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1.
目的探讨经支气管镜介导氩气刀治疗中央型晚期肺癌气道狭窄的临床效果。方法对55例经支气管镜活检确诊的合并中心气道狭窄的晚期肺癌患者,在支气管镜引导下行氩气刀治疗,并追踪观察。以病变狭窄获得再通、临床症状改善进行疗效评价。结果 55例患者共行氩气刀治疗150次,临床评价完全有效12例(21.82%),部分有效25例(45.45%),轻度有效17例(30.91%),无效1例(1.81%)。结论经支气管镜介导氩气刀治疗中央型晚期肺癌疗效好、并发症少、安全性高。  相似文献   

2.
目的探讨经支气管镜氩气刀治疗气管内肿物的临床效果。方法对18例气道内肿物的患者进行APC治疗,以病变狭窄再通情况、症状缓解情况进行疗效评价。结果 18例患者共进行了36次APC治疗,其中完全有效5例(27.8%),部分有效8例(44.4%),轻度有效4例(22.2%),无效1例(5.6%)。结论 APC治疗气道内肿物取得较好疗效。  相似文献   

3.
目的探讨支气管镜介入热消融术治疗中央型晚期肺癌气道狭窄的临床效果及安全性。方法回顾性分析56例经支气管镜活检病理确诊的合并中心气道狭窄的晚期肺癌患者,在局部麻醉下采用支气管镜介导下联合应用氩气刀和高频电刀治疗;以病变狭窄获得再通、临床症状改善进行即时疗效评价,疗效判断标准:完全有效,患者呼吸困难症状消失,腔内新生物完全清除,气道恢复通畅;部分有效,患者呼吸困难症状改善,腔内新生物大部分被清除,超过50%的狭窄管腔重新开放;轻度有效,患者呼吸困难症状改善,腔内新生物小部分被清除,管腔狭窄改善不足50%,经引流狭窄远端肺部炎症消散;无效,腔内新生物未清除,患者呼吸困难无改善。结果 56例患者共行肿瘤热消融术治疗105次,一般每个患者治疗1~4次,最多一例治疗11次。临床评价完全有效8例(14.3%),部分有效27例(48.2%),轻度有效21例(37.5%),即时有效率为100%。术中、术后患者未出现严重并发症。结论局部麻醉下行支气管镜介入热消融术治疗中央型晚期肺癌疗效佳,并发症少,麻醉风险低,患者耐受好,值得借鉴和临床推广。  相似文献   

4.
目的探讨经纤维支气管镜球囊扩张术治疗结核性气道狭窄的临床价值。方法对22例结核性气管和支气管狭窄患者,在内镜直视下进行球囊扩张治疗,并在术前和最后一次球囊扩张术治疗后当天评价气道开放、近期疗效和肺功能改善情况。结果 22例患者经纤维支气管镜球囊扩张后临床症状明显缓解,即刻疗效达到了95.5%,狭窄段气道直径明显增大(P0.01),气促评分明显降低,术后FEV1明显上升(P0.05)。结论纤维支气管镜下球囊扩张治疗结核性气道狭窄能较好的改善肺通气功能,缓解气促症状,尤其以纤维疤痕为主的气道狭窄疗效好,是一种简单、安全、有效的治疗方法。  相似文献   

5.
目的观察电子支气管镜下氩气刀联合高频电刀及冷冻刀治疗良恶性肿瘤所致气道狭窄的临床疗效。方法对33例良恶性肿瘤导致气道阻塞患者,经电子支气管镜下进行氩气刀、高频电刀及冷冻刀治疗,观察疗效和并发症的发生率。结果 33例患者共进行63次治疗,近期完全有效10例(30.3%),部分有效9例(27.3%),轻度有效12例(36.4%),无效2例(6.0%),33例患者中,术后12例出现痰血,6例出现38.0℃以下低热,无气胸、纵隔气肿、大咯血等严重并发症。结论支气管镜下氩气刀联合高频电刀及冷冻刀治疗良恶性肿瘤引起的气道阻塞疗效显著,对良性肿瘤避免了开胸手术,可达到临床根治;对恶性肿瘤疗效直接,是非常有效的姑息治疗手段。  相似文献   

6.
经纤维支气管镜氩气刀治疗气道狭窄的探讨   总被引:1,自引:0,他引:1  
目的评价经纤维支气管镜氩气刀治疗气道狭窄的应用价值。方法纤支镜对23例气道狭窄患者进行治疗,从狭窄再通疗效、并发症进行评价。结果23例患者进行了治疗,显效14例(61%);有效6例(26%),无效3例(13%)。结论经纤支镜APC治疗气道狭窄是有效、安全、并发症少的方法。  相似文献   

7.
目的 分析良性中央气道狭窄的病因,评价可弯曲支气管镜下腔内介入治疗方法对良性中央气道狭窄的疗效.方法 回顾1999年1月至2006年12月长海医院呼吸内科收治的良性中央气道狭窄患者386例,分析其病因构成,观察可弯曲支气管镜下腔内激光、高频电刀、氩等离子体凝固、冷冻、球囊扩张及支架置入等方法治疗前后的气道直径、FEV1及气促指数的变化,评价其疗效.采用SPSS 10.0软件统计数据,计量资料以(-x)±s表示,治疗前后疗效比较采用配对t检验.结果 386例良性中央气道狭窄患者中支气管结核248例(64.25%),长期气管插管及气管造口术后58例(15.03%),创伤14例(3.63%),吸人性烧伤12例(3.11%),其他包括良性肿瘤(11例,2.85%)、复发性多软骨炎(8例,2.07%)、放疗后损伤(7例,1.81%)、阻塞性气管支气管曲霉病(5例,1.30%)、矽肺(5例,1.30%)、结节病(4例,1.03%)、支气管吻合术后狭窄(4例,1.03%)、气管支气管淀粉样变(4例,1.03%)、骨化性气管支气管病(3例,0.78%)及支气管异物性肉芽肿(3例,0.78%).386例中行支气管镜下腔内介入治疗的患者有347(89.89%),经治疗后胸闷、气促、咳嗽、咳痰等症状均明显好转,气道直径由治疗前的(2.49±1.57)mm增加到(6.41±1.70)mm(t=47.427,P<0.01),气促指数由治疗前的2.40±0.79减少到0.64±0.50(t=44.226,P<0.01).其中住院的115例患者FEV1由治疗前的(2.11±0.60)L增加到(3.46±0.75)L(t=20.128,P<0.01).386例中26例仅用1种腔内介入治疗方法,且单次治疗获得临床治愈;其余360例患者均联合2种以上介入治疗方法.术后3个月的远期疗效为65.54%(253/386).结论 目前,支气管结核是导致良性中央气道狭窄的主要原因.应用支气管镜下腔内介入方法治疗良性中央气道狭窄可获得明显的近期疗效,但远期疗效的维持常需反复多次、联合多种腔内介入治疗才能达到.  相似文献   

8.
目的探讨喉罩通气全麻下经支气管镜介入治疗恶性中心气道狭窄的疗效及安全性。方法分析2013年04月-2014年08月在我科住院15例恶性中心气道狭窄患者临床资料。比较喉罩通气全麻下经支气管镜介入治疗前后患者气促评分、气道狭窄程度、肺功能指标变化及介入术后并发症。结果 15例患者经喉罩通气全麻下介入治疗后气道狭窄程度由术前的(72.1±8.7)%下降至术后(20.1±10.4)%(P0.05),气促评分由术前(3.1±0.7)下降至术后(1.1±0.4)(P0.05),FEV1由术前(57.3±7.5)%上升至术后(78.9±9.2)%(P0.05)。结论喉罩通气全麻下经支气管镜介入治疗恶性中心气道狭窄安全有效。  相似文献   

9.
目的 探讨经纤维支气管镜下高频电凝术、氩等离子凝固术(argon plasma coagulation,APC)方法治疗肺癌伴气道阻塞的疗效、并发症及不良反应.方法 17例经细胞学或病理确诊的肺癌患者,支气管镜下明确有气道阻塞和(或)阻塞性肺炎、肺不张,经支气管镜下行高频电凝术和(或)氩等离子凝固术,术后追踪观察气道狭窄再通程度及患者临床症状并予以评价.结果 17例患者经高频电凝术或氩等离子凝固术治疗共计24次后,临床评价完全有效1例,部分有效13例,轻度有效2例,无效1例,无严重并发症发生.结论 经支气管镜下行高频电凝术、氩等离子凝固术等介入治疗方法能完全或部分消除瘤体,减轻肿瘤负荷,缓解患者症状,且创伤小、并发症及不良反应少,是临床治疗晚期肺癌伴气道阻塞的有效方法,值得进一步推广.  相似文献   

10.
目的探讨经支气管镜介入冷冻联合氩气刀治疗结核性大气道狭窄的疗效。方法对28例支气管结核患者的狭窄气道进行冷冻联合氩气刀治疗,比较治疗前后的临床表现、影像学及镜下改变等指标来进行疗效评价。结果 28例患者经过平均1.6个月和平均4.7次/人的治疗,完全有效57.1%(16/28),部分有效35.7%(10/28),轻度有效7.1%(2/28),无效0例。术中有2例出现气胸,其余的未见明显不良反应,经过1~4月的随访,4例出现再次狭窄而采取支架植入治疗,长期有效率达71.4%(20/28)。结论冷冻联合氩气刀治疗支气管结核是一项安全、有效、简便的支气管治疗方法。  相似文献   

11.
难治性中心气道狭窄的综合介入治疗   总被引:3,自引:0,他引:3  
目的 评价5种介入技术联合应用在难治性中心气道狭窄治疗中的价值.方法 2001年1月至2008年6月第四军医大学唐都医院呼吸科收住的138例难治性中心气道狭窄患者,经临床、肺功能评价后,根据狭窄的病因、类型、部位、程度、长度以及狭窄远端肺组织和气道功能的不同,选择高频电力、氩等离子体凝固(APC)、冷冻、支架置入和高压球囊扩张等5种技术中的2种(包括2种)以上方法.138例中高频电刀+APC治疗42例,高频电刀+冷冻+APC治疗54例,高频电刀+冷冻+APC+支架置入治疗29例,冷冻+APC+高压球囊扩张治疗13例.达到理想效果1个月后评价气道开放、近期疗效和肺功能改善情况.结果 138例患者近期总有效率为100%,气道直径术前为(2.6±1.5)mm,术后为(6.2±1.7)mm;气促评分由术前的(2.4±0.8)减少到术后的(0.7 4±0.6).FEV_1由术前的(1.8±0.6)%上升到术后的(3.1±0.7)%.23例良性病变(包括4例良性肿瘤,15例结核性狭窄和4例其他肉芽肿狭窄)的患者,3个月随访有5例发生再狭窄需要介入治疗,有效率为78.3%(18/23),6个月随访有3例再狭窄需要介入治疗,有效率为86.9%(20/23),12个月随访23例患者均未见明显狭窄.恶性肿瘤狭窄患者未进行远期随访.结论 高频电刀、APC、冷冻、支架置入和高压球囊扩张等5种介入技术联合应用,对难治性中心气道狭窄有较好的效果,该方法并发症少,安令可行,值得临床推广应用.  相似文献   

12.
氩等离子体凝固切除中心气道内阻塞性病变的疗效   总被引:1,自引:1,他引:1  
目的了解氩等离子体凝固切除中心气道内阻塞性病变的疗效。方法2003年11月至2006年12月收治的53例伴有中心气道阻塞性病变患者,男37例,女16例,平均年龄55(14~82)岁,其中恶性肿瘤28例,良性肿瘤13例,其他疾病12例。使用局部麻醉或全身麻醉,支气管镜下应用德国ERBE公司氩等离子体凝固300型机切除病变。根据病变切除程度、狭窄再通和临床资料判断疗效。结果53例患者的病变分布于86处,有效切除病变的成功率分别为:气管内病变97%(35/36),主支气管79%(22/28),叶支气管和中间段支气管64%(14/22);良性病变的成功率(92%,34/37)高于恶性病变(76%,37/49)。中心气道严重阻塞致呼吸衰竭的患者18例,全身麻醉下经氩等离子体凝固治疗即刻缓解。结论氩等离子体凝固适用于切除中心大气道的腔内增生性病变;治疗后即刻起效,可以用于抢救急诊重症病例。重症患者应该给予全身麻醉和机械通气,以提高介入治疗的成功率和安全性。  相似文献   

13.
目的探讨局部麻醉下氩等离子体凝固在气道疾病中应用的有效性及安全性。方法局部麻醉下经电子支气管镜应用氩等离子体凝固(APC)300型氩气刀治疗77例患者的气道阻塞性疾病。结果77例伴有92处中心气道阻塞的患者接受APC300型氩气刀治疗167次,24例恶性肿瘤有效率为84.0%,53例良性肿瘤及支气管结核有效率为94.3%;疗效还与病变位置有关,位于气管的病变有效率为100%,主支气管及右中间段支气管的病变疗效为95.3%,而叶支气管的病变疗效为82.4%。结论在局部麻醉下采用APC300型氩气刀可以有效、安全地治疗气道疾病,特别是大气道的良性病变。  相似文献   

14.
15.
Argon plasma coagulation (APC) is a thermal coagulation technique that uses ionized argon to transmit high-frequency electrical current, contact free, to tissue. APC has been used in surgery for more than 20 years, particularly for the hemostasis of superficial bleeding. Although APC has become well established in gastrointestinal endoscopy since its introduction in 1991, very few reports of its use in bronchoscopy exist to date. From June 1994 to June 1998, 364 patients (80 women, 284 men), 88% with a confirmed malignant tumor, were treated prospectively in a total of 482 sessions. The single most common indication was recanalization of malignant airway stenoses (186 patients). The defined therapy objective was achieved with good results in 67% of patients. More than 90% of interventions were performed with rigid bronchoscopy. Despite less penetration compared with Nd:YAG laser, extensive bronchial tumors were treatable, in which coagulated tumor fractions were removed either with forceps or bronchoscope tip. The second indication was bleeding in the central airways (119 patients). Acute hemostasis was achieved in 118 patients, 20% in whom the flexible technique under local anesthesia was used. In 34 patients, APC was successfully used to recanalize occluded stents. Rare indications included benign endobronchial tumor, fistula conditioning before fibrin adhesion, and the treatment of scar tissue stenosis. Summarizing all complications, a rate of 3.7% "per treatment" was recorded. Two patients died within 24 hours; their deaths were not directly related to APC. APC is an effective and safe technique for the treatment of bronchologic tumor ablation and hemostasis and can be used with local anaesthetic with flexible bronchoscopy or rigid bronchoscopy with general anesthesia. Compared with Nd:YAG laser, APC is an economic alternative technique offering more effective hemostasis. Furthermore, APC is of particular value as a compliment to well-known techniques, increasing the options in interventional bronchoscopy.  相似文献   

16.
目的 通过临床病例资料的分析,对厅前常用的治疗良性瘢痕性气道狭窄的介入技术进行评价,并对影响疗效的相关因素进行讨论.以期寻找最佳的治疗方法.方法 研究选择2004年12月至2009年12月收入北京天坛医院呼吸科的良性瘢痕增生性气道狭窄患者36例,其中男15例、女21例,年龄13~82岁,平均(40±21)岁.根据采用的介入治疗方法不同将患者分为3组,A组使用电凝治疗;B组经电凝治疗后改为针形电刀、球囊扩张和(或冷冻治疗);C组不使用电凝治疗,采用球囊扩张、冷冻和(或)针形电刀治疗.评价不同介入处理方法的疗效及并发症情况,各组间病例资料的比较采用四格表卡方检验.结果 36例患者中治愈9例,治愈率为25%(9/36),有效10例,总体有效率为53%(19/36);无效12例,失败5例,总体无效率47%(17/36).其中电凝治疗有效者1例(1/12,8%),治疗后狭窄段延长8例(8/12,67%);球囊扩张及冷冻和(或)针形电刀治疗有效者14例(14/17,82%),治疗后狭窄段延长2例(2/17,12%).与电凝治疗相比,球囊扩张及冷冻和(或)针形电刀治疗的有效率明显提高,再狭窄率明显减少.结论 急性期气道复张治疗中,目前常用的电凝方法可加重气道再狭窄并最终导致治疗失败,而急性期应用球囊扩张联合针形电刀及冷冻是较为合理且有效的气道复张治疗方法.
Abstract:
Objective To evaluate the efficacy of different interventional bronchoscopic techniques for the management of benign cicatricial hyperplasia airway stenosis,and to study the factors associated with the treatment effects.Methotis From December 2004 to December 2009,36 patients with cicatricial airway stenosis were admitted to our department.An investigation was made to analyze the effects by different interventional bronchoscopie treatments.The most suitable treatment modality for cicatricial airway stenosis was explored and described.Results For the 36 patients,the disease was cured in 9,improved in 10,not improved in 12,and failure in 5.The care rate,effective rate and ineffective rate were 25%,53%and 47%,respectively.Further analysis showed that the effective rate was 8%and 82%respectively for the electrical coagulation therapy and the balloon dilation eombined with needle electrical knife and/or cryotherapy.Restenosis extension after operation occurred in 67%of the cases by electrical coagulation therapy,but only 12% of casesby the balloon dilation combined with needle electrical knife and/or cryotherapy.Conclusions Our experience demonstrated that for the treatment of airway cicatricial stenosis,electrical coagulation might induce and worsen serious airway restenosis resulting in failure of treatment.On the other hand,balloon dilation combined with needle dectrical knife and/or cryotherapy might be a relative safe and effective therapy for airway cicatricial stenosis.  相似文献   

17.
STUDY OBJECTIVES: To assess the efficacy and complications of interventional bronchoscopic techniques in treating airway stenosis due to tracheobronchial tuberculosis. DESIGN: Case series. SETTING: Respiratory care centers at two tertiary care referral teaching hospitals in Japan, Hiroshima City Hospital and Okayama Red Cross Hospital. PATIENTS AND INTERVENTIONS: A total of 30 patients were admitted to the hospital with a diagnosis of tracheobronchial tuberculosis between January 1991 and January 2002. Of those 11 patients received interventional bronchoscopy, including stent placement, laser photoresection, argon plasma coagulation (APC), balloon dilatation, cryotherapy, and endobronchial ultrasonography (EBUS). One patient with complete bronchial obstruction underwent a left pneumonectomy. RESULTS: Six patients underwent stent placement after balloon dilatation, while the remaining five patients underwent only balloon dilatation. In six patients, Dumon stents were successfully placed to reestablish the patency of the central airways. Two patients first had Ultraflex stents implanted but had problems with granulation tissue formation and stent deterioration caused by metal fatigue due to chronic coughing. Dumon stents then were placed within the Ultraflex stents after the patient had received treatment with APC and mechanical reaming using the bevel of a rigid bronchoscope. In four patients, EBUS images demonstrated the destruction of bronchial cartilage or the thickening of the bronchial wall. The main complications of Dumon stents are migration and granulation tissue formation, necessitating stent removal, or replacement, and the application of cryotherapy to the granuloma at the edge of the stent. CONCLUSION: Interventional bronchoscopy should be considered feasible for management of tuberculous tracheobronchial stenosis. Dumon stents seem to be appropriate, since removal or replacement is always possible. Ultraflex stents should not be used in these circumstances because removal is difficult and their long-term safety is uncertain. EBUS could provide useful information in evaluating the condition of the airway wall in cases of tracheobronchial tuberculosis with potential for bronchoscopic intervention.  相似文献   

18.
目的探讨经人工气道支气管镜下冷冻联合氩等离子电凝(APC)治疗晚期中央型肺癌的可行性、安全性。方法回顾分析我院2011年2月至2012年12月经人工气道在支气管镜下对41例晚期中央型肺癌,行冷冻,并联合APC治疗的临床资料进行分析,术后一周评价疗效。评价指标包括术前、术后咳嗽、咯血、发热症状,呼吸困难指数、影像学检查、支气管镜复查气道狭窄情况等。结果患者咳嗽减轻13例(31.7%),咯血缓解14例(34.1%),发热缓解9例(22.0%),术前呼吸困难指数3.5±0.42,术后1.8±0.33;影像学提示阻塞性肺炎、肺不张消退12例(29.3%),好转27例(65.9%),无变化者2例;气管镜复查完全有效17例(41.5%),部分有效21例(51.2%),无效3例(7.3%)。结论经人工气道支气管镜下冷冻联合APC治疗中央气道肿瘤可以缓解咳嗽、咯血、发热、呼吸困难等症状,并发症少,安全性高,值得临床推广。  相似文献   

19.
中央气道阻塞性病变的病因诊断及疗效分析   总被引:1,自引:0,他引:1  
目的 探讨中央气道阻塞的病因、临床特点及诊治手段.方法 回顾性分析2007年4月至2009年6月就诊于解放军总医院呼吸科的中央气道阻塞性病变患者40例,归纳其临床特点.结果 40例中央气道阻塞病变患者中,男29例,女11例,年龄30~82岁,中位年龄为54岁;其中气管鳞癌患者13例(13/40),各种良性肿瘤6例(6/40),腺样囊性癌5例(5/40),食管鳞癌4例(4/40),3例为气管内异物(3/40),慢性炎症3例(3/40),气管结核各2例,纵隔恶性畸胎瘤、M浆细胞瘤、淋巴瘤及气管骨形成症各1例.40例中咳嗽36例,气短或呼吸困难21例,气管鳞癌患者咳血或痰中带血症状多见(11/13).所有患者均行胸部CT检查,21例行气道三维重建,均发现病变.6例行肺功能检查,均可见通气功能障碍及流速-容量环平台.除1例患者不耐受检查,39例患者行气管镜检查均发现病变,32例气道内器质性病变在气管镜检查中经活检钳取得组织标本,初次病理阳性率100%.40例中11例行气管镜下肿瘤圈套术及氩等离子电凝(APC),全部耐受,2 d后临床症状均缓解.结论 中央气道阻塞病因复杂,以恶性病变为主,常见症状为咳嗽及呼吸困难,无特异性表现,胸部CT联合气道重建、气管镜及病理检查可为诊断提供准确信息,根据不同病因及不同病变部位选择治疗方法,尤其APC、电切等介入治疗手段对恶性病变短期疗效明显,安全性好.
Abstract:
Objective To explore the etiology, clinical features, diagnosis and treatment of central airway obstruction (CAO), and therefore to raise awareness of this disease.Methods Forty patients with central airway obstruction were analyzed retrospectively and their clinical characteristics were described.Results Among these 40 cases of CAO, the diagnoses included squamous cell carcinoma (n = 13 ),adenoid cysts ( n = 5 ) , esophageal squamous cell carcinoma ( n = 4 ) , and benign tumor ( n = 6 ).The presenting symptoms included cough(n = 36), shortness of breath or difficulty breathing(n = 21 ), and bemoptysis or bloody sputum which was more common in cases with airway squamous cell carcinoma ( n =11 ).All the patients underwent chest CT examination, and the lesions were evident in all the cases.Twenty-one cases underwent three-dimensional reconstruction of the airway.Six patients underwent pulmonary function test, and ventilatory abnormalities were revealed, and showed the characteristic blunting of the flow-volume loop.Thirty-nine cases underwent bronchoscopy and correct clinical diagnosis was made.Eleven patients received interventional therapy with argon plasma coagulation ( APC ), and their symptoms were all relieved within 2 days.Conclusions CAO may be caused by variety of diseases, but the most common cause is malignancy.The common symptoms of CAO are cough and dyspnea.Chest CT with airway reconstruction, bronchoscopy and pathological examination can provide accurate information for diagnosis.The choice of treatment modalities depends on the size, location and the pathology of the lesions.APC is a safe and effective therapy for short-term management of malignant lesions.  相似文献   

20.
目的 探讨目前经气管镜介入治疗结核性气道狭窄的临床效果、并发症及展望.方法 回顾性分析北京天坛医院2006年10月至2008年10月间经气管镜介入治疗结核性气道狭窄的临床资料.结果 目前的介入方法如氩等离子体凝固术、冷冻术、球囊扩张、金属支架放置等联合治疗结核性气道狭窄12例,全部即时效果理想,经治疗后胸闷、气促、咳嗽、咯痰等症状均明显好转,气道直径由治疗前的(2.71±1.89)mrn增加到(8.42±.75)mm(P<0.01).气促指数由治疗前的(2.83±1.14)减少到(0.83±0.69)(P <0.01).远期再狭窄率为75%,对再次介入治疗依然反应良好.结论 目前经气管镜介入治疗结核性气道狭窄是一种可供选择的治疗方法,但远期再狭窄发生率较高.  相似文献   

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