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Bon Seok Koo MD Yeo-Hoon Yoon MD Jin-Man Kim MD Eun Chang Choi MD Young Chang Lim MD 《Annals of surgical oncology》2009,16(5):1344-1347
Background The extent of neck dissection (ND) appropriate for necks yielding clinical evidence of metastases of papillary thyroid carcinoma
(PTC) is controversial. The need for Ievel IIb lymph node (LN) dissection is particularly uncertain in view of its association
with postoperative shoulder dysfunction. In the present study, we examined the frequency, pattern, and predictive factors
of level IIb LN metastases in PTC patients with clinically positive lateral neck nodes.
Methods We reviewed the medical records of 76 PTC patients who underwent therapeutic lateral ND for the treatment of clinically positive
lateral neck nodes between March 2005 and July 2008. ND specimens were separately obtained for analyzing LN involvement with
respect to neck level.
Results Metastatic disease at levels II, III, IV, and V, was seen in 40 (52.6%), 55 (72.4%), 52 (68.4%), and 12 (15.8%) of the patients,
respectively. The metastasis rate in level IIb was 11.8% (9 of 76). By univariate analysis, the rate of level IIb LN metastasis
was significantly higher in patients with positive level IIa LNs and positive LNs in all lateral neck levels (levels IIa +
III + IV) (P < .05). Multivariate analysis showed that positive LN involvement in all lateral neck levels (IIa + III + IV) was an independent
predictive factor of level IIb LN metastasis (P = .044, odds ratio = 9.692).
Conclusions Level IIb LN dissection may be omitted in the treatment of positive neck nodes in PTC patients if multilevel involvement including
level IIa involvement is absent. 相似文献
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Background
Delphian lymph node (DLN) metastasis has long been considered a prognostic marker of head and neck malignancy. These days, the significance of DLN in thyroid cancer has come to the fore. The objective of the present study was to evaluate the clinical significance of DLN metastasis in patients with papillary thyroid cancer (PTC).Patients and methods
The study was carried out between July 2009 and December 2011, and DLN was detected in 245 of 898 PTC patients who underwent total thyroidectomy and bilateral central compartment neck dissection. In those 245 patients DLN status was correlated with clinical and pathologic factors, including age, gender, tumor size, extrathyroidal extension (ETE), lymphovascular invasion (LVI), and central and lateral nodal metastasis.Results
DLN metastasis was found in 20 % of the patients studied (49 of 245), and DLN metastasis was correlated with tumor size, multicentricity, bilaterality, and LVI excluding ETE (all p < 0.05). The proportion of male patients was higher in the DLN metastasis positive group than in the DLN metastasis negative group (34.7 vs. 13.3 %; p < 0.05). Most of the patients (95.9 %) with DLN metastasis had other central neck node metastasis, and the metastatic central lymph node ratio was higher (0.38 ± 0.23 versus 0.09 ± 0.16; p < 0.001) and lateral neck node metastasis was more common (2.6 vs. 32.7 % <0.001) than in patients without DLN metastasis. For central and lateral compartment nodal metastasis, DLN status had sensitivity, specificity, positive and negative predictive values of 100, 37.4, 58.1, and 100 %, and 85.3, 76.2, 97.4, and 32.7 %, respectively. Multivariate analysis showed that the factors affecting DLN involvement were tumor size and LVI. Patients with positive DLN were ~1.6 times more likely to have further central compartment disease and 3.6 times more likely to have lateral compartment disease.Conclusions
DLN metastasis in patients with PTC is related to a number of poor prognostic factors. Furthermore DLN involvement implies that the patients are predicted to have heavy burden of central neck node metastasis and are more likely to have further lateral neck node metastasis. It is recommended that DLN is evaluated and dissected in all patients with thyroid cancer. If DLN metastasis is suspected, the surgeon should thoroughly dissect the central neck compartment and pay particular attention to the lateral lymph node compartments. 相似文献6.
目的探讨甲状腺乳头状癌颈部淋巴结的转移规律及合理的手术方式。方法回顾性分析我院2004年9月至2009年9月期间收治的221例甲状腺乳头状癌患者的临床资料。结果本组行甲状腺全切除术32例,次全切除术189例。术后病理学诊断单侧甲状腺癌202例(91.40%),双侧甲状腺癌19例(8.60%)。甲状腺的原发肿瘤直径0.2~8.0 cm,平均3.5 cm。有包膜侵犯50例;多灶性33例。每侧颈清扫淋巴结数目10~24个,平均14.3个。颈部淋巴结转移总发生率为37.56%(83/221),中央组(Ⅵ区)淋巴结转移发生率为33.94%(75/221),颈深组(Ⅱ+Ⅲ+Ⅳ区)淋巴结转移发生率为18.10%(40/221)。当肿瘤直径>1.0 cm、肿瘤突破甲状腺包膜、多发灶或年龄>45岁时Ⅵ区及Ⅱ+Ⅲ+Ⅳ区的同侧淋巴结转移发生率明显增加(P<0.05)。结论甲状腺乳头状癌最常见的淋巴结转移为Ⅵ区淋巴结,其次为Ⅱ+Ⅲ+Ⅳ区淋巴结,初次手术应常规清扫Ⅵ区淋巴结,当肿块直径>1.0 cm、癌肿突破甲状腺包膜时或B超、CT等影像学检查有颈部淋巴结转移时,应清扫Ⅱ+Ⅲ+Ⅳ区淋巴结。 相似文献
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Background
The purpose of the present study was to evaluate the reliability of central lymph node metastases in predicting lateral node involvement in papillary thyroid carcinoma (PTC). 相似文献8.
目的评估乳头状甲状腺癌(PTC)颈淋巴结的转移方式及相关影响因素在颈部不同区域淋巴结转移中的意义。方法回顾性分析笔者所在医院甲状腺外科2008年12月至2011年12月3年期间行手术治疗的223例PTC患者的临床资料,就患者性别、年龄、术前TSH水平、肿瘤直径、是否为多灶、是否侵及甲状腺被膜及其周围组织、是否合并桥本甲状腺炎、是否合并结节性甲状腺肿以及肿瘤的T分期等因素与颈部不同区域的淋巴结转移之间的关系进行分析。结果单变量分析结果显示,年龄≥45岁及合并结节性甲状腺肿与中央区淋巴结转移有关(P〈0.05),多发病灶与颈侧区淋巴结转移有关(P〈0.05);多变量分析结果显示,年龄≥45岁及合并结节性甲状腺肿是中央区淋巴结转移的保护因素(P〈0.05),多发病灶是颈侧区淋巴结转移的危险因素(P〈0.05)。Ⅱ-Ⅳ区是颈侧区淋巴结转移的常见区域,其中Ⅲ区转移率最高,达100%;当出现跳跃性转移时,Ⅱ-Ⅳ区是转移高发区域。结论对年龄〈45岁的PTC患者应常规进行中央区淋巴结清扫;如果患者同时合并结节性甲状腺肿,中央区淋巴结转移的风险会显著降低;当原发肿瘤为多发病灶时,应加强术中对Ⅱ-Ⅳ区淋巴结的探查,尤其是Ⅲ区淋巴结;当可疑跳跃性转移出现时,Ⅱ-Ⅳ区淋巴结应是常规清扫范围。 相似文献
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Background
We aimed to study whether positron emission tomography/computed tomography (PET/CT) findings are associated with lymph node staging, as outlined by the 7th edition American Joint Committee on Cancer (AJCC) TNM staging system in patients with esophageal squamous cell carcinoma (ESCC). 相似文献10.
Background
Although occult lymph node metastasis to the lateral neck compartment is common in papillary thyroid carcinoma, the incidence and patterns of lateral neck node metastasis in papillary carcinoma are not known. We hypothesized that sentinel lymph node biopsy (SLNB) with radioisotope in the detection of occult lateral neck node metastasis would be useful in characterizing metastasis in papillary carcinoma. 相似文献11.
Jin Young Kwak MD Eun-Kyung Kim MD Min Jung Kim MD Eun Ju Son MD Woong Youn Chung MD Cheong Soo Park MD Kee-Hyun Nam MD 《Annals of surgical oncology》2009,16(5):1348-1355
Background Preoperative prediction of lateral lymph node metastasis (LNM) is important to prevent recurrence; however, there are few
published data in predicting factors of lateral LNM before surgery. The present study investigated the factors affecting LNM
in patients with papillary thyroid microcarcinoma (PTMC).
Methods A retrospective cohort study was conducted with data obtained from 671 patients with PTMC between 2004 and 2006. We reviewed
the clinical, ultrasound (US), and pathology records of patients and analyzed the association between lateral LNM and clinical
factors, US features of PTMC, and pathologic features.
Results The rate of lateral LNM was 3.7% in 671 PTMCs. We found a statistically significant association between lateral LNM and US
features of PTMC (upper pole location, contact of >25% with the adjacent capsule, and presence of calcifications), and pathologic
features (central LNM) in multivariate analysis (P < .05). The odds ratios of statistically significant factors were 4.7 (95% confidence interval [95% CI], 1.8–12.6), 10.8
(95% CI, 3.3–34.6), 4.8 (95% CI, 1.6–13.7), and 6.9 (95% CI, 2.4–20) at upper pole location, contact of >25% with the adjacent
capsule, presence of calcifications on US, and pathologic central LNM, respectively.
Conclusions In patients with PTMC, independent factors in predicting lateral LNM were US features of PTMC (upper pole location, >25% contact
with the adjacent capsule, and presence of calcifications) and pathologic features (central LNM). When these US features are
detected on preoperative US, lateral neck nodes should be meticulously evaluated by a multimodal approach. 相似文献
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Griffin Martha J. Baik Fred M. Brandwein-Weber Margaret Qazi Muhammad Yue Lauren E. Osorio Marcela Urken Mark L. 《World journal of surgery》2020,44(6):1892-1897
World Journal of Surgery - Current American Thyroid Association (ATA) guidelines state that patients with intermediate-risk papillary thyroid cancer (PTC) may benefit from remnant ablation. One... 相似文献
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We report a case of axillary lymph node metastasis (LNM) from papillary thyroid carcinoma (PTC) in a 21-year-old man. The
patient presented with bilateral cervical and right axillary lymphadenopathy, and computed tomography (CT) showed a primary
tumor of the thyroid and gross lymphadenopathy from the neck to the right axilla. We performed a total thyroidectomy with
therapeutic nodal dissection. The resection of the primary thyroid tumor and all the node metastases was curative. Pathological
examination confirmed that the resected lesions were PTC and nodal metastases from the primary tumor. Six years after the
operation, cervical, upper mediastinal, and axillary lymph node recurrence developed and multiple lung metastases were found
on a CT scan. He was treated with radioactive iodine therapy. Axillary LNM from PTC is unusual and seems to be associated
with a poor prognosis. Thus, comprehensive treatment strategies are needed to improve the outcome of patients with PTC who
present with axillary LNM. 相似文献
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Background : Autophagy is believed to be important in tumorigenesis and tumor progression. The human beclin-1 gene, a key regulator of autophagy formation, located on chromosome 17q21, has been identified as the mammalian orthologue of Atg6 (autophagy-related gene) and may be a haploinsufficient tumor suppressor gene. Loss of expression or point mutation could serve as a mechanism of loss of beclin-1 tumor suppressor function in cancers. However, our recent study revealed that point mutation of the beclin-1 gene is a rare event in papillary thyroid carcinoma (PTC).Methods : We investigated the expression of beclin-1 in human PTC. Tissue samples from 86 cases of papillary thyroid carcinoma were used for the present study. 57 cases of papillary thyroid carcinoma were with lymph node metastasis. The expression of beclin-1 in tumor, normal tissue adjacent to tumor, distant normal tissue, metastatic lymph node and normal lymph node was examined with immunohistochemistry. The beclin-1 expression between tumor and normal tissue, metastatic and normal lymph node was also analyzed.Results : The expression of beclin-1 was detected in 88.4% (76/86) of the tumors and 98.2% (56/57) of metastatic lymph nodes. In contrast, normal tissues adjacent to tumor, distant normal tissues and normal lymph nodes showed no or very weak expression of beclin-1. Beclin-1 was significantly correlated with tumorigenesis and lymph node metastasis in human PTC.Conclusions : High expression of beclin-1 in PTC and metastatic lymph node suggest that neo-expression of beclin-1 may play a role in tumorigenesis and lymph node metastasis in human PTC. 相似文献
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Clinical Significance of Lymph Node Metastasis of Thyroid Papillary Carcinoma Located in One Lobe 总被引:5,自引:4,他引:1
Ito Y Jikuzono T Higashiyama T Asahi S Tomoda C Takamura Y Miya A Kobayashi K Matsuzuka F Kuma K Miyauchi A 《World journal of surgery》2006,30(10):1821-1828
Background Previous studies have shown that lymph node metastasis can be of prognostic value. In this study, we investigated the clinical
significance of node metastasis focusing on metastasis in the central compartment for patients with papillary carcinoma located
in one lobe.
Patients and Methods We investigated the frequency of lymph node metastasis in 759 patients with papillary carcinoma to determine whether and how
such metastasis affects disease-free survival (DFS).
Results Central node metastasis was observed in 63% of patients, and the frequency was increased in relation to tumor size. The frequency
of lateral node metastasis was 62.0%, which was also directly related to tumor size. On multivariate analysis of cases showing
tumor larger than 1 cm, central node metastasis was recognized as an independent prognostic factor of DFS. The frequency of
metastasis to the paratracheal nodes contralateral to the tumor was drastically elevated for tumors larger than 1 cm, but
metastasis to this region did not independently predict worse DFS.
Conclusion Central node metastasis independently predicts a worse DFS for patients with papillary carcinoma larger than 1 cm. 相似文献
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Shinya Morita Kenji Mizoguchi Masanobu Suzuki Keiji Iizuka 《World journal of surgery》2010,34(11):2564-2569
Background
The aim of this study was to evaluate the accuracy of [18F]-fluoro-2-deoxy-d-glucose-positron emission tomography/computed tomography, ultrasonography, and enhanced computed tomography alone in the preoperative diagnosis of lymph node metastasis in patients with papillary thyroid carcinoma. 相似文献18.
Superior Located Papillary Thyroid Microcarcinoma is a Risk Factor for Lateral Lymph Node Metastasis
Annals of Surgical Oncology - It is important to identify prognostic factors for lateral lymph node metastasis (LLNM) in papillary thyroid microcarcinoma (PTMC) because they determine the extent of... 相似文献
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Because of the rarity of mediastinal lymph node metastasis, no evidence exists regarding risk factors indicating its presence.
This study aimed to identify risk factors representing potential triggers of imaging for mediastinal lymph node metastasis.
Carried out was an analysis of 392 consecutive patients with node-positive papillary thyroid cancer referred to a tertiary
surgical center. Significant univariate associations (P ≤ 0.001) existed, after correction for multiple testing, between mediastinal lymph node metastasis and poor tumor differentiation
(24% versus 2%), number of positive lymph nodes (mean 14.4 versus 7.3 nodes), and distant metastasis (43% versus 11%). Only
nominally significant were age at first tumor diagnosis (47.7 versus 39.1 years; P = 0.042), extrathyroidal tumor extension (76% versus 53%; P = 0.044), and bilateral lymph node metastasis (81% versus 49%; P = 0.006). In the initial and optimized multivariate logistic regression models, which included all significant variables from
the above analysis, only poor tumor differentiation (odds ratio 11.6–14.6) and distant metastasis (odds ratio 5.4–6.1) represented
significant (P ≤ 0.005) predictors of mediastinal lymph node metastasis. These two variables featured excellent negative predictive values
of 96%. Regarding prediction of mediastinal lymph node metastasis, poor tumor differentiation was more discriminatory than
distant metastasis, as reflected in a better accuracy (94% versus 86%) and positive predictive value (42% versus 18%). We
conclude that, subject to validation in independent series, patients with poorly differentiated papillary thyroid cancers,
which are rare, should be ideal candidates for mediastinal imaging because 5 of 12 patients (42%) having this condition in
the present investigation harbored mediastinal lymph node metastasis. 相似文献
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Ito Y Higashiyama T Takamura Y Miya A Kobayashi K Matsuzuka F Kuma K Miyauchi A 《World journal of surgery》2007,31(11):2085-2091
Background Although papillary carcinoma usually shows mild characteristics, it metastasizes and shows recurrence to the lymph node in
high incidences. Of the two representative lymph node compartments to which papillary carcinoma metastasizes, the central
compartment can be routinely dissected via the surgical incision made for thyroidectomy. However, the routine application
of prophylactic lateral node dissection (modified radical neck dissection [MND]) remains controversial. In this study, we
investigated risk factors for lymph node recurrence of papillary carcinoma to determine the appropriate application of prophylactic
MND.
Methods We investigated risk factors for lymph node recurrence in 1,231 patients without preoperatively detectable lateral node metastasis
who underwent thyroidectomy, central node dissection, and prophylactic MND for papillary carcinoma between 1987 and 1995.
Results The incidence of lateral node metastasis and the number of metastatic lateral nodes significantly increased with carcinoma
size. The lymph node disease-free survival (LN-DFS) was also significantly worse in carcinoma with a maximal diameter greater
than 3 cm. Massive extrathyroid extension, male gender, and age 55 years or older also reflected a poorer LN-DFS. The 10-year
LN-DFS rates of patients with carcinoma having two and three or four of these features were low at 88.5% and 64.7%, respectively,
although the rates of those with carcinoma having no or only one characteristic were better than 95%.
Conclusions Prophylactic MND is recommended for cases of papillary carcinoma demonstrating two or more of the following four characteristics;
male gender, age 55 years or older, maximal tumor diameter larger than 3 cm, and massive extrathyroid extension. 相似文献