Gastroscopic Observation of 22 Cases with Special Types of Early Gastric Cancer

ＧａｓｔｒｏｓｃｏｐｉｃＯｂｓｅｒｖａｔｉｏｎｏｆ２２ＣａｓｅｓｗｉｔｈＳｐｅｃｉａｌＴｙｐｅｓｏｆＥａｒｌｙＧａｓｔｒｉｃＣａｎｃｅｒ￥ＳｈｅｎＹｕｎｚｈｉ，ｅｔａｌ．ＡＣＴＡＡＣＡＤＥＭＩＡＥＭＥＤＩＣＩＮＡＥＮＡＮＪＩＮＧ，１９９４，１４（１）...     

Fructus Bruceae Emulsion in Treatment of 10 Cases of Prostate Carcinoma

ＦｒｕｃｔｕｓＢｒｕｃｅａｅＥｍｕｌｓｉｏｎｉｎＴｒｅａｔｍｅｎｔｏｆ１０ＣａｓｅｓｏｆＰｒｏｓｔａｔｅＣａｒｃｉｎｏｍａＮａｎＸｕｎ－ｙｉ（南勋义）；ＺＨＡＮＧＹｕｅ（张越）；ＨＥＤａ－ｌｉｎ（贺大林）；ＤＡＮＧＪｉａｎ－ｇｏｎｇ（党建功）；ｗＡＮ...     

Colonic Dialysis Therapy of Chinese Herbal Medicine in Abstinence of Heroin Addicts-Report of 75 Cases

Ｃｏｌｏｎｉｃ　Ｄｉａｌｙｓｉｓ　Ｔｈｅｒａｐｙ　ｏｆ　Ｃｈｉｎｅｓｅ　Ｈｅｒｂａｌ　Ｍｅｄｉｃｉｎｅ　ｉｎ　Ａｂｓｔｉｎｅｎｃｅ　ｏｆ　Ｈｅｒｏｉｎ　Ａｄｄｉｃｔｓ－Ｒｅｐｏｒｔ　ｏｆ　７５　ＣａｓｅｓＳＨＡＬｉ－ｊｕｎ；ＺＨＡＮＧＺｈｉ－ｘｉａｎ...     

Forensic Pathological Expertise of Medical Tangle Analysis of 139 Autopsy Cases

ＦｏｒｅｎｓｉｃＰａｔｈｏｌｏｇｉｃａｌＥｘｐｅｒｔｉｓｅｏｆＭｅｄｉｃａｌＴａｎｇｌｅＡｎａｌｙｓｉｓｏｆ１３９ＡｕｔｏｐｓｙＣａｓｅｓＺＨＡＮＧＹｉ－ｇｕ（张益鹄）；ＷＡＮＧＺｕｏ－ｆｅｉ（王佐飞）；ＨＵＡＮＧＧｕａｎｇ－ｚｈａｏ（黄光照）（Ｄｅ...     

Construction of Shuttle Expression Plasmid and Stable Expression of Foreign Gene in Mycobacteria and E．Coli

ＣｏｎｓｔｒｕｃｔｉｏｎｏｆＳｈｕｔｔｌｅＥｘｐｒｅｓｓｉｏｎＰｌａｓｍｉｄａｎｄＳｔａｂｌｅＥｘｐｒｅｓｓｉｏｎｏｆ　ＦｏｒｅｉｇｎＧｅｎｅｉｎＭｙｃｏｂａｃｔｅｒｉａａｎｄＥ．ＣｏｌｉＨＵＡＮＧＦＵＹｏｎｇ－ｍｕ（皇甫永修）；ＺＨＡＮＧＤａ－ｊｕ...     

Efficacy of Fructus Bruceae Emulsion withChemotherapy in Treatment of Advanced Pulmonary Carcinoma

ＥｆｆｉｃａｃｙｏｆＦｒｕｃｔｕｓＢｒｕｃｅａｅＥｍｕｌｓｉｏｎｗｉｔｈＣｈｅｍｏｔｈｅｒａｐｙｉｎＴｒｅａｔｍｅｎｔｏｆＡｄｖａｎｃｅｄＰｕｌｍｏｎａｒｙＣａｒｃｉｎｏｍａＳＵＮＫａｉ（孙慨）；ＷＥＩＧｕｉ－ｚｈｅｎ（魏桂珍）ａｎｄＷＡＮＧＹａ－ｘ...     

Screening of Anti-SIV Drugs from Chinese Medicinal Herbs

ＳｃｒｅｅｎｉｎｇｏｆＡｎｔｉ－ＳＩＶＤｒｕｇｓｆｒｏｍＣｈｉｎｅｓｅＭｅｄｉｃｉｎａｌＨｅｒｂｓＧｕａｎＣｈｏｎｇ－ｆｅｎ（关崇芬）；ＷａｎｇＹｉ－ｚｈｅ（王忆浙）；（ＩｎｓｔｉｔｕｔｅｏｆＢａｓｉｃＴｈｅｏｒｙ，ＣｈｉｎａＡｃａｄｅｍｙｏｆＴｒａ...     

Synthesis of Glycoproteins by Mucosa of Gastric Antrum in Chronic GastritisB

ＳｙｎｔｈｅｓｉｓｏｆＧｌｙｃｏｐｒｏｔｅｉｎｓｂｙＭｕｃｏｓａｏｆＧａｓｔｒｉｃＡｎｔｒｕｍｉｎＣｈｒｏｎｉｃＧａｓｔｒｉｔｉｓＢＴＩＡＮＤｅ－ａｎ（ＤｅｐａｒｔｍｅｎｔｏｆＧａｓｔｒｏｅｎｔｅｒｏｌｅｇｙ，ＴｏｎｇｊｉＨｏｓｐｉｔａｌ，Ｔｏｎｇｊ...     

Gastroscopic Observation and Analysis of 89 Cases of Portal Hypertensive Gastroduodenal Mucosal Lesions

ＧａｓｔｒｏｓｃｏｐｉｃＯｂｓｅｒｖａｔｉｏｎａｎｄＡｎａｌｙｓｉｓｏｆ８９ＣａｓｅｓｏｆＰｏｒｔａｌＨｙｐｅｒｔｅｎｓｉｖｅＧａｓｔｒｏｄｕｏｄｅｎａｌＭｕｃｏｓａｌＬｅｓｉｏｎｓ￥ＣｈｏｕＺｅｎｇｆｅｎ（周曾芬）（ＤｅｐａｒｔｍｅｎｔｏｆＧａｓｔ...     

Clinical report of seven cases of bone marrow form of acute radiation sickness

Ｃｌｉｎｉｃａｌｒｅｐｏｒｔｏｆｓｅｖｅｎｃａｓｅｓｏｆｂｏｎｅｍａｒｒｏｗｆｏｒｍｏｆａｃｕｔｅｒａｄｉａｔｉｏｎｓｉｃｋｎｅｓｓ￥ＧｒｏｕｐｏｆＦｉｒｓｔＡｉｄａｎｄＴｒｅａｔｍｅｎｔ．ＧｒｏｕｐｏｆＡｄｖｉｓｏｒｓＡｂｓｔｒａｃｔ：ＯｎＪｕｎｅ...     

门脉高压性血管病变研究

采用免疫组化技术，辅以形态观察，研究３０例肝硬变患者胃冠状静脉的病理变化。发现其内膜受损，组织炎性水肿，中膜平滑肌增殖肥大，细胞外基质增多，管壁因而纤维化、硬化并增厚。表明肝硬变门静脉高压症可合并“门脉高压性血管病变。”     

Portal Hypertensive Vascular Lesions

（杨镇）（刘仁则）（杨榕光）（裘法祖）ＰｏｒｔａｌＨｙｐｅｒｔｅｎｓｉｖｅＶａｓｃｕｌａｒＬｅｓｉｏｎｓＹＡＮＧＺｈｅｎ；ＬＩＵＲｅｎｚｈｅ；ＹＡＮＧＲｏｎｇｇｕａｎｇ；ＱｉｕＦａｚｕ（ＤｅｐａｒｔｍｅｎｔｏｆＳｕｒｇｅｒｙ，ＴｏｇｎｊｉＨｏｓｐｉｔ...     

多层螺旋CT肝脏灌注预测肝硬化门静脉高压并上消化道出血风险性价值

目的 探究多层螺旋CT肝脏灌注预测肝硬化门静脉高压并上消化道出血风险性价值。方法 对笔者医院肝硬化门静脉高压者进行研究,其中未出血者31例,出血者21例,另选取30例体检正常者作为对照组,所有研究对象均进行CT灌注成像。对比3组肝动脉灌注量（HAP）、门静脉灌注量（PVP）、肝脏总灌注量（THP）、肝动脉灌注指数（HPI）以及静脉内径参数：门静脉直径（PVD）、脾静脉直径（SVD）、肠系膜上静脉直径（SMVD）、胃冠状静脉直径（GCVD）水平,统计脾门-胃底静脉血管截面数量、血管总面积,创建受试者工作特征曲线（ROC）,对比不同指标曲线下面积（AUC）。结果 与对照组比较,肝硬化门静脉高压患者PVP、THP降低,HPI升高,出血组变化程度高于未升高组;与对照组比较,肝硬化门静脉高压患者PVD、SVD、SMVD、GCVD水平以及血管截面数量、血管总面积均升高,且出血组静脉内径变化程度高于未出血组,差异均有统计学意义（P<0.05）。Logistic多因素回归分析显示,GCVD、血管截面数量、血管面积与上消化道出血发生具有显著相关性（OR=1.398,OR=1.427,OR=1.394）,差异有统计学意义（P<0.05）。ROC曲线显示血管面积AUC值（0.826）高于GCVD、血管截面数量（0.702、0.768）,预测价值最高。结论 GCVD、血管截面数量、血管面积均能够预测肝硬化门静脉高压并上消化道出血,其中静脉血管面积预测价值最高。     

Pathological morphology alteration of the splanchnic vascular wall in portal h ypertensive patients

目的：研究门静脉高压症患内脏血管壁的病理形态学改变。方法：50例门静脉高压症患在行脾切除和贲门周围血管离断术时,取脾动脉、静脉和胃冠状静脉,行光镜和电镜观察。免疫组化法分析脾动脉壁诱导型一氧化氮合成酶（iNOS）的表达。结果：脾动脉的内弹力膜和中膜内弹力纤维断裂和变性。脾动脉平滑肌细胞可见萎缩、凋亡和表型改变。平滑肌细胞的胞浆内可见iNOS阳性表达。肝硬化患可见内脏静脉内膜增生,静脉壁有广泛的附壁血栓,类粥样硬化斑块形成,平滑肌细胞肥大,静脉肌纤维明显增粗和增厚,管壁细胞外基质增加。结论：门静脉高压症可合并内脏动脉和静脉的血管病变,在门静脉高压症的发病机制中,门静脉高压、内脏高动力循环和内脏血管病变之间具有相互影响的关系。     

Liver cirrhosis as a real risk factor for necrotising fasciitis: a three-year population-based follow-up study

INTRODUCTION

Necrotising fasciitis (NF) is often found in patients with diabetes mellitus, chronic renal failure, alcoholism, malignancy or liver cirrhosis. However, it remains unknown whether liver cirrhosis is an independent risk factor for the occurrence of NF. This study aimed to determine whether liver cirrhosis is an independent risk factor for the occurrence of NF, and to identify the relationship between severity of liver cirrhosis and occurrence of NF.

METHODS

The National Health Insurance Research Database, maintained by Taiwan’s National Health Insurance programme, was retrospectively analysed, and the hospitalisation data of 40,802 cirrhotic patients and 40,865 randomly selected, age- and gender-matched non-cirrhotic control patients was collected. The medical records of all patients were individually followed for a three-year period from the patients’ first hospitalisation in 2004.

RESULTS

During the three-year follow-up period, there were 299 (0.7%) cirrhotic patients with NF and 160 (0.4%) non-cirrhotic patients with NF. Cox regression analysis showed that liver cirrhosis was a risk factor for the occurrence of NF during the study period (hazard ratio 1.982; p < 0.001). Among cirrhotic patients, those with complicated liver cirrhosis had a higher risk for the occurrence of NF than patients with non-complicated liver cirrhosis (hazard ratio 1.320; p = 0.028).

CONCLUSION

Cirrhotic patients had a higher risk for the occurrence of NF than non-cirrhotic patients, and the risk for NF was especially high among patients with complicated liver cirrhosis.     

超声引导下中心静脉导管技术治疗糖尿病合并胃癌的疗效分析

目的 探究超声引导下中心静脉导管技术对糖尿病合并胃癌患者的治疗效果及对脂肪因子、胰岛素样生长因子1(IGF-1)表达的影响。方法 选取2018年1月—2019年6月在大连市中心医院接受治疗的糖尿病合并胃癌患者150例,将所有患者随机分为直接盲穿组和超声引导组,每组75例。采用酶联免疫吸附试验检测抵抗素、瘦素、脂联素水平。采用流式细胞仪检测外周血胰岛素样生长因子受体1(IGFR-1)、人第10号染色体缺失的磷酸酶及张力蛋白同源的基因（PTEN）、IGF-1水平。统计穿刺成功和术中血管损伤、导管漂移患者。结果 超声引导组患者治疗前后抵抗素、瘦素、脂联素、癌胚抗原、糖类抗原19-9的降低幅度大于直接盲穿组（P <0.05）。超声引导组IGFR-1、IGF-1蛋白相对表达量低于直接盲穿组（P <0.05）,PTEN蛋白相对表达量高于直接盲穿组（P <0.05）。超声引导组患者一次穿刺成功率、总成功率高于直接盲穿组（P <0.05）,血管损伤发生率、导管漂移发生率低于直接盲穿组（P <0.05）。超声引导组总有效率高于直接盲穿组（P <0.05）,不良反应发生...     

经皮经肝组织黏合剂介入栓塞治疗食管静脉曲张疗效分析

目的 探讨经皮经肝TH胶栓塞治疗食管静脉曲张的临床疗效和影响因素.方法 经皮经肝门静脉穿刺插管将TH胶注射到食管下段曲张静脉、胃底贲门周围静脉和冠状静脉主干,实现曲张静脉及其供血静脉的永久栓塞.本技术治疗肝硬化食管静脉曲张92例,术前均有消化道出血病史,18例为急症出血时栓塞.术后胃镜和CT评价治疗效果.结果 89例栓塞成功,成功率96.7%(89/92),3例1个月内死亡.余86例根据TH胶栓塞范围,分为食管-胃底型40例;胃底-贲门型栓塞33例;冠状静脉主干型栓塞13例.40例食管-胃底型栓塞者食管静脉曲张均改善(100%),其中29例静脉曲张消失(72.5%);33例胃底-贲门型栓塞者29例明显缓解(87.8%),15例静脉曲张消失(45.5%);而13例主干型栓塞者,仅2例缓解(15.4%),静脉曲张均未消失.随访6～52个月(平均31.5个月),总静脉曲张复发率14.1%(10/71),3种栓塞类型静脉曲张复发率分别为7.5%(3/40)、17.2%(5/29)和2/2,组间差异有统计学意义,食管胃底型栓塞组静脉曲张复发率明显低于胃底贲门型及冠状静脉主干型(P＜0.01);再出血率16.3%(14/86),食管胃底型再出血率7.5%(3/40),胃底型再出血率15.2%(5/33),主干型再出血率69.2%(9/13),三者差异有统计学意义(P=0.0092).随访期间总病死率24.7.6%(22/89),食管胃底型与胃底贲门型病死率差异无统计学意义,但主干型栓塞病死率明显较高(P=0.013).89例患者均未出现严重的异位栓塞.结论 经皮经肝TH胶栓塞能使食管下段曲张静脉及其供血血管永久性栓塞,是防治食管静脉曲张破裂出血的有效方法,其远期疗效与TH胶栓塞范围密切相关.     

胃癌组织中VEGF-C、VEGF-D、VEGFR-3蛋白表达及其临床意义

目的 探讨胃癌原发灶、癌旁及胃周淋巴结组织中血管内皮生长因子C(VEGF-C)、血管内皮生长因子D(VEGF-D)、血管内皮生长因子受体3(VEGFR-3)蛋白表达与各临床参数的关系.方法 通过免疫组化方法对60例胃癌患者的癌、癌旁及胃周淋巴结组织中VEGF-C、VEGF-D、VEGFR-3蛋白水平进行检测,并分析各临床参数包括肿瘤分化程度、Lauren分型、肿瘤浸润深度、是否有淋巴结转移、幽门螺杆菌(H.pylori)感染与否等对胃癌组织中VEGF-C、VEGF-D、VEGFR-3蛋白表达水平的影响.结果 胃癌组织中VEGF-C、VEGF-D蛋白表达水平高于癌旁组织(2.82士1.66 vs 2.13±1.75,4.81±2.30 vs 3.78±1.94,n=60,P均＜0.05).VEGFR-3蛋白表达水平在胃癌组织和癌旁组织中差异无统计学意义(P＞0.05).胃癌转移的淋巴结组织中VEGF-C、VEGF-D、VEGFR-3的蛋白表达水平(3.77±2.43、2.86士1.95、2.55±2.11,n=44)均高于未转移淋巴结组织(2.25士2.01、1.98士1.73、0.76±1.13,n=59,P均＜0.05).关于各临床参数的分析结果显示VEGF-C、VEGF-D的蛋白表达水平在伴有淋巴结转移的胃癌组织中高于未出现淋巴结转移的胃癌组织(P＜0.05),H.pylori感染阳性的胃癌组织中VEGFR-3的蛋白表达水平高于H.pylori阴性的胃癌组织(P＜0.05).结论 VEGF-C、VEGF-D蛋白表达水平在胃癌原发灶及转移淋巴结中上调,且与胃癌的淋巴转移有关.     

Changes in serum ammonia concentration in cirrhotic patients with Helicobacter pylori infection

Objective To study whether liver cirrhosis associated with Helicobacter pylori (H. pylori) infection will induce increased serum ammonia and whether the peripher al serum ammonia reflects the level of portal vein serum ammonia. Methods Blood was taken from the portal vein and the cubital vein in cirrhotic patients with and without H. pylori infection and non-cirrhotic patients (splenic rupture) with and without H. pylori infection, and the serum ammonia was measured.Results The mean levels of serum ammonia in the group of cirrhotic patients with H. pylori infection were 167.82±8.97 μmol/L (portal vein) and 142.2±13.35 μmol/L (cubital vein). They were increased significantly as compared with cirrhotic patients without H. pylori infection (47.68±12.03 μmol/L portal vein and 37.23±7.04 μmol/L cubital vein), and also compared with the groups of splenic rupture patients with and without H. pylori infection ( P &lt;0.01). There was no significant difference between the serum ammonia level of the cubital vein and portal vein (P&gt;0.05).Conclusions H. pylori infection can induce an increase in serum ammonia in patients with liver dysfunction, and the peripheral serum ammonia measurement may replace the portal vein serum ammonia as a monitoring method. Eradication of H. pylori in cirrhotic patients may prevent hepatic encephalopathy (HE).     

重组血管内皮生长因子165对肝硬化大鼠肝功能的影响

 目的探讨经门静脉导入重组血管内皮生长因子165 对肝硬化大鼠肝功能的影响。方法雄性SD 大鼠50 只,体质量180~220 g,完全随机分成正常组10 只、诱导模型组40 只。采用硫代乙酰胺诱导肝硬化模型方法,10 周后成模25 只。模型组随机分为肝硬化实验组15 只和肝硬化对照组10 只。实验组经门静脉插管植入Alzet 微渗泵灌注血管内皮生长因子入门静脉,持续作用2 周。正常组和肝硬化对照组行开腹后关腹对照处理。2 周后处死各组大鼠,HE 染色观察大鼠肝脏病理组织学改变;全自动生化分析仪检测血清中的丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、白蛋白（ALB）和总胆红素（TBIL）含量。结果肝硬化对照组肝细胞变性坏死、弥漫纤维结缔组织增生,有假小叶形成。而肝硬化实验组变性坏死程度减轻,纤维结缔组织增生范围缩小,纤维化分级有明显改善,差异具有统计学意义（P < 0.01）。肝硬化对照组ALT、AST、TBIL均显著升高,ALB 下降,同正常组相比差异具有统计学意义（P < 0.01）。肝硬化实验组同肝硬化对照组比较,ALT、AST、TBIL 均显著下降,ALB 上升,差异具有统计学意义[（115.71±12.63）U/L vs （192.36±21.84）U/L;（196.26±18.45）U/L vs （295.11±31.78）U/L;（6.32±1.32）μmol/L vs（10.69±2.47）μmol/L;（14.57±1.92）g/L vs（9.90±1.27）g/L;P < 0.01）]。结论经门静脉灌注血管内皮生长因子165具有改善肝硬化大鼠肝脏功能的作用。