双针法硬化灌注治疗婴幼儿面部化脓性肉芽肿23例安全性分析

目的寻找一种简单、安全有效的注射方法,治疗婴幼儿面部化脓性肉芽肿。方法采用双针法对化脓性肉芽肿(PG)进行硬化灌注治疗,使PG失血供,达到坏死脱落的目的。观察婴幼儿PG患者的临床治愈率和疗效。结果 23例患儿共治疗24次,均达临床治愈标准,1次治愈率达95.7%,术后无瘢痕或其他明显不良反应。随访最长12个月无复发。结论采用双针法硬化灌注治疗婴幼儿化脓性肉芽肿,安全有效,且操作简单不受剂量限制,是一种安全的、值得推广的治疗方法。     

电灼法治疗化脓性肉芽肿60例

我科近四年来,运用高频电针电灼法治疗化脓性肉芽肿患者6 0例(Granulomapyogenicum) ,取得了满意的效果,现报告如下:1　资料与方法1 1　临床资料　6 0例患者均为门诊经临床确诊的患者。其临床表现为绿豆、黄豆大小,极少数有花生米大小的鲜红或棕红色的柱状赘肉,表面血痂或出血。其中男32例,女2 8例。年龄14～6 6岁,病程15天～2个月。部位在面、额、口唇、手、足等处,但以头面、手部多见。1 2　治疗方法与护理1 2 1　治疗方法　局部皮肤常规消毒后,用2 %利多卡因作局部浸润麻醉。然后用多功能电离子手术治疗仪(GX -Ⅲ型,广西科学院应用研…     

二氧化碳激光治疗与液氮冷冻治疗化脓性肉芽肿的疗效比较

笔者自2004年1月-2008年8月治疗化脓性肉芽肿患者96例,分别采用二氧化碳(CO2)激光治疗与液氮冷冻治疗,并对两组疗效进行比较,现将结果 报道如下.     

液氮冷冻治疗化脓性肉芽肿46例疗效分析

目的评价液氮冷冻治疗化脓性肉芽肿的临床疗效。方法回顾性分析2004年8月~2006年4月本科门诊采用液氮冷冻治疗并随访观察6个月的46例化脓性肉芽肿患者病例资料。结果经过1~3次(平均1.41次)液氮冷冻治疗后所有患者均获痊愈,每位患者均有不同程度的疼痛,持续时间1~6天(平均2.8天),所有患者均无局部感染情况出现。随访结束时,除1例出现较原发皮疹小的平整瘢痕组织外,余无明显不良反应。。结论液氮冷冻治疗化脓性肉芽肿是一种操作简单、安全、有效的治疗方法。     

液氮冷冻治疗化脓性肉芽肿

化脓性肉芽肿形态各异,我们根据具体病情,采取不同冷冻方法治疗了185例患者,取得了满意的效果,现总结如下。     

夹刮法治疗肢端化脓性肉芽肿76例

化脓性肉芽肿是皮肤科门诊比较常见一种良性血管结节状增生病变。可发生于任何年龄,以家庭主妇、园林工人、农民等中老年人多见。常好发于身体容易受外伤的部位,如手足、面部、头皮、躯干等。我院皮肤科就诊的化脓性肉芽肿患者以修剪指甲、刀切、铁丝刮破、玻璃划伤等原因居多。皮肤黏膜破溃创面因消毒处理不当,造成毛细血管和微小静脉呈分叶状增生而形成外观息肉状损害。     

化脓性肉芽肿三种治疗方法的疗效观察

目的比较液氮冷冻、二氧化碳(CO2)激光和微波三种物理治疗方法对化脓性肉芽肿的治疗效果及术后瘢痕情况。方法将218例化脓性肉芽肿患者分为三组,分别用液氮冷冻、CO2激光、微波进行治疗并观察各组疗效。结果三种方法治疗有效率比较无明显差异(P0.05),液氮冷冻组与CO2激光组、微波组在一次性治愈率方面差异有显著性(P0.01)。同时微波组瘢痕最轻,激光组最重(:CO2激光组液氮冷冻组微波组)。结论本组实验三种物理治疗方法对化脓性肉芽肿疗效均良好,一次性治愈率CO2激光和微波优于液氮冷冻;微波治疗对组织损伤较小,瘢痕形成较轻。     

液氮冷冻治疗头面部化脓性肉芽肿35例疗效观察

目的：评价液氮冷冻治疗头面部化脓性肉芽肿的临床疗效。方法：回顾性分析2007年10月～2009年10月我科门诊采用液氮冷冻治疗的35例头面部化脓性肉芽肿患者临床资料,观察疗效和不良反应。结果：经过2～3次（平均2.69次）液氮冷冻治疗后所有患者均获痊愈,每位患者均有不同程度的疼痛,持续时间1～3天（平均1.3天）,所有患者均无局部感染出现。结论：液氮冷冻治疗面部化脓性肉芽肿是一种操作简单、安全、有效的治疗方法,值得临床推广应用。     

电灼术联合聚甲酚磺醛治疗化脓性肉芽肿疗效观察

目的:评价电灼术联合聚甲酚磺醛治疗化脓性肉芽肿的临床疗效。方法:选择77例化脓性肉芽肿患者电灼治疗,术后给予聚甲酚磺醛止血、抗感染。结果:手术时间1~10 min,出血量0~0.5 mL。随访3个月,一次性治愈74例(96.1%),显效3例(3.9%)。结论:电灼法联合聚甲酚磺醛治疗化脓性肉芽肿效果显著,手术时间短,操作简单易行,止血效果好。     

长脉冲Nd:YAG 1064nm激光治疗化脓性肉芽肿疗效观察

目的:探讨长脉冲Nd∶YAG 1 064 nm激光治疗化脓性肉芽肿的疗效和安全性。方法:采用长脉冲Nd∶YAG 1 064 nm激光治疗化脓性肉芽肿32例,能量密度:70~100 J/cm2,脉宽:45 ms,光斑大小:6 mm。1个月后复查,皮损未愈者再次治疗至皮损消失。观察患者治疗后效果及不良反应。结果:长脉冲Nd∶YAG 1 064 nm激光治疗化脓性肉芽肿1次痊愈率为75%,2次痊愈率为87.5%,总痊愈率为100%,愈后无1例患者出现瘢痕、色素沉着或色素减退,随访3个月无复发。结论:长脉冲Nd∶YAG1 064 nm激光治疗化脓性肉芽肿临床疗效好,安全性高及不良反应少,值得临床推广。     

误诊为化脓性肉芽肿的黑素瘤1例

患者女,78岁。左足内踝出现结节伴出血10年余,加重1月。曾以"化脓性肉芽肿"予以冷冻治疗,后皮损大部分消退,出血症状缓解。皮肤科情况:左足内踝下方4.0cm处可见直径0.5cm大圆形淡红色丘疹,表面光滑,伴少量鳞屑,质中,边缘呈环状,皮损中央有鲜血流出,周围可见卫星状大小不等的色素斑点。诊断:黑素瘤。     

Nail disorders associated with cast immobilization of the forearm and wrist: report of two cases and review of the literature

Cast immobilization is used in the management of various injuries of joints and/or limbs. A variety of nail disorders have been reported in association with cast immobilization of the forearm and wrist among a limited number of patients so far. The mechanism was not clearly identified in some of these cases. Here, the authors report two patients with nail disorders appeared after the removal of immobilization cast of forearm and wrist and review the literature.     

A Randomized, Placebo-Controlled Trial of Topical Retinol in the Treatment of Cellulite

Background

Cellulite occurs to varying degrees on the thighs and buttocks of many otherwise healthy women. Among the many purported treatments for cellulite, only a handful have been tested in clinical trials.

Objective

The aim of this study was to critically explore the reputed effect of topical retinol in the treatment of cellulite.

Materials and Methods

The study compared the effect of topical retinol to a placebo formulation in a left-right randomized trial in order to eliminate the massage-effect. The study was conducted in 15 women aged from 26 to 44 years who had requested liposuction to improve mild to moderate cellulite.

Results

After 6-months of treatment, skin elasticity was increased by 10.7% while viscosity was decreased by 15.8% at the retinol-treated site. Such an effect on the tensile properties of skin was more prominent where the mattress phenomenon was the only evidence of cellulite. The lumpy-bumpy appearance of the skin showed either little response or was not responsive to the treatment. Although gross microanatomical differences were not disclosed between the comparative sites at completion of the study, evidence for a shift in the phenotype of connective tissue cells was obtained. The main retinol-related change consisted of a 2- to 5-fold increase in the number of factor XIIIa⁺ dendrocytes both in the dermis and fibrous strands of the hypodermis.

Conclusions

We hypothesize that the functional and phenotypic changes seen in this study were linked and represent the result of a direct or indirect modulating effect of retinol on cellulite. Such features ultimately improve the resting tensions inside the skin which should in turn smooth the skin surface.     

喷昔洛韦凝胶治疗复发性生殖器疱疹的随机双盲平行对照临床试验

目的评价1%喷昔洛韦凝胶治疗复发性生殖器疱疹的临床疗效及安全性。方法采用随机双盲、有效对照、平行分组试验,与1%喷昔洛韦乳膏作对照进行疗效和安全性比较。结果观察可供疗效评价的生殖器疱疹病例55例,其中试验组27例,对照组28例。痊愈率70.37%(对照组75.00%),有效率88.89%(对照组100.00%)。不良反应发生率为3.70%(对照组3.57%)。两组的痊愈率、有效率及不良反应发生率在统计学上均无显著性差异。结论1%喷昔洛韦凝胶治疗生殖器疱疹的疗效和不良反应发生率与1%喷昔洛韦乳膏相似,1%喷昔洛韦凝胶生殖器疱疹具有较好的疗效和安全性。     

特比萘芬合用地巴唑治疗甲真菌病的随机双盲对照研究

目的 观察特比萘芬与地巴唑联合治疗甲真菌病的疗效。方法 甲真菌病患者随机分组,治疗组口服特比萘芬250mg每日1次,同时口服地巴唑10mg每日3次;对照组口服特比萘芬250mg每日1次,同时口服安慰剂。治疗组指甲真菌病疗程为6周,趾甲疗程为8周;对照组指甲真菌病疗程为8周,趾甲疗程为10周。观察2种方法的疗效。结果 治疗后第24周随访,治疗组54例痊愈率为70.4%(38/54例),有效率为83.3%(45/54例);对照组51例痊愈率为66.7%(34/51例),有效率为80.4%(41/51例),两组比较差异均无显著性(P>0.05)。结论 特比萘芬与血管扩张剂联合治疗甲真80.4%(41/51例),两组比较差异均无显著菌病能缩短疗程,且无明显不良反应。     

Granuloma as a complication of polycaprolactone-based dermal filler injection: ultrasound and histopathology studies

In aesthetic medicine, there has been an ongoing search for an ideal dermal filler to offer zero complication rate. Polycaprolactone-based dermal filler (PCL) has been available since 2009.

The purpose of the paper was to present a case of granuloma as a complication of PCL injection, which has not been reported so far by other researchers. A 68-year-old female was injected with PCL. One year later, nodules accompanied by bluish skin discoloration developed within the injection site. Ultrasound and histopathology studies were performed. The examinations confirmed the presence of foreign body granuloma after PCL, which makes it the first reported case worldwide. The published data analyses showed general lack of studies and case reports to address this issue. The PCL, like an injection of any soft tissue filler, may lead to serious complications, such as granuloma formation. This makes further research legitimate and necessary.     

左西替利嗪与西替利嗪治疗慢性荨麻疹多中心随机双盲对照研究

目的 研究和比较左西替利嗪和西替利嗪治疗慢性荨麻疹的疗效和安全性.方法 选择慢性荨麻疹患者为研究对象,采用多中心、随机、双盲、对照临床研究.试验组盐酸左西替利嗪片每日1次,每次5mg,对照组盐酸西替利嗪片每日1次,每次10mg,均连续服用28d.分别于用药后第7、14、28天随访,观察疗效和不良反应.结果 入选病例132例,可评价疗效和安全性病例均为130例.ITT分析左西替利嗪组治疗后第7、14、28天有效率分别为73.44%、82.81%、89.06%,西替利嗪组有效率分别为77.27%、81.82%、81.82%,两组比较差异无显著性.左西替利嗪组和西替利嗪组不良反应发生率分别为14.06%和18.18%,主要有口干、嗜睡.结论 左西替利嗪治疗慢性荨麻疹安全有效.