩ阳性３５例，肿物最小为１．５ｃｍ×１．５ｃｍ×１．２ｃｍ。３６例乳腺良性疾患中＾９９ｍＴｃ－ＭＩＢＩ阴性３０例；６例阳性中有５例为较大的乳腺腺瘤，１例为浆细胞乳腺炎。＾     

继发性甲状腺功能亢进的^99Tc^m—MIBI双时相显像

目的 评价＾９９Ｔｃ＾ｍ－甲氧基异丁基异腈（ＭＩＢＩ）双时相显像法在肾性继发性甲状旁腺功能亢进（ＳＨＰ）患者中的诊断价值。方法 ２０例因慢性肾功能衰竭行血液透析患者,临床诊断与ＳＨＰ,均行双时相法＾９９Ｔｃ＾ｍ－ＭＩＢＩ甲状旁腺显像,运用甲状旁腺／甲状腺（ＰＴ／Ｔ）比值及甲状旁腺指数（ＰＴＩ）观察阳性病灶对ＭＩＢＩ的清除,３例行颈部探查术并作甲状腺自体移植,结果 ８例显像阳性,其中３例手术摘除９枚     

^99Tc^m—MIBI心肌断层显像用于直接PTCA及静脉溶栓治疗AMI的？…

目的 比较直接经皮冠状动脉腔内成形术和静脉溶栓疗法在急性心肌梗死治疗中的效果。方法 １２４例ＡＭＩ患者（直接ＰＴＣＡ组６０例,溶栓组６４例）均于发病２周时和１２周后行＾９９Ｔｃ＾ｍ－甲基异丁基异腈（ＭＩＢＩ）心肌断层显像,将左室心肌分为２０个节段,并对心肌摄取＾９９Ｔｃ＾ｍ－ＭＩＢＩ的程度进行打分,分别计算发病２周时心肌显像的总积分,发病后１２周心肌显像的总积分和两者相减的积分。     

对缺氧代谢敏感的鼠心肌线粒体膜^99Tc^m—MIBI特异性结合蛋白 …

探讨＾９９Ｔｃ＾ｍ－甲氧基异丁基异腈心肌线粒体非膜电位依赖性结合机制。方法分离ＳＤ大鼠心肌线粒体片段和制作心肌超薄切片。用薄层层析法（ＴＬＣ）和ＳＤＳ聚丙酰胺凝胶电泳法（ＳＤＳ－ＰＡＧＥ）分析＾９９Ｔｃ＾ｍ－ＭＩＢＩ特异性结合蛋白。采用有氧－缺氧－再给氧程序分析＾９９Ｔｃ－ＭＩＢＩ对心肌摄取和清除＾９９Ｔｃ＾ｍ－ＭＩＢＩ的影响。结果在ＴＬＣ上可见２个结合９９Ｔｃ＾ｍ－ＭＩＢＩ计数峰。其中之一Ｋｄ值     

~(99m)Tc-MIBI显像对乳腺肿块鉴别诊断的价值

目的　评价99mTc MIBI乳腺肿块显像的规律及特征以及诊断乳腺癌原发病灶的价值。方法　 2 8例患者 ,因乳腺可触及肿块而进行99mTc MIBI显像检查。另外有 14例乳腺未触及异常肿块的患者作为对照组。由肘静脉注射99mTc MIBI 1110MBq ,分别于注射后 5 ,30和 6 0min进行显像 ,于左侧位、右侧位及前后位观察 ,视野包括双侧乳腺及双侧腋窝 ,所有患者在显像 1周内行手术治疗 ,并行活组织病理学检查。结果　99mTc MIBI乳腺显像 ,原发病灶探查的敏感性是 89% ,特异性 90 %。可检查到的最小乳腺肿块为 1.2cm× 1.5cm× 0 .8cm ,病理检查为腺癌 ,乳腺肿块的显像与组织病理学结构有密切的联系。结论　99mTc MIBI乳腺显像在鉴别良恶性肿瘤方面是有效的检查手段     

99Tcm-tetrofosmin在乳腺癌及其转移灶显像中的应用

99Tcm-tetrofosmin作为亲肿瘤显像剂,对乳腺癌原发病灶和腋窝淋巴结转移的诊断有良好的灵敏度、特异性和准确率,可应用于乳腺癌全身骨转移和术后复发的诊断,其应用于乳腺癌前哨淋巴结转移的诊断、作为P-糖蛋白功能显像剂和三维立体定位引导孔针型活检等领域有着良好的发展前景.99Tcm-tetrofosmin乳腺癌及转移灶显像可与其他乳腺癌检查方法相结合提高乳腺癌诊断的准确率.     

99Tcm标记抗粘蛋白McAb乳腺癌放射免疫显像的临床研究

目的　评价99Tcm 标记抗乳腺癌粘蛋白单克隆抗体 (McAb)放射免疫显像 (RII)诊断乳腺癌的临床价值。方法　选择 17例乳腺肿瘤患者进行RII。结果　 9例原发性乳腺癌中 8例RII阳性 ,灵敏度 88 89% ;5例原发性乳腺癌伴腋淋巴结转移及 1例右乳腺浸润性导管癌根治术 5a后出现右腋淋巴结转移 ,RII发现其中 5例出现淋巴结转移 ;而 6例乳腺良性病变和 1例右乳腺单纯癌根治术7a后随访 ,RII阴性。结论　99Tcm 标记抗粘蛋白McAbRII可作为乳腺癌特异性诊断的重要辅助手段 ,并对淋巴结转移、术后复发等具有一定的诊断价值。     

Axillary lymph node uptake of Tc-99m MIBI resulting from extravasation should not be misinterpretated as metastasis

Ipsilateral axillary lymph node visualization due to extravasation of Tc-99m MDP intravenous injection has been well documented. A patient with suspected angina underwent Tc-99m MIBI myocardial SPECT who had extravasation of Tc-99m MIBI in the antecubital region resulting in ipsilateral axillary lymph node uptake. This finding should not be misinterpreted as lymphatic nodal metastasis in a patient with breast cancer or lung cancer.     

Detection of axillary lymph node metastases in breast carcinoma by technetium-99m sestamibi breast scintigraphy,ultrasound and conventional mammography

Axillary lymph node status is important in the staging of breast carcinoma. To evaluate the accuracy of technetium-99m sestamibi breast scintigraphy in detecting metastatic axillary lymph nodes as compared with other accepted imaging modalities, we performed^99mTc-sestamibi breast scintigraphy, conventional mammography and ultrasound in 36 patients with primary untreated breast carcinoma. With histopathology as the gold standard,^99mTc-sestamibi breast scintigraphy was found to yield true-positive results in 7 of 11 cases (64%) of axillary lymph node metastases and true-negative results in 18 of 20 cases (90%); it has an accuracy of 81%, a positive predictive value of 77.8% and a negative predictive value of 81.8%.     

Scintigraphic evolution of a breast cancer with Tc-99m MIBI scintimammography

Early detection and prompt treatment of breast cancer are the main tools to decrease mortality rates. Several diagnostic techniques such as mammography, magnetic resonance imaging, and ultrasound are used, but none of these are conclusive. The authors describe a 56-year-old woman who was suspected of having breast cancer on mammography. Tc-99m MIBI scintimammography showed a small mass with elevated radiotracer uptake located near the pectoral muscle of the patient's left breast. The possible tumor was confirmed with fine-needle aspiration biopsy. After the diagnosis was established, the patient did not allow any treatment. Eighteen months later, a second scintimammography was performed, showing a large mammary tumor with a high radiotracer uptake, a new small lesion located in the left upper quadrant, and axillary lymph node involvement. Chemotherapy treatment was instituted and after treatment, Tc-99m MIBI scintimammography was normal. This case report provides further evidence for Tc-99m MIBI scintimammography for the detection of breast cancer as well as to evaluate the response to chemotherapy.     

Comparative evaluation of Tc-99m MIBI and Tl-201 chloride SPECT in non-small-cell lung cancer mediastinal lymph node metastases

PURPOSE: To compare the utility of Tc-99m MIBI SPECT and Tl-201 chloride SPECT for presurgical assessment of lung cancer mediastinal lymph node metastases. METHODS: Forty-one patients with non-small-cell lung cancer underwent dual-isotope imaging with Tl-201 chloride and Tc-99m MIBI and were evaluated for mediastinal lymph node involvement. RESULTS: The sensitivity rates of early and delayed Tc-99m MIBI SPECT and of early and delayed Tl-201 chloride SPECT for detecting mediastinal nodal metastases were 69%, 69%, 92%, and 92%, respectively. The corresponding specificity rates were 96%, 96%, 93%, and 96%. CONCLUSION: Tl-201 chloride SPECT is superior to Tc-99m MIBI SPECT when used to detect mediastinal lymph node metastases in patients with non-small-cell lung cancer.     

乳腺癌及腋淋巴结转移~(99)Tc~m-tetrofosmin与~(99)Tc~m-MIBI显像的对比研究

目的　比较99Tcm tetrofosmin和99Tcm 甲氧基异丁基异腈 (MIBI)显像诊断乳腺癌和腋淋巴结转移的临床价值。方法　对 5 2例乳腺肿瘤患者进行99Tcm tetrofosmin和99Tcm MIBI显像。患者均在 2周内行外科手术治疗 ,并做病理检查。结果　 2 6例患者病理检查证实为乳腺癌 ,其中 30例为良性病变。99Tcm tetrofosmin显像发现乳腺癌 2 1例 ,其中 11例合并腋淋巴结转移 ;99Tcm MIBI显像发现乳腺癌 19例 ,其中 12例合并腋淋巴结转移。99Tcm tetrofosmin和99Tcm MIBI显像对乳腺癌诊断的灵敏度、特异性和准确性分别为 80 8%、76 7%、78 6 %和 73 1%、73 3%、73 2 % ;诊断腋淋巴结转移的灵敏度、特异性和准确性分别为 6 8 8%、80 0 %、76 0 %和 75 0 %、80 0 %、76 9%。结论　99Tcm tetrofosmin显像对乳腺癌的检出优于99Tcm MIBI显像     

Identification of sentinel lymph node in stage I-II breast cancer with lymphoscintigraphy and surgical gamma probe: comparison of Tc-99m MIBI and Tc-99m sulfur colloid

AIM: To evaluate the efficacy of the surgical gamma probe (SGP) after peritumoral injection of Tc-99m MIBI and filtered Tc-99m sulfur colloid (SC) in sentinel lymph node (SLN) detection in stage I and II breast cancer for deciding on the need for axillary dissection. MATERIALS AND METHODS: Thirty patients with stage I-II breast cancer had peritumoral injection of Tc-99m MIBI (74 MBq/0.2 mL [2 mCi/0.2 mL] at 4 different locations) and 42 different patients had peritumoral injection of filtered Tc-99m sulfur colloid (50 MBq/0.2 mL [1.3 mCi/0.2 mL] at 4 different locations). Anterior, lateral, and anterolateral spot images were acquired at 10, 30, 45, 60, and 120 minutes and 24 hours are injection in 5 patients. During surgery, counts were obtained from the injection site, affected breast tissue, internal mammary, axillary, and supraclavicular regions and the contralateral side using the gamma probe. Peritumoral blue dye was also injected during surgery. The first lymph nodes with counts at least twice the background tissue and/or with blue dye uptake were surgically isolated. Modified radical mastectomy and axillary dissection were performed. RESULTS: Histopathologic evaluation was made on SLN and other excised tissues. In the Tc-99m sulfur colloid group, lymphatic drainage and lymph nodes were demonstrated with lymphoscintigraphy in 31 of 42 patients. SLN was detected by SGP in 35 of 42 patients. In the Tc-99m MIBI group, lymphatic drainage and lymph nodes were visualized with lymphoscintigraphy in 23 of 30 patients. SLN was detected in 25 of 30 patients with SGP in this group. CONCLUSION: In patients with stage I-II breast cancer, SLN could be successfully demonstrated with lymphoscintigraphy and SGP by the peritumoral injection of filtered Tc-99m sulfur colloid and Tc-99m MIBI.